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from pipline import Transformer_Regression, extract_regions_Last , compute_ratios
import torch
import torchvision.transforms as transforms
from torch.nn import functional as F
import cv2
import gradio as gr
import numpy as np
from PIL import Image


device = torch.device('cuda' if torch.cuda.is_available() else 'cpu')

## Define some parameters
image_shape = 384     #### 512 got 87
batch_size=1
dim_patch=4
num_classes=3
label_smoothing=0.1
scale=1
import time
start = time.time()
torch.manual_seed(0)
#import random


tfms = transforms.Compose([
    transforms.Resize((image_shape, image_shape)),
    transforms.ToTensor(),
    transforms.Normalize(0.5,0.5)
    #transforms.Normalize((0.485, 0.456, 0.406), (0.229, 0.224, 0.225)),
    #transforms.Normalize(mean=(0.48145466, 0.4578275, 0.40821073), std=(0.26862954, 0.26130258, 0.27577711))

])

def Final_Compute_regression_results_Sample(Model, batch_sampler,num_head=2):
    Model.eval()
    score_cup = []
    score_disc = []
    yreg_pred = []
    yreg_true = []
    with torch.no_grad():
        #for batch_sampler in loader:
            train_batch_tfms = batch_sampler['image'].to(device=device)
            #ytrue_seg = batch_sampler['image_original'] #.detach().cpu().numpy()
            ytrue_seg = batch_sampler['image_original']  # .detach().cpu().numpy()
            scores = Model(train_batch_tfms.unsqueeze(0))

            yseg_pred = F.interpolate(scores['seg'], size=(ytrue_seg.shape[0], ytrue_seg.shape[1]), mode='bilinear',
                                      align_corners=True)


            # Regions_crop=extract_regions_Last(np.array(batch_sampler['image_original'][0]),yseg_pred[0].detach().cpu().numpy())
            Regions_crop = extract_regions_Last(np.array(batch_sampler['image_original']),
                                        yseg_pred.argmax(1).long()[0].detach().cpu().numpy())
            Regions_crop['image'] = Image.fromarray(np.uint8(Regions_crop['image'])).convert('RGB')

            ### Get back if two heads
            ytrue_seg_crop = ytrue_seg[Regions_crop['cord'][0]:Regions_crop['cord'][1],
                     Regions_crop['cord'][2]:Regions_crop['cord'][3]]
            ytrue_seg_crop = np.expand_dims(ytrue_seg_crop, axis=0)

            if num_head==2:
                scores = Model((tfms(Regions_crop['image']).unsqueeze(0)).to(device))
                yseg_pred_crop = F.interpolate(scores['seg_aux_1'], size=(ytrue_seg_crop.shape[1], ytrue_seg_crop.shape[2]),
                                           mode='bilinear', align_corners=True)
                yseg_pred[:, :, Regions_crop['cord'][0]:Regions_crop['cord'][1],
                Regions_crop['cord'][2]:Regions_crop['cord'][3]] = yseg_pred_crop
            # yseg_pred[:, :, Regions_crop['cord'][0]:Regions_crop['cord'][1],
            # Regions_crop['cord'][2]:Regions_crop['cord'][3]]+yseg_pred_crop
            yseg_pred = torch.softmax(yseg_pred, dim=1)
            yseg_pred = yseg_pred.argmax(1).long()
            yseg_pred = ((yseg_pred).long()).detach().cpu().numpy()
            ratios = compute_ratios(yseg_pred[0])
            yreg_pred.append(ratios.vcdr)

            ### Plot
            p_img = batch_sampler['image'].to(device=device).unsqueeze(0)
            p_img = F.interpolate(p_img, size=(yseg_pred.shape[1], yseg_pred.shape[2]),
                                   mode='bilinear', align_corners=True)
            ### Get reversed image
            image_orig = (p_img[0] * 0.5 + 0.5).permute(1, 2, 0).detach().cpu().numpy()
            image_orig=np.uint8(image_orig*255)
            ####
            # train_batch_tfms
            #plt.imshow(image_orig)
            # make a copy as these operations are destructive
            image_cont = image_orig.copy()
            ###### plot for Prediction....
            # threshold for 2 value
            ret, thresh = cv2.threshold(np.uint8(yseg_pred[0]), 1, 2, 0)
            # find and draw contour for 2 value (red)
            conts, hir = cv2.findContours(thresh, cv2.RETR_EXTERNAL, cv2.CHAIN_APPROX_NONE)
            cv2.drawContours(image_cont, conts, -1, (0, 255, 0), 2)
            #threshold for 1 value
            ret, thresh = cv2.threshold(np.uint8(yseg_pred[0]), 0, 2, 0)
            #find and draw contour for 1 value (blue)
            conts, hir = cv2.findContours(thresh, cv2.RETR_EXTERNAL, cv2.CHAIN_APPROX_NONE)
            cv2.drawContours(image_cont, conts, -1, (0, 0, 255), 2)
            #plot contoured image

            # plt.imshow(image_cont)
            # plt.axis('off')

            # print('Vertical cup to disc ratio:')
            # print(ratios.vcdr)
            if ratios.vcdr < 0.6:
                glaucoma = 'None'
            else:
                glaucoma = 'May be there is a risk of Glaucoma'

            # print('Galucoma:')


    return image_cont, ratios.vcdr, glaucoma, Regions_crop

#load model
DeepLab=Transformer_Regression(image_dim=image_shape,dim_patch=dim_patch,num_classes=3,scale=scale,feat_dim=128)
DeepLab.to(device=device)
DeepLab.load_state_dict(torch.load("TrainAll_Maghrabi84_50iteration_SWIN.pth.tar", map_location=torch.device(device)))

def infer(img):
    # img = cv2.cvtColor(img, cv2.COLOR_BGR2RGB)

    sample_batch = dict()
    sample_batch['image_original'] = img

    im_retina_pil = Image.fromarray(img)

    im_retina_pil = tfms(im_retina_pil)
    sample_batch['image'] = im_retina_pil

    # plt.figure('Head2')
    result, ratio, diagnosis, cropped = Final_Compute_regression_results_Sample(DeepLab, sample_batch, num_head=2)

    # cropped = cv2.cvtColor(np.asarray(cropped), cv2.COLOR_BGR2RGB)
    cropped = result[cropped['cord'][0] :cropped['cord'][1] ,
                     cropped['cord'][2]  :cropped['cord'][3] ]

    return ratio, diagnosis, result, cropped


title = "Glaucoma Detection in Retinal Fundus Images"
description = "The method detects disc and cup in the retinal image, then it computes the Vertical cup to disc ratio"

outputs = [gr.Textbox(label="Vertical cup to disc ratio:"), gr.Textbox(label="predicted diagnosis (Rule of thumb ~0.6 or greater is suspicious)"), gr.Image(label='labeled image'), gr.Image(label='zoomed in')]
with gr.Blocks(css='#title {text-align : center;} ') as demo:
    with gr.Row():
        gr.Markdown(
            f'''
            # {title}
            {description}

            ''',
            elem_id='title'
        )
    with gr.Row():
        with gr.Column():
            prompt = gr.Image(label="Upload Your Retinal Fundus Image")
            btn = gr.Button(value='Submit')
            examples = gr.Examples(
                ['M00027.png','M00056.png','M00073.png','M00093.png', 'M00018.png', 'M00034.png'],
                inputs=[prompt], fn=infer, outputs=[outputs], cache_examples=False)
        with gr.Column():
            with gr.Row():
                text1 = gr.Textbox(label="Vertical Cup to Disc Ratio:")
                text2 = gr.Textbox(label="Predicted Diagnosis (Rule of thumb ~0.6 or greater is suspicious)")
            img = gr.Image(label='Detected disc and cup')
            zoom = gr.Image(label='Croppped')

            outputs = [text1,text2,img,zoom]

            btn.click(fn=infer, inputs=prompt, outputs=outputs)


if __name__ == '__main__':
    demo.launch()