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ChemistryVision

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BACE-V-SMILES

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You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(cc(F)c1)CC(NC(=O)C(N1CCC(CCCC)C1=O)CCc1ccccc1)C(O)C[NH2+]Cc1cc(OC)ccc1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Ic1cc(ccc1)C1([NH2+]CC(O)C(NC(=O)C)Cc2cc(F)cc(F)c2)CCCCC1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: O(C)c1ccc(cc1)-c1cc(ccc1)C1CC1C1(N=C(N)N(C)C(=O)C1)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(F)ccc1CC(NC(=O)C)C(O)C[NH2+]C1CC2(Oc3ncc(cc13)CC(C)(C)C)CCC2 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: O=C(N[C@H]([C@H](O)C[NH2+][C@H]1CC(Cc2nn(cc12)CC(C)(C)C)(C)C)Cc1ccccc1)C BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S1CC[C@@](N=C1N)(C)c1ccc(OC)cc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: O1C2COCCC2(N=C1N)c1cc(NC(=O)c2nc(oc2)C)ccc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S1(=O)(=O)N(c2cc(cc3c2n(cc3CC)CC1)C(=O)NC([C@H](O)C[NH2+]CCF)Cc1ccccc1)C BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: O1c2c(cc(cc2)-c2cncnc2)C2(N=C(N)N(C)C2=O)CC1(C)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Clc1cc2CC(N=C(NC(Cc3ccccc3)C(=O)[O-])c2cc1)(C)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: O=C1N(C)C(=[NH2+])NC1(c1cc(ccc1)-c1cccnc1)c1ccccc1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Clc1cc(cnc1)-c1cc2c(OC(CC23N=C(N)N(C)C3=O)(C)C)cc1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(cc(F)c1)CC(NC(=O)C(N1CCC(COC)C1=O)CCc1ccccc1)C(O)C[NH2+]Cc1cc(OC)ccc1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S(=O)(=O)(N(C)c1cc(cc(c1)C(=O)NC(C(O)CC(OC)COCC=C)COc1cc(F)cc(F)c1)C(=O)NC(C)c1ccccc1)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S(=O)(=O)(N(C1CCCCC1)c1cc(ccc1)C(=O)NC(Cc1ccccc1)C(O)C[NH2+]C(C(=O)NC1CCCCC1)C)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S1(Oc2cc(cc3c2n(cc3CC)CC1)C(=O)NC([C@H](O)C[NH2+]C1CC1)Cc1ccccc1)(=O)=O BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1ccc(cc1-c1cccnc1F)[C@@]1(N=C(N)N(C)C1=O)c1cc(C)c(OC)cc1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(ccc1C(F)(F)F)CC(NC(=O)C)C(O)C[NH2+]C1CC2(Oc3ncc(cc13)CC(C)(C)C)CCC2 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Oc1ccc(cc1-c1nccc(c1)C#CC)C1(N=C(C)C(=N1)N)C1CC1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(cc(F)c1)C[C@H](NC(=O)C)[C@H](O)C[NH2+]C1(CCCCC1)c1cc(-n2nccc2)ccc1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S1c2c(cc(cc2)-c2cncnc2)C2(N=C(N)N(C)C2=O)CC1(C)C BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: O1CCN(CC1)C(=O)CN1C(C)=C(C(=O)N[C@H]([C@H](O)C[NH2+]C2CC2)Cc2ccccc2)[C@H](C)C(C(OCc2ccccc2)=O)=C1C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Clc1ccccc1-c1n(Cc2nc(N)ccc2)c(cc1)-c1ccc(Oc2nnccc2)cc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(cc(F)c1)CC(NC(=O)C)C(O)C[NH2+]C1(CCC(=O)NC1)c1cc(ccc1)C(C)(C)C BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(cc(F)c1)CC(NC(=O)C)C(O)C[NH2+]C1(CCCOC1)c1cc(-n2nccc2)ccc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1ccc(cc1)Cc1cc(ccc1)C1([NH+]=C(N2C1=NCCC2)N)c1ccccc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: O1CCCCOc2nc(cc(c2)C(=O)NC(Cc2cc1ccc2)C(O)C[NH2+]C1(CC1)c1cc(ccc1)C(C)C)COC BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S(=O)(=O)(CC)c1cc(cc(N(S(=O)(=O)C)c2ccccc2)c1)C(=O)NC(Cc1ccccc1)C(O)C[NH2+]Cc1cc(ccc1)C(F)(F)F BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(cc(F)c1)CC(NC(=O)C)C(O)C[NH2+]C1(CCCCC1)c1cc(N2CCCOCC2=O)ccc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(cc(F)c1)CC(NC(=O)C)C(O)C[NH2+]C1(CCC(CC1)CCO)c1cc(ccc1)C(C)(C)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S(=O)(=O)(N(C)c1cc(cc(c1)C(=O)NCC([NH3+])(Cc1ccccc1)CO)C(=O)NC(C)c1ccc(F)cc1)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Clc1ccccc1-c1n(Cc2nc(N)c(NCCCO)cc2)c(cc1)-c1ccc(OCCCCC)cc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(cc(F)c1)CC(NC(=O)C)C(O)C[NH2+]C1(CCCCC1)c1cc(N2CCCOCC2=O)ccc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1ccc(cc1-c1cncnc1)C1(N=C(N)c2c1cc(F)cc2F)c1cc(ncc1)C(F)F BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: s1cc(cc1-c1ccc(cc1)C1CC1C=1N=C(N)N(C)C(=O)C=1)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Clc1ccc(nc1)C(=O)Nc1cc(ccc1)C1(N=C(N)C[NH+](C1)C)C BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: s1cc(nc1-c1cc(ccc1)CC(NC(=O)COC)C(O)C[NH2+]C1CC2(Oc3ncc(cc13)CC(C)(C)C)CCC2)C BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Clc1cc2nc(n(c2cc1)CCCC(=O)N(Cc1cc(F)ccc1)C)N BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(N2C1=NCCC2)N)c1ccncc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S1CCC(=NC1(C)c1cc(ccc1)-c1cc(OC)ccc1)N BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: O=C(NCC=C)c1ccc(cc1)-c1n(Cc2nc(N)ccc2)c(cc1)-c1ccccc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(cc(F)c1)CC(NC(=O)C(N1CCC(C(O)CCC)C1=O)C)C(O)C1[NH2+]CC(OCCC)C1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(cc(F)c1)CC(NC(=O)c1c2c(n(c1)C(=O)NCCCC)cccc2)C(O)C[NH2+]Cc1cc(OC)ccc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(cc(F)c1)CC(NC(=O)C(N1CCC(CCCC)C1=O)CCc1ccccc1)C(O)C[NH2+]Cc1cc(OC)ccc1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1ccc(cc1C#N)CC(NC(=O)C)C(O)C[NH2+]C1CC2(Oc3ncc(cc13)CC(C)(C)C)CCC2 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S1(=O)(=O)N(c2cc(cc3n(cc(CC1)c23)CC)C(=O)NC([C@H](O)C[NH2+]CCF)Cc1ccccc1)C BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: s1ccc(C2(N=C(N)N(C)C2=O)c2cc(ccc2)-c2cncnc2)c1C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S1(=O)(=O)N(C2(CC([NH+](CC2)Cc2cc(OCC)c(O)cc2)C)CN1C)c1cc(F)ccc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Clc1cc(-c2cc3c(OC(CC34N=C(N)N(C)C4=O)(C)C)cc2)c(F)cc1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S1(=O)(=O)N(c2cc(cc3c2n(cc3CC)CC1)C(=O)N[C@H]([C@H](O)C[NH2+]C1CCOCC1)Cc1ccccc1)CC BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S(=O)(=O)(N(C)c1cc(cc(NCCC([NH3+])(Cc2ccccc2)CO)c1)C(=O)NC(C)c1ccc(F)cc1)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S1(=O)(=O)N(C2(CC([NH+](CC2)Cc2cc(OC(C)C)ccc2)C)CN1c1ccncc1)c1cc(F)ccc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: O(C(=O)C=1[C@H](C)C(C(=O)N[C@H]([C@H](O)C[NH2+]C2CC2)Cc2ccccc2)=C(N(CC(=O)N(C)C)C=1C)C)Cc1ccccc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1ncccc1-c1cc(ccc1)C1(N=C(N)N(C)C1=O)c1cc(C)c(OC)cc1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Clc1cc(cnc1)-c1cc(ccc1)C12N=C(OC1COCC2)N BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Clc1cc(-c2cc3c(OC(CC34N=C(N)N(C)C4=O)(C)C)cc2)c(F)cc1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1ncccc1-c1cc2c(OC(CC23N=C(N)N(C)C3=O)(C)C)cc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Clc1cc2nc(n(c2cc1)CCCO)N BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(cc(F)c1)CC(NC(=O)C)C(O)C[NH2+]C1(CCCCC1)c1cc(ccc1)C(CC)(C)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S(=O)(=O)(N1C(C)=C(C(=O)N[C@H](C)c2ccccc2)[C@@H](C)C(C(=O)N[C@H]([C@H](O)C[NH2+]C2CC2)Cc2ccccc2)=C1C)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1ncccc1-c1cc(ccc1)C1(N=C(N)N(C)C1=O)c1cn(nc1)CCC(C)C BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S(=O)(=O)(N(C)c1cc(cc(c1)C(=O)NC(C(O)CC(OC)C(=O)NC(C(C)C)C(=O)NCc1ccccc1)COc1cc(F)cc(F)c1)C(=O)NC(C)c1ccccc1)C BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: s1cc(cc1)-c1cc(ccc1)C1([NH2+]CC(O)C(NC(=O)C)Cc2cc(F)cc(F)c2)CCCCC1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S1(=O)(=O)CC(Cc2cc(OCCC)c(N)c(F)c2)C(O)C([NH2+]Cc2cc(ccc2)C(C)(C)C)C1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: OC(C(NC(=O)c1cc(N(C(=O)C)c2ccccc2)ccc1)Cc1ccccc1)C[NH2+]C(C(=O)NC1CCCCC1)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(ccc1F)CC(NC(=O)C)C(O)C[NH2+]C1CC2(Oc3ncc(cc13)CC(C)(C)C)CCC2 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Clc1cc2nc(n(c2cc1)CCCC(=O)NCC1CCCCC1)N BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: FC(F)Oc1ccc(cc1)[C@@]1(N=C(N)N(C)C1=O)c1cc(ccc1)\C=C\CCCOC BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(cc(F)c1)CC(NC(=O)c1cc(cc(c1)C)C(=O)N(CCC)CCC)[C@@H](O)C[NH2+]Cc1cc(OC)ccc1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(cc(F)c1)CC(NC(=O)c1c2cc(ccc2n(c1)C(=O)N(CCCC)C)C(F)(F)F)C(O)C[NH2+]Cc1cc(OC)ccc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: FC(F)Oc1ccc(cc1)[C@@]1(N=C(N)N(C)C1=O)c1cc(ccc1)\C=C\CCOC BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(cc(F)c1)CC(NC(=O)C)C(O)C[NH2+]C1(CCC(CC1)C#N)c1cc(ccc1)C(C)(C)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S1(=O)(=O)N(c2cc(cc3c2n(cc3CC)CC1)C(=O)NC(Cc1ccccc1)C(O)C[NH2+]C1CCOCC1)C BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Clc1cc2CC([NH+]=C(N[C@@H](Cc3ccccc3)C3=NOC(=O)[N-]3)c2cc1)(C)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1ccc(cc1-c1cncnc1)C1(N=C(N)N(C)C1=O)c1cn(nc1)CC BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)NC(Cc1ccccc1)C(O)C[NH2+]C(C(=O)NC1CCCCC1)C)c1cc(ccc1)C#N)C BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)NC(Cc1ccccc1)C(O)C[NH2+]C1CC1)c1ccccc1)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: FC(F)(F)c1cc(ccc1)C[NH2+]CC(O)C(NC(=O)c1cc(N2CCCC2=O)c2c(n(nc2)CC)c1)Cc1ccccc1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Clc1cc(cc(Cl)c1NC(=O)C)C\N=C(\NC(=O)Cn1c2c(cccc2)cc1)/N BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: FC(F)(F)c1cc(ccc1)C[NH2+]CC(O)C(NC(=O)c1cc(N2CCCC2=O)c2ncn(c2c1)CC)Cc1ccccc1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Clc1cc2nc(n(c2cc1)C(CC(=O)N(CC1CCCCC1)C)CC)N BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: O1CC2(N=C1N)c1cc(ccc1Oc1c2cc(cc1)CCC)-c1cncnc1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: O=C1N(Cc2ccc(cc2)CNC(=O)NCCCC)C(NC1(CC1CCCCC1)CC1CCCCC1)=N BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: O(C)c1cc(NC[C@@H](O)[C@@H](NC(=O)C=2[C@H](CCC)C(C(=O)C)=C(N(CC(OC(C)C)=O)C=2C)C)Cc2ccccc2)ccc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: O(C)c1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S1(=O)(=O)N(CCCC1)c1cc(cc(NCC)c1)C(=O)NC(Cc1ccccc1)C(O)C[NH2+]C1CC1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(cnc1)-c1cc(ccc1)C1(N=C(N)[C@@H]2N1CCCC2)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1cc(cc(F)c1)CC(NC(=O)c1cc(cc(c1)/C(=N\OCC(C)C)/C)C(=O)N(CCC)CCC)C(O)C[NH2+]Cc1cc(OC)ccc1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: O=C1N(C)C(=NC(C1)(C)C1CC1c1cc(ccc1)\C=C\c1ccccc1)N BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: O1C2COCCC2(N=C1N)c1cc(NC(=O)c2nc(oc2)C)ccc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Clc1ccc(nc1)C(=O)Nc1cc(C2(N=C(OCC2)N)C)c(F)cc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: [NH+]=1[C@](N=C(c2ccccc2)C=1N)(C)c1cc(ccc1)-c1cccnc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: O(C)c1ccccc1C[NH2+]CC(O)C(NC(=O)c1c2cccnc2n(c1)C(=O)N(CCCC)C)Cc1ccccc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: OC(C(NC(=O)C1CC(CCC1)C1(NC(=O)C)CCCC1)Cc1ccccc1)CC(C(=O)NCCCC)C BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1ncccc1-c1cc(ccc1)C1(N=C(N)N(C)C1=O)c1cc(nc(c1)CC)CC BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Clc1cc(cc(Cl)c1NC(=O)C)CNC(NC(=O)Cn1c2cc(ccc2cc1)C#N)=N BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1ccc(cc1OCCF)[C@]1(N=C(N)N(C)C1=O)c1ccc(OC(F)F)cc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: S1(=O)(=O)N(CCCC1)c1cc(cc(c1)/C(=N\O)/C)C(=O)N[C@H]([C@@H](O)C[NH2+]Cc1cc(OC)ccc1)Cc1cc(F)cc(F)c1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1ncccc1-c1cc(ccc1)C1(N=C(OC1)N)c1ccc(OC(F)F)cc1 BACE-1 Inhibit: You should only answer with Yes or No.

No

You are an expert chemist, your task is to predict the property of molecule using your experienced chemical property prediction knowledge. Please strictly follow the format, no other information can be provided. Given the SMILES string of a molecule, predict the molecular properties of a given chemical compound based on its structure, by analyzing whether it can inhibit (Yes) the Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) or cannot inhibit (No) BACE1. Consider factors such as molecular weight, atom count, bond types, and functional groups in order to assess the compound's drug-likeness and its potential to serve as an effective therapeutic agent for Alzheimer's disease. Please answer with only Yes or No. A few examples are provided in the beginning. SMILES: S(=O)(=O)(c1cc(cc(c1)C(=O)NC(Cc1cc(F)cc(F)c1)C(O)C[NH2+]Cc1cc(OC)ccc1)C(=O)N(CCC)CCC)c1ccccc1 BACE-1 Inhibit: Yes SMILES: S(=O)(=O)(N(c1cc(ccc1)C(=O)N[C@H]([C@H](O)C[NH2+][C@H](C(=O)NC1CCCCC1)C)Cc1ccccc1)c1ccccc1)C BACE-1 Inhibit: Yes SMILES: n1cc(ccc1)-c1cc(ccc1)C1(N=C(C)C(=N1)N)c1ccccc1 BACE-1 Inhibit: No SMILES: O1C2CCCCC2(N=C1N)c1cc(ccc1)-c1cncnc1 BACE-1 Inhibit: No Below is the molecule whose property you have to predict. Along with is the image structure of the molecule. SMILES: Fc1ccc(F)cc1-c1cc(ccc1)[C@]1(N=C(N)N(C)C1=O)c1ccncc1 BACE-1 Inhibit: You should only answer with Yes or No.

Yes