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+                    GNU GENERAL PUBLIC LICENSE
+                       Version 3, 29 June 2007
+
+ Copyright (C) 2007 Free Software Foundation, Inc. <https://fsf.org/>
+ Everyone is permitted to copy and distribute verbatim copies
+ of this license document, but changing it is not allowed.
+
+                            Preamble
+
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+  IN NO EVENT UNLESS REQUIRED BY APPLICABLE LAW OR AGREED TO IN WRITING
+WILL ANY COPYRIGHT HOLDER, OR ANY OTHER PARTY WHO MODIFIES AND/OR CONVEYS
+THE PROGRAM AS PERMITTED ABOVE, BE LIABLE TO YOU FOR DAMAGES, INCLUDING ANY
+GENERAL, SPECIAL, INCIDENTAL OR CONSEQUENTIAL DAMAGES ARISING OUT OF THE
+USE OR INABILITY TO USE THE PROGRAM (INCLUDING BUT NOT LIMITED TO LOSS OF
+DATA OR DATA BEING RENDERED INACCURATE OR LOSSES SUSTAINED BY YOU OR THIRD
+PARTIES OR A FAILURE OF THE PROGRAM TO OPERATE WITH ANY OTHER PROGRAMS),
+EVEN IF SUCH HOLDER OR OTHER PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF
+SUCH DAMAGES.
+
+  17. Interpretation of Sections 15 and 16.
+
+  If the disclaimer of warranty and limitation of liability provided
+above cannot be given local legal effect according to their terms,
+reviewing courts shall apply local law that most closely approximates
+an absolute waiver of all civil liability in connection with the
+Program, unless a warranty or assumption of liability accompanies a
+copy of the Program in return for a fee.
+
+                     END OF TERMS AND CONDITIONS
+
+            How to Apply These Terms to Your New Programs
+
+  If you develop a new program, and you want it to be of the greatest
+possible use to the public, the best way to achieve this is to make it
+free software which everyone can redistribute and change under these terms.
+
+  To do so, attach the following notices to the program.  It is safest
+to attach them to the start of each source file to most effectively
+state the exclusion of warranty; and each file should have at least
+the "copyright" line and a pointer to where the full notice is found.
+
+    <one line to give the program's name and a brief idea of what it does.>
+    Copyright (C) <year>  <name of author>
+
+    This program is free software: you can redistribute it and/or modify
+    it under the terms of the GNU General Public License as published by
+    the Free Software Foundation, either version 3 of the License, or
+    (at your option) any later version.
+
+    This program is distributed in the hope that it will be useful,
+    but WITHOUT ANY WARRANTY; without even the implied warranty of
+    MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
+    GNU General Public License for more details.
+
+    You should have received a copy of the GNU General Public License
+    along with this program.  If not, see <https://www.gnu.org/licenses/>.
+
+Also add information on how to contact you by electronic and paper mail.
+
+  If the program does terminal interaction, make it output a short
+notice like this when it starts in an interactive mode:
+
+    <program>  Copyright (C) <year>  <name of author>
+    This program comes with ABSOLUTELY NO WARRANTY; for details type `show w'.
+    This is free software, and you are welcome to redistribute it
+    under certain conditions; type `show c' for details.
+
+The hypothetical commands `show w' and `show c' should show the appropriate
+parts of the General Public License.  Of course, your program's commands
+might be different; for a GUI interface, you would use an "about box".
+
+  You should also get your employer (if you work as a programmer) or school,
+if any, to sign a "copyright disclaimer" for the program, if necessary.
+For more information on this, and how to apply and follow the GNU GPL, see
+<https://www.gnu.org/licenses/>.
+
+  The GNU General Public License does not permit incorporating your program
+into proprietary programs.  If your program is a subroutine library, you
+may consider it more useful to permit linking proprietary applications with
+the library.  If this is what you want to do, use the GNU Lesser General
+Public License instead of this License.  But first, please read
+<https://www.gnu.org/licenses/why-not-lgpl.html>.

data/cfg.py

@@ -0,0 +1,59 @@
+import argparse
+
+
+def parse_args():    
+    parser = argparse.ArgumentParser()
+    parser.add_argument('-net', type=str, default='sam', help='net type')
+    parser.add_argument('-baseline', type=str, default='unet', help='baseline net type')
+    parser.add_argument('-encoder', type=str, default='default', help='encoder type')
+    parser.add_argument('-seg_net', type=str, default='transunet', help='net type')
+    parser.add_argument('-mod', type=str, default='sam_adpt', help='mod type:seg,cls,val_ad')
+    parser.add_argument('-exp_name', default='msa_test_isic', type=str, help='net type')
+    parser.add_argument('-type', type=str, default='map', help='condition type:ave,rand,rand_map')
+    parser.add_argument('-vis', type=int, default=None, help='visualization')
+    parser.add_argument('-reverse', type=bool, default=False, help='adversary reverse')
+    parser.add_argument('-pretrain', type=bool, default=False, help='adversary reverse')
+    parser.add_argument('-val_freq',type=int,default=5,help='interval between each validation')
+    parser.add_argument('-gpu', type=bool, default=True, help='use gpu or not')
+    parser.add_argument('-gpu_device', type=int, default=0, help='use which gpu')
+    parser.add_argument('-sim_gpu', type=int, default=0, help='split sim to this gpu')
+    parser.add_argument('-epoch_ini', type=int, default=1, help='start epoch')
+    parser.add_argument('-image_size', type=int, default=256, help='image_size')
+    parser.add_argument('-out_size', type=int, default=256, help='output_size')
+    parser.add_argument('-patch_size', type=int, default=2, help='patch_size')
+    parser.add_argument('-dim', type=int, default=512, help='dim_size')
+    parser.add_argument('-depth', type=int, default=1, help='depth')
+    parser.add_argument('-heads', type=int, default=16, help='heads number')
+    parser.add_argument('-mlp_dim', type=int, default=1024, help='mlp_dim')
+    parser.add_argument('-w', type=int, default=4, help='number of workers for dataloader')
+    parser.add_argument('-b', type=int, default=2, help='batch size for dataloader')
+    parser.add_argument('-s', type=bool, default=True, help='whether shuffle the dataset')
+    parser.add_argument('-warm', type=int, default=1, help='warm up training phase')
+    parser.add_argument('-lr', type=float, default=1e-4, help='initial learning rate')
+    parser.add_argument('-uinch', type=int, default=1, help='input channel of unet')
+    parser.add_argument('-imp_lr', type=float, default=3e-4, help='implicit learning rate')
+    parser.add_argument('-weights', type=str, default = 0, help='the weights file you want to test')
+    parser.add_argument('-base_weights', type=str, default = 0, help='the weights baseline')
+    parser.add_argument('-sim_weights', type=str, default = 0, help='the weights sim')
+    parser.add_argument('-distributed', default='none' ,type=str,help='multi GPU ids to use')
+    parser.add_argument('-dataset', default='isic' ,type=str,help='dataset name')
+    parser.add_argument('-sam_ckpt', default=None , help='sam checkpoint address')
+    parser.add_argument('-thd', type=bool, default=False , help='3d or not')
+    parser.add_argument('-chunk', type=int, default=None , help='crop volume depth')
+    parser.add_argument('-num_sample', type=int, default=4 , help='sample pos and neg')
+    parser.add_argument('-roi_size', type=int, default=96 , help='resolution of roi')
+    parser.add_argument('-evl_chunk', type=int, default=None , help='evaluation chunk')
+    parser.add_argument('-mid_dim', type=int, default=None , help='middle dim of adapter or the rank of lora matrix')
+    parser.add_argument('-multimask_output', type=int, default=1 , help='the number of masks output for multi-class segmentation, set 2 for REFUGE dataset.')
+    parser.add_argument(
+    '-data_path',
+    type=str,
+    default='../data',
+    help='The path of segmentation data')
+    # '../dataset/RIGA/DiscRegion'
+    # '../dataset/ISIC'
+    opt = parser.parse_args()
+
+    return opt
+
+# required=True, 

data/conf/__init__.py

@@ -0,0 +1,15 @@
+""" dynamically load settings
+
+author baiyu
+"""
+import conf.global_settings as settings
+
+
+class Settings:
+    def __init__(self, settings):
+
+        for attr in dir(settings):
+            if attr.isupper():
+                setattr(self, attr, getattr(settings, attr))
+
+settings = Settings(settings)

data/conf/global_settings.py

@@ -0,0 +1,54 @@
+""" configurations for this project
+
+author Junde
+"""
+import os
+from datetime import datetime
+
+#CIFAR100 dataset path (python version)
+#CIFAR100_PATH = '/nfs/private/cifar100/cifar-100-python'
+
+#mean and std of cifar100 dataset
+CIFAR100_TRAIN_MEAN = (0.5070751592371323, 0.48654887331495095, 0.4409178433670343)
+CIFAR100_TRAIN_STD = (0.2673342858792401, 0.2564384629170883, 0.27615047132568404)
+
+GLAUCOMA_TRAIN_MEAN = (0.5070751592371323, 0.48654887331495095, 0.4409178433670343)
+GLAUCOMA_TRAIN_STD = (0.2673342858792401, 0.2564384629170883, 0.27615047132568404)
+
+MASK_TRAIN_MEAN = (2.654204690220496/255)
+MASK_TRAIN_STD = (21.46473779720519/255)
+
+#CIFAR100_TEST_MEAN = (0.5088964127604166, 0.48739301317401956, 0.44194221124387256)
+#CIFAR100_TEST_STD = (0.2682515741720801, 0.2573637364478126, 0.2770957707973042)
+
+#directory to save weights file
+CHECKPOINT_PATH = 'checkpoint'
+
+#total training epoches
+EPOCH = 100 
+step_size = 10
+i = 1
+MILESTONES = []
+while i * 5 <= EPOCH:
+    MILESTONES.append(i* step_size)
+    i += 1
+
+#initial learning rate
+#INIT_LR = 0.1
+
+#time of we run the script
+TIME_NOW = datetime.now().strftime("%F_%H-%M-%S.%f")
+
+#tensorboard log dir
+LOG_DIR = 'runs'
+
+#save weights file per SAVE_EPOCH epoch
+SAVE_EPOCH = 10
+
+
+
+
+
+
+
+

data/dataset/__init__.py

@@ -0,0 +1,230 @@
+import numpy as np
+import torchvision.transforms as transforms
+from torch.utils.data import DataLoader, random_split
+from torch.utils.data.sampler import SubsetRandomSampler
+
+from utils import *
+
+from .atlas import Atlas
+from .brat import Brat
+from .ddti import DDTI
+from .isic import ISIC2016
+from .kits import KITS
+from .lidc import LIDC
+from .lnq import LNQ
+from .pendal import Pendal
+from .refuge import REFUGE
+from .segrap import SegRap
+from .stare import STARE
+from .toothfairy import ToothFairy
+from .wbc import WBC
+
+
+def get_dataloader(args):
+    transform_train = transforms.Compose([
+        transforms.Resize((args.image_size,args.image_size)),
+        transforms.ToTensor(),
+    ])
+
+    transform_train_seg = transforms.Compose([
+        transforms.Resize((args.out_size,args.out_size)),
+        transforms.ToTensor(),
+    ])
+
+    transform_test = transforms.Compose([
+        transforms.Resize((args.image_size, args.image_size)),
+        transforms.ToTensor(),
+    ])
+
+    transform_test_seg = transforms.Compose([
+        transforms.Resize((args.out_size,args.out_size)),
+        transforms.ToTensor(),
+    ])
+    
+    if args.dataset == 'isic':
+        '''isic data'''
+        isic_train_dataset = ISIC2016(args, args.data_path, transform = transform_train, transform_msk= transform_train_seg, mode = 'Training')
+        isic_test_dataset = ISIC2016(args, args.data_path, transform = transform_test, transform_msk= transform_test_seg, mode = 'Test')
+
+        nice_train_loader = DataLoader(isic_train_dataset, batch_size=args.b, shuffle=True, num_workers=8, pin_memory=True)
+        nice_test_loader = DataLoader(isic_test_dataset, batch_size=args.b, shuffle=False, num_workers=8, pin_memory=True)
+        '''end'''
+
+    elif args.dataset == 'decathlon':
+        nice_train_loader, nice_test_loader, transform_train, transform_val, train_list, val_list = get_decath_loader(args)
+
+
+    elif args.dataset == 'REFUGE':
+        '''REFUGE data'''
+        refuge_train_dataset = REFUGE(args, args.data_path, transform = transform_train, transform_msk= transform_train_seg, mode = 'Training')
+        refuge_test_dataset = REFUGE(args, args.data_path, transform = transform_test, transform_msk= transform_test_seg, mode = 'Test')
+
+        nice_train_loader = DataLoader(refuge_train_dataset, batch_size=args.b, shuffle=True, num_workers=8, pin_memory=True)
+        nice_test_loader = DataLoader(refuge_test_dataset, batch_size=args.b, shuffle=False, num_workers=8, pin_memory=True)
+        '''end'''
+
+    elif args.dataset == 'LIDC':
+        '''LIDC data'''
+        # dataset = LIDC(data_path = args.data_path)
+        dataset = MyLIDC(args, data_path = args.data_path,transform = transform_train, transform_msk= transform_train_seg)
+
+        dataset_size = len(dataset)
+        indices = list(range(dataset_size))
+        split = int(np.floor(0.2 * dataset_size))
+        np.random.shuffle(indices)
+        train_sampler = SubsetRandomSampler(indices[split:])
+        test_sampler = SubsetRandomSampler(indices[:split])
+
+        nice_train_loader = DataLoader(dataset, batch_size=args.b, sampler=train_sampler, num_workers=8, pin_memory=True)
+        nice_test_loader = DataLoader(dataset, batch_size=args.b, sampler=test_sampler, num_workers=8, pin_memory=True)
+        '''end'''
+
+    elif args.dataset == 'DDTI':
+        '''DDTI data'''
+        refuge_train_dataset = DDTI(args, args.data_path, transform = transform_train, transform_msk= transform_train_seg, mode = 'Training')
+        refuge_test_dataset = DDTI(args, args.data_path, transform = transform_test, transform_msk= transform_test_seg, mode = 'Test')
+
+        nice_train_loader = DataLoader(refuge_train_dataset, batch_size=args.b, shuffle=True, num_workers=8, pin_memory=True)
+        nice_test_loader = DataLoader(refuge_test_dataset, batch_size=args.b, shuffle=False, num_workers=8, pin_memory=True)
+        '''end'''
+
+    elif args.dataset == 'Brat':
+        '''Brat data'''
+        dataset = Brat(args, data_path = args.data_path,transform = transform_train, transform_msk= transform_train_seg)
+
+        dataset_size = len(dataset)
+        indices = list(range(dataset_size))
+        split = int(np.floor(0.3 * dataset_size))
+        np.random.shuffle(indices)
+        train_sampler = SubsetRandomSampler(indices[split:])
+        test_sampler = SubsetRandomSampler(indices[:split])
+
+        nice_train_loader = DataLoader(dataset, batch_size=args.b, sampler=train_sampler, num_workers=8, pin_memory=True)
+        nice_test_loader = DataLoader(dataset, batch_size=args.b, sampler=test_sampler, num_workers=8, pin_memory=True)
+        '''end'''
+
+    elif args.dataset == 'STARE':
+        '''STARE data'''
+        # dataset = LIDC(data_path = args.data_path)
+        dataset = STARE(args, data_path = args.data_path, transform = transform_train, transform_msk= transform_train_seg)
+
+        dataset_size = len(dataset)
+        indices = list(range(dataset_size))
+        split = int(np.floor(0.2 * dataset_size))
+        np.random.shuffle(indices)
+        train_sampler = SubsetRandomSampler(indices[split:])
+        test_sampler = SubsetRandomSampler(indices[:split])
+
+        nice_train_loader = DataLoader(dataset, batch_size=args.b, sampler=train_sampler, num_workers=8, pin_memory=True)
+        nice_test_loader = DataLoader(dataset, batch_size=args.b, sampler=test_sampler, num_workers=8, pin_memory=True)
+        '''end'''
+
+    elif args.dataset == 'kits':
+        '''kits data'''
+        dataset = KITS(args, data_path = args.data_path,transform = transform_train, transform_msk= transform_train_seg)
+
+        dataset_size = len(dataset)
+        indices = list(range(dataset_size))
+        split = int(np.floor(0.3 * dataset_size))
+        np.random.shuffle(indices)
+        train_sampler = SubsetRandomSampler(indices[split:])
+        test_sampler = SubsetRandomSampler(indices[:split])
+
+        nice_train_loader = DataLoader(dataset, batch_size=args.b, sampler=train_sampler, num_workers=8, pin_memory=True)
+        nice_test_loader = DataLoader(dataset, batch_size=args.b, sampler=test_sampler, num_workers=8, pin_memory=True)
+        '''end'''
+
+    elif args.dataset == 'WBC':
+        '''WBC data'''
+        dataset = WBC(args, data_path = args.data_path,transform = transform_train, transform_msk= transform_train_seg)
+
+        dataset_size = len(dataset)
+        indices = list(range(dataset_size))
+        split = int(np.floor(0.3 * dataset_size))
+        np.random.shuffle(indices)
+        train_sampler = SubsetRandomSampler(indices[split:])
+        test_sampler = SubsetRandomSampler(indices[:split])
+
+        nice_train_loader = DataLoader(dataset, batch_size=args.b, sampler=train_sampler, num_workers=8, pin_memory=True)
+        nice_test_loader = DataLoader(dataset, batch_size=args.b, sampler=test_sampler, num_workers=8, pin_memory=True)
+        '''end'''
+
+    elif args.dataset == 'segrap':
+        '''segrap data'''
+        dataset = SegRap(args, data_path = args.data_path,transform = transform_train, transform_msk= transform_train_seg)
+
+        dataset_size = len(dataset)
+        indices = list(range(dataset_size))
+        split = int(np.floor(0.3 * dataset_size))
+        np.random.shuffle(indices)
+        train_sampler = SubsetRandomSampler(indices[split:])
+        test_sampler = SubsetRandomSampler(indices[:split])
+
+        nice_train_loader = DataLoader(dataset, batch_size=args.b, sampler=train_sampler, num_workers=8, pin_memory=True)
+        nice_test_loader = DataLoader(dataset, batch_size=args.b, sampler=test_sampler, num_workers=8, pin_memory=True)
+        '''end'''
+
+    elif args.dataset == 'toothfairy':
+        '''toothfairy data'''
+        dataset = ToothFairy(args, data_path = args.data_path,transform = transform_train, transform_msk= transform_train_seg)
+
+        dataset_size = len(dataset)
+        indices = list(range(dataset_size))
+        split = int(np.floor(0.3 * dataset_size))
+        np.random.shuffle(indices)
+        train_sampler = SubsetRandomSampler(indices[split:])
+        test_sampler = SubsetRandomSampler(indices[:split])
+
+        nice_train_loader = DataLoader(dataset, batch_size=args.b, sampler=train_sampler, num_workers=8, pin_memory=True)
+        nice_test_loader = DataLoader(dataset, batch_size=args.b, sampler=test_sampler, num_workers=8, pin_memory=True)
+        '''end'''
+
+    elif args.dataset == 'atlas':
+        '''atlas data'''
+        dataset = Atlas(args, data_path = args.data_path,transform = transform_train, transform_msk= transform_train_seg)
+
+        dataset_size = len(dataset)
+        indices = list(range(dataset_size))
+        split = int(np.floor(0.3 * dataset_size))
+        np.random.shuffle(indices)
+        train_sampler = SubsetRandomSampler(indices[split:])
+        test_sampler = SubsetRandomSampler(indices[:split])
+
+        nice_train_loader = DataLoader(dataset, batch_size=args.b, sampler=train_sampler, num_workers=8, pin_memory=True)
+        nice_test_loader = DataLoader(dataset, batch_size=args.b, sampler=test_sampler, num_workers=8, pin_memory=True)
+        '''end'''
+
+    elif args.dataset == 'pendal':
+        '''pendal data'''
+        dataset = Pendal(args, data_path = args.data_path,transform = transform_train, transform_msk= transform_train_seg)
+
+        dataset_size = len(dataset)
+        indices = list(range(dataset_size))
+        split = int(np.floor(0.3 * dataset_size))
+        np.random.shuffle(indices)
+        train_sampler = SubsetRandomSampler(indices[split:])
+        test_sampler = SubsetRandomSampler(indices[:split])
+
+        nice_train_loader = DataLoader(dataset, batch_size=args.b, sampler=train_sampler, num_workers=8, pin_memory=True)
+        nice_test_loader = DataLoader(dataset, batch_size=args.b, sampler=test_sampler, num_workers=8, pin_memory=True)
+        '''end'''
+
+    elif args.dataset == 'lnq':
+        '''lnq data'''
+        dataset = LNQ(args, data_path = args.data_path,transform = transform_train, transform_msk= transform_train_seg)
+
+        dataset_size = len(dataset)
+        indices = list(range(dataset_size))
+        split = int(np.floor(0.3 * dataset_size))
+        np.random.shuffle(indices)
+        train_sampler = SubsetRandomSampler(indices[split:])
+        test_sampler = SubsetRandomSampler(indices[:split])
+
+        nice_train_loader = DataLoader(dataset, batch_size=args.b, sampler=train_sampler, num_workers=8, pin_memory=True)
+        nice_test_loader = DataLoader(dataset, batch_size=args.b, sampler=test_sampler, num_workers=8, pin_memory=True)
+        '''end'''
+
+    else:
+        print("the dataset is not supported now!!!")
+        
+    return nice_train_loader, nice_test_loader

data/dataset/atlas.py

@@ -0,0 +1,86 @@
+import json
+import os
+import pickle
+
+import nibabel as nib
+import numpy as np
+import pandas as pd
+import torch
+import torch.nn.functional as F
+from PIL import Image
+from torch.utils.data import Dataset
+
+from utils import generate_click_prompt, random_box, random_click
+
+
+class Atlas(Dataset):
+    def __init__(self, args, data_path , transform = None, transform_msk = None, mode = 'Training',prompt = 'click', plane = False):
+
+
+        self.args = args
+        self.data_path = os.path.join(data_path,'train')
+        with open(os.path.join(self.data_path,'dataset.json'),'r') as file:
+            data = json.load(file)
+        self.name_list = data['training']
+        self.mode = mode
+        self.prompt = prompt
+        self.img_size = args.image_size
+
+        self.transform = transform
+        self.transform_msk = transform_msk
+
+    def __len__(self):
+        return len(self.name_list)
+
+
+    def __getitem__(self, index):
+        point_label = 1
+        label = 1 
+
+        """Get the images"""
+        img_name = self.name_list[index]['image']
+        mask_name = self.name_list[index]['label']
+
+        img = nib.load(os.path.join(self.data_path,img_name)).get_fdata()
+        mask = nib.load(os.path.join(self.data_path,mask_name)).get_fdata()
+
+        mask[mask!=label] = 0
+        mask[mask==label] = 1
+        # if self.mode == 'Training':
+        #     label = 0 if self.label_list[index] == 'benign' else 1
+        # else:
+        #     label = int(self.label_list[index])
+        img = np.transpose(img,(1,2,0))
+        mask = np.transpose(mask,(1,2,0))
+
+        # img = np.resize(mask,(self.args.image_size, self.args.image_size,128))
+        # mask = np.resize(mask,(self.args.out_size,self.args.out_size,128))
+
+        # # img = np.resize(img,(self.args.image_size, self.args.image_size,img.shape[-1]))
+        # # mask = np.resize(mask,(self.args.out_size,self.args.out_size,mask.shape[-1]))
+
+        img = torch.tensor(img).unsqueeze(0)
+        mask = torch.tensor(mask).unsqueeze(0)
+
+        if self.prompt == 'click':
+            point_label, pt = random_click(np.array(mask), point_label)
+        # if self.transform:
+        #     state = torch.get_rng_state()
+        #     img = self.transform(img)
+        #     torch.set_rng_state(state)
+
+        #     if self.transform_msk:
+        #         mask = self.transform_msk(mask)
+                
+        #     # if (inout == 0 and point_label == 1) or (inout == 1 and point_label == 0):
+        #     #     mask = 1 - mask
+        name = img_name
+        image_meta_dict = {'filename_or_obj':name}
+        return {
+            'image':img,
+            'label': mask,
+            'p_label':point_label,
+            'pt':pt,
+            'image_meta_dict':image_meta_dict,
+        }
+

data/dataset/brat.py

@@ -0,0 +1,90 @@
+import os
+import pickle
+
+import numpy as np
+import pandas as pd
+import torch
+import torch.nn.functional as F
+from PIL import Image
+from torch.utils.data import Dataset
+
+from utils import generate_click_prompt, random_box, random_click
+
+
+class Brat(Dataset):
+    def __init__(self, args, data_path , transform = None, transform_msk = None, mode = 'Training',prompt = 'click', plane = False):
+
+        self.args = args
+        self.data_path = os.path.join(data_path,'Data')
+        self.name_list = os.listdir(self.data_path)
+        self.mode = mode
+        self.prompt = prompt
+        self.img_size = args.image_size
+
+        self.transform = transform
+        self.transform_msk = transform_msk
+
+    def __len__(self):
+        return len(self.name_list)
+
+    def load_all_levels(self,path):
+        import nibabel as nib
+        data_dir = os.path.join(self.data_path)
+        levels = ['t1','flair','t2','t1ce']
+        raw_image = [nib.load(os.path.join
+        (data_dir,path,path+'_'+level+'.nii.gz')).get_fdata() for level in levels]
+        raw_seg = nib.load(os.path.join(data_dir,path,path+'_seg.nii.gz')).get_fdata()
+
+        return raw_image[0], raw_seg
+
+    def __getitem__(self, index):
+        # if self.mode == 'Training':
+        #     point_label = random.randint(0, 1)
+        #     inout = random.randint(0, 1)
+        # else:
+        #     inout = 1
+        #     point_label = 1
+        point_label = 1
+        label = 4   # the class to be segmented
+
+        """Get the images"""
+        name = self.name_list[index]
+        img,mask = self.load_all_levels(name)
+
+        mask[mask!=label] = 0
+        mask[mask==label] = 1
+        # if self.mode == 'Training':
+        #     label = 0 if self.label_list[index] == 'benign' else 1
+        # else:
+        #     label = int(self.label_list[index])
+
+        
+        img = np.resize(img,(self.args.image_size, self.args.image_size,img.shape[-1]))
+        mask = np.resize(mask,(self.args.out_size,self.args.out_size,mask.shape[-1]))
+
+        img = torch.tensor(img).unsqueeze(0)
+        mask = torch.tensor(mask).unsqueeze(0)
+        mask = torch.clamp(mask,min=0,max=1).int()
+
+        if self.prompt == 'click':
+            point_label, pt = random_click(np.array(mask), point_label)
+        # if self.transform:
+        #     state = torch.get_rng_state()
+        #     img = self.transform(img)
+        #     torch.set_rng_state(state)
+
+        #     if self.transform_msk:
+        #         mask = self.transform_msk(mask)
+                
+        #     # if (inout == 0 and point_label == 1) or (inout == 1 and point_label == 0):
+        #     #     mask = 1 - mask
+        name = name.split('/')[-1].split(".jpg")[0]
+        image_meta_dict = {'filename_or_obj':name}
+        return {
+            'image':img,
+            'label': mask,
+            'p_label':point_label,
+            'pt':pt,
+            'image_meta_dict':image_meta_dict,
+        }
+

data/dataset/ddti.py

@@ -0,0 +1,99 @@
+import os
+
+import cv2
+import numpy as np
+import pandas as pd
+import torch
+from PIL import Image
+from torch.utils.data import Dataset
+
+from utils import random_box, random_click
+
+
+class DDTI(Dataset):
+    def __init__(self, args, data_path , transform = None, transform_msk = None, mode = 'Training',prompt = 'click', plane = False):
+
+        self.name_list = os.listdir(os.path.join(data_path,mode,'images'))
+        self.data_path = data_path
+        self.mode = mode
+        self.prompt = prompt
+        self.img_size = args.image_size
+
+        self.transform = transform
+        self.transform_msk = transform_msk
+
+    def __len__(self):
+        return len(self.name_list)
+
+    def find_connected_components(self,mask):
+        mask = np.clip(mask,0,1)
+        num_labels, labels = cv2.connectedComponents(mask.astype(np.uint8))
+        point = []
+        point_labels = []
+
+        for label in range(1, num_labels):
+            component_mask = np.where(labels == label, 1, 0)
+            area = np.sum(component_mask)
+
+            if area > 400:
+                point_label, random_point = random_click(component_mask)
+                point.append(random_point)
+                point_labels.append(point_label)
+                # print(f"Random point in component {label}: {random_point}, label: {point_labels}")
+        if(len(point)==1):
+            point.append(point[0])
+            point_labels.append(point_labels[0])
+        if(len(point)>2):
+            point = point[:2]
+            point_labels = point_labels[:2]
+        point = np.array(point)
+        point_labels = np.array(point_labels)
+        return point_labels,point
+    
+    def __getitem__(self, index):
+        point_label = 1
+
+        """Get the images"""
+        name = self.name_list[index]
+        img_path = os.path.join(self.data_path, self.mode, 'images', name)
+        msk_path = os.path.join(self.data_path, self.mode, 'masks', name)
+
+        img = Image.open(img_path).convert('RGB')
+        mask = Image.open(msk_path).convert('L')
+
+        # if self.mode == 'Training':
+        #     label = 0 if self.label_list[index] == 'benign' else 1
+        # else:
+        #     label = int(self.label_list[index])
+
+        newsize = (self.img_size, self.img_size)
+        mask = mask.resize(newsize)
+
+        if self.prompt == 'click':
+            # two prompt
+            point_label, pt = self.find_connected_components(np.array(mask))
+            # one prompt
+            # point_label, pt = random_click(np.array(mask) / 255, point_label)
+
+        if self.transform:
+            state = torch.get_rng_state()
+            img = self.transform(img)
+            torch.set_rng_state(state)
+
+
+            if self.transform_msk:
+                mask = self.transform_msk(mask)
+                
+            # if (inout == 0 and point_label == 1) or (inout == 1 and point_label == 0):
+            #     mask = 1 - mask
+        mask = torch.clamp(mask,min=0,max=1).int()
+
+        name = name.split('/')[-1].split(".jpg")[0]
+        image_meta_dict = {'filename_or_obj':name}
+        return {
+            'image':img,
+            'label': mask,
+            'p_label':point_label,
+            'pt':pt,
+            'image_meta_dict':image_meta_dict,
+        }

data/dataset/isic.py

@@ -0,0 +1,78 @@
+import os
+
+import numpy as np
+import pandas as pd
+import torch
+from PIL import Image
+from torch.utils.data import Dataset
+
+from utils import random_box, random_click
+
+
+class ISIC2016(Dataset):
+    def __init__(self, args, data_path , transform = None, transform_msk = None, mode = 'Training',prompt = 'click', plane = False):
+
+        df = pd.read_csv(os.path.join(data_path, 'ISBI2016_ISIC_Part1_' + mode + '_GroundTruth.csv'), encoding='gbk')
+        self.name_list = df.iloc[:,1].tolist()
+        self.label_list = df.iloc[:,2].tolist()
+        self.data_path = data_path
+        self.mode = mode
+        self.prompt = prompt
+        self.img_size = args.image_size
+
+        self.transform = transform
+        self.transform_msk = transform_msk
+
+    def __len__(self):
+        return len(self.name_list)
+
+    def __getitem__(self, index):
+        # if self.mode == 'Training':
+        #     point_label = random.randint(0, 1)
+        #     inout = random.randint(0, 1)
+        # else:
+        #     inout = 1
+        #     point_label = 1
+        point_label = 1
+
+        """Get the images"""
+        name = self.name_list[index]
+        img_path = os.path.join(self.data_path, name)
+        
+        mask_name = self.label_list[index]
+        msk_path = os.path.join(self.data_path, mask_name)
+
+        img = Image.open(img_path).convert('RGB')
+        mask = Image.open(msk_path).convert('L')
+
+        # if self.mode == 'Training':
+        #     label = 0 if self.label_list[index] == 'benign' else 1
+        # else:
+        #     label = int(self.label_list[index])
+
+        newsize = (self.img_size, self.img_size)
+        mask = mask.resize(newsize)
+
+        if self.prompt == 'click':
+            point_label, pt = random_click(np.array(mask) / 255, point_label)
+
+        if self.transform:
+            state = torch.get_rng_state()
+            img = self.transform(img)
+            torch.set_rng_state(state)
+
+
+            if self.transform_msk:
+                mask = self.transform_msk(mask).int()
+                
+            # if (inout == 0 and point_label == 1) or (inout == 1 and point_label == 0):
+            #     mask = 1 - mask
+        name = name.split('/')[-1].split(".jpg")[0]
+        image_meta_dict = {'filename_or_obj':name}
+        return {
+            'image':img,
+            'label': mask,
+            'p_label':point_label,
+            'pt':pt,
+            'image_meta_dict':image_meta_dict,
+        }

data/dataset/kits.py

@@ -0,0 +1,87 @@
+import os
+import pickle
+
+import nibabel as nib
+import numpy as np
+import pandas as pd
+import torch
+import torch.nn.functional as F
+from PIL import Image
+from torch.utils.data import Dataset
+
+from utils import generate_click_prompt, random_box, random_click
+
+
+class KITS(Dataset):
+    def __init__(self, args, data_path , transform = None, transform_msk = None, mode = 'Training',prompt = 'click', plane = False):
+
+
+        self.args = args
+        self.data_path = os.path.join(data_path,'kits21','data')
+        self.name_list = os.listdir(self.data_path)
+        self.mode = mode
+        self.prompt = prompt
+        self.img_size = args.image_size
+
+        self.transform = transform
+        self.transform_msk = transform_msk
+
+    def __len__(self):
+        return len(self.name_list)
+
+
+    def __getitem__(self, index):
+        # if self.mode == 'Training':
+        #     point_label = random.randint(0, 1)
+        #     inout = random.randint(0, 1)
+        # else:
+        #     inout = 1
+        #     point_label = 1
+        point_label = 1
+
+
+        """Get the images"""
+        name = self.name_list[index]
+        img = nib.load(os.path.join(self.data_path,name,'imaging.nii.gz')).get_fdata()
+        mask = nib.load(os.path.join(self.data_path,name,'aggregated_AND_seg.nii.gz')).get_fdata()
+
+        mask = np.clip(mask,0,1)
+        # if self.mode == 'Training':
+        #     label = 0 if self.label_list[index] == 'benign' else 1
+        # else:
+        #     label = int(self.label_list[index])
+        img = np.transpose(img,(1,2,0))
+        mask = np.transpose(mask,(1,2,0))
+
+        # img = np.resize(mask,(self.args.image_size, self.args.image_size,img.shape[-1]))
+        # mask = np.resize(mask,(self.args.out_size,self.args.out_size,mask.shape[-1]))
+
+        img = np.resize(img,(self.args.image_size, self.args.image_size,img.shape[-1]))
+        mask = np.resize(mask,(self.args.out_size,self.args.out_size,mask.shape[-1]))
+
+        img = torch.tensor(img).unsqueeze(0)
+        mask = torch.tensor(mask).unsqueeze(0)
+        mask = torch.clamp(mask,min=0,max=1).int()
+
+        if self.prompt == 'click':
+            point_label, pt = random_click(np.array(mask), point_label)
+        # if self.transform:
+        #     state = torch.get_rng_state()
+        #     img = self.transform(img)
+        #     torch.set_rng_state(state)
+
+        #     if self.transform_msk:
+        #         mask = self.transform_msk(mask)
+                
+        #     # if (inout == 0 and point_label == 1) or (inout == 1 and point_label == 0):
+        #     #     mask = 1 - mask
+        name = name.split('/')[-1].split(".jpg")[0]
+        image_meta_dict = {'filename_or_obj':name}
+        return {
+            'image':img,
+            'label': mask,
+            'p_label':point_label,
+            'pt':pt,
+            'image_meta_dict':image_meta_dict,
+        }
+

data/dataset/lidc.py

@@ -0,0 +1,96 @@
+import os
+import pickle
+
+import numpy as np
+import pandas as pd
+import torch
+import torch.nn.functional as F
+from PIL import Image
+from torch.utils.data import Dataset
+
+from utils import random_box, random_click
+
+
+class LIDC(Dataset):
+    names = []
+    images = []
+    labels = []
+    series_uid = []
+
+    def __init__(self, data_path, transform=None, transform_msk = None, prompt = 'click'):
+        self.prompt = prompt
+        self.transform = transform
+        self.transform_msk = transform_msk
+        
+        max_bytes = 2**31 - 1
+        data = {}
+        for file in os.listdir(data_path):
+            filename = os.fsdecode(file)
+            if '.pickle' in filename:
+                file_path = data_path + filename
+                bytes_in = bytearray(0)
+                input_size = os.path.getsize(file_path)
+                with open(file_path, 'rb') as f_in:
+                    for _ in range(0, input_size, max_bytes):
+                        bytes_in += f_in.read(max_bytes)
+                new_data = pickle.loads(bytes_in)
+                data.update(new_data)
+                
+        
+        for key, value in data.items():
+            self.names.append(key)
+            self.images.append(value['image'].astype(float))
+            self.labels.append(value['masks'])
+            self.series_uid.append(value['series_uid'])
+
+        assert (len(self.images) == len(self.labels) == len(self.series_uid))
+
+        for img in self.images:
+            assert np.max(img) <= 1 and np.min(img) >= 0
+        for label in self.labels:
+            assert np.max(label) <= 1 and np.min(label) >= 0
+
+        del new_data
+        del data
+
+    def __len__(self):
+        return len(self.images)
+
+    def __getitem__(self, index):
+
+        point_label = 1
+
+        """Get the images"""
+        img = np.expand_dims(self.images[index], axis=0)
+        name = self.names[index]
+        multi_rater = self.labels[index]
+
+        # first click is the target most agreement among raters, otherwise, background agreement
+        if self.prompt == 'click':
+            point_label, pt = random_click(np.array(np.mean(np.stack(multi_rater), axis=0)) / 255, point_label)
+
+        # Convert image (ensure three channels) and multi-rater labels to torch tensors
+        img = torch.from_numpy(img).type(torch.float32)
+        img = img.repeat(3, 1, 1) 
+        multi_rater = [torch.from_numpy(single_rater).type(torch.float32) for single_rater in multi_rater]
+
+        multi_rater = torch.stack(multi_rater, dim=0)
+        multi_rater = multi_rater.unsqueeze(1)
+
+        if self.prompt == 'box':
+            x_min, x_max, y_min, y_max = random_box(multi_rater)
+            box = [x_min, x_max, y_min, y_max]
+
+        mask = multi_rater.mean(dim=0) # average
+
+        image_meta_dict = {'filename_or_obj':name}
+        return {
+            'image':img,
+            'multi_rater': multi_rater,
+            'label': mask,
+            'p_label':point_label,
+            'pt':pt,
+            'box': box,
+            'image_meta_dict':image_meta_dict,
+        }
+

data/dataset/lnq.py

@@ -0,0 +1,80 @@
+import json
+import os
+import pickle
+
+import nibabel as nib
+import numpy as np
+import pandas as pd
+import SimpleITK as sitk
+import torch
+import torch.nn.functional as F
+from PIL import Image
+from torch.utils.data import Dataset
+
+from utils import generate_click_prompt, random_box, random_click
+
+
+class LNQ(Dataset):
+    def __init__(self, args, data_path , transform = None, transform_msk = None, mode = 'Training',prompt = 'click', plane = False):
+
+
+        self.args = args
+        self.data_path = os.path.join(data_path,'train')
+
+        files = os.listdir(self.data_path)
+
+        self.name_list = [file for file in files if file.endswith('.png')]
+        self.mode = mode
+        self.prompt = prompt
+        self.img_size = args.image_size
+
+        self.transform = transform
+        self.transform_msk = transform_msk
+
+    def __len__(self):
+        return len(self.name_list)
+
+
+    def __getitem__(self, index):
+        point_label = 1
+        label = 1 
+
+        """Get the images"""
+        name = self.name_list[index].split('.')[0]
+        img_name = name + '-ct.nrrd'
+        mask_name = name + '-seg.nrrd'
+
+        img = sitk.GetArrayFromImage(sitk.ReadImage(os.path.join(self.data_path,img_name)))
+        mask = sitk.GetArrayFromImage(sitk.ReadImage(os.path.join(self.data_path,mask_name)))
+
+        mask[mask!=label] = 0
+        mask[mask==label] = 1
+        # if self.mode == 'Training':
+        #     label = 0 if self.label_list[index] == 'benign' else 1
+        # else:
+        #     label = int(self.label_list[index])
+        img = np.transpose(img,(1,2,0))
+        mask = np.transpose(mask,(1,2,0))
+
+        # img = np.resize(mask,(self.args.image_size, self.args.image_size,128))
+        # mask = np.resize(mask,(self.args.out_size,self.args.out_size,128))
+
+        # # img = np.resize(img,(self.args.image_size, self.args.image_size,img.shape[-1]))
+        # # mask = np.resize(mask,(self.args.out_size,self.args.out_size,mask.shape[-1]))
+
+        img = torch.tensor(img).unsqueeze(0).int()
+        mask = torch.tensor(mask).unsqueeze(0).int()
+
+        if self.prompt == 'click':
+            point_label, pt = random_click(np.array(mask), point_label)
+
+        name = img_name
+        image_meta_dict = {'filename_or_obj':name}
+        return {
+            'image':img,
+            'label': mask,
+            'p_label':point_label,
+            'pt':pt,
+            'image_meta_dict':image_meta_dict,
+        }
+

data/dataset/pendal.py

@@ -0,0 +1,71 @@
+import os
+import pickle
+
+import nibabel as nib
+import numpy as np
+import pandas as pd
+import torch
+import torch.nn.functional as F
+from PIL import Image
+from torch.utils.data import Dataset
+
+from utils import generate_click_prompt, random_box, random_click
+
+
+class Pendal(Dataset):
+    def __init__(self, args, data_path , transform = None, transform_msk = None, mode = 'Training',prompt = 'click', plane = False):
+
+        self.args = args
+        self.data_path = data_path
+        self.name_list = os.listdir(os.path.join(self.data_path,'Images'))
+        self.mode = mode
+        self.prompt = prompt
+        self.img_size = args.image_size
+
+        self.transform = transform
+        self.transform_msk = transform_msk
+
+    def __len__(self):
+        return len(self.name_list)
+
+
+    def __getitem__(self, index):
+        # if self.mode == 'Training':
+        #     point_label = random.randint(0, 1)
+        #     inout = random.randint(0, 1)
+        # else:
+        #     inout = 1
+        #     point_label = 1
+        point_label = 1
+
+        """Get the images"""
+        name = self.name_list[index]
+        img = Image.open(os.path.join(self.data_path, 'Images',name)).convert('RGB')
+        mask = Image.open(os.path.join(self.data_path, 'Segmentation1',name)).convert('L')
+
+        mask = np.array(mask)
+        mask[mask==mask.min()]=0
+        mask[mask>0] = 255
+
+        if self.prompt == 'click':
+            point_label, pt = random_click(np.array(mask) / 255, point_label)
+
+        if self.transform:
+            state = torch.get_rng_state()
+            img = self.transform(img)
+            torch.set_rng_state(state)
+
+
+            if self.transform_msk:
+                mask = Image.fromarray(mask)
+                mask = self.transform_msk(mask).int()
+
+        image_meta_dict = {'filename_or_obj':name}
+        return {
+            'image':img,
+            'label': mask,
+            'p_label':point_label,
+            'pt':pt,
+            'image_meta_dict':image_meta_dict,
+        }
+

data/dataset/refuge.py

@@ -0,0 +1,91 @@
+import os
+
+import numpy as np
+import pandas as pd
+import torch
+import torch.nn.functional as F
+from PIL import Image
+from torch.utils.data import Dataset
+
+from utils import random_box, random_click
+
+
+class REFUGE(Dataset):
+    def __init__(self, args, data_path , transform = None, transform_msk = None, mode = 'Training',prompt = 'none', plane = False):
+        self.data_path = data_path
+        self.subfolders = [f.path for f in os.scandir(os.path.join(data_path, mode + '-400')) if f.is_dir()]
+        self.mode = mode
+        self.prompt = prompt
+        self.img_size = args.image_size
+        self.mask_size = args.out_size
+
+        self.transform = transform
+        self.transform_msk = transform_msk
+
+    def __len__(self):
+        return len(self.subfolders)
+
+    def __getitem__(self, index):
+        point_label = 1
+
+        """Get the images"""
+        subfolder = self.subfolders[index]
+        name = subfolder.split('/')[-1]
+
+        # raw image and raters path
+        img_path = os.path.join(subfolder, name + '.jpg')
+        multi_rater_cup_path = [os.path.join(subfolder, name + '_seg_cup_' + str(i) + '.png') for i in range(1, 8)]
+        multi_rater_disc_path = [os.path.join(subfolder, name + '_seg_disc_' + str(i) + '.png') for i in range(1, 8)]
+
+        # raw image and raters images
+        img = Image.open(img_path).convert('RGB')
+        multi_rater_cup = [Image.open(path).convert('L') for path in multi_rater_cup_path]
+        multi_rater_disc = [Image.open(path).convert('L') for path in multi_rater_disc_path]
+
+        # resize raters images for generating initial point click
+        newsize = (self.img_size, self.img_size)
+        multi_rater_cup_np = [np.array(single_rater.resize(newsize)) for single_rater in multi_rater_cup]
+        multi_rater_disc_np = [np.array(single_rater.resize(newsize)) for single_rater in multi_rater_disc]
+
+        # first click is the target agreement among most raters
+        if self.prompt == 'click':
+            point_label, pt = random_click(np.array(np.mean(np.stack(multi_rater_cup_np), axis=0)) / 255, point_label)
+            point_label, pt_disc = random_click(np.array(np.mean(np.stack(multi_rater_disc_np), axis=0)) / 255, point_label)
+        else:
+            # you may want to get rid of click prompts
+            pt = np.array([0, 0], dtype=np.int32)
+            
+        if self.transform:
+            state = torch.get_rng_state()
+            img = self.transform(img)
+            multi_rater_cup = [torch.as_tensor((self.transform(single_rater) >0.5).float(), dtype=torch.float32) for single_rater in multi_rater_cup]
+            multi_rater_cup = torch.stack(multi_rater_cup, dim=0)
+            # transform to mask size (out_size) for mask define
+            mask_cup = F.interpolate(multi_rater_cup, size=(self.mask_size, self.mask_size), mode='bilinear', align_corners=False).mean(dim=0)
+
+            multi_rater_disc = [torch.as_tensor((self.transform(single_rater) >0.5).float(), dtype=torch.float32) for single_rater in multi_rater_disc]
+            multi_rater_disc = torch.stack(multi_rater_disc, dim=0)
+            mask_disc = F.interpolate(multi_rater_disc, size=(self.mask_size, self.mask_size), mode='bilinear', align_corners=False).mean(dim=0)
+            torch.set_rng_state(state)
+            
+            mask = torch.concat([mask_cup, mask_disc], dim=0)
+
+        if self.prompt == 'box':
+            x_min_cup, x_max_cup, y_min_cup, y_max_cup = random_box(multi_rater_cup)
+            box_cup = [x_min_cup, x_max_cup, y_min_cup, y_max_cup]
+            x_min_disc, x_max_disc, y_min_disc, y_max_disc = random_box(multi_rater_disc)
+            box_disc = [x_min_disc, x_max_disc, y_min_disc, y_max_disc]
+        else:
+            # you may want to get rid of box prompts
+            box_cup = [0, 0, 0, 0]
+            box_disc = [0, 0, 0, 0]
+
+        image_meta_dict = {'filename_or_obj':name}
+        return {
+            'image':img,
+            'label': mask,
+            'p_label':point_label,
+            'pt':pt,
+            'box': box_cup,
+            'image_meta_dict':image_meta_dict,
+        }

data/dataset/segrap.py

@@ -0,0 +1,65 @@
+import os
+import pickle
+
+import nibabel as nib
+import numpy as np
+import pandas as pd
+import torch
+import torch.nn.functional as F
+from PIL import Image
+from torch.utils.data import Dataset
+
+from utils import generate_click_prompt, random_box, random_click
+
+
+class SegRap(Dataset):
+    def __init__(self, args, data_path , transform = None, transform_msk = None, mode = 'Training',prompt = 'click', plane = False):
+
+        self.args = args
+        self.data_path = data_path
+        self.name_list = os.listdir(os.path.join(self.data_path,'SegRap2023_Training_Set_120cases_OneHot_Labels','Task001'))
+        self.mode = mode
+        self.prompt = prompt
+        self.img_size = args.image_size
+
+        self.transform = transform
+        self.transform_msk = transform_msk
+
+    def __len__(self):
+        return len(self.name_list)
+
+
+    def __getitem__(self, index):
+        # if self.mode == 'Training':
+        #     point_label = random.randint(0, 1)
+        #     inout = random.randint(0, 1)
+        # else:
+        #     inout = 1
+        #     point_label = 1
+        point_label = 1
+        label = 1 # 待分割的类别
+
+        """Get the images"""
+        name = self.name_list[index].split('.')[0]
+        img = nib.load(os.path.join(self.data_path,'SegRap2023_Training_Set_120cases',name,'image.nii.gz')).get_fdata()
+        mask = nib.load(os.path.join(self.data_path,'SegRap2023_Training_Set_120cases_OneHot_Labels','Task001',name+'.nii.gz')).get_fdata()
+
+        img = np.resize(img,(self.args.image_size, self.args.image_size,img.shape[-1]))
+        mask = np.resize(mask,(self.args.out_size,self.args.out_size,mask.shape[-1]))
+        mask[mask!=label] = 0
+        mask[mask==label] = 1
+        
+        img = torch.tensor(img).unsqueeze(0)
+        mask = torch.tensor(mask).unsqueeze(0).int()
+        if self.prompt == 'click':
+            point_label, pt = random_click(np.array(mask), point_label)
+
+        image_meta_dict = {'filename_or_obj':name}
+        return {
+            'image':img,
+            'label': mask,
+            'p_label':point_label,
+            'pt':pt,
+            'image_meta_dict':image_meta_dict,
+        }
+

data/dataset/stare.py

@@ -0,0 +1,75 @@
+import os
+
+import numpy as np
+import pandas as pd
+import torch
+from PIL import Image
+from torch.utils.data import Dataset
+
+from utils import random_box, random_click
+
+
+class STARE(Dataset):
+    def __init__(self, args, data_path , transform = None, transform_msk = None, mode = 'Training',prompt = 'click', plane = False):
+
+        self.data_path = data_path
+        self.name_list = os.listdir(os.path.join(data_path,'masks'))
+        self.prompt = prompt
+        self.img_size = args.image_size
+
+        self.transform = transform
+        self.transform_msk = transform_msk
+
+    def __len__(self):
+        return len(self.name_list)
+
+    def __getitem__(self, index):
+        # if self.mode == 'Training':
+        #     point_label = random.randint(0, 1)
+        #     inout = random.randint(0, 1)
+        # else:
+        #     inout = 1
+        #     point_label = 1
+        point_label = 1
+
+        """Get the images"""
+        name = self.name_list[index].split('.')[0]
+
+        img_path = os.path.join(self.data_path, 'images',name+'.ppm')
+        
+        msk_path = os.path.join(self.data_path, 'masks', name+'.ah.ppm')
+
+        img = Image.open(img_path).convert('RGB')
+        mask = Image.open(msk_path).convert('L')
+
+        # if self.mode == 'Training':
+        #     label = 0 if self.label_list[index] == 'benign' else 1
+        # else:
+        #     label = int(self.label_list[index])
+
+        newsize = (self.img_size, self.img_size)
+        mask = mask.resize(newsize)
+
+        if self.prompt == 'click':
+            point_label, pt = random_click(np.array(mask) / 255, point_label)
+
+        if self.transform:
+            state = torch.get_rng_state()
+            img = self.transform(img)
+            torch.set_rng_state(state)
+
+
+            if self.transform_msk:
+                mask = self.transform_msk(mask).int()
+                
+            # if (inout == 0 and point_label == 1) or (inout == 1 and point_label == 0):
+            #     mask = 1 - mask
+        name = name.split('/')[-1].split(".jpg")[0]
+        image_meta_dict = {'filename_or_obj':name}
+        return {
+            'image':img,
+            'label': mask,
+            'p_label':point_label,
+            'pt':pt,
+            'image_meta_dict':image_meta_dict,
+        }

data/dataset/toothfairy.py

@@ -0,0 +1,80 @@
+import os
+import pickle
+
+import nibabel as nib
+import numpy as np
+import pandas as pd
+import torch
+import torch.nn.functional as F
+from PIL import Image
+from torch.utils.data import Dataset
+
+from utils import generate_click_prompt, random_box, random_click
+
+
+class ToothFairy(Dataset):
+    def __init__(self, args, data_path , transform = None, transform_msk = None, mode = 'Training',prompt = 'click', plane = False):
+
+
+        self.args = args
+        self.data_path = os.path.join(data_path,'Dataset')
+        self.name_list = os.listdir(self.data_path)
+        self.mode = mode
+        self.prompt = prompt
+        self.img_size = args.image_size
+
+        self.transform = transform
+        self.transform_msk = transform_msk
+
+    def __len__(self):
+        return len(self.name_list)
+
+
+    def __getitem__(self, index):
+        point_label = 1
+
+
+        """Get the images"""
+        name = self.name_list[index]
+        img = np.load(os.path.join(self.data_path,name,'data.npy'))
+        mask = np.load(os.path.join(self.data_path,name,'gt_sparse.npy'))
+
+        # if self.mode == 'Training':
+        #     label = 0 if self.label_list[index] == 'benign' else 1
+        # else:
+        #     label = int(self.label_list[index])
+        img = np.transpose(img,(1,2,0))
+        mask = np.transpose(mask,(1,2,0))
+
+        # img = np.resize(mask,(self.args.image_size, self.args.image_size,img.shape[-1]))
+        # mask = np.resize(mask,(self.args.out_size,self.args.out_size,mask.shape[-1]))
+
+        img = np.resize(img,(self.args.image_size, self.args.image_size,img.shape[-1]))
+        mask = np.resize(mask,(self.args.out_size,self.args.out_size,mask.shape[-1]))
+
+        img = torch.tensor(img).unsqueeze(0)
+        mask = torch.tensor(mask).unsqueeze(0)
+        mask = torch.clamp(mask,min=0,max=1).int()
+
+        if self.prompt == 'click':
+            point_label, pt = random_click(np.array(mask), point_label)
+        # if self.transform:
+        #     state = torch.get_rng_state()
+        #     img = self.transform(img)
+        #     torch.set_rng_state(state)
+
+        #     if self.transform_msk:
+        #         mask = self.transform_msk(mask)
+                
+        #     # if (inout == 0 and point_label == 1) or (inout == 1 and point_label == 0):
+        #     #     mask = 1 - mask
+        name = name.split('/')[-1].split(".jpg")[0]
+        image_meta_dict = {'filename_or_obj':name}
+        return {
+            'image':img,
+            'label': mask,
+            'p_label':point_label,
+            'pt':pt,
+            'image_meta_dict':image_meta_dict,
+        }
+

data/dataset/wbc.py

@@ -0,0 +1,65 @@
+import glob
+import os
+
+import numpy as np
+import pandas as pd
+import torch
+from PIL import Image
+from torch.utils.data import Dataset
+
+from utils import random_box, random_click
+
+
+class WBC(Dataset):
+    def __init__(self, args, data_path , transform = None, transform_msk = None, mode = 'Training',prompt = 'click', plane = False):
+
+        self.data_path = os.path.join(data_path,'Dataset1')
+        self.name_list = glob.glob(self.data_path + "/*.bmp")
+        self.mode = mode
+        self.prompt = prompt
+        self.img_size = args.image_size
+
+        self.transform = transform
+        self.transform_msk = transform_msk
+
+    def __len__(self):
+        return len(self.name_list)
+
+    def __getitem__(self, index):
+        point_label = 1     # available: 1 2
+
+        """Get the images"""
+        name = os.path.basename(self.name_list[index]).split('.')[0]
+
+        img_path = os.path.join(self.data_path, name + '.bmp')
+        msk_path = os.path.join(self.data_path, name + '.png')
+
+        img = Image.open(img_path).convert('RGB')
+        mask = Image.open(msk_path).convert('L')
+
+        mask = np.array(mask) // 127
+        mask[mask!=point_label] = 0
+        mask[mask==point_label] = 255
+
+        if self.prompt == 'click':
+            point_label, pt = random_click(np.array(mask) / 255, point_label)
+
+        if self.transform:
+            state = torch.get_rng_state()
+            img = self.transform(img)
+            torch.set_rng_state(state)
+
+            if self.transform_msk:
+                mask = Image.fromarray(mask)
+                mask = self.transform_msk(mask).int()
+                
+            # if (inout == 0 and point_label == 1) or (inout == 1 and point_label == 0):
+            #     mask = 1 - mask
+        image_meta_dict = {'filename_or_obj':name}
+        return {
+            'image':img,
+            'label': mask,
+            'p_label':point_label,
+            'pt':pt,
+            'image_meta_dict':image_meta_dict,
+        }

data/environment.yml

@@ -0,0 +1,319 @@
+name: sam_adapt
+channels:
+  - pytorch
+  - conda-forge
+  - defaults
+dependencies:
+  - _libgcc_mutex=0.1=main
+  - _openmp_mutex=5.1=1_gnu
+  - abseil-cpp=20211102.0=hd4dd3e8_0
+  - absl-py=1.3.0=py310h06a4308_0
+  - aiohttp=3.8.3=py310h5eee18b_0
+  - async-timeout=4.0.2=py310h06a4308_0
+  - attrs=22.1.0=py310h06a4308_0
+  - blas=1.0=mkl
+  - blosc=1.21.3=h6a678d5_0
+  - bottleneck=1.3.5=py310ha9d4c09_0
+  - brotli=1.0.9=h5eee18b_7
+  - brotli-bin=1.0.9=h5eee18b_7
+  - brotlipy=0.7.0=py310h7f8727e_1002
+  - brunsli=0.1=h2531618_0
+  - bzip2=1.0.8=h7b6447c_0
+  - c-ares=1.19.0=h5eee18b_0
+  - ca-certificates=2023.11.17=hbcca054_0
+  - cffi=1.15.1=py310h5eee18b_3
+  - cfitsio=3.470=h5893167_7
+  - charls=2.2.0=h2531618_0
+  - cloudpickle=2.2.1=py310h06a4308_0
+  - comm=0.1.4=pyhd8ed1ab_0
+  - contourpy=1.0.5=py310hdb19cb5_0
+  - cpuonly=2.0=0
+  - cryptography=39.0.1=py310h9ce1e76_0
+  - cudatoolkit=11.3.1=h2bc3f7f_2
+  - cytoolz=0.12.0=py310h5eee18b_0
+  - dask-core=2023.4.1=py310h06a4308_0
+  - dbus=1.13.18=hb2f20db_0
+  - debugpy=1.6.7=py310h6a678d5_0
+  - decorator=5.1.1=pyhd8ed1ab_0
+  - expat=2.4.9=h6a678d5_0
+  - ffmpeg=4.3=hf484d3e_0
+  - fontconfig=2.14.1=h4c34cd2_2
+  - freetype=2.12.1=h4a9f257_0
+  - frozenlist=1.3.3=py310h5eee18b_0
+  - fsspec=2023.4.0=py310h06a4308_0
+  - giflib=5.2.1=h5eee18b_3
+  - glib=2.69.1=he621ea3_2
+  - gmp=6.2.1=h295c915_3
+  - gnutls=3.6.15=he1e5248_0
+  - grpc-cpp=1.48.2=h5bf31a4_0
+  - grpcio=1.48.2=py310h5bf31a4_0
+  - gst-plugins-base=1.14.1=h6a678d5_1
+  - gstreamer=1.14.1=h5eee18b_1
+  - icu=58.2=he6710b0_3
+  - idna=3.4=py310h06a4308_0
+  - imagecodecs=2021.8.26=py310h46e8fbd_2
+  - imageio=2.26.0=py310h06a4308_0
+  - importlib-metadata=6.0.0=py310h06a4308_0
+  - importlib_metadata=6.0.0=hd8ed1ab_0
+  - intel-openmp=2021.4.0=h06a4308_3561
+  - ipykernel=6.26.0=pyhf8b6a83_0
+  - joblib=1.1.1=py310h06a4308_0
+  - jpeg=9e=h5eee18b_1
+  - jupyter_client=8.6.0=pyhd8ed1ab_0
+  - jupyter_core=5.5.0=py310hff52083_0
+  - jxrlib=1.1=h7b6447c_2
+  - kiwisolver=1.4.4=py310h6a678d5_0
+  - krb5=1.19.4=h568e23c_0
+  - lame=3.100=h7b6447c_0
+  - lazy_loader=0.1=py310h06a4308_0
+  - lcms2=2.12=h3be6417_0
+  - ld_impl_linux-64=2.38=h1181459_1
+  - lerc=3.0=h295c915_0
+  - libaec=1.0.4=he6710b0_1
+  - libbrotlicommon=1.0.9=h5eee18b_7
+  - libbrotlidec=1.0.9=h5eee18b_7
+  - libbrotlienc=1.0.9=h5eee18b_7
+  - libclang=14.0.6=default_hc6dbbc7_1
+  - libclang13=14.0.6=default_he11475f_1
+  - libcurl=7.88.1=h91b91d3_0
+  - libdeflate=1.17=h5eee18b_0
+  - libedit=3.1.20221030=h5eee18b_0
+  - libev=4.33=h7f8727e_1
+  - libevent=2.1.12=h8f2d780_0
+  - libffi=3.4.2=h6a678d5_6
+  - libgcc=7.2.0=h69d50b8_2
+  - libgcc-ng=11.2.0=h1234567_1
+  - libgfortran-ng=11.2.0=h00389a5_1
+  - libgfortran5=11.2.0=h1234567_1
+  - libgomp=11.2.0=h1234567_1
+  - libiconv=1.16=h7f8727e_2
+  - libidn2=2.3.2=h7f8727e_0
+  - libllvm14=14.0.6=hdb19cb5_2
+  - libnghttp2=1.46.0=hce63b2e_0
+  - libpng=1.6.39=h5eee18b_0
+  - libpq=12.9=h16c4e8d_3
+  - libprotobuf=3.20.3=he621ea3_0
+  - libsodium=1.0.18=h36c2ea0_1
+  - libssh2=1.10.0=h8f2d780_0
+  - libstdcxx-ng=11.2.0=h1234567_1
+  - libtasn1=4.19.0=h5eee18b_0
+  - libtiff=4.5.0=h6a678d5_2
+  - libunistring=0.9.10=h27cfd23_0
+  - libuuid=1.41.5=h5eee18b_0
+  - libwebp=1.2.4=h11a3e52_1
+  - libwebp-base=1.2.4=h5eee18b_1
+  - libxcb=1.15=h7f8727e_0
+  - libxkbcommon=1.0.1=h5eee18b_1
+  - libxml2=2.10.3=hcbfbd50_0
+  - libxslt=1.1.37=h2085143_0
+  - libzopfli=1.0.3=he6710b0_0
+  - locket=1.0.0=py310h06a4308_0
+  - lz4-c=1.9.4=h6a678d5_0
+  - markdown=3.4.1=py310h06a4308_0
+  - markupsafe=2.1.1=py310h7f8727e_0
+  - matplotlib=3.7.1=py310h06a4308_1
+  - matplotlib-base=3.7.1=py310h1128e8f_1
+  - matplotlib-inline=0.1.6=pyhd8ed1ab_0
+  - mkl=2021.4.0=h06a4308_640
+  - mkl-service=2.4.0=py310h7f8727e_0
+  - mkl_fft=1.3.1=py310hd6ae3a3_0
+  - mkl_random=1.2.2=py310h00e6091_0
+  - monai=1.1.0=pyhd8ed1ab_0
+  - multidict=6.0.2=py310h5eee18b_0
+  - munkres=1.1.4=pyh9f0ad1d_0
+  - ncurses=6.4=h6a678d5_0
+  - nest-asyncio=1.5.8=pyhd8ed1ab_0
+  - nettle=3.7.3=hbbd107a_1
+  - networkx=2.8.4=py310h06a4308_1
+  - nspr=4.33=h295c915_0
+  - nss=3.74=h0370c37_0
+  - numexpr=2.8.4=py310h8879344_0
+  - numpy=1.24.3=py310hd5efca6_0
+  - numpy-base=1.24.3=py310h8e6c178_0
+  - oauthlib=3.2.2=py310h06a4308_0
+  - openh264=2.1.1=h4ff587b_0
+  - openjpeg=2.4.0=h3ad879b_0
+  - openssl=1.1.1w=h7f8727e_0
+  - packaging=23.0=py310h06a4308_0
+  - pandas=1.5.3=py310h1128e8f_0
+  - parso=0.8.3=pyhd8ed1ab_0
+  - pcre=8.45=h295c915_0
+  - pexpect=4.8.0=pyh1a96a4e_2
+  - pickleshare=0.7.5=py_1003
+  - pillow=9.4.0=py310h6a678d5_0
+  - pip=23.0.1=py310h06a4308_0
+  - platformdirs=4.1.0=pyhd8ed1ab_0
+  - ply=3.11=py310h06a4308_0
+  - protobuf=3.20.3=py310h6a678d5_0
+  - ptyprocess=0.7.0=pyhd3deb0d_0
+  - pure_eval=0.2.2=pyhd8ed1ab_0
+  - pycparser=2.21=pyhd8ed1ab_0
+  - pyjwt=2.4.0=py310h06a4308_0
+  - pyopenssl=23.0.0=py310h06a4308_0
+  - pyparsing=3.0.9=py310h06a4308_0
+  - pyqt=5.15.7=py310h6a678d5_1
+  - pysocks=1.7.1=py310h06a4308_0
+  - python=3.10.11=h7a1cb2a_2
+  - python-dateutil=2.8.2=pyhd8ed1ab_0
+  - python_abi=3.10=2_cp310
+  - pytorch-mutex=1.0=cpu
+  - pytz=2022.7=py310h06a4308_0
+  - pyu2f=0.1.5=pyhd8ed1ab_0
+  - pywavelets=1.4.1=py310h5eee18b_0
+  - pyyaml=6.0=py310h5eee18b_1
+  - pyzmq=23.0.0=py310h330234f_0
+  - qt-main=5.15.2=h8373d8f_8
+  - qt-webengine=5.15.9=hbbf29b9_6
+  - qtwebkit=5.212=h3fafdc1_5
+  - re2=2022.04.01=h295c915_0
+  - readline=8.2=h5eee18b_0
+  - requests=2.29.0=py310h06a4308_0
+  - scikit-image=0.20.0=py310h6a678d5_0
+  - scikit-learn=1.2.2=py310h6a678d5_0
+  - scipy=1.10.1=py310hd5efca6_0
+  - seaborn=0.12.2=py310h06a4308_0
+  - setuptools=66.0.0=py310h06a4308_0
+  - sip=6.6.2=py310h6a678d5_0
+  - six=1.16.0=pyh6c4a22f_0
+  - snappy=1.1.9=h295c915_0
+  - sqlite=3.41.2=h5eee18b_0
+  - stack_data=0.6.2=pyhd8ed1ab_0
+  - tensorboard=2.11.0=py310h06a4308_0
+  - tensorboard-data-server=0.6.1=py310h52d8a92_0
+  - tensorboard-plugin-wit=1.8.1=py310h06a4308_0
+  - tk=8.6.12=h1ccaba5_0
+  - toml=0.10.2=pyhd8ed1ab_0
+  - toolz=0.12.0=py310h06a4308_0
+  - torchaudio=0.12.1=py310_cpu
+  - tornado=6.2=py310h5eee18b_0
+  - tqdm=4.65.0=py310h2f386ee_0
+  - typing_extensions=4.5.0=py310h06a4308_0
+  - tzdata=2023c=h04d1e81_0
+  - unicodedata2=14.0.0=py310h5764c6d_1
+  - urllib3=1.26.15=py310h06a4308_0
+  - wheel=0.38.4=py310h06a4308_0
+  - xz=5.4.2=h5eee18b_0
+  - yaml=0.2.5=h7b6447c_0
+  - yarl=1.8.1=py310h5eee18b_0
+  - zeromq=4.3.4=h9c3ff4c_1
+  - zfp=0.5.5=h295c915_6
+  - zipp=3.11.0=py310h06a4308_0
+  - zlib=1.2.13=h5eee18b_0
+  - zstd=1.5.5=hc292b87_0
+  - pip:
+      - aiosignal==1.2.0
+      - alembic==1.10.4
+      - appdirs==1.4.4
+      - astor==0.8.1
+      - asttokens==2.2.1
+      - backcall==0.2.0
+      - beautifulsoup4==4.12.2
+      - blinker==1.6.2
+      - cachetools==4.2.2
+      - certifi==2022.12.7
+      - charset-normalizer==2.0.4
+      - click==8.1.3
+      - cmaes==0.9.1
+      - colorama==0.4.6
+      - colorlog==6.7.0
+      - contextlib2==21.6.0
+      - coverage==6.5.0
+      - coveralls==3.3.1
+      - cucim==23.4.1
+      - cycler==0.11.0
+      - databricks-cli==0.17.7
+      - docker==6.1.1
+      - docopt==0.6.2
+      - einops==0.6.1
+      - entrypoints==0.4
+      - exceptiongroup==1.1.1
+      - executing==1.2.0
+      - filelock==3.12.0
+      - fire==0.5.0
+      - flask==2.3.2
+      - fonttools==4.25.0
+      - future==0.18.3
+      - gdown==4.7.1
+      - gitdb==4.0.10
+      - gitpython==3.1.31
+      - google-auth==2.6.0
+      - google-auth-oauthlib==0.4.4
+      - greenlet==2.0.2
+      - gunicorn==20.1.0
+      - h5py==3.8.0
+      - huggingface-hub==0.14.1
+      - iniconfig==2.0.0
+      - ipython==8.13.1
+      - itk==5.3.0
+      - itk-core==5.3.0
+      - itk-filtering==5.3.0
+      - itk-io==5.3.0
+      - itk-numerics==5.3.0
+      - itk-registration==5.3.0
+      - itk-segmentation==5.3.0
+      - itsdangerous==2.1.2
+      - jedi==0.18.2
+      - jinja2==3.1.2
+      - json-tricks==3.16.1
+      - jsonschema==4.17.3
+      - kornia==0.4.1
+      - lmdb==1.4.1
+      - lucent==0.1.0
+      - mako==1.2.4
+      - mlflow==2.3.1
+      - nibabel==5.1.0
+      - ninja==1.11.1
+      - nni==2.10
+      - nptyping==2.5.0
+      - opencv-python==4.7.0.72
+      - openslide-python==1.1.2
+      - optuna==3.1.1
+      - partd==1.2.0
+      - pluggy==1.0.0
+      - pooch==1.4.0
+      - prettytable==3.7.0
+      - prompt-toolkit==3.0.38
+      - psutil==5.9.5
+      - pyarrow==11.0.0
+      - pyasn1==0.4.8
+      - pyasn1-modules==0.2.8
+      - pydicom==2.3.1
+      - pygments==2.15.1
+      - pynrrd==1.0.0
+      - pyqt5-sip==12.11.0
+      - pyrsistent==0.19.3
+      - pytest==7.3.1
+      - pytest-mock==3.10.0
+      - pythonwebhdfs==0.2.3
+      - pytorch-ignite==0.4.10
+      - querystring-parser==1.2.4
+      - regex==2023.5.5
+      - requests-oauthlib==1.3.0
+      - responses==0.23.1
+      - rsa==4.7.2
+      - safetensors==0.4.1
+      - schema==0.7.5
+      - simplejson==3.19.1
+      - smmap==5.0.0
+      - soupsieve==2.4.1
+      - sqlalchemy==2.0.12
+      - sqlparse==0.4.4
+      - tabulate==0.9.0
+      - tensorboardx==2.2
+      - termcolor==2.3.0
+      - threadpoolctl==2.2.0
+      - tifffile==2021.7.2
+      - timm==0.9.12
+      - tokenizers==0.12.1
+      - tomli==2.0.1
+      - torch==1.12.1+cu113
+      - torch-lucent==0.1.8
+      - torchvision==0.13.1+cu113
+      - traitlets==5.9.0
+      - transformers==4.21.3
+      - typeguard==3.0.2
+      - types-pyyaml==6.0.12.9
+      - wcwidth==0.2.6
+      - websocket-client==1.5.1
+      - websockets==11.0.3
+      - werkzeug==2.3.4