Upload app.py

app.py

@@ -0,0 +1,512 @@
+import os
+HF_TOKEN = os.getenv("HF_TOKEN")
+
+import numpy as np
+import pandas as pd
+
+import sklearn
+import sklearn.metrics
+from sklearn.metrics import roc_auc_score, roc_curve, precision_recall_curve, auc, precision_score, recall_score, f1_score, classification_report, accuracy_score, confusion_matrix, ConfusionMatrixDisplay, matthews_corrcoef
+from sklearn.model_selection import train_test_split
+from sklearn.calibration import calibration_curve
+
+from scipy import stats as st
+from random import randrange
+from matplotlib import pyplot as plt
+from scipy.special import softmax
+
+import xgboost as xgb
+import lightgbm as lgb
+import catboost as cb
+from catboost import Pool
+from sklearn.ensemble import RandomForestClassifier
+
+
+import optuna
+
+import shap
+
+import gradio as gr
+
+import random
+
+#Read and redefine data.
+
+from datasets import load_dataset
+data = load_dataset("mertkarabacak/NSQIP-CDA", data_files="cda_imputed.csv", use_auth_token = HF_TOKEN)
+
+data = pd.DataFrame(data['train'])
+variables = ['SEX', 'TRANST', 'AGE', 'SURGSPEC', 'HEIGHT', 'WEIGHT', 'DIABETES', 'SMOKE', 'DYSPNEA', 'FNSTATUS2', 'VENTILAT', 'HXCOPD', 'ASCITES', 'HXCHF', 'HYPERMED', 'RENAFAIL', 'DIALYSIS', 'DISCANCR', 'WNDINF', 'STEROID', 'WTLOSS', 'BLEEDDIS', 'TRANSFUS', 'PRSODM', 'PRBUN', 'PRCREAT', 'PRWBC', 'PRHCT', 'PRPLATE', 'ASACLAS', 'READMISSION1', 'BMI', 'RACE', 'LEVELS', 'ADVERSE_OUTCOME']
+data = data[variables]
+
+data['SEX'] = data['SEX'].replace(['male'], 'Male')
+data['SEX'] = data['SEX'].replace(['female'], 'Female')
+
+print(data.columns)
+
+#Define outcomes.
+
+x = data
+y1 = data.pop('ADVERSE_OUTCOME')
+y1 = (y1 == "Yes").astype(int)
+
+categorical_columns = list(x.select_dtypes('object').columns)
+
+x = x.astype({col: "category" for col in categorical_columns})
+
+#Prepare data for AE (y1).
+
+y1_data_xgb = xgb.DMatrix(x, label=y1, enable_categorical=True)
+y1_data_lgb = lgb.Dataset(x, label=y1) 
+y1_data_cb = Pool(data=x, label=y1, cat_features=categorical_columns)
+
+#Prepare data for Random Forest models.
+
+x_rf = x
+categorical_columns = list(x_rf.select_dtypes('category').columns)
+x_rf = x_rf.astype({col: "category" for col in categorical_columns})
+le = sklearn.preprocessing.LabelEncoder()
+for col in categorical_columns:
+        x_rf[col] = le.fit_transform(x_rf[col].astype(str))
+d1 = dict.fromkeys(x_rf.select_dtypes(np.int64).columns, str)
+x_rf = x_rf.astype(d1)
+
+#Assign unique values as answer options.
+
+unique_sex = ['Male', 'Female']
+unique_race = ['White', 'Black or African American', 'Hispanic', 'Asian', 'Other', 'Unknown']
+unique_transt = ['Not transferred', 'Transferred', 'Unknown']
+unique_diabetes = ['No', 'Yes']
+unique_smoke = ['No', 'Yes']
+unique_dyspnea = ['No', 'Yes']
+unique_ventilat = ['No', 'Yes']
+unique_hxcopd = ['No', 'Yes']
+unique_ascites = ['No', 'Yes']
+unique_hxchf = ['No', 'Yes']
+unique_hypermed = ['No', 'Yes']
+unique_renafail = ['No', 'Yes']
+unique_dialysis = ['No', 'Yes']
+unique_discancr = ['No', 'Yes']
+unique_steroid = ['No', 'Yes']
+unique_wtloss = ['No', 'Yes']
+unique_bleeddis = ['No', 'Yes']
+unique_transfus = ['No', 'Yes']
+unique_wndinf = ['No', 'Yes']
+unique_asaclas = ['1-No Disturb', '2-Mild Disturb','3-Severe Disturb']
+unique_fnstatus2 = ['Independent', 'Partially Dependent', 'Totally Dependent', 'Unknown']
+unique_surgspec = ['Neurosurgery', 'Orthopedics']
+unique_levels = ['Single', 'Multiple']
+
+#Assign hyperparameters.
+
+y1_xgb_params = {'objective': 'binary:logistic', 'booster': 'gbtree', 'lambda': 0.3506223423303318, 'alpha': 0.010119011691233883, 'max_depth': 9, 'eta': 0.965102554386191, 'gamma': 1.119572508228617e-08, 'grow_policy': 'depthwise'}
+
+y1_lgb_params = {'objective': 'binary', 'boosting_type': 'gbdt', 'lambda_l1': 8.520929262020913e-05, 'lambda_l2': 1.6655311531708117, 'num_leaves': 136, 'feature_fraction': 0.7509810402777333, 'bagging_fraction': 0.9102746088494693, 'bagging_freq': 1, 'min_child_samples': 55}
+
+y1_cb_params = {'objective': 'Logloss', 'colsample_bylevel': 0.062057010685389026, 'depth': 3, 'boosting_type': 'Plain', 'bootstrap_type': 'MVS'}
+
+y1_rf_params = {'criterion': 'gini', 'bootstrap': 'auto', 'max_features': 'auto', 'max_depth': 95, 'n_estimators': 10, 'min_samples_leaf': 1, 'min_samples_split': 2}
+
+
+#Modeling for y1/AE.
+
+y1_model_xgb = xgb.train(params=y1_xgb_params, dtrain=y1_data_xgb)
+y1_explainer_xgb = shap.TreeExplainer(y1_model_xgb)
+
+y1_model_lgb = lgb.train(params=y1_lgb_params, train_set=y1_data_lgb)
+y1_explainer_lgb = shap.TreeExplainer(y1_model_lgb)
+
+y1_model_cb = cb.train(pool=y1_data_cb, params=y1_cb_params)
+y1_explainer_cb = shap.TreeExplainer(y1_model_cb)
+
+from sklearn.ensemble import RandomForestClassifier as rf
+y1_rf = rf(**y1_rf_params)
+y1_model_rf = y1_rf.fit(x_rf, y1)
+y1_explainer_rf = shap.TreeExplainer(y1_model_rf)
+
+
+#Define predict for y1/AE.
+
+def y1_predict_xgb(*args):
+    df_xgb = pd.DataFrame([args], columns=x.columns)
+    df_xgb = df_xgb.astype({col: "category" for col in categorical_columns})
+    pos_pred = y1_model_xgb.predict(xgb.DMatrix(df_xgb, enable_categorical=True))
+    return {"Prolonged LOS": float(pos_pred[0]), "Not Prolonged LOS": 1 - float(pos_pred[0])}
+
+def y1_predict_lgb(*args):
+    df = pd.DataFrame([args], columns=data.columns)
+    df = df.astype({col: "category" for col in categorical_columns})
+    pos_pred = y1_model_lgb.predict(df)
+    return {"Prolonged LOS": float(pos_pred[0]), "Not Prolonged LOS": 1 - float(pos_pred[0])}
+
+def y1_predict_cb(*args):
+    df_cb = pd.DataFrame([args], columns=x.columns)
+    df_cb = df_cb.astype({col: "category" for col in categorical_columns})
+    pos_pred = y1_model_cb.predict(Pool(df_cb, cat_features = categorical_columns), prediction_type='Probability')
+    return {"Prolonged LOS": float(pos_pred[0][1]), "Not Prolonged LOS": float(pos_pred[0][0])}
+
+def y1_predict_rf(*args):
+    df = pd.DataFrame([args], columns=x_rf.columns)
+    df = df.astype({col: "category" for col in categorical_columns})
+    d = dict.fromkeys(df.select_dtypes(np.int64).columns, np.int32)
+    df = df.astype(d)
+    pos_pred = y1_model_rf.predict_proba(df)
+    return {"Prolonged LOS": float(pos_pred[0][1]), "Not Prolonged LOS": float(pos_pred[0][0])}
+
+
+#Define interpret for y1/AE.
+
+def y1_interpret_xgb(*args):
+    df = pd.DataFrame([args], columns=x.columns)
+    df = df.astype({col: "category" for col in categorical_columns})
+    shap_values = y1_explainer_xgb.shap_values(xgb.DMatrix(df, enable_categorical=True))
+    scores_desc = list(zip(shap_values[0], x.columns))
+    scores_desc = sorted(scores_desc)
+    fig_m = plt.figure(facecolor='white')
+    fig_m.set_size_inches(14, 10)
+    plt.barh([s[1] for s in scores_desc], [s[0] for s in scores_desc])
+    plt.title("Feature Shap Values", fontsize = 24, pad = 20, fontweight = 'bold')
+    plt.yticks(fontsize=12)
+    plt.xlabel("Shap Value", fontsize = 16, labelpad=8, fontweight = 'bold')
+    plt.ylabel("Feature", fontsize = 16, labelpad=14, fontweight = 'bold')
+    return fig_m
+
+def y1_interpret_lgb(*args):
+    df = pd.DataFrame([args], columns=x.columns)
+    df = df.astype({col: "category" for col in categorical_columns})
+    shap_values = y1_explainer_lgb.shap_values(df)
+    scores_desc = list(zip(shap_values[0][0], x.columns))
+    scores_desc = sorted(scores_desc)
+    fig_m = plt.figure(facecolor='white')
+    fig_m.set_size_inches(14, 10)
+    plt.barh([s[1] for s in scores_desc], [s[0] for s in scores_desc])
+    plt.title("Feature Shap Values", fontsize = 24, pad = 20, fontweight = 'bold')
+    plt.yticks(fontsize=12)
+    plt.xlabel("Shap Value", fontsize = 16, labelpad=8, fontweight = 'bold')
+    plt.ylabel("Feature", fontsize = 16, labelpad=14, fontweight = 'bold')
+    return fig_m
+
+def y1_interpret_cb(*args):
+    df = pd.DataFrame([args], columns=x.columns)
+    df = df.astype({col: "category" for col in categorical_columns})
+    shap_values = y1_explainer_cb.shap_values(Pool(df, cat_features = categorical_columns))
+    scores_desc = list(zip(shap_values[0], x.columns))
+    scores_desc = sorted(scores_desc)
+    fig_m = plt.figure(facecolor='white')
+    fig_m.set_size_inches(14, 10)
+    plt.barh([s[1] for s in scores_desc], [s[0] for s in scores_desc])
+    plt.title("Feature Shap Values", fontsize = 24, pad = 20, fontweight = 'bold')
+    plt.yticks(fontsize=12)
+    plt.xlabel("Shap Value", fontsize = 16, labelpad=8, fontweight = 'bold')
+    plt.ylabel("Feature", fontsize = 16, labelpad=14, fontweight = 'bold')
+    return fig_m
+
+def y1_interpret_rf(*args):
+    df = pd.DataFrame([args], columns=x_rf.columns)
+    df = df.astype({col: "category" for col in categorical_columns})
+    shap_values = y1_explainer_rf.shap_values(df)
+    scores_desc = list(zip(shap_values[0][0], x_rf.columns))
+    scores_desc = sorted(scores_desc)
+    fig_m = plt.figure(facecolor='white')
+    fig_m.set_size_inches(14, 10)
+    plt.barh([s[1] for s in scores_desc], [s[0] for s in scores_desc])
+    plt.title("Feature Shap Values", fontsize = 24, pad = 20, fontweight = 'bold')
+    plt.yticks(fontsize=12)
+    plt.xlabel("Shap Value", fontsize = 16, labelpad=8, fontweight = 'bold')
+    plt.ylabel("Feature", fontsize = 16, labelpad=14, fontweight = 'bold')
+    return fig_m
+
+
+with gr.Blocks(title = "NSQIP-CDA") as demo:
+    
+    gr.Markdown(
+        """ 
+    """
+    )
+        
+    gr.Markdown(
+        """
+    # Prediction Tool
+
+    ## Adverse Short-Term Postoperative Outcomes Following Cervical Disc Arthroplasty
+
+    **The publication describing the details of this predictive tool will be posted here upon the acceptance of publication.**
+
+    ### Disclaimer
+
+    The American College of Surgeons National Surgical Quality Improvement Program and the hospitals participating in the ACS NSQIP are the source of the data used herein; they have not been verified and are not responsible for the statistical validity of the data analysis or the conclusions derived by the authors.
+
+    The predictive tool located on this web page is for general health information only. This prediction tool should not be used in place of professional medical service for any disease or concern. Users of the prediction tool shouldn't base their decisions about their own health issues on the information presented here. You should ask any questions to your own doctor or another healthcare professional. 
+
+    The authors of the study mentioned above make no guarantees or representations, either express or implied, as to the completeness, timeliness, comparative or contentious nature, or utility of any information contained in or referred to in this prediction tool. The risk associated with using this prediction tool or the information in this predictive tool is not at all assumed by the authors. The information contained in the prediction tools may be outdated, not complete, or incorrect because health-related information is subject to frequent change and multiple confounders.
+
+    No express or implied doctor-patient relationship is established by using the prediction tool. The prediction tools on this website are not validated by the authors. Users of the tool are not contacted by the authors, who also do not record any specific information about them.
+
+    You are hereby advised to seek the advice of a doctor or other qualified healthcare provider before making any decisions, acting, or refraining from acting in response to any healthcare problem or issue you may be experiencing at any time, now or in the future. By using the prediction tool, you acknowledge and agree that neither the authors nor any other party are or will be liable or otherwise responsible for any decisions you make, actions you take, or actions you choose not to take as a result of using any information presented here.
+
+    By using this tool, you accept all of the above terms.
+
+    """
+    )
+        
+    gr.Markdown(
+        """
+
+    ### Prolonged Length of Stay Prediction Model for PCF Surgery
+
+        """
+    )
+
+
+    with gr.Row():
+
+        with gr.Column():
+
+            AGE = gr.Slider(label="Age", minimum=17, maximum=99, step=1, randomize=True)
+
+            SEX = gr.Radio(
+                label="Sex",
+                choices=unique_sex,
+                type='index',
+                value=lambda: random.choice(unique_sex),
+            )
+
+            RACE = gr.Radio(
+                label="Race",
+                choices=unique_race,
+                type='index',
+                value=lambda: random.choice(unique_race),
+            )
+
+            HEIGHT = gr.Slider(label="Height (in meters)", minimum=1.0, maximum=2.25, step=0.01, randomize=True)
+
+            WEIGHT = gr.Slider(label="Weight (in kilograms)", minimum=20, maximum=200, step=1, randomize=True)
+
+            BMI = gr.Slider(label="BMI", minimum=10, maximum=70, step=1, randomize=True)
+
+            TRANST = gr.Radio(
+                label="Transfer Status",
+                choices=unique_transt,
+                type='index',
+                value=lambda: random.choice(unique_transt),
+            )
+
+            SURGSPEC = gr.Radio(
+                label="Surgical Specialty",
+                choices=unique_surgspec,
+                type='index',
+                value=lambda: random.choice(unique_surgspec),
+            )
+
+            SMOKE = gr.Radio(
+                label="Smoking Status",
+                choices=unique_smoke,
+                type='index',
+                value=lambda: random.choice(unique_smoke),
+            )
+
+            DIABETES = gr.Radio(
+                label="Diabetes",
+                choices=unique_diabetes,
+                type='index',
+                value=lambda: random.choice(unique_diabetes),
+            )
+
+            DYSPNEA = gr.Radio(
+                label="Dyspnea",
+                choices=unique_dyspnea,
+                type='index',
+                value=lambda: random.choice(unique_dyspnea),
+            )
+
+            VENTILAT = gr.Radio(
+                label="Ventilator Dependency",
+                choices=unique_ventilat,
+                type='index',
+                value=lambda: random.choice(unique_ventilat),
+            )
+
+            HXCOPD = gr.Radio(
+                label="History of COPD",
+                choices=unique_hxcopd,
+                type='index',
+                value=lambda: random.choice(unique_hxcopd),
+            )
+
+            ASCITES = gr.Radio(
+                label="Ascites",
+                choices=unique_ascites,
+                type='index',
+                value=lambda: random.choice(unique_ascites),
+            )
+
+            HXCHF = gr.Radio(
+                label="History of Congestive Heart Failure",
+                choices=unique_hxchf,
+                type='index',
+                value=lambda: random.choice(unique_hxchf),
+            )
+
+            HYPERMED = gr.Radio(
+                label="Hypertension Despite Medication",
+                choices=unique_hypermed,
+                type='index',
+                value=lambda: random.choice(unique_hypermed),
+            )
+
+            RENAFAIL = gr.Radio(
+                label="Renal Failure",
+                choices=unique_renafail,
+                type='index',
+                value=lambda: random.choice(unique_renafail),
+            )
+
+            DIALYSIS = gr.Radio(
+                label="Dialysis",
+                choices=unique_dialysis,
+                type='index',
+                value=lambda: random.choice(unique_dialysis),
+            )
+
+            STEROID = gr.Radio(
+                label="Steroid",
+                choices=unique_steroid,
+                type='index',
+                value=lambda: random.choice(unique_steroid),
+            )
+
+            WTLOSS = gr.Radio(
+                label="Weight Loss",
+                choices=unique_wtloss,
+                type='index',
+                value=lambda: random.choice(unique_wtloss),
+            )
+
+            BLEEDDIS = gr.Radio(
+                label="Bleeding Disorder",
+                choices=unique_bleeddis,
+                type='index',
+                value=lambda: random.choice(unique_bleeddis),
+            )
+
+            TRANSFUS = gr.Radio(
+                label="Transfusion",
+                choices=unique_transfus,
+                type='index',
+                value=lambda: random.choice(unique_transfus),
+            )
+
+            WNDINF = gr.Radio(
+                label="Wound Infection",
+                choices=unique_wndinf,
+                type='index',
+                value=lambda: random.choice(unique_wndinf),
+            )
+
+            DISCANCR = gr.Radio(
+                label="Disseminated Cancer",
+                choices=unique_discancr,
+                type='index',
+                value=lambda: random.choice(unique_discancr),
+            )
+
+            FNSTATUS2 = gr.Radio(
+                label="Functional Status",
+                choices=unique_fnstatus2,
+                type='index',
+                value=lambda: random.choice(unique_fnstatus2),
+            )
+
+            PRSODM = gr.Slider(label="Sodium", minimum=min(x['PRSODM']), maximum=max(x['PRSODM']), step=1, randomize=True)
+
+            PRBUN = gr.Slider(label="BUN", minimum=min(x['PRBUN']), maximum=max(x['PRBUN']), step=1, randomize=True)
+
+            PRCREAT = gr.Slider(label="Creatine", minimum=min(x['PRCREAT']),maximum=max(x['PRCREAT']), step=0.1, randomize=True)
+
+            PRWBC = gr.Slider(label="WBC", minimum=min(x['PRWBC']), maximum=max(x['PRWBC']), step=0.1, randomize=True)
+
+            PRHCT = gr.Slider(label="Hematocrit", minimum=min(x['PRHCT']), maximum=max(x['PRHCT']), step=0.1, randomize=True)
+
+            PRPLATE = gr.Slider(label="Platelet", minimum=min(x['PRPLATE']), maximum=max(x['PRPLATE']), step=1, randomize=True)
+
+            ASACLAS = gr.Radio(
+                label="ASA Class",
+                choices=unique_asaclas,
+                type='index',
+                value=lambda: random.choice(unique_asaclas),
+
+            )
+
+            LEVELS = gr.Radio(
+                label="Levels",
+                choices=unique_levels,
+                type='index',
+                value=lambda: random.choice(unique_levels),
+            )
+
+        with gr.Column():
+
+            with gr.Row():
+                y1_predict_btn_xgb = gr.Button(value="Predict (XGBoost)")
+                y1_predict_btn_lgb = gr.Button(value="Predict (LightGBM)")
+                y1_predict_btn_cb = gr.Button(value="Predict (CatBoost)")
+                y1_predict_btn_rf = gr.Button(value="Predict (Random Forest)")
+            label = gr.Label()
+
+            with gr.Row():
+                y1_interpret_btn_xgb = gr.Button(value="Explain (XGBoost)")
+                y1_interpret_btn_lgb = gr.Button(value="Explain (LightGBM)")
+                y1_interpret_btn_cb = gr.Button(value="Explain (CatBoost)")
+                y1_interpret_btn_rf = gr.Button(value="Explain (Random Forest)") 
+
+            plot = gr.Plot()
+
+            y1_predict_btn_xgb.click(
+                y1_predict_xgb,
+                inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, VENTILAT, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, WNDINF, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, LEVELS,],
+                outputs=[label]
+            )
+
+            y1_predict_btn_lgb.click(
+                y1_predict_lgb,
+                inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, VENTILAT, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, WNDINF, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, LEVELS,],
+                outputs=[label]
+            )
+
+            y1_predict_btn_cb.click(
+                y1_predict_cb,
+                inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, VENTILAT, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, WNDINF, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, LEVELS,],
+                outputs=[label]
+            )
+
+            y1_predict_btn_rf.click(
+                y1_predict_rf,
+                inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, VENTILAT, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, WNDINF, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, LEVELS,],
+                outputs=[label]
+            )
+
+            y1_interpret_btn_xgb.click(
+                y1_interpret_xgb,
+                inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, VENTILAT, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, WNDINF, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, LEVELS,],
+                outputs=[plot],
+            )
+
+            y1_interpret_btn_lgb.click(
+                y1_interpret_lgb,
+                inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, VENTILAT, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, WNDINF, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, LEVELS,],
+                outputs=[plot],
+            )
+
+            y1_interpret_btn_cb.click(
+                y1_interpret_cb,
+                inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, VENTILAT, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, WNDINF, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, LEVELS,],
+                outputs=[plot],
+            )
+
+            y1_interpret_btn_rf.click(
+                y1_interpret_rf,
+                inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, VENTILAT, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, WNDINF, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, LEVELS,],
+                outputs=[plot],
+            )
+
+demo.launch()