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DS.d100
18373731
[ { "id": "DS.d100.s0", "type": "", "text": [ "Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence." ], "offsets": [ [ 0, 104 ] ] }, { "id": "DS.d100.s1", "type": "", "text": [ "Here, we addressed this issue and found that cyclo(His-Pro) triggered nuclear accumulation of NF-E2-related factor-2 (Nrf2), a transcription factor that up-regulates antioxidant-/electrophile-responsive element (ARE-EpRE)-related genes, in PC12 cells." ], "offsets": [ [ 105, 356 ] ] } ]
[ { "id": "DS.d100.s0.e0", "type": "compound", "text": [ "Cyclo(His-Pro" ], "offsets": [ [ 0, 13 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65137" } ] }, { "id": "DS.d100.s0.e1", "type": "protein", "text": [ "Nrf2" ], "offsets": [ [ 53, 57 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54968" }, { "db_name": "UniProt", "db_id": "Q60795" } ] }, { "id": "DS.d100.s1.e0", "type": "compound", "text": [ "cyclo(His-Pro" ], "offsets": [ [ 150, 163 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65137" } ] }, { "id": "DS.d100.s1.e1", "type": "protein", "text": [ "NF-E2-related factor-2" ], "offsets": [ [ 199, 221 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54968" }, { "db_name": "UniProt", "db_id": "Q16236" }, { "db_name": "UniProt", "db_id": "Q60795" } ] }, { "id": "DS.d100.s1.e2", "type": "protein", "text": [ "Nrf2" ], "offsets": [ [ 223, 227 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54968" }, { "db_name": "UniProt", "db_id": "Q60795" } ] } ]
[]
[]
[ { "id": "DS.d100.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d100.s0.e0", "arg2_id": "DS.d100.s0.e1", "normalized": [] }, { "id": "DS.d100.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d100.s1.e0", "arg2_id": "DS.d100.s1.e1", "normalized": [] }, { "id": "DS.d100.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d100.s1.e0", "arg2_id": "DS.d100.s1.e2", "normalized": [] } ]
DS.d101
18374997
[ { "id": "DS.d101.s0", "type": "", "text": [ "In women, Plg levels were higher in individuals with diagnosed ischemic heart disease (IHD) and increased with triglycerides (TG) and glucose level." ], "offsets": [ [ 0, 148 ] ] } ]
[ { "id": "DS.d101.s0.e0", "type": "protein", "text": [ "Plg" ], "offsets": [ [ 10, 13 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20918" }, { "db_name": "UniProt", "db_id": "Q01177" } ] }, { "id": "DS.d101.s0.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 134, 141 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] } ]
[]
[]
[]
DS.d102
18375536
[ { "id": "DS.d102.s0", "type": "", "text": [ "To investigate overnight variations in absolute values and patterns of cytokines including interleukin 6 (IL6) and tumour necrosis factor alpha (TNFalpha) in rheumatoid arthritis (RA), and to relate any changes to those occurring in blood cortisol." ], "offsets": [ [ 0, 248 ] ] } ]
[ { "id": "DS.d102.s0.e0", "type": "protein", "text": [ "interleukin 6" ], "offsets": [ [ 91, 104 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P41693" } ] }, { "id": "DS.d102.s0.e1", "type": "protein", "text": [ "IL6" ], "offsets": [ [ 106, 109 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d102.s0.e2", "type": "protein", "text": [ "TNFalpha" ], "offsets": [ [ 145, 153 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d102.s0.e3", "type": "compound", "text": [ "cortisol" ], "offsets": [ [ 239, 247 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] } ]
[]
[]
[]
DS.d103
18378405
[ { "id": "DS.d103.s0", "type": "", "text": [ "Using a cell culture model of synaptic NMDA receptor-dependent synaptic potentiation, we find that this is mediated exclusively by NR2B-containing N-methyl-D-aspartate receptors, as implicated by NR2B-specific antagonists and the use of selective vs. non-selective doses of the NR2A-preferring antagonist NVP-AAM077." ], "offsets": [ [ 0, 316 ] ] } ]
[ { "id": "DS.d103.s0.e0", "type": "protein", "text": [ "N-methyl-D-aspartate receptors" ], "offsets": [ [ 147, 177 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P35439" }, { "db_name": "UniProt", "db_id": "Q9R1M7" } ] }, { "id": "DS.d103.s0.e1", "type": "compound", "text": [ "NVP" ], "offsets": [ [ 305, 308 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4463" } ] } ]
[]
[]
[ { "id": "DS.d103.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d103.s0.e1", "arg2_id": "DS.d103.s0.e0", "normalized": [] } ]
DS.d104
18379782
[ { "id": "DS.d104.s0", "type": "", "text": [ "Dexrazoxane protects against doxorubicin-induced cardiomyopathy: upregulation of Akt and Erk phosphorylation in a rat model." ], "offsets": [ [ 0, 124 ] ] } ]
[ { "id": "DS.d104.s0.e0", "type": "compound", "text": [ "Dexrazoxane" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "30623" }, { "db_name": "PubChem", "db_id": "71384" } ] }, { "id": "DS.d104.s0.e1", "type": "protein", "text": [ "Akt" ], "offsets": [ [ 81, 84 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31750" }, { "db_name": "UniProt", "db_id": "Q8INB9" } ] } ]
[]
[]
[ { "id": "DS.d104.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d104.s0.e0", "arg2_id": "DS.d104.s0.e1", "normalized": [] } ]
DS.d105
18380536
[ { "id": "DS.d105.s0", "type": "", "text": [ "Intracellular oxidative status was assessed by analysis of GSH/GSSG levels and time course of ROS production and glutathione reductase (GR) activity." ], "offsets": [ [ 0, 149 ] ] } ]
[ { "id": "DS.d105.s0.e0", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 59, 62 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d105.s0.e1", "type": "compound", "text": [ "GSSG" ], "offsets": [ [ 63, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65359" } ] }, { "id": "DS.d105.s0.e2", "type": "protein", "text": [ "glutathione reductase" ], "offsets": [ [ 113, 134 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O15770" }, { "db_name": "UniProt", "db_id": "P06715" }, { "db_name": "UniProt", "db_id": "P11804" }, { "db_name": "UniProt", "db_id": "P23189" }, { "db_name": "UniProt", "db_id": "P41921" }, { "db_name": "UniProt", "db_id": "P43783" }, { "db_name": "UniProt", "db_id": "P48638" }, { "db_name": "UniProt", "db_id": "P48639" }, { "db_name": "UniProt", "db_id": "P70619" }, { "db_name": "UniProt", "db_id": "P78965" }, { "db_name": "UniProt", "db_id": "Q60151" }, { "db_name": "UniProt", "db_id": "Q6BPI1" }, { "db_name": "UniProt", "db_id": "Q6C5H4" }, { "db_name": "UniProt", "db_id": "Q6FRV2" }, { "db_name": "UniProt", "db_id": "Q6HA23" }, { "db_name": "UniProt", "db_id": "Q74ZK4" }, { "db_name": "UniProt", "db_id": "Q873E8" }, { "db_name": "UniProt", "db_id": "Q94655" } ] } ]
[]
[]
[]
DS.d106
18380539
[ { "id": "DS.d106.s0", "type": "", "text": [ "A recently discussed cardiovascular risk factor, asymmetric dimethylarginine (ADMA), is known to act as an endogenous inhibitor of endothelial nitric oxide synthase." ], "offsets": [ [ 0, 165 ] ] } ]
[ { "id": "DS.d106.s0.e0", "type": "compound", "text": [ "asymmetric dimethylarginine" ], "offsets": [ [ 49, 76 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "123831" } ] }, { "id": "DS.d106.s0.e1", "type": "compound", "text": [ "ADMA" ], "offsets": [ [ 78, 82 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "123831" } ] }, { "id": "DS.d106.s0.e2", "type": "protein", "text": [ "nitric oxide synthase" ], "offsets": [ [ 143, 164 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q27571" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] } ]
[]
[]
[ { "id": "DS.d106.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d106.s0.e1", "arg2_id": "DS.d106.s0.e2", "normalized": [] }, { "id": "DS.d106.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d106.s0.e0", "arg2_id": "DS.d106.s0.e2", "normalized": [] } ]
DS.d107
18380542
[ { "id": "DS.d107.s0", "type": "", "text": [ "The net exercise-induced increase in 6-keto-PGF (1alpha) concentration, expressed as the difference between the end-exercise minus pre-exercise concentration positively correlated with VO(2max) (r=0.78, p=0.004) as well as with the net VO(2) increase at exhaustion (r=0.81, p=0.003), but not with other respiratory, cardiac, metabolic or inflammatory parameters of the exercise (minute ventilation, heart rate, plasma lactate, IL-6 or TNF-alpha concentrations)." ], "offsets": [ [ 0, 461 ] ] } ]
[ { "id": "DS.d107.s0.e0", "type": "protein", "text": [ "PGF" ], "offsets": [ [ 44, 47 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P49763" }, { "db_name": "UniProt", "db_id": "Q9XS47" } ] }, { "id": "DS.d107.s0.e1", "type": "compound", "text": [ "lactate" ], "offsets": [ [ 418, 425 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "612" } ] }, { "id": "DS.d107.s0.e2", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 427, 431 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d107.s0.e3", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 435, 444 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] } ]
[]
[]
[]
DS.d108
18380545
[ { "id": "DS.d108.s0", "type": "", "text": [ "Adenosine A(3) receptor agonist N(6)-(3-iodobenzyl) adenosine-5 '-N-methyluronamide (IB-MECA) has been tested from the point of view of potentiating the effects of hematopoietic growth factors interleukin-3 (IL-3), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and granulocyte colony-stimulating factor (G-CSF) on the growth of hematopoietic progenitor cells for granulocytes and macrophages (GM-CFC) in suspension of normal mouse bone marrow cells in vitro." ], "offsets": [ [ 0, 495 ] ] }, { "id": "DS.d108.s1", "type": "", "text": [ "Significant elevation of numbers of GM-CFC evoked by the combinations of IB-MECA with IL-3, SCF, or GM-CSF as compared with these growth factors alone has been noted." ], "offsets": [ [ 496, 662 ] ] }, { "id": "DS.d108.s2", "type": "", "text": [ "Combination of IB-MECA with G-CSF did not induce significantly higher numbers of GM-CFC in comparison with G-CSF alone." ], "offsets": [ [ 663, 782 ] ] }, { "id": "DS.d108.s3", "type": "", "text": [ "Joint action of three drugs, namely of IB-MECA+ IL-3+ GM-CSF, produced significantly higher numbers of GM-CFC in comparison with the combinations of IB-MECA+ IL-3, IB-MECA+ GM-CSF, or IL-3+ GM-CSF." ], "offsets": [ [ 783, 980 ] ] } ]
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[]
[]
[]
DS.d109
18381637
[ { "id": "DS.d109.s0", "type": "", "text": [ "Rabbit marrow mesenchymal stem cells (MSCs) and gelatin microparticles (MPs) loaded with insulin-like growth factor-1 (IGF-1), transforming growth factor-beta1 (TGF-beta1), or a combination of both growth factors were mixed with OPF, a poly(ethylene glycol)-diacrylate crosslinker and the radical initiators ammonium persulfate and N,N,N',N'-tetramethylethylenediamine, and then crosslinked at 37 degrees C for 8 min to form hydrogel composites." ], "offsets": [ [ 0, 445 ] ] } ]
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[]
[]
[]
DS.d110
18381638
[ { "id": "DS.d110.s0", "type": "", "text": [ "Fibronectin modulates osteoblast behavior on Nitinol." ], "offsets": [ [ 0, 53 ] ] } ]
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[]
[]
[ { "id": "DS.d110.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d110.s0.e1", "arg2_id": "DS.d110.s0.e0", "normalized": [] } ]
DS.d111
18384163
[ { "id": "DS.d111.s0", "type": "", "text": [ "Real-time RT-PCR showed that the expression of osteoblast marker genes such as CBFalpha1 and alkaline phosphatase was increased in hyaluronic acid-based hydrogel, and the expression level was dependent on the molecular weight of hyaluronic acid, RGD peptide, and BMP-2." ], "offsets": [ [ 0, 269 ] ] } ]
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[]
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DS.d112
18386138
[ { "id": "DS.d112.s0", "type": "", "text": [ "Treatment of H9c2 cell with low concentrations of Dox causes alterations in fibrous structural proteins including the nuclear lamina and sarcomeric cardiac myosin, as well as mitochondrial depolarization and fragmentation, membrane blebbing with cell shape changes, and phosphatidylserine externalization." ], "offsets": [ [ 0, 305 ] ] } ]
[ { "id": "DS.d112.s0.e0", "type": "protein", "text": [ "structural proteins" ], "offsets": [ [ 84, 103 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q04765" }, { "db_name": "UniProt", "db_id": "Q04766" } ] }, { "id": "DS.d112.s0.e1", "type": "compound", "text": [ "phosphatidylserine" ], "offsets": [ [ 270, 288 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445141" }, { "db_name": "PubChem", "db_id": "6323481" }, { "db_name": "PubChem", "db_id": "44147587" } ] } ]
[]
[]
[]
DS.d113
18387753
[ { "id": "DS.d113.s0", "type": "", "text": [ "We monitored bcr-abl transcript levels by quantitative real time PCR in 50 tunisian patients treated with imatinib for chronic myeloid leukemia in chronic phase for a median of 29 months (3-60) after they started imatinib." ], "offsets": [ [ 0, 222 ] ] } ]
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[]
[]
[]
DS.d114
18389169
[ { "id": "DS.d114.s0", "type": "", "text": [ "The non-covalent interaction of brilliant red (BR) with lysozyme was investigated by the UV spectrometry, circular dichroism (CD) and isothermal titration calorimetry (ITC)." ], "offsets": [ [ 0, 173 ] ] } ]
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[]
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DS.d115
18390571
[ { "id": "DS.d115.s0", "type": "", "text": [ "Recent studies suggest that crystals of monosodium urate (MSU), deposited in joints of patients with acute gouty arthritis, activate the NACHT domain, leucine-rich repeat and pyrin domain-containing protein (NALP)3 inflammasome." ], "offsets": [ [ 0, 228 ] ] } ]
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[]
[]
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DS.d116
18393628
[ { "id": "DS.d116.s0", "type": "", "text": [ "Nicotine, muscarine, and chlorpyrifos induced the phosphorylation of extracellular signal-regulated kinases 1 and 2." ], "offsets": [ [ 0, 116 ] ] } ]
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[]
[]
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DS.d117
18393672
[ { "id": "DS.d117.s0", "type": "", "text": [ "Adult bone marrow (BM)-derived insulin-producing cells (IPCs) are capable of regulating blood glucose levels in chemically induced hyperglycemic mice." ], "offsets": [ [ 0, 150 ] ] }, { "id": "DS.d117.s1", "type": "", "text": [ "Treatment with benfotiamine activated glucose metabolism in INS-1 cells in high-glucose culture conditions, and appeared to maximize the BM-derived IPCs ability to synthesize insulin." ], "offsets": [ [ 151, 334 ] ] }, { "id": "DS.d117.s2", "type": "", "text": [ "Benfotiamine was not shown to induce the glucose receptor Glut-2, however it was shown to activate glucokinase, the enzyme responsible for conversion of glucose to glucose-6-phosphate." ], "offsets": [ [ 335, 519 ] ] }, { "id": "DS.d117.s3", "type": "", "text": [ "However, in cells where the pentose phosphate pathway was blocked by oxythiamine treatment, there was a clear downregulation of Glut-2, glucokinase, insulin, and GAPDH." ], "offsets": [ [ 520, 688 ] ] } ]
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}, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d117.s2.e0", "type": "compound", "text": [ "Benfotiamine" ], "offsets": [ [ 335, 347 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3032771" } ] }, { "id": "DS.d117.s2.e1", "type": "protein", "text": [ "Glut-2" ], "offsets": [ [ 393, 399 ] ], "normalized": [ { "db_name": "UniProt", "db_id": 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[]
[]
[ { "id": "DS.d117.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d117.s0.e1", "arg2_id": "DS.d117.s0.e0", "normalized": [] }, { "id": "DS.d117.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d117.s1.e0", "arg2_id": "DS.d117.s1.e2", "normalized": [] }, { "id": "DS.d117.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d117.s2.e3", "arg2_id": "DS.d117.s2.e2", "normalized": [] }, { "id": "DS.d117.s2.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d117.s2.e0", "arg2_id": "DS.d117.s2.e2", "normalized": [] }, { "id": "DS.d117.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d117.s3.e0", "arg2_id": "DS.d117.s3.e4", "normalized": [] }, { "id": "DS.d117.s3.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d117.s3.e0", "arg2_id": "DS.d117.s3.e2", "normalized": [] }, { "id": "DS.d117.s3.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d117.s3.e0", "arg2_id": "DS.d117.s3.e3", "normalized": [] }, { "id": "DS.d117.s3.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d117.s3.e0", "arg2_id": "DS.d117.s3.e1", "normalized": [] } ]
DS.d118
18394828
[ { "id": "DS.d118.s0", "type": "", "text": [ ") and two oxygen tensions (5 and 20%) were compared for their ability to sustain blastocyst survival and IFNT production from days 8 to 11 post-insemination." ], "offsets": [ [ 0, 157 ] ] }, { "id": "DS.d118.s1", "type": "", "text": [ "In conclusion, culturing blastocysts of cattle in a 5% oxygen environment with M199 containing serum sustains embryo viability and permits constitutive and inducible IFNT production." ], "offsets": [ [ 158, 340 ] ] }, { "id": "DS.d118.s2", "type": "", "text": [ "Incubation in 20% oxygen increases IFNT production." ], "offsets": [ [ 341, 392 ] ] } ]
[ { "id": "DS.d118.s0.e0", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 10, 16 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] }, { "id": "DS.d118.s0.e1", "type": "protein", "text": [ "IFNT" ], "offsets": [ [ 105, 109 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46633" }, { "db_name": "UniProt", "db_id": "P28171" }, { "db_name": "UniProt", "db_id": "P28172" }, { "db_name": "UniProt", "db_id": "Q95187" } ] }, { "id": "DS.d118.s1.e0", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 213, 219 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] }, { "id": "DS.d118.s1.e1", "type": "protein", "text": [ "IFNT" ], "offsets": [ [ 324, 328 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46633" }, { "db_name": "UniProt", "db_id": "P28171" }, { "db_name": "UniProt", "db_id": "P28172" }, { "db_name": "UniProt", "db_id": "Q95187" } ] }, { "id": "DS.d118.s2.e0", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 359, 365 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] }, { "id": "DS.d118.s2.e1", "type": "protein", "text": [ "IFNT" ], "offsets": [ [ 376, 380 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46633" }, { "db_name": "UniProt", "db_id": "P28171" }, { "db_name": "UniProt", "db_id": "P28172" }, { "db_name": "UniProt", "db_id": "Q95187" } ] } ]
[]
[]
[ { "id": "DS.d118.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d118.s1.e0", "arg2_id": "DS.d118.s1.e1", "normalized": [] }, { "id": "DS.d118.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d118.s2.e0", "arg2_id": "DS.d118.s2.e1", "normalized": [] } ]
DS.d119
18395421
[ { "id": "DS.d119.s0", "type": "", "text": [ "Histologic examination investigated deposition of extracellular matrix (ECM) including collagen, elastin, hyaluronic acid (HA), fibronectin, and decorin in the lamina propria of the scarred vocal folds." ], "offsets": [ [ 0, 202 ] ] } ]
[ { "id": "DS.d119.s0.e0", "type": "protein", "text": [ "ECM" ], "offsets": [ [ 72, 75 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q13201" } ] }, { "id": "DS.d119.s0.e1", "type": "protein", "text": [ "elastin" ], "offsets": [ [ 97, 104 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11547" } ] }, { "id": "DS.d119.s0.e2", "type": "compound", "text": [ "hyaluronic acid" ], "offsets": [ [ 106, 121 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24759" }, { "db_name": "PubChem", "db_id": "453618" }, { "db_name": "PubChem", "db_id": "3084050" }, { "db_name": "PubChem", "db_id": "24728612" } ] }, { "id": "DS.d119.s0.e3", "type": "protein", "text": [ "fibronectin" ], "offsets": [ [ 128, 139 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07589" }, { "db_name": "UniProt", "db_id": "P11722" }, { "db_name": "UniProt", "db_id": "Q28275" }, { "db_name": "UniProt", "db_id": "Q28377" }, { "db_name": "UniProt", "db_id": "Q28749" }, { "db_name": "UniProt", "db_id": "Q91289" }, { "db_name": "UniProt", "db_id": "Q91400" } ] } ]
[]
[]
[]
DS.d120
18396353
[ { "id": "DS.d120.s0", "type": "", "text": [ "A series of novel bis-pyridinium oximes connected by bis-methoxymethyl benzene, 1,4-bis-methoxymethyl (cis)-but-2-ene and 1,4-bis-methoxymethyl but-2-yne linkers were synthesized and their in vitro reactivation efficacy was evaluated against diisopropyl phosphorofluoridate (DFP) inhibited acetylcholinesterase (AChE) and compared with the established antidote 2-PAM and obidoxime." ], "offsets": [ [ 0, 381 ] ] } ]
[ { "id": "DS.d120.s0.e0", "type": "compound", "text": [ "methoxymethyl benzene" ], "offsets": [ [ 57, 78 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10869" } ] }, { "id": "DS.d120.s0.e1", "type": "compound", "text": [ "diisopropyl phosphorofluoridate" ], "offsets": [ [ 242, 273 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5936" } ] }, { "id": "DS.d120.s0.e2", "type": "protein", "text": [ "acetylcholinesterase" ], "offsets": [ [ 290, 310 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92081" } ] }, { "id": "DS.d120.s0.e3", "type": "protein", "text": [ "AChE" ], "offsets": [ [ 312, 316 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42275" }, { "db_name": "UniProt", "db_id": "O62763" }, { "db_name": "UniProt", "db_id": "P04058" }, { "db_name": "UniProt", "db_id": "P07140" }, { "db_name": "UniProt", "db_id": "P07692" }, { "db_name": "UniProt", "db_id": "P21836" }, { "db_name": "UniProt", "db_id": "P22303" }, { "db_name": "UniProt", "db_id": "P23795" }, { "db_name": "UniProt", "db_id": "P36196" }, { "db_name": "UniProt", "db_id": "P37136" }, { "db_name": "UniProt", "db_id": "P56161" }, { "db_name": "UniProt", "db_id": "Q27677" }, { "db_name": "UniProt", "db_id": "Q29499" }, { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q869C3" }, { "db_name": "UniProt", "db_id": "Q86GC8" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92035" }, { "db_name": "UniProt", "db_id": "Q92081" }, { "db_name": "UniProt", "db_id": "Q9DDE3" } ] }, { "id": "DS.d120.s0.e4", "type": "compound", "text": [ "obidoxime" ], "offsets": [ [ 371, 380 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "107688" } ] } ]
[]
[]
[]
DS.d121
18396355
[ { "id": "DS.d121.s0", "type": "", "text": [ "In-vitro regeneration of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing xylene linker." ], "offsets": [ [ 0, 122 ] ] }, { "id": "DS.d121.s1", "type": "", "text": [ "A series of bis-pyridinium oximes connected by xylene linker were synthesized and their in-vitro reactivation potential was evaluated against acetylcholinesterase (AChE) inhibited by nerve agent, sarin." ], "offsets": [ [ 123, 325 ] ] }, { "id": "DS.d121.s2", "type": "", "text": [ "Among the synthesized compounds, alpha,alpha'xylene-bis-(3,3'-(hydroxyiminomethyl) pyridinium) dibromide (3b) was found to be most potent reactivator for AChE inhibited by sarin." ], "offsets": [ [ 326, 504 ] ] } ]
[ { "id": "DS.d121.s0.e0", "type": "compound", "text": [ "sarin" ], "offsets": [ [ 25, 30 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7871" } ] }, { "id": "DS.d121.s0.e1", "type": "protein", "text": [ "acetylcholinesterase" ], "offsets": [ [ 54, 74 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92081" } ] }, { "id": "DS.d121.s0.e2", "type": "compound", "text": [ "xylene" ], "offsets": [ [ 108, 114 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7237" } ] }, { "id": "DS.d121.s1.e0", "type": "compound", "text": [ "xylene" ], "offsets": [ [ 170, 176 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7237" } ] }, { "id": "DS.d121.s1.e1", "type": "protein", "text": [ "acetylcholinesterase" ], "offsets": [ [ 265, 285 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92081" } ] }, { "id": "DS.d121.s1.e2", "type": "protein", "text": [ "AChE" ], "offsets": [ [ 287, 291 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42275" }, { "db_name": "UniProt", "db_id": "O62763" }, { "db_name": "UniProt", "db_id": "P04058" }, { "db_name": "UniProt", "db_id": "P07140" }, { "db_name": "UniProt", "db_id": "P07692" }, { "db_name": "UniProt", "db_id": "P21836" }, { "db_name": "UniProt", "db_id": "P22303" }, { "db_name": "UniProt", "db_id": "P23795" }, { "db_name": "UniProt", "db_id": "P36196" }, { "db_name": "UniProt", "db_id": "P37136" }, { "db_name": "UniProt", "db_id": "P56161" }, { "db_name": "UniProt", "db_id": "Q27677" }, { "db_name": "UniProt", "db_id": "Q29499" }, { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q869C3" }, { "db_name": "UniProt", "db_id": "Q86GC8" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92035" }, { "db_name": "UniProt", "db_id": "Q92081" }, { "db_name": "UniProt", "db_id": "Q9DDE3" } ] }, { "id": "DS.d121.s1.e3", "type": "compound", "text": [ "sarin" ], "offsets": [ [ 319, 324 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7871" } ] }, { "id": "DS.d121.s2.e0", "type": "protein", "text": [ "AChE" ], "offsets": [ [ 480, 484 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42275" }, { "db_name": "UniProt", "db_id": "O62763" }, { "db_name": "UniProt", "db_id": "P04058" }, { "db_name": "UniProt", "db_id": "P07140" }, { "db_name": "UniProt", "db_id": "P07692" }, { "db_name": "UniProt", "db_id": "P21836" }, { "db_name": "UniProt", "db_id": "P22303" }, { "db_name": "UniProt", "db_id": "P23795" }, { "db_name": "UniProt", "db_id": "P36196" }, { "db_name": "UniProt", "db_id": "P37136" }, { "db_name": "UniProt", "db_id": "P56161" }, { "db_name": "UniProt", "db_id": "Q27677" }, { "db_name": "UniProt", "db_id": "Q29499" }, { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q869C3" }, { "db_name": "UniProt", "db_id": "Q86GC8" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92035" }, { "db_name": "UniProt", "db_id": "Q92081" }, { "db_name": "UniProt", "db_id": "Q9DDE3" } ] }, { "id": "DS.d121.s2.e1", "type": "compound", "text": [ "sarin" ], "offsets": [ [ 498, 503 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7871" } ] } ]
[]
[]
[ { "id": "DS.d121.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d121.s0.e0", "arg2_id": "DS.d121.s0.e1", "normalized": [] }, { "id": "DS.d121.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d121.s0.e2", "arg2_id": "DS.d121.s0.e1", "normalized": [] }, { "id": "DS.d121.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d121.s2.e1", "arg2_id": "DS.d121.s2.e0", "normalized": [] } ]
DS.d122
18396356
[ { "id": "DS.d122.s0", "type": "", "text": [ "Of the compounds synthesized, compound 2a, which has a primary amide at warhead region of the inhibitor most potently inhibited mu-calpain with an IC(50) value of 2.81+/-1.26 microM, which is ca." ], "offsets": [ [ 0, 195 ] ] } ]
[ { "id": "DS.d122.s0.e0", "type": "compound", "text": [ "compound 2a" ], "offsets": [ [ 30, 41 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "398803" } ] }, { "id": "DS.d122.s0.e1", "type": "protein", "text": [ "calpain" ], "offsets": [ [ 131, 138 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27730" } ] } ]
[]
[]
[ { "id": "DS.d122.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d122.s0.e0", "arg2_id": "DS.d122.s0.e1", "normalized": [] } ]
DS.d123
18397836
[ { "id": "DS.d123.s0", "type": "", "text": [ "Recent studies have focused on possible functional disorders of the enteric nervous system within the abomasal wall, since cattle with abomasal displacement have an increased activity of neuronal nitric oxide synthase, as well as decreased acetylcholine sensitivity." ], "offsets": [ [ 0, 266 ] ] } ]
[ { "id": "DS.d123.s0.e0", "type": "protein", "text": [ "nitric oxide synthase" ], "offsets": [ [ 196, 217 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q27571" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] }, { "id": "DS.d123.s0.e1", "type": "compound", "text": [ "acetylcholine" ], "offsets": [ [ 240, 253 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "187" } ] } ]
[]
[]
[]
DS.d124
18397960
[ { "id": "DS.d124.s0", "type": "", "text": [ "Earlier publications have suggested a possible role for the efflux transporter breast cancer resistance protein (BCRP) in acquired resistance to disease-modifying antirheumatic drugs (DMARDs) such as leflunomide and its metabolite A771726 (teriflunomide)." ], "offsets": [ [ 0, 255 ] ] } ]
[ { "id": "DS.d124.s0.e0", "type": "protein", "text": [ "breast cancer resistance protein" ], "offsets": [ [ 79, 111 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UNQ0" } ] }, { "id": "DS.d124.s0.e1", "type": "protein", "text": [ "BCRP" ], "offsets": [ [ 113, 117 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UNQ0" } ] }, { "id": "DS.d124.s0.e2", "type": "compound", "text": [ "leflunomide" ], "offsets": [ [ 200, 211 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3899" } ] }, { "id": "DS.d124.s0.e3", "type": "compound", "text": [ "A771726" ], "offsets": [ [ 231, 238 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54684141" } ] }, { "id": "DS.d124.s0.e4", "type": "compound", "text": [ "teriflunomide" ], "offsets": [ [ 240, 253 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54684141" } ] } ]
[]
[]
[ { "id": "DS.d124.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d124.s0.e4", "arg2_id": "DS.d124.s0.e1", "normalized": [] }, { "id": "DS.d124.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d124.s0.e2", "arg2_id": "DS.d124.s0.e1", "normalized": [] }, { "id": "DS.d124.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d124.s0.e3", "arg2_id": "DS.d124.s0.e0", "normalized": [] }, { "id": "DS.d124.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d124.s0.e2", "arg2_id": "DS.d124.s0.e0", "normalized": [] }, { "id": "DS.d124.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d124.s0.e4", "arg2_id": "DS.d124.s0.e0", "normalized": [] }, { "id": "DS.d124.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d124.s0.e3", "arg2_id": "DS.d124.s0.e1", "normalized": [] } ]
DS.d125
18398609
[ { "id": "DS.d125.s0", "type": "", "text": [ "Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2'-deoxycytidine." ], "offsets": [ [ 0, 108 ] ] } ]
[ { "id": "DS.d125.s0.e0", "type": "protein", "text": [ "cytidine deaminase" ], "offsets": [ [ 14, 32 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0ABF6" }, { "db_name": "UniProt", "db_id": "P0ABF7" }, { "db_name": "UniProt", "db_id": "P19079" }, { "db_name": "UniProt", "db_id": "P32320" }, { "db_name": "UniProt", "db_id": "P44325" }, { "db_name": "UniProt", "db_id": "P47298" }, { "db_name": "UniProt", "db_id": "P47718" }, { "db_name": "UniProt", "db_id": "P56389" }, { "db_name": "UniProt", "db_id": "P75051" }, { "db_name": "UniProt", "db_id": "Q06549" }, { "db_name": "UniProt", "db_id": "Q322V3" }, { "db_name": "UniProt", "db_id": "Q32EM3" }, { "db_name": "UniProt", "db_id": "Q3IBX5" }, { "db_name": "UniProt", "db_id": "Q3Z062" }, { "db_name": "UniProt", "db_id": "Q4QK60" }, { "db_name": "UniProt", "db_id": "Q57MF5" }, { "db_name": "UniProt", "db_id": "Q5E4R6" }, { "db_name": "UniProt", "db_id": "Q5PE68" }, { "db_name": "UniProt", "db_id": "Q65RG8" }, { "db_name": "UniProt", "db_id": "Q66C79" }, { "db_name": "UniProt", "db_id": "Q6D3B4" }, { "db_name": "UniProt", "db_id": "Q6LRI0" }, { "db_name": "UniProt", "db_id": "Q7MK48" }, { "db_name": "UniProt", "db_id": "Q7N6K3" }, { "db_name": "UniProt", "db_id": "Q7VMJ6" }, { "db_name": "UniProt", "db_id": "Q87Q52" }, { "db_name": "UniProt", "db_id": "Q8DA31" }, { "db_name": "UniProt", "db_id": "Q8EDG1" }, { "db_name": "UniProt", "db_id": "Q8FFV3" }, { "db_name": "UniProt", "db_id": "Q8X648" }, { "db_name": "UniProt", "db_id": "Q8Z5A8" }, { "db_name": "UniProt", "db_id": "Q8ZG08" }, { "db_name": "UniProt", "db_id": "Q8ZNM0" }, { "db_name": "UniProt", "db_id": "Q9CP11" }, { "db_name": "UniProt", "db_id": "Q9KD53" }, { "db_name": "UniProt", "db_id": "Q9KSM5" }, { "db_name": "UniProt", "db_id": "Q9S3M0" } ] }, { "id": "DS.d125.s0.e1", "type": "compound", "text": [ "zebularine" ], "offsets": [ [ 36, 46 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "100016" }, { "db_name": "PubChem", "db_id": "328839" }, { "db_name": "PubChem", "db_id": "16760709" }, { "db_name": "PubChem", "db_id": "46783268" } ] }, { "id": "DS.d125.s0.e2", "type": "compound", "text": [ "5-aza-2'-deoxycytidine" ], "offsets": [ [ 85, 107 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "451668" } ] } ]
[]
[]
[ { "id": "DS.d125.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d125.s0.e1", "arg2_id": "DS.d125.s0.e0", "normalized": [] } ]
DS.d126
18398611
[ { "id": "DS.d126.s0", "type": "", "text": [ "An individual's response to fludarabine may be influenced by the amount of CD4 (+) and CD8(+) T-lymphocyte suppression." ], "offsets": [ [ 0, 119 ] ] } ]
[ { "id": "DS.d126.s0.e0", "type": "compound", "text": [ "fludarabine" ], "offsets": [ [ 28, 39 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "657237" } ] }, { "id": "DS.d126.s0.e1", "type": "protein", "text": [ "CD4" ], "offsets": [ [ 75, 78 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01730" }, { "db_name": "UniProt", "db_id": "P05542" }, { "db_name": "UniProt", "db_id": "P16003" }, { "db_name": "UniProt", "db_id": "P16004" }, { "db_name": "UniProt", "db_id": "P33705" }, { "db_name": "UniProt", "db_id": "P46630" }, { "db_name": "UniProt", "db_id": "P79184" }, { "db_name": "UniProt", "db_id": "P79185" }, { "db_name": "UniProt", "db_id": "Q08336" }, { "db_name": "UniProt", "db_id": "Q08338" }, { "db_name": "UniProt", "db_id": "Q08339" }, { "db_name": "UniProt", "db_id": "Q08340" }, { "db_name": "UniProt", "db_id": "Q29037" }, { "db_name": "UniProt", "db_id": "Q9XS78" } ] } ]
[]
[]
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DS.d127
18398624
[ { "id": "DS.d127.s0", "type": "", "text": [ "We hypothesise that arginine aspartate acts as a chemical or pharmacological chaperone, and suggest amino acid supplementation as a possible therapy in PDHA1 mutations with mild phenotypes." ], "offsets": [ [ 0, 189 ] ] } ]
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[]
[]
[]
DS.d128
18400050
[ { "id": "DS.d128.s0", "type": "", "text": [ "mRNA expressions of matrix metallopeptidase-9, inducible nitric oxide synthase and pro-inflammatory cytokines interleukin-1 beta and tumour necrosis factor-alpha in EAN sciatic nerves were greatly decreased by administration of minocycline as well." ], "offsets": [ [ 0, 248 ] ] } ]
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[]
[]
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DS.d129
18400404
[ { "id": "DS.d129.s0", "type": "", "text": [ "Then the review evaluates the involvement of KARs activated by the endogenous agonist glutamate in the generation and propagation of epileptiform activity." ], "offsets": [ [ 0, 155 ] ] } ]
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[]
[]
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DS.d130
18403016
[ { "id": "DS.d130.s0", "type": "", "text": [ "Glutamate cysteine ligase (GCL), synthesizing gamma-glutamylcysteine from glutamate and cysteine, is the rate-limiting enzyme in glutathione (GSH) biosynthesis." ], "offsets": [ [ 0, 160 ] ] } ]
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[]
[]
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DS.d131
18403053
[ { "id": "DS.d131.s0", "type": "", "text": [ "We observed that lactacystin inhibited the proteasome activities and increased the level and insolubility of different tau species, including phosphorylated tau." ], "offsets": [ [ 0, 161 ] ] } ]
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[]
[]
[ { "id": "DS.d131.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d131.s0.e0", "arg2_id": "DS.d131.s0.e1", "normalized": [] } ]
DS.d132
18404246
[ { "id": "DS.d132.s0", "type": "", "text": [ "Serine and cysteine proteases proved to be suitable tools for the production of amino acids and peptides conjugated to 4-aminoantipyrine, whereas metalloproteases do not seem to be very qualified for accepting this nucleophile." ], "offsets": [ [ 0, 227 ] ] } ]
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"db_name": "UniProt", "db_id": "P63131" }, { "db_name": "UniProt", "db_id": "P84454" }, { "db_name": "UniProt", "db_id": "Q09SZ9" }, { "db_name": "UniProt", "db_id": "Q0R5R2" }, { "db_name": "UniProt", "db_id": "Q0R5R3" }, { "db_name": "UniProt", "db_id": "Q1A249" }, { "db_name": "UniProt", "db_id": "Q1A267" }, { "db_name": "UniProt", "db_id": "Q4U0X6" }, { "db_name": "UniProt", "db_id": "Q73368" }, { "db_name": "UniProt", "db_id": "Q74120" }, { "db_name": "UniProt", "db_id": "Q75002" }, { "db_name": "UniProt", "db_id": "Q76634" }, { "db_name": "UniProt", "db_id": "Q77373" }, { "db_name": "UniProt", "db_id": "Q79666" }, { "db_name": "UniProt", "db_id": "Q89928" }, { "db_name": "UniProt", "db_id": "Q8AII1" }, { "db_name": "UniProt", "db_id": "Q8I7P9" }, { "db_name": "UniProt", "db_id": "Q9IDV9" }, { "db_name": "UniProt", "db_id": "Q9Q720" }, { "db_name": "UniProt", "db_id": "Q9QBY3" }, { "db_name": "UniProt", "db_id": "Q9QBZ1" }, { "db_name": "UniProt", "db_id": "Q9QBZ5" }, { "db_name": "UniProt", "db_id": "Q9QSR3" }, { "db_name": "UniProt", "db_id": "Q9WC54" }, { "db_name": "UniProt", "db_id": "Q9WC63" }, { "db_name": "UniProt", "db_id": "Q9Y6I0" } ] }, { "id": "DS.d132.s0.e1", "type": "compound", "text": [ "4-aminoantipyrine" ], "offsets": [ [ 119, 136 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2151" } ] } ]
[]
[]
[]
DS.d133
18405417
[ { "id": "DS.d133.s0", "type": "", "text": [ "Role of serotonin 5-HT1A receptors in the antidepressant-like effect and the antinociceptive effect of venlafaxine in mice." ], "offsets": [ [ 0, 123 ] ] }, { "id": "DS.d133.s1", "type": "", "text": [ "The present study was undertaken to evaluate the potential role of 5-HT1A receptors in the antidepressant-like effect and antinociceptive effect of venlafaxine." ], "offsets": [ [ 124, 284 ] ] }, { "id": "DS.d133.s2", "type": "", "text": [ "These findings show that 5-HT1A receptors play differing roles in modulating the antidepressant-like and antinociceptive effects of venlafaxine in the models investigated." ], "offsets": [ [ 285, 456 ] ] }, { "id": "DS.d133.s3", "type": "", "text": [ "In contrast, the antinociceptive effect of venlafaxine is probably potentiated due to the blockade of somatodendritic 5-HT1A receptors in the same raphe nuclei, facilitating the descending monoaminergic pain control system." ], "offsets": [ [ 457, 680 ] ] } ]
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[]
[]
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DS.d134
18407279
[ { "id": "DS.d134.s0", "type": "", "text": [ "Moreover, beta-glucuronidase hydrolysis of baicalin sequentially yielded glucuronic acid and baicalein as confirmed by co-TLC with authentic samples." ], "offsets": [ [ 0, 149 ] ] } ]
[ { "id": "DS.d134.s0.e0", "type": "protein", "text": [ "beta-glucuronidase" ], "offsets": [ [ 10, 28 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05804" } ] }, { "id": "DS.d134.s0.e1", "type": "compound", "text": [ "baicalin" ], "offsets": [ [ 43, 51 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "64982" } ] }, { "id": "DS.d134.s0.e2", "type": "compound", "text": [ "baicalein" ], "offsets": [ [ 93, 102 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5281605" } ] } ]
[]
[]
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DS.d135
18407527
[ { "id": "DS.d135.s0", "type": "", "text": [ "The effect of this diet alone or after 2 weeks of treatment with rosiglitazone or glimepiride on glucose homeostasis, lipid profile, and levels of resistin and leptin was studied." ], "offsets": [ [ 0, 179 ] ] }, { "id": "DS.d135.s1", "type": "", "text": [ "Rosiglitazone corrected the altered parameters measured, except for liver TGs ; similarly, glimepiride reinstated the inverted parameters but raised insulin level and, consequently, the HOMA index." ], "offsets": [ [ 180, 377 ] ] } ]
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[]
[]
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DS.d136
18409068
[ { "id": "DS.d136.s0", "type": "", "text": [ "AZD0530 inhibited tumor growth in a manner independent of dose and inhibited phosphorylation of FAK and paxillin in a dose-dependent manner in a Calu-6 xenograft model." ], "offsets": [ [ 0, 168 ] ] } ]
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[]
[]
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DS.d137
18409071
[ { "id": "DS.d137.s0", "type": "", "text": [ "Activation of ErbB3, EGFR and Erk is essential for growth of human breast cancer cell lines with acquired resistance to fulvestrant." ], "offsets": [ [ 0, 132 ] ] }, { "id": "DS.d137.s1", "type": "", "text": [ "Treatment with the EGFR inhibitor gefitinib preferentially inhibited growth and reduced the S phase fraction in the resistant cell lines concomitant with inhibition of Erk and unaltered Akt activation." ], "offsets": [ [ 133, 334 ] ] } ]
[ { "id": "DS.d137.s0.e0", "type": "protein", "text": [ "EGFR" ], "offsets": [ [ 21, 25 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00533" }, { "db_name": "UniProt", "db_id": "P13387" }, { "db_name": "UniProt", "db_id": "P55245" } ] }, { "id": "DS.d137.s0.e1", "type": "compound", "text": [ "fulvestrant" ], "offsets": [ [ 120, 131 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104741" } ] }, { "id": "DS.d137.s1.e0", "type": "compound", "text": [ "gefitinib" ], "offsets": [ [ 167, 176 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "123631" } ] }, { "id": "DS.d137.s1.e1", "type": "protein", "text": [ "Akt" ], "offsets": [ [ 319, 322 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31750" }, { "db_name": "UniProt", "db_id": "Q8INB9" } ] } ]
[]
[]
[]
DS.d138
18410309
[ { "id": "DS.d138.s0", "type": "", "text": [ "Melatonin protects from hepatic reperfusion injury through inhibition of IKK and JNK pathways and modification of cell proliferation." ], "offsets": [ [ 0, 133 ] ] }, { "id": "DS.d138.s1", "type": "", "text": [ "Melatonin significantly improved animal survival and decreased transaminase levels, the indices for necrosis, liver damage, leukocyte infiltration, and iNOS expression." ], "offsets": [ [ 134, 302 ] ] }, { "id": "DS.d138.s2", "type": "", "text": [ "At the same time, melatonin reduced the expression of both PCNA 0.05)." ], "offsets": [ [ 303, 373 ] ] }, { "id": "DS.d138.s3", "type": "", "text": [ "Melatonin is hepatoprotective most likely via mechanisms including inhibition of IKK and JNK pathways and regulation of cell proliferation." ], "offsets": [ [ 374, 513 ] ] } ]
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[]
[]
[ { "id": "DS.d138.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d138.s0.e0", "arg2_id": "DS.d138.s0.e1", "normalized": [] }, { "id": "DS.d138.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d138.s1.e0", "arg2_id": "DS.d138.s1.e1", "normalized": [] }, { "id": "DS.d138.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d138.s2.e0", "arg2_id": "DS.d138.s2.e1", "normalized": [] }, { "id": "DS.d138.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d138.s3.e0", "arg2_id": "DS.d138.s3.e1", "normalized": [] } ]
DS.d139
18410522
[ { "id": "DS.d139.s0", "type": "", "text": [ "Here, we report that the citrus bioflavonoid luteolin reduces amyloid-beta (Abeta) peptide generation in both human 'Swedish' mutant APP transgene-bearing neuron-like cells and primary neurons." ], "offsets": [ [ 0, 193 ] ] }, { "id": "DS.d139.s1", "type": "", "text": [ "We also find that luteolin induces changes consistent with GSK-3 inhibition that (i) decrease amyloidogenic gamma-secretase APP processing, and (ii) promote presenilin-1 (PS1) carboxyl-terminal fragment (CTF) phosphorylation." ], "offsets": [ [ 194, 419 ] ] }, { "id": "DS.d139.s2", "type": "", "text": [ "As validation of these findings in vivo, we find that luteolin, when applied to the Tg2576 mouse model of AD, decreases soluble Abeta levels, reduces GSK-3 activity, and disrupts PS1-APP association." ], "offsets": [ [ 420, 619 ] ] } ]
[ { "id": "DS.d139.s0.e0", "type": "compound", "text": [ "bioflavonoid" ], "offsets": [ [ 32, 44 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280805" } ] }, { "id": "DS.d139.s0.e1", "type": "compound", "text": [ "luteolin" ], "offsets": [ [ 45, 53 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280445" } ] }, { "id": "DS.d139.s0.e2", "type": "protein", "text": [ "APP" ], "offsets": [ [ 133, 136 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O73683" }, { "db_name": "UniProt", "db_id": "O93279" }, { "db_name": "UniProt", "db_id": "P05067" }, { "db_name": "UniProt", "db_id": "P08592" }, { "db_name": "UniProt", "db_id": "P0A3Z1" }, { "db_name": "UniProt", "db_id": "P0A3Z2" }, { "db_name": "UniProt", "db_id": "P0A3Z3" }, { "db_name": "UniProt", "db_id": "P0A3Z4" }, { "db_name": "UniProt", "db_id": "P12023" }, { "db_name": "UniProt", "db_id": "P29216" }, { "db_name": "UniProt", "db_id": "P47566" }, { "db_name": "UniProt", "db_id": "P53601" }, { "db_name": "UniProt", "db_id": "P75313" }, { "db_name": "UniProt", "db_id": "P79307" }, { "db_name": "UniProt", "db_id": "Q11207" }, { "db_name": "UniProt", "db_id": "Q28053" }, { "db_name": "UniProt", "db_id": "Q28280" }, { "db_name": "UniProt", "db_id": "Q28748" }, { "db_name": "UniProt", "db_id": "Q28757" }, { "db_name": "UniProt", "db_id": "Q29149" }, { "db_name": "UniProt", "db_id": "Q5IS80" }, { "db_name": "UniProt", "db_id": "Q60495" }, { "db_name": "UniProt", "db_id": "Q95241" } ] }, { "id": "DS.d139.s1.e0", "type": "compound", "text": [ "luteolin" ], "offsets": [ [ 212, 220 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280445" } ] }, { "id": "DS.d139.s1.e1", "type": "protein", "text": [ "GSK-3" ], "offsets": [ [ 253, 258 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P51136" }, { "db_name": "UniProt", "db_id": "P83101" } ] }, { "id": "DS.d139.s1.e2", "type": "protein", "text": [ "APP" ], "offsets": [ [ 318, 321 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O73683" }, { "db_name": "UniProt", "db_id": "O93279" }, { "db_name": "UniProt", "db_id": "P05067" }, { "db_name": "UniProt", "db_id": "P08592" }, { "db_name": "UniProt", "db_id": "P0A3Z1" }, { "db_name": "UniProt", "db_id": "P0A3Z2" }, { "db_name": "UniProt", "db_id": "P0A3Z3" }, { "db_name": "UniProt", "db_id": "P0A3Z4" }, { "db_name": "UniProt", "db_id": "P12023" }, { "db_name": "UniProt", "db_id": "P29216" }, { "db_name": "UniProt", "db_id": "P47566" }, { "db_name": "UniProt", "db_id": "P53601" }, { "db_name": "UniProt", "db_id": "P75313" }, { "db_name": "UniProt", "db_id": "P79307" }, { "db_name": "UniProt", "db_id": "Q11207" }, { "db_name": "UniProt", "db_id": "Q28053" }, { "db_name": "UniProt", "db_id": "Q28280" }, { "db_name": "UniProt", "db_id": "Q28748" }, { "db_name": "UniProt", "db_id": "Q28757" }, { "db_name": "UniProt", "db_id": "Q29149" }, { "db_name": "UniProt", "db_id": "Q5IS80" }, { "db_name": "UniProt", "db_id": "Q60495" }, { "db_name": "UniProt", "db_id": "Q95241" } ] }, { "id": "DS.d139.s1.e3", "type": "protein", "text": [ "presenilin-1" ], "offsets": [ [ 351, 363 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12976" }, { "db_name": "UniProt", "db_id": "P49768" }, { "db_name": "UniProt", "db_id": "P49769" }, { "db_name": "UniProt", "db_id": "P79802" }, { "db_name": "UniProt", "db_id": "P97887" }, { "db_name": "UniProt", "db_id": "Q4JIM4" }, { "db_name": "UniProt", "db_id": "Q5R780" }, { "db_name": "UniProt", "db_id": "Q6RH31" }, { "db_name": "UniProt", "db_id": "Q8HXW5" }, { "db_name": "UniProt", "db_id": "Q9W6T7" }, { "db_name": "UniProt", "db_id": "Q9XT97" } ] }, { "id": "DS.d139.s1.e4", "type": "protein", "text": [ "PS1" ], "offsets": [ [ 365, 368 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P49768" }, { "db_name": "UniProt", "db_id": "P79802" }, { "db_name": "UniProt", "db_id": "Q8HXW5" }, { "db_name": "UniProt", "db_id": "Q9W6T7" } ] }, { "id": "DS.d139.s2.e0", "type": "compound", "text": [ "luteolin" ], "offsets": [ [ 474, 482 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280445" } ] }, { "id": "DS.d139.s2.e1", "type": "protein", "text": [ "GSK-3" ], "offsets": [ [ 570, 575 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P51136" }, { "db_name": "UniProt", "db_id": "P83101" } ] }, { "id": "DS.d139.s2.e2", "type": "protein", "text": [ "PS1" ], "offsets": [ [ 599, 602 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P49768" }, { "db_name": "UniProt", "db_id": "P79802" }, { "db_name": "UniProt", "db_id": "Q8HXW5" }, { "db_name": "UniProt", "db_id": "Q9W6T7" } ] }, { "id": "DS.d139.s2.e3", "type": "protein", "text": [ "APP" ], "offsets": [ [ 603, 606 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O73683" }, { "db_name": "UniProt", "db_id": "O93279" }, { "db_name": "UniProt", "db_id": "P05067" }, { "db_name": "UniProt", "db_id": "P08592" }, { "db_name": "UniProt", "db_id": "P0A3Z1" }, { "db_name": "UniProt", "db_id": "P0A3Z2" }, { "db_name": "UniProt", "db_id": "P0A3Z3" }, { "db_name": "UniProt", "db_id": "P0A3Z4" }, { "db_name": "UniProt", "db_id": "P12023" }, { "db_name": "UniProt", "db_id": "P29216" }, { "db_name": "UniProt", "db_id": "P47566" }, { "db_name": "UniProt", "db_id": "P53601" }, { "db_name": "UniProt", "db_id": "P75313" }, { "db_name": "UniProt", "db_id": "P79307" }, { "db_name": "UniProt", "db_id": "Q11207" }, { "db_name": "UniProt", "db_id": "Q28053" }, { "db_name": "UniProt", "db_id": "Q28280" }, { "db_name": "UniProt", "db_id": "Q28748" }, { "db_name": "UniProt", "db_id": "Q28757" }, { "db_name": "UniProt", "db_id": "Q29149" }, { "db_name": "UniProt", "db_id": "Q5IS80" }, { "db_name": "UniProt", "db_id": "Q60495" }, { "db_name": "UniProt", "db_id": "Q95241" } ] } ]
[]
[]
[ { "id": "DS.d139.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d139.s0.e1", "arg2_id": "DS.d139.s0.e2", "normalized": [] }, { "id": "DS.d139.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d139.s0.e0", "arg2_id": "DS.d139.s0.e2", "normalized": [] }, { "id": "DS.d139.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d139.s1.e0", "arg2_id": "DS.d139.s1.e2", "normalized": [] }, { "id": "DS.d139.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d139.s1.e0", "arg2_id": "DS.d139.s1.e3", "normalized": [] }, { "id": "DS.d139.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d139.s1.e0", "arg2_id": "DS.d139.s1.e4", "normalized": [] }, { "id": "DS.d139.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d139.s1.e0", "arg2_id": "DS.d139.s1.e1", "normalized": [] }, { "id": "DS.d139.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d139.s2.e0", "arg2_id": "DS.d139.s2.e3", "normalized": [] }, { "id": "DS.d139.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d139.s2.e0", "arg2_id": "DS.d139.s2.e2", "normalized": [] }, { "id": "DS.d139.s2.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d139.s2.e0", "arg2_id": "DS.d139.s2.e1", "normalized": [] } ]
DS.d140
18410527
[ { "id": "DS.d140.s0", "type": "", "text": [ "Since biliverdin and bilirubin are downstream products of heme degradation by heme oxygenase (HO), it has been suggested that HO-activity protects against curcumin-induced apoptosis." ], "offsets": [ [ 0, 182 ] ] } ]
[ { "id": "DS.d140.s0.e0", "type": "compound", "text": [ "biliverdin" ], "offsets": [ [ 6, 16 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280353" }, { "db_name": "PubChem", "db_id": "5315455" }, { "db_name": "PubChem", "db_id": "5353439" }, { "db_name": "PubChem", "db_id": "6183357" } ] }, { "id": "DS.d140.s0.e1", "type": "compound", "text": [ "bilirubin" ], "offsets": [ [ 21, 30 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280352" } ] }, { "id": "DS.d140.s0.e2", "type": "compound", "text": [ "heme" ], "offsets": [ [ 58, 62 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4971" } ] }, { "id": "DS.d140.s0.e3", "type": "protein", "text": [ "heme oxygenase" ], "offsets": [ [ 78, 92 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19998" }, { "db_name": "UniProt", "db_id": "O73688" }, { "db_name": "UniProt", "db_id": "O78497" }, { "db_name": "UniProt", "db_id": "P51271" }, { "db_name": "UniProt", "db_id": "P71119" } ] } ]
[]
[]
[ { "id": "DS.d140.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d140.s0.e1", "arg2_id": "DS.d140.s0.e3", "normalized": [] }, { "id": "DS.d140.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d140.s0.e0", "arg2_id": "DS.d140.s0.e3", "normalized": [] } ]
DS.d141
18410529
[ { "id": "DS.d141.s0", "type": "", "text": [ "Here, we examine the effect of resistin on glucose uptake in human trophoblast cells and we demonstrate that transplacental glucose transport is mediated by glucose transporter (GLUT)-1." ], "offsets": [ [ 0, 186 ] ] }, { "id": "DS.d141.s1", "type": "", "text": [ "ERK1 and 2 activation stimulated GLUT-1 synthesis and resulted in increase of placental glucose uptake." ], "offsets": [ [ 187, 290 ] ] }, { "id": "DS.d141.s2", "type": "", "text": [ "High resistin levels (50-100 ng/ml) seem able to affect glucose-uptake, presumably by decreasing the cell surface glucose transporter." ], "offsets": [ [ 291, 425 ] ] } ]
[ { "id": "DS.d141.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 43, 50 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d141.s0.e1", "type": "protein", "text": [ "glucose transporter" ], "offsets": [ [ 157, 176 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P23586" } ] }, { "id": "DS.d141.s1.e0", "type": "protein", "text": [ "ERK1" ], "offsets": [ [ 187, 191 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27361" }, { "db_name": "UniProt", "db_id": "P28869" }, { "db_name": "UniProt", "db_id": "P42525" }, { "db_name": "UniProt", "db_id": "Q07176" } ] }, { "id": "DS.d141.s1.e1", "type": "protein", "text": [ "GLUT-1" ], "offsets": [ [ 220, 226 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P79365" } ] }, { "id": "DS.d141.s1.e2", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 275, 282 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d141.s2.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 347, 354 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d141.s2.e1", "type": "protein", "text": [ "glucose transporter" ], "offsets": [ [ 405, 424 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P23586" } ] } ]
[]
[]
[ { "id": "DS.d141.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d141.s0.e0", "arg2_id": "DS.d141.s0.e1", "normalized": [] }, { "id": "DS.d141.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d141.s1.e2", "arg2_id": "DS.d141.s1.e1", "normalized": [] }, { "id": "DS.d141.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d141.s1.e2", "arg2_id": "DS.d141.s1.e0", "normalized": [] }, { "id": "DS.d141.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d141.s2.e0", "arg2_id": "DS.d141.s2.e1", "normalized": [] } ]
DS.d142
18410530
[ { "id": "DS.d142.s0", "type": "", "text": [ "CpG methylation as well as histone H3 methylation of lysines 9 and 27 contribute independently to ARF gene silencing in adenocarcinoma cell lines and can be reversed by 5-aza-2'-deoxycytidine." ], "offsets": [ [ 0, 192 ] ] } ]
[ { "id": "DS.d142.s0.e0", "type": "compound", "text": [ "CpG" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6804" } ] }, { "id": "DS.d142.s0.e1", "type": "protein", "text": [ "ARF" ], "offsets": [ [ 98, 101 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O48920" }, { "db_name": "UniProt", "db_id": "P34727" }, { "db_name": "UniProt", "db_id": "P34728" }, { "db_name": "UniProt", "db_id": "P51823" }, { "db_name": "UniProt", "db_id": "Q94650" } ] }, { "id": "DS.d142.s0.e2", "type": "compound", "text": [ "5-aza-2'-deoxycytidine" ], "offsets": [ [ 169, 191 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "451668" } ] } ]
[]
[]
[ { "id": "DS.d142.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d142.s0.e0", "arg2_id": "DS.d142.s0.e1", "normalized": [] }, { "id": "DS.d142.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d142.s0.e2", "arg2_id": "DS.d142.s0.e1", "normalized": [] } ]
DS.d143
18410982
[ { "id": "DS.d143.s0", "type": "", "text": [ "Gly-Pro-, Gly-Pro-Met- and Ala-Ala-Phe-N'-(2-hexyl-1,3-dioxo-2,3-dihydro-1H-benzo(de)isoquinolin-6-yl)-hydrazides are synthesized by guanidinium/uronium type condensing reagent and used as fluorogenic substrates to localize dipeptidyl peptidase IV and tripeptidyl peptidase I activities in mammalian tissue sections." ], "offsets": [ [ 0, 316 ] ] } ]
[ { "id": "DS.d143.s0.e0", "type": "compound", "text": [ "Gly-Pro" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "79101" } ] }, { "id": "DS.d143.s0.e1", "type": "compound", "text": [ "Gly-Pro" ], "offsets": [ [ 10, 17 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "79101" } ] }, { "id": "DS.d143.s0.e2", "type": "compound", "text": [ "guanidinium" ], "offsets": [ [ 133, 144 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3520" } ] }, { "id": "DS.d143.s0.e3", "type": "protein", "text": [ "dipeptidyl peptidase IV" ], "offsets": [ [ 224, 247 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P14740" }, { "db_name": "UniProt", "db_id": "P22411" }, { "db_name": "UniProt", "db_id": "P27487" }, { "db_name": "UniProt", "db_id": "P28843" }, { "db_name": "UniProt", "db_id": "P81425" }, { "db_name": "UniProt", "db_id": "Q9N2I7" } ] }, { "id": "DS.d143.s0.e4", "type": "protein", "text": [ "tripeptidyl peptidase I" ], "offsets": [ [ 252, 275 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O14773" }, { "db_name": "UniProt", "db_id": "O89023" }, { "db_name": "UniProt", "db_id": "Q5IS74" }, { "db_name": "UniProt", "db_id": "Q5RFL1" }, { "db_name": "UniProt", "db_id": "Q60HH1" }, { "db_name": "UniProt", "db_id": "Q71JP6" }, { "db_name": "UniProt", "db_id": "Q9EQV6" }, { "db_name": "UniProt", "db_id": "Q9XSB8" } ] } ]
[]
[]
[ { "id": "DS.d143.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d143.s0.e0", "arg2_id": "DS.d143.s0.e3", "normalized": [] }, { "id": "DS.d143.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d143.s0.e2", "arg2_id": "DS.d143.s0.e3", "normalized": [] }, { "id": "DS.d143.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d143.s0.e0", "arg2_id": "DS.d143.s0.e4", "normalized": [] } ]
DS.d144
18413191
[ { "id": "DS.d144.s0", "type": "", "text": [ "However, increased blood glucose (200 mg/dl) significantly impaired the inhibitory effect of ASA (84% for GPIIb.005; 48% for P-selectin, P=NS)." ], "offsets": [ [ 0, 143 ] ] } ]
[ { "id": "DS.d144.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 25, 32 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d144.s0.e1", "type": "protein", "text": [ "GPIIb" ], "offsets": [ [ 106, 111 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08514" }, { "db_name": "UniProt", "db_id": "P53711" }, { "db_name": "UniProt", "db_id": "Q9QUM0" } ] } ]
[]
[]
[]
DS.d145
18413206
[ { "id": "DS.d145.s0", "type": "", "text": [ "The expressions of MCP-1 mRNA in renal tissues were markedly up-regulated in untreated diabetic rats, and these could be notably reduced by rosiglitazone treatment." ], "offsets": [ [ 0, 164 ] ] }, { "id": "DS.d145.s1", "type": "", "text": [ "In conclusion, rosiglitazone may have a potential therapeutic target in DN, which may be partly attributed to lowering of the expression of MCP-1 in the local kidney and the urinary excretion of MCP-1." ], "offsets": [ [ 165, 366 ] ] } ]
[ { "id": "DS.d145.s0.e0", "type": "protein", "text": [ "MCP-1" ], "offsets": [ [ 19, 24 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10148" }, { "db_name": "UniProt", "db_id": "P13500" }, { "db_name": "UniProt", "db_id": "P14844" }, { "db_name": "UniProt", "db_id": "P28291" }, { "db_name": "UniProt", "db_id": "P28292" }, { "db_name": "UniProt", "db_id": "P42831" }, { "db_name": "UniProt", "db_id": "P52203" }, { "db_name": "UniProt", "db_id": "P61274" }, { "db_name": "UniProt", "db_id": "P61275" }, { "db_name": "UniProt", "db_id": "Q08782" }, { "db_name": "UniProt", "db_id": "Q9TTQ3" } ] }, { "id": "DS.d145.s0.e1", "type": "compound", "text": [ "rosiglitazone" ], "offsets": [ [ 140, 153 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "77999" } ] }, { "id": "DS.d145.s1.e0", "type": "compound", "text": [ "rosiglitazone" ], "offsets": [ [ 180, 193 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "77999" } ] }, { "id": "DS.d145.s1.e1", "type": "protein", "text": [ "MCP-1" ], "offsets": [ [ 305, 310 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10148" }, { "db_name": "UniProt", "db_id": "P13500" }, { "db_name": "UniProt", "db_id": "P14844" }, { "db_name": "UniProt", "db_id": "P28291" }, { "db_name": "UniProt", "db_id": "P28292" }, { "db_name": "UniProt", "db_id": "P42831" }, { "db_name": "UniProt", "db_id": "P52203" }, { "db_name": "UniProt", "db_id": "P61274" }, { "db_name": "UniProt", "db_id": "P61275" }, { "db_name": "UniProt", "db_id": "Q08782" }, { "db_name": "UniProt", "db_id": "Q9TTQ3" } ] }, { "id": "DS.d145.s1.e2", "type": "protein", "text": [ "MCP-1" ], "offsets": [ [ 360, 365 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10148" }, { "db_name": "UniProt", "db_id": "P13500" }, { "db_name": "UniProt", "db_id": "P14844" }, { "db_name": "UniProt", "db_id": "P28291" }, { "db_name": "UniProt", "db_id": "P28292" }, { "db_name": "UniProt", "db_id": "P42831" }, { "db_name": "UniProt", "db_id": "P52203" }, { "db_name": "UniProt", "db_id": "P61274" }, { "db_name": "UniProt", "db_id": "P61275" }, { "db_name": "UniProt", "db_id": "Q08782" }, { "db_name": "UniProt", "db_id": "Q9TTQ3" } ] } ]
[]
[]
[ { "id": "DS.d145.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d145.s0.e1", "arg2_id": "DS.d145.s0.e0", "normalized": [] }, { "id": "DS.d145.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d145.s1.e0", "arg2_id": "DS.d145.s1.e1", "normalized": [] } ]
DS.d146
18414844
[ { "id": "DS.d146.s0", "type": "", "text": [ "The homomeric P2X (7) receptor is extraordinary in that in addition to distinctive localization and biological functions it exhibits several hallmark properties, for example, the receptor is potently inhibited by divalent cations such as calcium, magnesium, zinc and copper." ], "offsets": [ [ 0, 274 ] ] } ]
[ { "id": "DS.d146.s0.e0", "type": "protein", "text": [ "P2X" ], "offsets": [ [ 14, 17 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13900" }, { "db_name": "UniProt", "db_id": "P16604" } ] }, { "id": "DS.d146.s0.e1", "type": "compound", "text": [ "magnesium" ], "offsets": [ [ 247, 256 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5462224" } ] }, { "id": "DS.d146.s0.e2", "type": "compound", "text": [ "copper" ], "offsets": [ [ 267, 273 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23978" } ] } ]
[]
[]
[ { "id": "DS.d146.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d146.s0.e2", "arg2_id": "DS.d146.s0.e0", "normalized": [] }, { "id": "DS.d146.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d146.s0.e1", "arg2_id": "DS.d146.s0.e0", "normalized": [] } ]
DS.d147
18414894
[ { "id": "DS.d147.s0", "type": "", "text": [ "Replacement doses of hydrocortisone (HC) (10 mg/m2/day) failed to produce a feedback inhibition of adrenocorticotropic hormone (ACTH), and testosterone levels remained high." ], "offsets": [ [ 0, 173 ] ] } ]
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[]
[]
[]
DS.d148
18414974
[ { "id": "DS.d148.s0", "type": "", "text": [ "Cadmium exposure diminished the activities of enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) as well as non-enzymatic antioxidant, reduced glutathione (GSH) and total thiols." ], "offsets": [ [ 0, 330 ] ] }, { "id": "DS.d148.s1", "type": "", "text": [ "On the other hand, the levels of oxidized glutathione (GSSG), lipid peroxidation, protein carbonylation, DNA fragmentation, concentration of superoxide radicals and activities of cytochrome P450 enzymes (CYP P450s) have been found to increase due to cadmium intoxication." ], "offsets": [ [ 331, 602 ] ] } ]
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"DS.d148.s0.e4", "type": "protein", "text": [ "CAT" ], "offsets": [ [ 108, 111 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P00485" }, { "db_name": "UniProt", "db_id": "P00486" }, { "db_name": "UniProt", "db_id": "P00487" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P06135" }, { "db_name": "UniProt", "db_id": "P07641" }, { "db_name": "UniProt", "db_id": "P11504" }, { "db_name": "UniProt", "db_id": "P20074" }, { "db_name": "UniProt", "db_id": "P22782" }, { "db_name": "UniProt", "db_id": "P25309" }, { "db_name": "UniProt", "db_id": "P25819" }, { "db_name": "UniProt", "db_id": "P26825" }, { "db_name": "UniProt", "db_id": "P26826" }, { "db_name": "UniProt", "db_id": "P32796" }, { "db_name": "UniProt", "db_id": "P36882" }, { "db_name": "UniProt", "db_id": "P36883" }, { "db_name": "UniProt", "db_id": "P43155" }, { "db_name": "UniProt", "db_id": "P47934" }, { "db_name": "UniProt", "db_id": "P49417" }, { "db_name": "UniProt", "db_id": "P52826" }, { "db_name": "UniProt", "db_id": "P58777" }, { "db_name": "UniProt", "db_id": "P62577" }, { "db_name": "UniProt", "db_id": "P62578" }, { "db_name": "UniProt", "db_id": "P62579" }, { "db_name": "UniProt", "db_id": "P62580" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q00614" }, { "db_name": "UniProt", "db_id": "Q02736" }, { "db_name": "UniProt", "db_id": "Q03058" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q704S8" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PWF7" } ] }, { "id": "DS.d148.s0.e5", "type": "protein", "text": [ "glutathione-S-transferase" ], "offsets": [ [ 114, 139 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O04437" }, { "db_name": "UniProt", "db_id": "O18598" }, { "db_name": "UniProt", "db_id": "P0A9D2" }, { "db_name": "UniProt", "db_id": "P0A9D3" }, { "db_name": "UniProt", "db_id": "P30116" }, { "db_name": "UniProt", "db_id": "P44521" }, { "db_name": "UniProt", "db_id": "P46088" }, { "db_name": "UniProt", "db_id": "P46419" }, { "db_name": "UniProt", "db_id": "P46423" }, { "db_name": "UniProt", "db_id": "P46426" }, { "db_name": "UniProt", "db_id": "P46428" }, { "db_name": "UniProt", "db_id": "P46437" }, { "db_name": "UniProt", "db_id": "P48438" }, { "db_name": "UniProt", "db_id": "P80894" }, { "db_name": "UniProt", "db_id": "P81065" }, { "db_name": "UniProt", "db_id": "P82996" }, { "db_name": "UniProt", "db_id": "P82997" }, { "db_name": "UniProt", "db_id": "P82998" }, { "db_name": "UniProt", "db_id": "P82999" }, { "db_name": "UniProt", "db_id": "P83000" }, { "db_name": "UniProt", "db_id": "P83001" }, { "db_name": "UniProt", "db_id": "P83246" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q08392" }, { "db_name": "UniProt", "db_id": "Q08393" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" }, { "db_name": "UniProt", "db_id": "Q96324" } ] }, { "id": "DS.d148.s0.e6", "type": "protein", "text": [ "GST" ], "offsets": [ [ 141, 144 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20432" }, { "db_name": "UniProt", "db_id": "P30104" }, { "db_name": "UniProt", "db_id": "P30106" }, { "db_name": "UniProt", "db_id": "P30107" }, { "db_name": "UniProt", "db_id": "P30108" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" } ] }, { "id": "DS.d148.s0.e7", "type": "protein", "text": [ "glutathione reductase" ], "offsets": [ [ 147, 168 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O15770" }, { "db_name": "UniProt", "db_id": "P06715" }, { "db_name": "UniProt", "db_id": "P11804" }, { "db_name": "UniProt", "db_id": "P23189" }, { "db_name": "UniProt", "db_id": "P41921" }, { "db_name": "UniProt", "db_id": "P43783" }, { "db_name": "UniProt", "db_id": "P48638" }, { "db_name": "UniProt", "db_id": "P48639" }, { "db_name": "UniProt", "db_id": "P70619" }, { "db_name": "UniProt", "db_id": "P78965" }, { "db_name": "UniProt", "db_id": "Q60151" }, { "db_name": "UniProt", "db_id": "Q6BPI1" }, { "db_name": "UniProt", "db_id": "Q6C5H4" }, { "db_name": "UniProt", "db_id": "Q6FRV2" }, { "db_name": "UniProt", "db_id": "Q6HA23" }, { "db_name": "UniProt", "db_id": "Q74ZK4" }, { "db_name": "UniProt", "db_id": "Q873E8" }, { "db_name": "UniProt", "db_id": "Q94655" } ] }, { "id": "DS.d148.s0.e8", "type": "protein", "text": [ "glutathione peroxidase" ], "offsets": [ [ 175, 197 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O32770" }, { "db_name": "UniProt", "db_id": "O59858" }, { "db_name": "UniProt", "db_id": "Q00277" }, { "db_name": "UniProt", "db_id": "Q9CFV1" } ] }, { "id": "DS.d148.s0.e9", "type": "protein", "text": [ "G6PD" ], "offsets": [ [ 243, 247 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00091" }, { "db_name": "UniProt", "db_id": "O24357" }, { "db_name": "UniProt", "db_id": "O51581" }, { "db_name": "UniProt", "db_id": "O54537" }, { "db_name": "UniProt", "db_id": "O55044" }, { "db_name": "UniProt", "db_id": "O68282" }, { "db_name": "UniProt", "db_id": "O83491" }, { "db_name": "UniProt", "db_id": "O84188" }, { "db_name": "UniProt", "db_id": "P05370" }, { "db_name": "UniProt", "db_id": "P0A584" }, { "db_name": "UniProt", "db_id": "P0A585" }, { "db_name": "UniProt", "db_id": "P0A586" }, { "db_name": "UniProt", "db_id": "P0A587" }, { "db_name": "UniProt", "db_id": "P0AC53" }, { "db_name": "UniProt", "db_id": "P0AC54" }, { "db_name": "UniProt", "db_id": "P11410" }, { "db_name": "UniProt", "db_id": "P11411" }, { "db_name": "UniProt", "db_id": "P11412" }, { "db_name": "UniProt", "db_id": "P11413" }, { "db_name": "UniProt", "db_id": "P12646" }, { "db_name": "UniProt", "db_id": "P15588" }, { "db_name": "UniProt", "db_id": "P21907" }, { "db_name": "UniProt", "db_id": "P29686" }, { "db_name": "UniProt", "db_id": "P37830" }, { "db_name": "UniProt", "db_id": "P37986" }, { "db_name": "UniProt", "db_id": "P41571" }, { "db_name": "UniProt", "db_id": "P41764" }, { "db_name": "UniProt", "db_id": "P44311" }, { "db_name": "UniProt", "db_id": "P48826" }, { "db_name": "UniProt", "db_id": "P48828" }, { "db_name": "UniProt", "db_id": "P48848" }, { "db_name": "UniProt", "db_id": "P48992" }, { "db_name": "UniProt", "db_id": "P54547" }, { "db_name": "UniProt", "db_id": "P54996" }, { "db_name": "UniProt", "db_id": "P56110" }, { "db_name": "UniProt", "db_id": "P57405" }, { "db_name": "UniProt", "db_id": "P73411" }, { "db_name": "UniProt", "db_id": "P77809" }, { "db_name": "UniProt", "db_id": "P80619" }, { "db_name": "UniProt", "db_id": "P97324" }, { "db_name": "UniProt", "db_id": "Q00612" }, { "db_name": "UniProt", "db_id": "Q23711" }, { "db_name": "UniProt", "db_id": "Q24625" }, { "db_name": "UniProt", "db_id": "Q25019" }, { "db_name": "UniProt", "db_id": "Q25537" }, { "db_name": "UniProt", "db_id": "Q27464" }, { "db_name": "UniProt", "db_id": "Q27638" }, { "db_name": "UniProt", "db_id": "Q29492" }, { "db_name": "UniProt", "db_id": "Q42919" }, { "db_name": "UniProt", "db_id": "Q43793" }, { "db_name": "UniProt", "db_id": "Q43839" }, { "db_name": "UniProt", "db_id": "Q7YS37" }, { "db_name": "UniProt", "db_id": "Q89AI7" }, { "db_name": "UniProt", "db_id": "Q8K9M2" }, { "db_name": "UniProt", "db_id": "Q8XCJ6" }, { "db_name": "UniProt", "db_id": "Q9PKK8" }, { "db_name": "UniProt", "db_id": "Q9X0N9" }, { "db_name": "UniProt", "db_id": "Q9Z3S2" }, { "db_name": "UniProt", "db_id": "Q9Z8U6" }, { "db_name": "UniProt", "db_id": "Q9ZKB2" } ] }, { "id": "DS.d148.s0.e10", "type": "compound", "text": [ "reduced glutathione" ], "offsets": [ [ 287, 306 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d148.s0.e11", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 308, 311 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d148.s1.e0", "type": "compound", "text": [ "oxidized glutathione" ], "offsets": [ [ 364, 384 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "975" }, { "db_name": "PubChem", "db_id": "65359" } ] }, { "id": "DS.d148.s1.e1", "type": "compound", "text": [ "GSSG" ], "offsets": [ [ 386, 390 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65359" } ] }, { "id": "DS.d148.s1.e2", "type": "compound", "text": [ "superoxide" ], "offsets": [ [ 472, 482 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5359597" } ] }, { "id": "DS.d148.s1.e3", "type": "protein", "text": [ "cytochrome P450" ], "offsets": [ [ 510, 525 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08469" } ] }, { "id": "DS.d148.s1.e4", "type": "protein", "text": [ "CYP" ], "offsets": [ [ 535, 538 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21568" }, { "db_name": "UniProt", "db_id": "P21569" }, { "db_name": "UniProt", "db_id": "P24525" }, { "db_name": "UniProt", "db_id": "P34887" }, { "db_name": "UniProt", "db_id": "Q26551" } ] }, { "id": "DS.d148.s1.e5", "type": "compound", "text": [ "cadmium" ], "offsets": [ [ 581, 588 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23973" } ] } ]
[]
[]
[ { "id": "DS.d148.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d148.s0.e0", "arg2_id": "DS.d148.s0.e3", "normalized": [] }, { "id": "DS.d148.s0.i9", "type": "compound-protein-interaction", "arg1_id": "DS.d148.s0.e0", "arg2_id": "DS.d148.s0.e6", "normalized": [] }, { "id": "DS.d148.s0.i11", "type": "compound-protein-interaction", "arg1_id": "DS.d148.s0.e0", "arg2_id": "DS.d148.s0.e9", "normalized": [] }, { "id": "DS.d148.s0.i13", "type": "compound-protein-interaction", "arg1_id": "DS.d148.s0.e0", "arg2_id": "DS.d148.s0.e2", "normalized": [] }, { "id": "DS.d148.s0.i17", "type": "compound-protein-interaction", "arg1_id": "DS.d148.s0.e0", "arg2_id": "DS.d148.s0.e1", "normalized": [] }, { "id": "DS.d148.s0.i19", "type": "compound-protein-interaction", "arg1_id": "DS.d148.s0.e0", "arg2_id": "DS.d148.s0.e7", "normalized": [] }, { "id": "DS.d148.s0.i20", "type": "compound-protein-interaction", "arg1_id": "DS.d148.s0.e0", "arg2_id": "DS.d148.s0.e8", "normalized": [] }, { "id": "DS.d148.s0.i22", "type": "compound-protein-interaction", "arg1_id": "DS.d148.s0.e0", "arg2_id": "DS.d148.s0.e5", "normalized": [] }, { "id": "DS.d148.s0.i24", "type": "compound-protein-interaction", "arg1_id": "DS.d148.s0.e0", "arg2_id": "DS.d148.s0.e4", "normalized": [] }, { "id": "DS.d148.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d148.s1.e5", "arg2_id": "DS.d148.s1.e4", "normalized": [] }, { "id": "DS.d148.s1.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d148.s1.e5", "arg2_id": "DS.d148.s1.e3", "normalized": [] } ]
DS.d149
18415015
[ { "id": "DS.d149.s0", "type": "", "text": [ "This paper describes (1) the preparation of the intact oligosaccharides from GM1 (II(3)NeuAcGgOse(4) Cer) and GbOse(4) Cer as examples to show the use of CGase to prepare intact glycan chains from GSLs, and (2) the specificity and detergent requirements of Rhodococcal EGCases for the release of glycan chains from different GSLs." ], "offsets": [ [ 0, 330 ] ] } ]
[ { "id": "DS.d149.s0.e0", "type": "protein", "text": [ "GM1" ], "offsets": [ [ 77, 80 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P48648" } ] }, { "id": "DS.d149.s0.e1", "type": "compound", "text": [ "glycan" ], "offsets": [ [ 178, 184 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "871" } ] }, { "id": "DS.d149.s0.e2", "type": "compound", "text": [ "glycan" ], "offsets": [ [ 296, 302 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "871" } ] } ]
[]
[]
[]
DS.d150
18415121
[ { "id": "DS.d150.s0", "type": "", "text": [ "The discovery of the PLN/HAX-1 interaction therefore unveils an important new link between Ca(2+) homeostasis and cell survival, with significant therapeutic potential." ], "offsets": [ [ 0, 168 ] ] } ]
[ { "id": "DS.d150.s0.e0", "type": "protein", "text": [ "PLN" ], "offsets": [ [ 21, 24 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P26677" }, { "db_name": "UniProt", "db_id": "P26678" }, { "db_name": "UniProt", "db_id": "P61012" }, { "db_name": "UniProt", "db_id": "P61013" }, { "db_name": "UniProt", "db_id": "P61015" } ] }, { "id": "DS.d150.s0.e1", "type": "protein", "text": [ "HAX-1" ], "offsets": [ [ 25, 30 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00165" }, { "db_name": "UniProt", "db_id": "O35387" } ] }, { "id": "DS.d150.s0.e2", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 91, 95 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] } ]
[]
[]
[]
DS.d151
18418358
[ { "id": "DS.d151.s0", "type": "", "text": [ "UFP-101 alone evoked effects similar to low N/OFQ doses, suggesting tonic inhibitory control over forelimb movement by endogenous N/OFQ." ], "offsets": [ [ 0, 136 ] ] } ]
[ { "id": "DS.d151.s0.e0", "type": "compound", "text": [ "UFP-101" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "25081457" } ] }, { "id": "DS.d151.s0.e1", "type": "protein", "text": [ "OFQ" ], "offsets": [ [ 46, 49 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q13519" } ] }, { "id": "DS.d151.s0.e2", "type": "protein", "text": [ "OFQ" ], "offsets": [ [ 132, 135 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q13519" } ] } ]
[]
[]
[]
DS.d152
18418709
[ { "id": "DS.d152.s0", "type": "", "text": [ "Treating MCF-7 cells with AVE-1642 Qdots, but not unconjugated Qdots alone, downregulated IGF1R levels and rendered cells refractory to IGF-I stimulation." ], "offsets": [ [ 0, 154 ] ] }, { "id": "DS.d152.s1", "type": "", "text": [ "Our data suggest that AVE-1642 Qdots can be used to detect IGF1R expression and measure changes in cell surface receptor levels." ], "offsets": [ [ 155, 283 ] ] } ]
[ { "id": "DS.d152.s0.e0", "type": "compound", "text": [ "AVE" ], "offsets": [ [ 26, 29 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16070039" } ] }, { "id": "DS.d152.s0.e1", "type": "protein", "text": [ "IGF1R" ], "offsets": [ [ 90, 95 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08069" }, { "db_name": "UniProt", "db_id": "Q05688" }, { "db_name": "UniProt", "db_id": "Q29000" } ] }, { "id": "DS.d152.s0.e2", "type": "protein", "text": [ "IGF-I" ], "offsets": [ [ 136, 141 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05017" }, { "db_name": "UniProt", "db_id": "P07455" }, { "db_name": "UniProt", "db_id": "P08025" }, { "db_name": "UniProt", "db_id": "P10763" }, { "db_name": "UniProt", "db_id": "P16545" }, { "db_name": "UniProt", "db_id": "P17085" }, { "db_name": "UniProt", "db_id": "P17647" }, { "db_name": "UniProt", "db_id": "P18254" }, { "db_name": "UniProt", "db_id": "P33712" }, { "db_name": "UniProt", "db_id": "P51457" }, { "db_name": "UniProt", "db_id": "P51458" }, { "db_name": "UniProt", "db_id": "P51462" }, { "db_name": "UniProt", "db_id": "Q02815" }, { "db_name": "UniProt", "db_id": "Q28933" }, { "db_name": "UniProt", "db_id": "Q68LC0" }, { "db_name": "UniProt", "db_id": "Q6GUL6" }, { "db_name": "UniProt", "db_id": "Q6IVA5" }, { "db_name": "UniProt", "db_id": "Q6JLX1" }, { "db_name": "UniProt", "db_id": "Q95222" } ] }, { "id": "DS.d152.s1.e0", "type": "compound", "text": [ "AVE" ], "offsets": [ [ 177, 180 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16070039" } ] }, { "id": "DS.d152.s1.e1", "type": "protein", "text": [ "IGF1R" ], "offsets": [ [ 214, 219 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08069" }, { "db_name": "UniProt", "db_id": "Q05688" }, { "db_name": "UniProt", "db_id": "Q29000" } ] } ]
[]
[]
[ { "id": "DS.d152.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d152.s0.e0", "arg2_id": "DS.d152.s0.e1", "normalized": [] }, { "id": "DS.d152.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d152.s0.e0", "arg2_id": "DS.d152.s0.e2", "normalized": [] }, { "id": "DS.d152.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d152.s1.e0", "arg2_id": "DS.d152.s1.e1", "normalized": [] } ]
DS.d153
18420260
[ { "id": "DS.d153.s0", "type": "", "text": [ "Although previous studies indicated reduced levels of sialic acid residues during apoptosis, elevated Sambucus nigra agglutinin (SNA) reactivity might be due to the degradation of high molecular weight glycoproteins (probably including cadherin) that masked the SNA-binding residues of the plasma membrane prior to apoptosis." ], "offsets": [ [ 0, 325 ] ] } ]
[ { "id": "DS.d153.s0.e0", "type": "compound", "text": [ "sialic acid" ], "offsets": [ [ 54, 65 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "906" }, { "db_name": "PubChem", "db_id": "444885" }, { "db_name": "PubChem", "db_id": "445063" } ] }, { "id": "DS.d153.s0.e1", "type": "protein", "text": [ "agglutinin" ], "offsets": [ [ 117, 127 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02872" }, { "db_name": "UniProt", "db_id": "P05046" }, { "db_name": "UniProt", "db_id": "P11218" }, { "db_name": "UniProt", "db_id": "P11219" }, { "db_name": "UniProt", "db_id": "P30617" }, { "db_name": "UniProt", "db_id": "P42088" }, { "db_name": "UniProt", "db_id": "P49329" }, { "db_name": "UniProt", "db_id": "P82859" }, { "db_name": "UniProt", "db_id": "P82953" } ] }, { "id": "DS.d153.s0.e2", "type": "protein", "text": [ "glycoproteins" ], "offsets": [ [ 202, 215 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08163" } ] } ]
[]
[]
[ { "id": "DS.d153.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d153.s0.e0", "arg2_id": "DS.d153.s0.e1", "normalized": [] } ]
DS.d154
18423787
[ { "id": "DS.d154.s0", "type": "", "text": [ "We detected a marked decrease in target mRNA, an accumulation of short interfering RNAs (siRNAs), and a decrease in quercetin content relative to kaempferol in leaf tissues, indicating that sequence-specific mRNA degradation of the F3'H gene was induced." ], "offsets": [ [ 0, 254 ] ] } ]
[ { "id": "DS.d154.s0.e0", "type": "compound", "text": [ "quercetin content" ], "offsets": [ [ 116, 133 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280343" } ] }, { "id": "DS.d154.s0.e1", "type": "compound", "text": [ "kaempferol" ], "offsets": [ [ 146, 156 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280863" } ] }, { "id": "DS.d154.s0.e2", "type": "protein", "text": [ "F3'H" ], "offsets": [ [ 232, 236 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9SD85" } ] } ]
[]
[]
[]
DS.d155
18423943
[ { "id": "DS.d155.s0", "type": "", "text": [ "Polyhydroxy phenolic compounds, such as flavonoids, vitamin E, rosmarinic acid and aristolochic acid, are able to inhibit PLA (2) from different sources." ], "offsets": [ [ 0, 153 ] ] } ]
[ { "id": "DS.d155.s0.e0", "type": "compound", "text": [ "vitamin E" ], "offsets": [ [ 52, 61 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2116" }, { "db_name": "PubChem", "db_id": "14985" }, { "db_name": "PubChem", "db_id": "1548900" }, { "db_name": "PubChem", "db_id": "1742129" } ] }, { "id": "DS.d155.s0.e1", "type": "compound", "text": [ "rosmarinic acid" ], "offsets": [ [ 63, 78 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5281792" } ] }, { "id": "DS.d155.s0.e2", "type": "compound", "text": [ "aristolochic acid" ], "offsets": [ [ 83, 100 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2236" } ] }, { "id": "DS.d155.s0.e3", "type": "protein", "text": [ "PLA" ], "offsets": [ [ 122, 125 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0C1C0" }, { "db_name": "UniProt", "db_id": "Q01172" }, { "db_name": "UniProt", "db_id": "Q6CZT4" } ] } ]
[]
[]
[ { "id": "DS.d155.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d155.s0.e1", "arg2_id": "DS.d155.s0.e3", "normalized": [] }, { "id": "DS.d155.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d155.s0.e0", "arg2_id": "DS.d155.s0.e3", "normalized": [] }, { "id": "DS.d155.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d155.s0.e2", "arg2_id": "DS.d155.s0.e3", "normalized": [] } ]
DS.d156
18425600
[ { "id": "DS.d156.s0", "type": "", "text": [ "Analysis of the protein domain features indicated typical conserved cysteine residues containing a single whey acidic protein (WAP) domain at the C-terminus." ], "offsets": [ [ 0, 157 ] ] } ]
[ { "id": "DS.d156.s0.e0", "type": "compound", "text": [ "cysteine" ], "offsets": [ [ 68, 76 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "594" }, { "db_name": "PubChem", "db_id": "5862" }, { "db_name": "PubChem", "db_id": "5360637" } ] }, { "id": "DS.d156.s0.e1", "type": "protein", "text": [ "whey acidic protein" ], "offsets": [ [ 106, 125 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P09837" } ] }, { "id": "DS.d156.s0.e2", "type": "protein", "text": [ "WAP" ], "offsets": [ [ 127, 130 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46655" }, { "db_name": "UniProt", "db_id": "P01173" }, { "db_name": "UniProt", "db_id": "P01174" }, { "db_name": "UniProt", "db_id": "P09412" }, { "db_name": "UniProt", "db_id": "P09837" }, { "db_name": "UniProt", "db_id": "Q9N0L8" } ] } ]
[]
[]
[]
DS.d157
18427801
[ { "id": "DS.d157.s0", "type": "", "text": [ "Cross-linked P2X (1/2) heteromers showed strongly reduced or absent function that was selectively recovered upon treatment with DTT." ], "offsets": [ [ 0, 132 ] ] } ]
[ { "id": "DS.d157.s0.e0", "type": "protein", "text": [ "P2X" ], "offsets": [ [ 13, 16 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13900" }, { "db_name": "UniProt", "db_id": "P16604" } ] }, { "id": "DS.d157.s0.e1", "type": "compound", "text": [ "DTT" ], "offsets": [ [ 128, 131 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "439196" }, { "db_name": "PubChem", "db_id": "439352" }, { "db_name": "PubChem", "db_id": "446094" } ] } ]
[]
[]
[ { "id": "DS.d157.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d157.s0.e1", "arg2_id": "DS.d157.s0.e0", "normalized": [] } ]
DS.d158
18431601
[ { "id": "DS.d158.s0", "type": "", "text": [ "Permeabilization of K. marxianus cells in relation to beta-galactosidase activity was carried out using cetyltrimethyl ammonium bromide (CTAB) to avoid the problem of enzyme extraction." ], "offsets": [ [ 0, 185 ] ] } ]
[ { "id": "DS.d158.s0.e0", "type": "protein", "text": [ "beta-galactosidase" ], "offsets": [ [ 54, 72 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O33815" }, { "db_name": "UniProt", "db_id": "O52629" }, { "db_name": "UniProt", "db_id": "O52847" }, { "db_name": "UniProt", "db_id": "P00722" }, { "db_name": "UniProt", "db_id": "P00723" }, { "db_name": "UniProt", "db_id": "P06219" }, { "db_name": "UniProt", "db_id": "P0C1Y0" }, { "db_name": "UniProt", "db_id": "P14288" }, { "db_name": "UniProt", "db_id": "P22498" }, { "db_name": "UniProt", "db_id": "P23989" }, { "db_name": "UniProt", "db_id": "P24131" }, { "db_name": "UniProt", "db_id": "P26257" }, { "db_name": "UniProt", "db_id": "P30812" }, { "db_name": "UniProt", "db_id": "P50388" }, { "db_name": "UniProt", "db_id": "P70753" }, { "db_name": "UniProt", "db_id": "P77989" }, { "db_name": "UniProt", "db_id": "P81650" }, { "db_name": "UniProt", "db_id": "Q1G9Z4" }, { "db_name": "UniProt", "db_id": "Q47077" }, { "db_name": "UniProt", "db_id": "Q48727" }, { "db_name": "UniProt", "db_id": "Q56307" }, { "db_name": "UniProt", "db_id": "Q59140" }, { "db_name": "UniProt", "db_id": "Q59750" }, { "db_name": "UniProt", "db_id": "Q9K9C6" } ] }, { "id": "DS.d158.s0.e1", "type": "compound", "text": [ "ammonium bromide" ], "offsets": [ [ 119, 135 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "25514" } ] }, { "id": "DS.d158.s0.e2", "type": "compound", "text": [ "CTAB" ], "offsets": [ [ 137, 141 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2681" } ] } ]
[]
[]
[ { "id": "DS.d158.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d158.s0.e2", "arg2_id": "DS.d158.s0.e0", "normalized": [] }, { "id": "DS.d158.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d158.s0.e1", "arg2_id": "DS.d158.s0.e0", "normalized": [] } ]
DS.d159
18431759
[ { "id": "DS.d159.s0", "type": "", "text": [ "Although the levels of IL-4, IL-13, IL-10, and GRO/KC were affected by polymer implantation, but not dependent on a specific polymer, IL-6 and TNFalpha were significantly greater in those animals implanted with PEU and SR, materials that do not promote fusion." ], "offsets": [ [ 0, 260 ] ] } ]
[ { "id": "DS.d159.s0.e0", "type": "protein", "text": [ "IL-4" ], "offsets": [ [ 23, 27 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O77762" }, { "db_name": "UniProt", "db_id": "P05112" }, { "db_name": "UniProt", "db_id": "P07750" }, { "db_name": "UniProt", "db_id": "P20096" }, { "db_name": "UniProt", "db_id": "P30367" }, { "db_name": "UniProt", "db_id": "P30368" }, { "db_name": "UniProt", "db_id": "P42202" }, { "db_name": "UniProt", "db_id": "P46652" }, { "db_name": "UniProt", "db_id": "P47966" }, { "db_name": "UniProt", "db_id": "P51492" }, { "db_name": "UniProt", "db_id": "P51744" }, { "db_name": "UniProt", "db_id": "P55030" }, { "db_name": "UniProt", "db_id": "P79155" }, { "db_name": "UniProt", "db_id": "P79339" }, { "db_name": "UniProt", "db_id": "Q04745" }, { "db_name": "UniProt", "db_id": "Q2PE74" }, { "db_name": "UniProt", "db_id": "Q3S4V6" }, { "db_name": "UniProt", "db_id": "Q58M18" }, { "db_name": "UniProt", "db_id": "Q60440" }, { "db_name": "UniProt", "db_id": "Q7YS71" }, { "db_name": "UniProt", "db_id": "Q865X5" }, { "db_name": "UniProt", "db_id": "Q865Y0" }, { "db_name": "UniProt", "db_id": "Q8HYB1" }, { "db_name": "UniProt", "db_id": "Q9MZR8" }, { "db_name": "UniProt", "db_id": "Q9XS58" } ] }, { "id": "DS.d159.s0.e1", "type": "protein", "text": [ "IL-13" ], "offsets": [ [ 29, 34 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20109" }, { "db_name": "UniProt", "db_id": "P35225" }, { "db_name": "UniProt", "db_id": "P42203" }, { "db_name": "UniProt", "db_id": "P61126" }, { "db_name": "UniProt", "db_id": "Q5I6E4" }, { "db_name": "UniProt", "db_id": "Q864V6" }, { "db_name": "UniProt", "db_id": "Q865W5" }, { "db_name": "UniProt", "db_id": "Q865X3" }, { "db_name": "UniProt", "db_id": "Q95J68" }, { "db_name": "UniProt", "db_id": "Q9N0W9" }, { "db_name": "UniProt", "db_id": "Q9XSV9" } ] }, { "id": "DS.d159.s0.e2", "type": "protein", "text": [ "IL-10" ], "offsets": [ [ 36, 41 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46673" }, { "db_name": "UniProt", "db_id": "O97798" }, { "db_name": "UniProt", "db_id": "P18893" }, { "db_name": "UniProt", "db_id": "P22301" }, { "db_name": "UniProt", "db_id": "P29456" }, { "db_name": "UniProt", "db_id": "P43480" }, { "db_name": "UniProt", "db_id": "P46651" }, { "db_name": "UniProt", "db_id": "P47965" }, { "db_name": "UniProt", "db_id": "P48411" }, { "db_name": "UniProt", "db_id": "P51496" }, { "db_name": "UniProt", "db_id": "P51497" }, { "db_name": "UniProt", "db_id": "P51746" }, { "db_name": "UniProt", "db_id": "P55029" }, { "db_name": "UniProt", "db_id": "P79338" }, { "db_name": "UniProt", "db_id": "Q0Z972" }, { "db_name": "UniProt", "db_id": "Q25BC1" }, { "db_name": "UniProt", "db_id": "Q28374" }, { "db_name": "UniProt", "db_id": "Q29055" }, { "db_name": "UniProt", "db_id": "Q29408" }, { "db_name": "UniProt", "db_id": "Q2PE73" }, { "db_name": "UniProt", "db_id": "Q5Q0V6" }, { "db_name": "UniProt", "db_id": "Q865X4" }, { "db_name": "UniProt", "db_id": "Q8MKG9" }, { "db_name": "UniProt", "db_id": "Q9JHK7" }, { "db_name": "UniProt", "db_id": "Q9TSJ4" }, { "db_name": "UniProt", "db_id": "Q9Z1Y5" } ] }, { "id": "DS.d159.s0.e3", "type": "protein", "text": [ "GRO" ], "offsets": [ [ 47, 50 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46678" }, { "db_name": "UniProt", "db_id": "O55235" }, { "db_name": "UniProt", "db_id": "P09340" }, { "db_name": "UniProt", "db_id": "P09341" } ] }, { "id": "DS.d159.s0.e4", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 134, 138 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d159.s0.e5", "type": "protein", "text": [ "TNFalpha" ], "offsets": [ [ 143, 151 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d159.s0.e6", "type": "compound", "text": [ "PEU" ], "offsets": [ [ 211, 214 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5327147" } ] } ]
[]
[]
[ { "id": "DS.d159.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d159.s0.e6", "arg2_id": "DS.d159.s0.e4", "normalized": [] } ]
DS.d160
18431773
[ { "id": "DS.d160.s0", "type": "", "text": [ "Incorporation of bromodeoxyuridine into newly synthesized DNA and the concentration of vinculin, beta-actin, osteopontin, and osteocalcin in cells on the scaffolds of all pore sizes were similar to the values obtained on standard tissue culture polystyrene, which indicated good biocompatibility of the scaffolds." ], "offsets": [ [ 0, 313 ] ] } ]
[ { "id": "DS.d160.s0.e0", "type": "compound", "text": [ "bromodeoxyuridine" ], "offsets": [ [ 17, 34 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6035" } ] }, { "id": "DS.d160.s0.e1", "type": "protein", "text": [ "vinculin" ], "offsets": [ [ 87, 95 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46037" }, { "db_name": "UniProt", "db_id": "P12003" }, { "db_name": "UniProt", "db_id": "P18206" }, { "db_name": "UniProt", "db_id": "P19826" }, { "db_name": "UniProt", "db_id": "P26234" }, { "db_name": "UniProt", "db_id": "Q04615" }, { "db_name": "UniProt", "db_id": "Q17162" }, { "db_name": "UniProt", "db_id": "Q64727" } ] }, { "id": "DS.d160.s0.e2", "type": "protein", "text": [ "beta-actin" ], "offsets": [ [ 97, 107 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18840" }, { "db_name": "UniProt", "db_id": "O42161" }, { "db_name": "UniProt", "db_id": "O93400" }, { "db_name": "UniProt", "db_id": "P15475" }, { "db_name": "UniProt", "db_id": "P29751" }, { "db_name": "UniProt", "db_id": "P48975" }, { "db_name": "UniProt", "db_id": "P60706" }, { "db_name": "UniProt", "db_id": "P60707" }, { "db_name": "UniProt", "db_id": "P60708" }, { "db_name": "UniProt", "db_id": "P60709" }, { "db_name": "UniProt", "db_id": "P60710" }, { "db_name": "UniProt", "db_id": "P60711" }, { "db_name": "UniProt", "db_id": "P60712" }, { "db_name": "UniProt", "db_id": "P60713" }, { "db_name": "UniProt", "db_id": "P68143" }, { "db_name": "UniProt", "db_id": "P79818" }, { "db_name": "UniProt", "db_id": "P83750" }, { "db_name": "UniProt", "db_id": "P83751" }, { "db_name": "UniProt", "db_id": "P84336" }, { "db_name": "UniProt", "db_id": "P84856" }, { "db_name": "UniProt", "db_id": "Q0PGG4" }, { "db_name": "UniProt", "db_id": "Q4L0Y2" }, { "db_name": "UniProt", "db_id": "Q5R1X3" }, { "db_name": "UniProt", "db_id": "Q711N9" }, { "db_name": "UniProt", "db_id": "Q71FK5" }, { "db_name": "UniProt", "db_id": "Q76N69" }, { "db_name": "UniProt", "db_id": "Q91ZK5" }, { "db_name": "UniProt", "db_id": "Q9Y702" } ] }, { "id": "DS.d160.s0.e3", "type": "protein", "text": [ "osteocalcin" ], "offsets": [ [ 126, 137 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02819" }, { "db_name": "UniProt", "db_id": "P02821" }, { "db_name": "UniProt", "db_id": "P02823" }, { "db_name": "UniProt", "db_id": "P0C225" }, { "db_name": "UniProt", "db_id": "P0C226" }, { "db_name": "UniProt", "db_id": "P15504" }, { "db_name": "UniProt", "db_id": "P28317" }, { "db_name": "UniProt", "db_id": "P39056" }, { "db_name": "UniProt", "db_id": "P81455" }, { "db_name": "UniProt", "db_id": "P83005" }, { "db_name": "UniProt", "db_id": "P83238" }, { "db_name": "UniProt", "db_id": "P83473" }, { "db_name": "UniProt", "db_id": "P83489" }, { "db_name": "UniProt", "db_id": "P84348" }, { "db_name": "UniProt", "db_id": "P84349" }, { "db_name": "UniProt", "db_id": "P84350" }, { "db_name": "UniProt", "db_id": "P84351" }, { "db_name": "UniProt", "db_id": "Q7LZI4" }, { "db_name": "UniProt", "db_id": "Q8HYY9" } ] }, { "id": "DS.d160.s0.e4", "type": "compound", "text": [ "polystyrene" ], "offsets": [ [ 245, 256 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7501" } ] } ]
[]
[]
[]
DS.d161
18431776
[ { "id": "DS.d161.s0", "type": "", "text": [ "To determine the capabilities of previously used microsphere scaffold to deliver growth factors simultaneously, this work investigated a long-term (about three months) release of bovine serum albumin (BSA) from microsphere scaffolds fabricated by using two different polymers, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV, 8% PHV), poly(lactide-co-glycolide) acid (PLGA, 5050) and a blend of PLGA and PHBV." ], "offsets": [ [ 0, 412 ] ] } ]
[ { "id": "DS.d161.s0.e0", "type": "protein", "text": [ "serum albumin" ], "offsets": [ [ 186, 199 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21847" }, { "db_name": "UniProt", "db_id": "P83517" } ] }, { "id": "DS.d161.s0.e1", "type": "protein", "text": [ "BSA" ], "offsets": [ [ 201, 204 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02769" } ] }, { "id": "DS.d161.s0.e2", "type": "compound", "text": [ "poly(3-hydroxybutyrate-co-3-hydroxyvalerate" ], "offsets": [ [ 277, 320 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "107801" } ] }, { "id": "DS.d161.s0.e3", "type": "compound", "text": [ "poly(lactide-co-glycolide" ], "offsets": [ [ 338, 363 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23111554" } ] }, { "id": "DS.d161.s0.e4", "type": "compound", "text": [ "PLGA" ], "offsets": [ [ 371, 375 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "36797" } ] }, { "id": "DS.d161.s0.e5", "type": "compound", "text": [ "PLGA" ], "offsets": [ [ 398, 402 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "36797" } ] } ]
[]
[]
[]
DS.d162
18433938
[ { "id": "DS.d162.s0", "type": "", "text": [ "Prediction of CCR5 receptor binding affinity of substituted 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas based on the heuristic method, support vector machine and projection pursuit regression." ], "offsets": [ [ 0, 200 ] ] }, { "id": "DS.d162.s1", "type": "", "text": [ "Quantitative structure-activity relationship (QSAR) models were developed to predict for CCR5 binding affinity of substituted 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas using linear free energy relationship (LFER)." ], "offsets": [ [ 201, 424 ] ] } ]
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"P61815" }, { "db_name": "UniProt", "db_id": "P68269" }, { "db_name": "UniProt", "db_id": "P68270" }, { "db_name": "UniProt", "db_id": "Q1ZY22" }, { "db_name": "UniProt", "db_id": "Q2HJ17" }, { "db_name": "UniProt", "db_id": "Q5ECR9" }, { "db_name": "UniProt", "db_id": "Q6WN98" }, { "db_name": "UniProt", "db_id": "Q71UI8" }, { "db_name": "UniProt", "db_id": "Q8HZT9" }, { "db_name": "UniProt", "db_id": "Q95NC0" }, { "db_name": "UniProt", "db_id": "Q95NC1" }, { "db_name": "UniProt", "db_id": "Q95NC2" }, { "db_name": "UniProt", "db_id": "Q95NC3" }, { "db_name": "UniProt", "db_id": "Q95NC4" }, { "db_name": "UniProt", "db_id": "Q95NC5" }, { "db_name": "UniProt", "db_id": "Q95NC6" }, { "db_name": "UniProt", "db_id": "Q95NC7" }, { "db_name": "UniProt", "db_id": "Q95NC8" }, { "db_name": "UniProt", "db_id": "Q95NC9" }, { "db_name": "UniProt", "db_id": "Q95ND0" }, { "db_name": "UniProt", "db_id": "Q95ND1" }, { "db_name": "UniProt", "db_id": "Q95ND2" }, { "db_name": "UniProt", "db_id": "Q95NE8" }, { "db_name": "UniProt", "db_id": "Q9BGN6" }, { "db_name": "UniProt", "db_id": "Q9TV42" }, { "db_name": "UniProt", "db_id": "Q9TV43" }, { "db_name": "UniProt", "db_id": "Q9TV45" }, { "db_name": "UniProt", "db_id": "Q9TV47" }, { "db_name": "UniProt", "db_id": "Q9TV48" }, { "db_name": "UniProt", "db_id": "Q9TV49" }, { "db_name": "UniProt", "db_id": "Q9XT76" } ] }, { "id": "DS.d162.s0.e1", "type": "compound", "text": [ "piperidinyl" ], "offsets": [ [ 83, 94 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5376415" } ] }, { "id": "DS.d162.s1.e0", "type": "protein", "text": [ "CCR5" ], "offsets": [ [ 290, 294 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62743" }, { "db_name": "UniProt", "db_id": "O97878" }, { "db_name": "UniProt", "db_id": "O97879" }, { "db_name": "UniProt", "db_id": "O97880" }, { "db_name": "UniProt", "db_id": "O97881" }, { "db_name": "UniProt", "db_id": "O97882" }, { "db_name": "UniProt", "db_id": "O97883" }, { "db_name": "UniProt", "db_id": "O97962" }, { "db_name": "UniProt", "db_id": "O97975" }, { "db_name": "UniProt", "db_id": "P51681" }, { "db_name": "UniProt", "db_id": "P56439" }, { "db_name": "UniProt", "db_id": "P56440" }, { "db_name": "UniProt", "db_id": "P56493" }, { "db_name": "UniProt", "db_id": "P60574" }, { "db_name": "UniProt", "db_id": "P61755" }, { "db_name": "UniProt", "db_id": "P61756" }, { "db_name": "UniProt", "db_id": "P61757" }, { "db_name": "UniProt", "db_id": "P61813" }, { "db_name": "UniProt", "db_id": "P61814" }, { "db_name": "UniProt", "db_id": "P61815" }, { "db_name": "UniProt", "db_id": "P68269" }, { "db_name": "UniProt", "db_id": "P68270" }, { "db_name": "UniProt", "db_id": "Q1ZY22" }, { "db_name": "UniProt", "db_id": "Q2HJ17" }, { "db_name": "UniProt", "db_id": "Q5ECR9" }, { "db_name": "UniProt", "db_id": "Q6WN98" }, { "db_name": "UniProt", "db_id": "Q71UI8" }, { "db_name": "UniProt", "db_id": "Q8HZT9" }, { "db_name": "UniProt", "db_id": "Q95NC0" }, { "db_name": "UniProt", "db_id": "Q95NC1" }, { "db_name": "UniProt", "db_id": "Q95NC2" }, { "db_name": "UniProt", "db_id": "Q95NC3" }, { "db_name": "UniProt", "db_id": "Q95NC4" }, { "db_name": "UniProt", "db_id": "Q95NC5" }, { "db_name": "UniProt", "db_id": "Q95NC6" }, { "db_name": "UniProt", "db_id": "Q95NC7" }, { "db_name": "UniProt", "db_id": "Q95NC8" }, { "db_name": "UniProt", "db_id": "Q95NC9" }, { "db_name": "UniProt", "db_id": "Q95ND0" }, { "db_name": "UniProt", "db_id": "Q95ND1" }, { "db_name": "UniProt", "db_id": "Q95ND2" }, { "db_name": "UniProt", "db_id": "Q95NE8" }, { "db_name": "UniProt", "db_id": "Q9BGN6" }, { "db_name": "UniProt", "db_id": "Q9TV42" }, { "db_name": "UniProt", "db_id": "Q9TV43" }, { "db_name": "UniProt", "db_id": "Q9TV45" }, { "db_name": "UniProt", "db_id": "Q9TV47" }, { "db_name": "UniProt", "db_id": "Q9TV48" }, { "db_name": "UniProt", "db_id": "Q9TV49" }, { "db_name": "UniProt", "db_id": "Q9XT76" } ] }, { "id": "DS.d162.s1.e1", "type": "compound", "text": [ "piperidinyl" ], "offsets": [ [ 350, 361 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5376415" } ] } ]
[]
[]
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DS.d163
18434046
[ { "id": "DS.d163.s0", "type": "", "text": [ "It is suggested that GABA acting through the GABA(A) receptor mechanism on the expression of GnRH gene and GnRH-R gene in the hypothalamus may be involved in two processes: the biosynthesis of GnRH and the release of this neurohormone in the hypothalamus." ], "offsets": [ [ 0, 255 ] ] } ]
[ { "id": "DS.d163.s0.e0", "type": "compound", "text": [ "GABA" ], "offsets": [ [ 21, 25 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "119" } ] }, { "id": "DS.d163.s0.e1", "type": "protein", "text": [ "GABA(A) receptor" ], "offsets": [ [ 45, 61 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P26714" }, { "db_name": "UniProt", "db_id": "Q08832" }, { "db_name": "UniProt", "db_id": "Q9BLY8" } ] }, { "id": "DS.d163.s0.e2", "type": "protein", "text": [ "GnRH" ], "offsets": [ [ 93, 97 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27429" } ] }, { "id": "DS.d163.s0.e3", "type": "protein", "text": [ "GnRH-R" ], "offsets": [ [ 107, 113 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18821" }, { "db_name": "UniProt", "db_id": "P30968" }, { "db_name": "UniProt", "db_id": "P30969" }, { "db_name": "UniProt", "db_id": "P32236" }, { "db_name": "UniProt", "db_id": "P32237" }, { "db_name": "UniProt", "db_id": "P49922" }, { "db_name": "UniProt", "db_id": "Q01776" }, { "db_name": "UniProt", "db_id": "Q19PY9" }, { "db_name": "UniProt", "db_id": "Q8CH60" }, { "db_name": "UniProt", "db_id": "Q8SPZ1" }, { "db_name": "UniProt", "db_id": "Q9MZI6" }, { "db_name": "UniProt", "db_id": "Q9TTI8" } ] }, { "id": "DS.d163.s0.e4", "type": "protein", "text": [ "GnRH" ], "offsets": [ [ 107, 111 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27429" } ] } ]
[]
[]
[ { "id": "DS.d163.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d163.s0.e0", "arg2_id": "DS.d163.s0.e3", "normalized": [] }, { "id": "DS.d163.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d163.s0.e0", "arg2_id": "DS.d163.s0.e2", "normalized": [] }, { "id": "DS.d163.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d163.s0.e0", "arg2_id": "DS.d163.s0.e1", "normalized": [] } ]
DS.d164
18435693
[ { "id": "DS.d164.s0", "type": "", "text": [ "TT-induced increases in cortisol, adrenocorticotropic hormone and prolactin were reduced only after 3-h REC." ], "offsets": [ [ 0, 108 ] ] } ]
[ { "id": "DS.d164.s0.e0", "type": "compound", "text": [ "cortisol" ], "offsets": [ [ 24, 32 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] }, { "id": "DS.d164.s0.e1", "type": "protein", "text": [ "adrenocorticotropic hormone" ], "offsets": [ [ 34, 61 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01189" }, { "db_name": "UniProt", "db_id": "P01190" }, { "db_name": "UniProt", "db_id": "P01191" }, { "db_name": "UniProt", "db_id": "P01192" }, { "db_name": "UniProt", "db_id": "P01193" }, { "db_name": "UniProt", "db_id": "P01194" }, { "db_name": "UniProt", "db_id": "P01196" }, { "db_name": "UniProt", "db_id": "P01197" }, { "db_name": "UniProt", "db_id": "P01201" }, { "db_name": "UniProt", "db_id": "P06297" }, { "db_name": "UniProt", "db_id": "P06298" }, { "db_name": "UniProt", "db_id": "P06299" }, { "db_name": "UniProt", "db_id": "P10000" }, { "db_name": "UniProt", "db_id": "P11280" }, { "db_name": "UniProt", "db_id": "P11885" }, { "db_name": "UniProt", "db_id": "P19402" }, { "db_name": "UniProt", "db_id": "P21252" }, { "db_name": "UniProt", "db_id": "P22923" }, { "db_name": "UniProt", "db_id": "P68000" }, { "db_name": "UniProt", "db_id": "P68001" }, { "db_name": "UniProt", "db_id": "P87352" }, { "db_name": "UniProt", "db_id": "Q04617" }, { "db_name": "UniProt", "db_id": "Q04618" }, { "db_name": "UniProt", "db_id": "Q91082" }, { "db_name": "UniProt", "db_id": "Q9YGK2" }, { "db_name": "UniProt", "db_id": "Q9YGK4" }, { "db_name": "UniProt", "db_id": "Q9YGK5" } ] }, { "id": "DS.d164.s0.e2", "type": "protein", "text": [ "prolactin" ], "offsets": [ [ 66, 75 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10765" }, { "db_name": "UniProt", "db_id": "P22393" }, { "db_name": "UniProt", "db_id": "P33089" }, { "db_name": "UniProt", "db_id": "P33090" }, { "db_name": "UniProt", "db_id": "P33091" }, { "db_name": "UniProt", "db_id": "P43001" } ] }, { "id": "DS.d164.s0.e3", "type": "protein", "text": [ "REC" ], "offsets": [ [ 104, 107 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UIJ5" } ] } ]
[]
[]
[]
DS.d165
18436224
[ { "id": "DS.d165.s0", "type": "", "text": [ "Quercetin inhibits vascular superoxide production induced by endothelin-1 : Role of NADPH oxidase, uncoupled eNOS and PKC." ], "offsets": [ [ 0, 122 ] ] }, { "id": "DS.d165.s3", "type": "", "text": [ "Furthermore, ET-1 increased intracellular O(2*)(-) production in all layers of the vessel, protein expression of NADPH oxidase subunit p47 (phox) without affecting p22 (phox) expression and lucigenin-enhanced chemiluminescence signal stimulated by calcium ionophore A23187." ], "offsets": [ [ 123, 396 ] ] }, { "id": "DS.d165.s5", "type": "", "text": [ "Moreover, quercetin but not isorhamnetin, inhibited the increased PKC activity induced by ET-1." ], "offsets": [ [ 397, 492 ] ] }, { "id": "DS.d165.s6", "type": "", "text": [ "Taken together these results indicate that ET-1-induced NADPH oxidase up-regulation and eNOS uncoupling via PKC leading to endothelial dysfunction and these effects were prevented by quercetin and isorhamnetin." ], "offsets": [ [ 493, 703 ] ] } ]
[ { "id": "DS.d165.s0.e0", "type": "compound", "text": [ "Quercetin" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280343" } ] }, { "id": "DS.d165.s0.e1", "type": "compound", "text": [ "superoxide" ], "offsets": [ [ 28, 38 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5359597" } ] }, { "id": "DS.d165.s0.e2", "type": "protein", "text": [ "endothelin-1" ], "offsets": [ [ 61, 73 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05305" }, { "db_name": "UniProt", "db_id": "Q28469" } ] }, { "id": "DS.d165.s0.e3", "type": "protein", "text": [ "eNOS" ], "offsets": [ [ 109, 113 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29473" }, { "db_name": "UniProt", "db_id": "P29474" }, { "db_name": "UniProt", "db_id": "P70313" }, { "db_name": "UniProt", "db_id": "P79209" }, { "db_name": "UniProt", "db_id": "P97270" }, { "db_name": "UniProt", "db_id": "Q28969" }, { "db_name": "UniProt", "db_id": "Q62600" } ] }, { "id": "DS.d165.s0.e4", "type": "protein", "text": [ "PKC" ], "offsets": [ [ 118, 121 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05130" }, { "db_name": "UniProt", "db_id": "P13677" }, { "db_name": "UniProt", "db_id": "P13678" }, { "db_name": "UniProt", "db_id": "P34722" } ] }, { "id": "DS.d165.s3.e1", "type": "protein", "text": [ "p47" ], "offsets": [ [ 258, 261 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O10300" }, { "db_name": "UniProt", "db_id": "P08567" }, { "db_name": "UniProt", "db_id": "P26642" }, { "db_name": "UniProt", "db_id": "P34051" }, { "db_name": "UniProt", "db_id": "Q12802" }, { "db_name": "UniProt", "db_id": "Q91375" }, { "db_name": "UniProt", "db_id": "Q9SZB9" }, { "db_name": "UniProt", "db_id": "Q9Y240" } ] }, { "id": "DS.d165.s3.e2", "type": "protein", "text": [ "p22" ], "offsets": [ [ 287, 290 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O75935" }, { "db_name": "UniProt", "db_id": "P03304" }, { "db_name": "UniProt", "db_id": "P11691" }, { "db_name": "UniProt", "db_id": "P15961" }, { "db_name": "UniProt", "db_id": "P16342" }, { "db_name": "UniProt", "db_id": "P17593" }, { "db_name": "UniProt", "db_id": "P17594" }, { "db_name": "UniProt", "db_id": "P19751" }, { "db_name": "UniProt", "db_id": "P23169" }, { "db_name": "UniProt", "db_id": "P24102" }, { "db_name": "UniProt", "db_id": "P50629" }, { "db_name": "UniProt", "db_id": "P50630" }, { "db_name": "UniProt", "db_id": "P50631" }, { "db_name": "UniProt", "db_id": "P50632" }, { "db_name": "UniProt", "db_id": "P50633" }, { "db_name": "UniProt", "db_id": "P50634" }, { "db_name": "UniProt", "db_id": "P82796" }, { "db_name": "UniProt", "db_id": "Q05903" }, { "db_name": "UniProt", "db_id": "Q66198" }, { "db_name": "UniProt", "db_id": "Q8V439" }, { "db_name": "UniProt", "db_id": "Q8V6W7" }, { "db_name": "UniProt", "db_id": "Q91A29" }, { "db_name": "UniProt", "db_id": "Q9PYA3" } ] }, { "id": "DS.d165.s3.e3", "type": "compound", "text": [ "calcium ionophore A23187" ], "offsets": [ [ 371, 395 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1959" }, { "db_name": "PubChem", "db_id": "11957499" } ] }, { "id": "DS.d165.s5.e0", "type": "compound", "text": [ "quercetin" ], "offsets": [ [ 407, 416 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280343" } ] }, { "id": "DS.d165.s5.e1", "type": "compound", "text": [ "isorhamnetin" ], "offsets": [ [ 425, 437 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5281654" } ] }, { "id": "DS.d165.s5.e2", "type": "protein", "text": [ "PKC" ], "offsets": [ [ 463, 466 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05130" }, { "db_name": "UniProt", "db_id": "P13677" }, { "db_name": "UniProt", "db_id": "P13678" }, { "db_name": "UniProt", "db_id": "P34722" } ] }, { "id": "DS.d165.s6.e1", "type": "protein", "text": [ "eNOS" ], "offsets": [ [ 581, 585 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29473" }, { "db_name": "UniProt", "db_id": "P29474" }, { "db_name": "UniProt", "db_id": "P70313" }, { "db_name": "UniProt", "db_id": "P79209" }, { "db_name": "UniProt", "db_id": "P97270" }, { "db_name": "UniProt", "db_id": "Q28969" }, { "db_name": "UniProt", "db_id": "Q62600" } ] }, { "id": "DS.d165.s6.e2", "type": "protein", "text": [ "PKC" ], "offsets": [ [ 601, 604 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05130" }, { "db_name": "UniProt", "db_id": "P13677" }, { "db_name": "UniProt", "db_id": "P13678" }, { "db_name": "UniProt", "db_id": "P34722" } ] }, { "id": "DS.d165.s6.e3", "type": "compound", "text": [ "quercetin" ], "offsets": [ [ 676, 685 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280343" } ] }, { "id": "DS.d165.s6.e4", "type": "compound", "text": [ "isorhamnetin" ], "offsets": [ [ 690, 702 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5281654" } ] } ]
[]
[]
[ { "id": "DS.d165.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d165.s0.e1", "arg2_id": "DS.d165.s0.e2", "normalized": [] }, { "id": "DS.d165.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d165.s0.e0", "arg2_id": "DS.d165.s0.e2", "normalized": [] }, { "id": "DS.d165.s5.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d165.s5.e0", "arg2_id": "DS.d165.s5.e2", "normalized": [] }, { "id": "DS.d165.s6.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d165.s6.e4", "arg2_id": "DS.d165.s6.e1", "normalized": [] }, { "id": "DS.d165.s6.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d165.s6.e4", "arg2_id": "DS.d165.s6.e2", "normalized": [] }, { "id": "DS.d165.s6.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d165.s6.e3", "arg2_id": "DS.d165.s6.e1", "normalized": [] }, { "id": "DS.d165.s6.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d165.s6.e3", "arg2_id": "DS.d165.s6.e2", "normalized": [] } ]
DS.d166
18436227
[ { "id": "DS.d166.s0", "type": "", "text": [ "We hypothesized that variants in PCSK9 that lower LDL cholesterol levels are associated with reduced prevalence and incidence of peripheral artery disease (PAD)." ], "offsets": [ [ 0, 161 ] ] } ]
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[]
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DS.d167
18436346
[ { "id": "DS.d167.s0", "type": "", "text": [ "A series of 2-aryl-naphtho(1,2-d) oxazole derivatives have been synthesized and evaluated for PTP-1B inhibitory activity." ], "offsets": [ [ 0, 121 ] ] } ]
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[]
[]
[]
DS.d168
18436348
[ { "id": "DS.d168.s0", "type": "", "text": [ "A new series of indanone and aurone derivatives have been synthesized and tested for in vitro AChE inhibitory activity by modified Ellman method." ], "offsets": [ [ 0, 145 ] ] } ]
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[]
[]
[]
DS.d169
18436399
[ { "id": "DS.d169.s0", "type": "", "text": [ "Polyunsaturated fatty acids differentially alter PGF (2alpha) and PGE (2) release from bovine trophoblast and endometrial tissues during short-term culture." ], "offsets": [ [ 0, 156 ] ] }, { "id": "DS.d169.s1", "type": "", "text": [ "Two studies tested the hypothesis that eicosapentaenoic (20:5omega3; EPA), docosahexaenoic acids (22:6omega3; DHA) or linoleic acid (C18 :2omega6; LIN) reduced bovine endometrial and trophoblast prostaglandin F(2alpha) (PGF (2alpha)) and prostaglandin E(2) (PGE (2)) release during short-term culture." ], "offsets": [ [ 157, 458 ] ] } ]
[ { "id": "DS.d169.s0.e0", "type": "compound", "text": [ "Polyunsaturated fatty acids" ], "offsets": [ [ 0, 27 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "56842239" } ] }, { "id": "DS.d169.s0.e1", "type": "protein", "text": [ "PGF" ], "offsets": [ [ 49, 52 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P49763" }, { "db_name": "UniProt", "db_id": "Q9XS47" } ] }, { "id": "DS.d169.s0.e2", "type": "protein", "text": [ "PGE" ], "offsets": [ [ 66, 69 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q29458" } ] }, { "id": "DS.d169.s1.e0", "type": "compound", "text": [ "docosahexaenoic acids" ], "offsets": [ [ 232, 253 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6433873" } ] }, { "id": "DS.d169.s1.e1", "type": "compound", "text": [ "linoleic acid" ], "offsets": [ [ 275, 288 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280450" } ] }, { "id": "DS.d169.s1.e2", "type": "compound", "text": [ "LIN" ], "offsets": [ [ 304, 307 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "96" } ] }, { "id": "DS.d169.s1.e3", "type": "protein", "text": [ "PGF" ], "offsets": [ [ 377, 380 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P49763" }, { "db_name": "UniProt", "db_id": "Q9XS47" } ] }, { "id": "DS.d169.s1.e4", "type": "protein", "text": [ "PGE" ], "offsets": [ [ 415, 418 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q29458" } ] } ]
[]
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DS.d170
18437529
[ { "id": "DS.d170.s0", "type": "", "text": [ "1-Deoxy-D-xylulose-5-phosphate synthase (DXS) catalyses the first committed step of the 2C-methyl-D-erythritol-4-phosphate (MEP) pathway, which is an alternative isoprenoids biosynthetic route that has been recently discovered." ], "offsets": [ [ 0, 227 ] ] } ]
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}, { "db_name": "UniProt", "db_id": "Q9RBN6" }, { "db_name": "UniProt", "db_id": "Q9RUB5" }, { "db_name": "UniProt", "db_id": "Q9X291" }, { "db_name": "UniProt", "db_id": "Q9Z6J9" }, { "db_name": "UniProt", "db_id": "Q9ZM94" } ] }, { "id": "DS.d170.s0.e1", "type": "compound", "text": [ "D-erythritol-4-phosphate" ], "offsets": [ [ 98, 122 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "192838" }, { "db_name": "PubChem", "db_id": "3262721" } ] }, { "id": "DS.d170.s0.e2", "type": "compound", "text": [ "MEP" ], "offsets": [ [ 124, 127 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7728" } ] } ]
[]
[]
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DS.d171
18437557
[ { "id": "DS.d171.s0", "type": "", "text": [ "To get insight into the underlying mechanisms, we compared the ability of recombinant wild type and variant (D327N) SHBG to influence estradiol effects in MCF-7 breast cancer cells." ], "offsets": [ [ 0, 181 ] ] }, { "id": "DS.d171.s1", "type": "", "text": [ "D327N SHBG was more effective than wild type protein in inhibiting estradiol-induced cell proliferation and anti-apoptosis." ], "offsets": [ [ 182, 305 ] ] } ]
[ { "id": "DS.d171.s0.e0", "type": "protein", "text": [ "SHBG" ], "offsets": [ [ 116, 120 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04278" }, { "db_name": "UniProt", "db_id": "P08689" }, { "db_name": "UniProt", "db_id": "P15196" }, { "db_name": "UniProt", "db_id": "P97497" }, { "db_name": "UniProt", "db_id": "Q62588" } ] }, { "id": "DS.d171.s0.e1", "type": "compound", "text": [ "estradiol" ], "offsets": [ [ 134, 143 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5757" } ] }, { "id": "DS.d171.s1.e0", "type": "protein", "text": [ "SHBG" ], "offsets": [ [ 188, 192 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04278" }, { "db_name": "UniProt", "db_id": "P08689" }, { "db_name": "UniProt", "db_id": "P15196" }, { "db_name": "UniProt", "db_id": "P97497" }, { "db_name": "UniProt", "db_id": "Q62588" } ] }, { "id": "DS.d171.s1.e1", "type": "compound", "text": [ "estradiol" ], "offsets": [ [ 249, 258 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5757" } ] } ]
[]
[]
[ { "id": "DS.d171.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d171.s0.e1", "arg2_id": "DS.d171.s0.e0", "normalized": [] }, { "id": "DS.d171.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d171.s1.e1", "arg2_id": "DS.d171.s1.e0", "normalized": [] } ]
DS.d172
18437699
[ { "id": "DS.d172.s0", "type": "", "text": [ "Our results suggest that Ni(II)-induced changes in cytokine secretion by monocytes are diverse and may be influenced by Nrf2 but are not likely influenced by changes in whole-cell Trx1 levels." ], "offsets": [ [ 0, 192 ] ] } ]
[ { "id": "DS.d172.s0.e0", "type": "compound", "text": [ "Ni(II" ], "offsets": [ [ 25, 30 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "934" } ] }, { "id": "DS.d172.s0.e1", "type": "protein", "text": [ "Nrf2" ], "offsets": [ [ 120, 124 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54968" }, { "db_name": "UniProt", "db_id": "Q60795" } ] }, { "id": "DS.d172.s0.e2", "type": "protein", "text": [ "Trx1" ], "offsets": [ [ 180, 184 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O14463" }, { "db_name": "UniProt", "db_id": "P29445" }, { "db_name": "UniProt", "db_id": "Q8KEA4" } ] } ]
[]
[]
[ { "id": "DS.d172.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d172.s0.e0", "arg2_id": "DS.d172.s0.e2", "normalized": [] }, { "id": "DS.d172.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d172.s0.e0", "arg2_id": "DS.d172.s0.e1", "normalized": [] } ]
DS.d173
18439591
[ { "id": "DS.d173.s0", "type": "", "text": [ "To test the hypothesis that increasing DHEAS levels is associated with improved insulin resistance in patients with polycystic ovary syndrome (PCOS)." ], "offsets": [ [ 0, 149 ] ] } ]
[ { "id": "DS.d173.s0.e0", "type": "compound", "text": [ "DHEAS" ], "offsets": [ [ 39, 44 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "12594" } ] }, { "id": "DS.d173.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 80, 87 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]
[]
[]
[ { "id": "DS.d173.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d173.s0.e0", "arg2_id": "DS.d173.s0.e1", "normalized": [] } ]
DS.d174
18440842
[ { "id": "DS.d174.s0", "type": "", "text": [ "Packed cell volume, total protein, creatinine, blood urea nitrogen, and sorbitol dehydrogenase concentrations decreased while foals were on PN, while serum chloride concentration increased." ], "offsets": [ [ 0, 189 ] ] } ]
[ { "id": "DS.d174.s0.e0", "type": "compound", "text": [ "creatinine" ], "offsets": [ [ 35, 45 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "588" } ] }, { "id": "DS.d174.s0.e1", "type": "compound", "text": [ "urea" ], "offsets": [ [ 53, 57 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1176" }, { "db_name": "PubChem", "db_id": "265993" } ] }, { "id": "DS.d174.s0.e2", "type": "compound", "text": [ "nitrogen" ], "offsets": [ [ 58, 66 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "947" }, { "db_name": "PubChem", "db_id": "123329" } ] }, { "id": "DS.d174.s0.e3", "type": "protein", "text": [ "sorbitol dehydrogenase" ], "offsets": [ [ 72, 94 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07846" }, { "db_name": "UniProt", "db_id": "P27867" }, { "db_name": "UniProt", "db_id": "Q00796" }, { "db_name": "UniProt", "db_id": "Q02912" }, { "db_name": "UniProt", "db_id": "Q06004" }, { "db_name": "UniProt", "db_id": "Q29318" }, { "db_name": "UniProt", "db_id": "Q4R639" }, { "db_name": "UniProt", "db_id": "Q58D31" }, { "db_name": "UniProt", "db_id": "Q59787" }, { "db_name": "UniProt", "db_id": "Q64442" }, { "db_name": "UniProt", "db_id": "Q9Z9U1" } ] }, { "id": "DS.d174.s0.e4", "type": "compound", "text": [ "chloride" ], "offsets": [ [ 156, 164 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "312" } ] } ]
[]
[]
[]
DS.d175
18442069
[ { "id": "DS.d175.s0", "type": "", "text": [ "The gene expressions of CYP1A1 and CYP2E1 in the placenta increased significantly in nicotine-treated groups on GD 15 and GD 18, but returned to the level similar to the corresponding control on GD 21." ], "offsets": [ [ 0, 201 ] ] }, { "id": "DS.d175.s1", "type": "", "text": [ "In nicotine group, there was a decrease of mdr1a expression on GD 15, GD 18, and GD 21, with the most significant decrease on GD 15." ], "offsets": [ [ 202, 334 ] ] } ]
[ { "id": "DS.d175.s0.e0", "type": "protein", "text": [ "CYP1A1" ], "offsets": [ [ 24, 30 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42231" }, { "db_name": "UniProt", "db_id": "O42430" }, { "db_name": "UniProt", "db_id": "O42457" }, { "db_name": "UniProt", "db_id": "P00185" }, { "db_name": "UniProt", "db_id": "P04798" }, { "db_name": "UniProt", "db_id": "P05176" }, { "db_name": "UniProt", "db_id": "P33616" }, { "db_name": "UniProt", "db_id": "P56590" }, { "db_name": "UniProt", "db_id": "P56591" }, { "db_name": "UniProt", "db_id": "P79716" }, { "db_name": "UniProt", "db_id": "P98181" }, { "db_name": "UniProt", "db_id": "Q00557" }, { "db_name": "UniProt", "db_id": "Q06367" }, { "db_name": "UniProt", "db_id": "Q3LFU0" }, { "db_name": "UniProt", "db_id": "Q5KQT7" }, { "db_name": "UniProt", "db_id": "Q6GUR1" }, { "db_name": "UniProt", "db_id": "Q6JZS3" }, { "db_name": "UniProt", "db_id": "Q92039" }, { "db_name": "UniProt", "db_id": "Q92095" }, { "db_name": "UniProt", "db_id": "Q92100" }, { "db_name": "UniProt", "db_id": "Q92109" }, { "db_name": "UniProt", "db_id": "Q92110" }, { "db_name": "UniProt", "db_id": "Q92116" }, { "db_name": "UniProt", "db_id": "Q92148" }, { "db_name": "UniProt", "db_id": "Q9W683" }, { "db_name": "UniProt", "db_id": "Q9YH64" } ] }, { "id": "DS.d175.s0.e1", "type": "protein", "text": [ "CYP2E1" ], "offsets": [ [ 35, 41 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18963" }, { "db_name": "UniProt", "db_id": "P05181" }, { "db_name": "UniProt", "db_id": "P08682" }, { "db_name": "UniProt", "db_id": "P33266" }, { "db_name": "UniProt", "db_id": "P51581" }, { "db_name": "UniProt", "db_id": "P79383" }, { "db_name": "UniProt", "db_id": "Q6GUQ4" } ] }, { "id": "DS.d175.s0.e2", "type": "compound", "text": [ "nicotine" ], "offsets": [ [ 85, 93 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "942" }, { "db_name": "PubChem", "db_id": "89594" }, { "db_name": "PubChem", "db_id": "157672" } ] }, { "id": "DS.d175.s1.e0", "type": "compound", "text": [ "nicotine" ], "offsets": [ [ 205, 213 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "942" }, { "db_name": "PubChem", "db_id": "89594" }, { "db_name": "PubChem", "db_id": "157672" } ] }, { "id": "DS.d175.s1.e1", "type": "protein", "text": [ "mdr1a" ], "offsets": [ [ 245, 250 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21447" } ] } ]
[]
[]
[ { "id": "DS.d175.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d175.s0.e2", "arg2_id": "DS.d175.s0.e1", "normalized": [] }, { "id": "DS.d175.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d175.s0.e2", "arg2_id": "DS.d175.s0.e0", "normalized": [] }, { "id": "DS.d175.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d175.s1.e0", "arg2_id": "DS.d175.s1.e1", "normalized": [] } ]
DS.d176
18442070
[ { "id": "DS.d176.s0", "type": "", "text": [ "The present study was designed to understand the effects of sublethal concentrations of dichlorvos (DIC) on hematological constituent (red blood corpuscles, white blood corpuscles (WBC), mean cell volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, platelet counts, hemoglobin and hematocrite levels) and serum damage marker enzymes (aspartate aminotransferase, alanin aminotransferase, alkaline phosphatase, and lactate dehydrogenase) in rats at subacute period under laboratory conditions." ], "offsets": [ [ 0, 519 ] ] } ]
[ { "id": "DS.d176.s0.e0", "type": "compound", "text": [ "dichlorvos" ], "offsets": [ [ 88, 98 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3039" } ] }, { "id": "DS.d176.s0.e1", "type": "protein", "text": [ "hemoglobin" ], "offsets": [ [ 222, 232 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15160" }, { "db_name": "UniProt", "db_id": "P17724" }, { "db_name": "UniProt", "db_id": "P73925" }, { "db_name": "UniProt", "db_id": "Q03459" } ] }, { "id": "DS.d176.s0.e2", "type": "protein", "text": [ "hemoglobin" ], "offsets": [ [ 251, 261 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15160" }, { "db_name": "UniProt", "db_id": "P17724" }, { "db_name": "UniProt", "db_id": "P73925" }, { "db_name": "UniProt", "db_id": "Q03459" } ] }, { "id": "DS.d176.s0.e3", "type": "protein", "text": [ "hemoglobin" ], "offsets": [ [ 251, 261 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15160" }, { "db_name": "UniProt", "db_id": "P17724" }, { "db_name": "UniProt", "db_id": "P73925" }, { "db_name": "UniProt", "db_id": "Q03459" } ] }, { "id": "DS.d176.s0.e4", "type": "protein", "text": [ "aspartate aminotransferase" ], "offsets": [ [ 362, 388 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O33822" }, { "db_name": "UniProt", "db_id": "O58489" }, { "db_name": "UniProt", "db_id": "O67781" }, { "db_name": "UniProt", "db_id": "O86459" }, { "db_name": "UniProt", "db_id": "O93744" }, { "db_name": "UniProt", "db_id": "P00509" }, { "db_name": "UniProt", "db_id": "P14909" }, { "db_name": "UniProt", "db_id": "P23034" }, { "db_name": "UniProt", "db_id": "P44425" }, { "db_name": "UniProt", "db_id": "P53001" }, { "db_name": "UniProt", "db_id": "P58661" }, { "db_name": "UniProt", "db_id": "P72173" }, { "db_name": "UniProt", "db_id": "Q4J8X2" }, { "db_name": "UniProt", "db_id": "Q55128" }, { "db_name": "UniProt", "db_id": "Q56114" }, { "db_name": "UniProt", "db_id": "Q56232" }, { "db_name": "UniProt", "db_id": "Q59228" }, { "db_name": "UniProt", "db_id": "Q60013" }, { "db_name": "UniProt", "db_id": "Q92JE7" }, { "db_name": "UniProt", "db_id": "Q972A2" }, { "db_name": "UniProt", "db_id": "Q9V0L2" }, { "db_name": "UniProt", "db_id": "Q9X0Y2" }, { "db_name": "UniProt", "db_id": "Q9ZE56" } ] }, { "id": "DS.d176.s0.e5", "type": "protein", "text": [ "alkaline phosphatase" ], "offsets": [ [ 415, 435 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60109" }, { "db_name": "UniProt", "db_id": "P81800" }, { "db_name": "UniProt", "db_id": "P83456" } ] } ]
[]
[]
[]
DS.d177
18442075
[ { "id": "DS.d177.s0", "type": "", "text": [ "Melatonin altered PHZ-induced responses significantly to a greater degree than vitamin E as evidenced by LPO status, SOD activity, and ABTS radical cation scavenging activity of antioxidants." ], "offsets": [ [ 0, 191 ] ] } ]
[ { "id": "DS.d177.s0.e0", "type": "compound", "text": [ "Melatonin" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "896" } ] }, { "id": "DS.d177.s0.e1", "type": "compound", "text": [ "PHZ" ], "offsets": [ [ 18, 21 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7516" } ] }, { "id": "DS.d177.s0.e2", "type": "compound", "text": [ "vitamin E" ], "offsets": [ [ 79, 88 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2116" }, { "db_name": "PubChem", "db_id": "14985" }, { "db_name": "PubChem", "db_id": "1548900" }, { "db_name": "PubChem", "db_id": "1742129" } ] }, { "id": "DS.d177.s0.e3", "type": "protein", "text": [ "LPO" ], "offsets": [ [ 105, 108 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P22079" }, { "db_name": "UniProt", "db_id": "P80025" } ] }, { "id": "DS.d177.s0.e4", "type": "protein", "text": [ "SOD" ], "offsets": [ [ 117, 120 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12933" }, { "db_name": "UniProt", "db_id": "O22668" }, { "db_name": "UniProt", "db_id": "O75007" }, { "db_name": "UniProt", "db_id": "P24705" }, { "db_name": "UniProt", "db_id": "P51547" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q01137" }, { "db_name": "UniProt", "db_id": "Q27666" }, { "db_name": "UniProt", "db_id": "Q9SM64" } ] }, { "id": "DS.d177.s0.e5", "type": "compound", "text": [ "ABTS radical cation" ], "offsets": [ [ 135, 154 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5464076" } ] } ]
[]
[]
[ { "id": "DS.d177.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d177.s0.e0", "arg2_id": "DS.d177.s0.e4", "normalized": [] }, { "id": "DS.d177.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d177.s0.e0", "arg2_id": "DS.d177.s0.e3", "normalized": [] } ]
DS.d178
18443829
[ { "id": "DS.d178.s0", "type": "", "text": [ "The hydrolysis reaction of p-nitrophenyl butyrate catalyzed by lipases was followed with in situ UV/vis diode array spectrophotometry." ], "offsets": [ [ 0, 134 ] ] }, { "id": "DS.d178.s1", "type": "", "text": [ "Five enzymes-Candida antarctica lipase B and Fusarium solani pisi cutinase wild-type and three single-mutation variants-were tested as catalysts in homogeneous conditions and immobilized on zeolite NaY, on a polyacrylate support and as cross-linked aggregates." ], "offsets": [ [ 135, 395 ] ] } ]
[ { "id": "DS.d178.s0.e0", "type": "compound", "text": [ "p-nitrophenyl butyrate" ], "offsets": [ [ 27, 49 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "75834" } ] }, { "id": "DS.d178.s0.e1", "type": "protein", "text": [ "lipases" ], "offsets": [ [ 63, 70 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q7M4U7" } ] }, { "id": "DS.d178.s1.e0", "type": "protein", "text": [ "lipase" ], "offsets": [ [ 167, 173 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q7M4U7" } ] }, { "id": "DS.d178.s1.e1", "type": "compound", "text": [ "NaY" ], "offsets": [ [ 333, 336 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445523" } ] }, { "id": "DS.d178.s1.e2", "type": "compound", "text": [ "polyacrylate" ], "offsets": [ [ 343, 355 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6581" } ] } ]
[]
[]
[ { "id": "DS.d178.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d178.s0.e0", "arg2_id": "DS.d178.s0.e1", "normalized": [] } ]
DS.d179
18443843
[ { "id": "DS.d179.s0", "type": "", "text": [ "At term, the impact of their coexposure was assessed by evaluating lipid peroxidation (LPO), activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), different ATPases and acetylcholinesterase (AChE) in erythrocytes, serum glucose, and levels of glutathione (GSH) and glycosylated hemoglobin (GHb) in blood." ], "offsets": [ [ 0, 365 ] ] }, { "id": "DS.d179.s1", "type": "", "text": [ "Catalase was decreased with endosulfan and the coexposure, but not with arsenic, whereas GSH was decreased with arsenic and endosulfan, but not with the coexposure." ], "offsets": [ [ 366, 530 ] ] }, { "id": "DS.d179.s2", "type": "", "text": [ "Na+-K+-ATPase activity was decreased in the endosulfan-treated and the coexposed birds." ], "offsets": [ [ 531, 618 ] ] } ]
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"normalized": [ { "db_name": "UniProt", "db_id": "O24339" }, { "db_name": "UniProt", "db_id": "O52762" }, { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O68146" }, { "db_name": "UniProt", "db_id": "O77229" }, { "db_name": "UniProt", "db_id": "O93662" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P04762" }, { "db_name": "UniProt", "db_id": "P07145" }, { "db_name": "UniProt", "db_id": "P0A323" }, { "db_name": "UniProt", "db_id": "P0A324" }, { "db_name": "UniProt", "db_id": "P0A325" }, { "db_name": "UniProt", "db_id": "P0A326" }, { "db_name": "UniProt", "db_id": "P0A327" }, { "db_name": "UniProt", "db_id": "P11934" }, { "db_name": "UniProt", "db_id": "P17336" }, { "db_name": "UniProt", "db_id": "P24168" }, { "db_name": "UniProt", "db_id": "P24270" }, { "db_name": "UniProt", "db_id": "P25890" }, { "db_name": "UniProt", "db_id": 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}, { "db_name": "UniProt", "db_id": "Q5HG86" }, { "db_name": "UniProt", "db_id": "Q5HPK8" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q6G9M4" }, { "db_name": "UniProt", "db_id": "Q6GH72" }, { "db_name": "UniProt", "db_id": "Q7A5T2" }, { "db_name": "UniProt", "db_id": "Q8CPD0" }, { "db_name": "UniProt", "db_id": "Q8FWU0" }, { "db_name": "UniProt", "db_id": "Q8NWV5" }, { "db_name": "UniProt", "db_id": "Q8X1P0" }, { "db_name": "UniProt", "db_id": "Q8Y3P9" }, { "db_name": "UniProt", "db_id": "Q926X0" }, { "db_name": "UniProt", "db_id": "Q99UE2" }, { "db_name": "UniProt", "db_id": "Q9AXH0" }, { "db_name": "UniProt", "db_id": "Q9KW19" }, { "db_name": "UniProt", "db_id": "Q9L4S1" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PT92" }, { "db_name": "UniProt", "db_id": "Q9PWF7" }, { "db_name": "UniProt", "db_id": "Q9Z598" }, { "db_name": "UniProt", "db_id": "Q9ZKX5" }, { "db_name": "UniProt", "db_id": "Q9ZN99" } ] }, { "id": "DS.d179.s0.e4", "type": "protein", "text": [ "glutathione peroxidase" ], "offsets": [ [ 145, 167 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O32770" }, { "db_name": "UniProt", "db_id": "O59858" }, { "db_name": "UniProt", "db_id": "Q00277" }, { "db_name": "UniProt", "db_id": "Q9CFV1" } ] }, { "id": "DS.d179.s0.e5", "type": "protein", "text": [ "glutathione-S-transferase" ], "offsets": [ [ 175, 200 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O04437" }, { "db_name": "UniProt", "db_id": "O18598" }, { "db_name": "UniProt", "db_id": "P0A9D2" }, { "db_name": "UniProt", "db_id": "P0A9D3" }, { "db_name": "UniProt", "db_id": "P30116" }, { "db_name": "UniProt", "db_id": "P44521" }, { "db_name": "UniProt", "db_id": "P46088" }, { "db_name": "UniProt", "db_id": "P46419" }, { "db_name": "UniProt", "db_id": "P46423" }, { "db_name": "UniProt", "db_id": "P46426" }, { "db_name": "UniProt", "db_id": "P46428" }, { "db_name": "UniProt", "db_id": "P46437" }, { "db_name": "UniProt", "db_id": "P48438" }, { "db_name": "UniProt", "db_id": "P80894" }, { "db_name": "UniProt", "db_id": "P81065" }, { "db_name": "UniProt", "db_id": "P82996" }, { "db_name": "UniProt", "db_id": "P82997" }, { "db_name": "UniProt", "db_id": "P82998" }, { "db_name": "UniProt", "db_id": "P82999" }, { "db_name": "UniProt", "db_id": "P83000" }, { "db_name": "UniProt", "db_id": "P83001" }, { "db_name": "UniProt", "db_id": "P83246" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q08392" }, { "db_name": "UniProt", "db_id": "Q08393" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" }, { "db_name": "UniProt", "db_id": "Q96324" } ] }, { "id": "DS.d179.s0.e6", "type": "protein", "text": [ "GST" ], "offsets": [ [ 202, 205 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20432" }, { "db_name": "UniProt", "db_id": "P30104" }, { "db_name": "UniProt", "db_id": "P30106" }, { "db_name": "UniProt", "db_id": "P30107" }, { "db_name": "UniProt", "db_id": "P30108" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" } ] }, { "id": "DS.d179.s0.e7", "type": "protein", "text": [ "acetylcholinesterase" ], "offsets": [ [ 230, 250 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92081" } ] }, { "id": "DS.d179.s0.e8", "type": "protein", "text": [ "AChE" ], "offsets": [ [ 252, 256 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42275" }, { "db_name": "UniProt", "db_id": "O62763" }, { "db_name": "UniProt", "db_id": "P04058" }, { "db_name": "UniProt", "db_id": "P07140" }, { "db_name": "UniProt", "db_id": "P07692" }, { "db_name": "UniProt", "db_id": "P21836" }, { "db_name": "UniProt", "db_id": "P22303" }, { "db_name": "UniProt", "db_id": "P23795" }, { "db_name": "UniProt", "db_id": "P36196" }, { "db_name": "UniProt", "db_id": "P37136" }, { "db_name": "UniProt", "db_id": "P56161" }, { "db_name": "UniProt", "db_id": "Q27677" }, { "db_name": "UniProt", "db_id": "Q29499" }, { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q869C3" }, { "db_name": "UniProt", "db_id": "Q86GC8" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92035" }, { "db_name": "UniProt", "db_id": "Q92081" }, { "db_name": "UniProt", "db_id": "Q9DDE3" } ] }, { "id": "DS.d179.s0.e9", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 281, 288 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d179.s0.e10", "type": "compound", "text": [ "glutathione" ], "offsets": [ [ 145, 156 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d179.s0.e11", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 317, 320 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d179.s0.e12", "type": "protein", "text": [ "hemoglobin" ], "offsets": [ [ 339, 349 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15160" }, { "db_name": "UniProt", "db_id": "P17724" }, { "db_name": "UniProt", "db_id": "P73925" }, { "db_name": "UniProt", "db_id": "Q03459" } ] }, { "id": "DS.d179.s1.e0", "type": "protein", "text": [ "Catalase" ], "offsets": [ [ 366, 374 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24339" }, { "db_name": "UniProt", "db_id": "O52762" }, { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O68146" }, { "db_name": "UniProt", "db_id": "O77229" }, { "db_name": "UniProt", "db_id": "O93662" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P04762" }, { "db_name": "UniProt", "db_id": "P07145" }, { "db_name": "UniProt", "db_id": "P0A323" }, { "db_name": "UniProt", "db_id": "P0A324" }, { "db_name": "UniProt", "db_id": "P0A325" }, { "db_name": "UniProt", "db_id": "P0A326" }, { "db_name": "UniProt", "db_id": "P0A327" }, { "db_name": "UniProt", "db_id": "P11934" }, { "db_name": "UniProt", "db_id": "P17336" }, { "db_name": "UniProt", "db_id": "P24168" }, { "db_name": "UniProt", "db_id": "P24270" }, { "db_name": "UniProt", "db_id": "P25890" }, { "db_name": "UniProt", "db_id": "P29422" }, { "db_name": "UniProt", "db_id": "P30265" }, { "db_name": "UniProt", "db_id": "P30266" }, { "db_name": "UniProt", "db_id": "P32290" }, { "db_name": "UniProt", "db_id": "P42321" }, { "db_name": "UniProt", "db_id": "P44390" }, { "db_name": "UniProt", "db_id": "P45737" }, { "db_name": "UniProt", "db_id": "P45739" }, { "db_name": "UniProt", "db_id": "P55304" }, { "db_name": "UniProt", "db_id": "P55306" }, { "db_name": "UniProt", "db_id": "P55310" }, { "db_name": "UniProt", "db_id": "P55311" }, { "db_name": "UniProt", "db_id": "P55313" }, { "db_name": "UniProt", "db_id": "P77872" }, { "db_name": "UniProt", "db_id": "P81138" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q27710" }, { "db_name": "UniProt", "db_id": "Q49XC1" }, { "db_name": "UniProt", "db_id": "Q4L643" }, { "db_name": "UniProt", "db_id": "Q59296" }, { "db_name": "UniProt", "db_id": "Q59337" }, { "db_name": "UniProt", "db_id": "Q59602" }, { "db_name": "UniProt", "db_id": "Q59714" }, { "db_name": "UniProt", "db_id": "Q5HG86" }, { "db_name": "UniProt", "db_id": "Q5HPK8" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q6G9M4" }, { "db_name": "UniProt", "db_id": "Q6GH72" }, { "db_name": "UniProt", "db_id": "Q7A5T2" }, { "db_name": "UniProt", "db_id": "Q8CPD0" }, { "db_name": "UniProt", "db_id": "Q8FWU0" }, { "db_name": "UniProt", "db_id": "Q8NWV5" }, { "db_name": "UniProt", "db_id": "Q8X1P0" }, { "db_name": "UniProt", "db_id": "Q8Y3P9" }, { "db_name": "UniProt", "db_id": "Q926X0" }, { "db_name": "UniProt", "db_id": "Q99UE2" }, { "db_name": "UniProt", "db_id": "Q9AXH0" }, { "db_name": "UniProt", "db_id": "Q9KW19" }, { "db_name": "UniProt", "db_id": "Q9L4S1" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PT92" }, { "db_name": "UniProt", "db_id": "Q9PWF7" }, { "db_name": "UniProt", "db_id": "Q9Z598" }, { "db_name": "UniProt", "db_id": "Q9ZKX5" }, { "db_name": "UniProt", "db_id": "Q9ZN99" } ] }, { "id": "DS.d179.s1.e1", "type": "compound", "text": [ "endosulfan" ], "offsets": [ [ 394, 404 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3224" } ] }, { "id": "DS.d179.s1.e2", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 455, 458 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d179.s1.e3", "type": "compound", "text": [ "endosulfan" ], "offsets": [ [ 490, 500 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3224" } ] }, { "id": "DS.d179.s2.e0", "type": "protein", "text": [ "Na+-K+-ATPase" ], "offsets": [ [ 531, 544 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13607" }, { "db_name": "UniProt", "db_id": "P17326" }, { "db_name": "UniProt", "db_id": "P28774" }, { "db_name": "UniProt", "db_id": "P35317" } ] }, { "id": "DS.d179.s2.e1", "type": "compound", "text": [ "endosulfan" ], "offsets": [ [ 575, 585 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3224" } ] } ]
[]
[]
[ { "id": "DS.d179.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d179.s1.e1", "arg2_id": "DS.d179.s1.e0", "normalized": [] }, { "id": "DS.d179.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d179.s2.e1", "arg2_id": "DS.d179.s2.e0", "normalized": [] } ]
DS.d180
18443897
[ { "id": "DS.d180.s0", "type": "", "text": [ "mRNA and protein levels of TNF-alpha, Fas, and caspase-8, which are closely related to cell apoptosis by a death ligand/receptor-dependent apoptosis pathway, were increased by L-carnitine treatment." ], "offsets": [ [ 0, 198 ] ] }, { "id": "DS.d180.s1", "type": "", "text": [ "In addition, L-carnitine treatment regulated mitochondria-dependent apoptosis pathways by inducing the up-regulation of caspase-9 and caspase-3 and the down-regulation of Bcl-2 in hepa1c1c 7 cells." ], "offsets": [ [ 199, 396 ] ] }, { "id": "DS.d180.s2", "type": "", "text": [ "Taken together, the findings of this study have demonstrated that L-carnitine could induce apoptosis in hepa1c1c7 cells by regulating Fas ligands and inhibiting the expression of Bcl-2." ], "offsets": [ [ 397, 582 ] ] } ]
[ { "id": "DS.d180.s0.e0", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 27, 36 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d180.s0.e1", "type": "protein", "text": [ "Fas" ], "offsets": [ [ 38, 41 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25446" }, { "db_name": "UniProt", "db_id": "Q63199" } ] }, { "id": "DS.d180.s0.e2", "type": "compound", "text": [ "L-carnitine" ], "offsets": [ [ 176, 187 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10918" } ] }, { "id": "DS.d180.s1.e0", "type": "compound", "text": [ "L-carnitine" ], "offsets": [ [ 212, 223 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10918" } ] }, { "id": "DS.d180.s1.e1", "type": "protein", "text": [ "Bcl-2" ], "offsets": [ [ 370, 375 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10417" }, { "db_name": "UniProt", "db_id": "P49950" } ] }, { "id": "DS.d180.s2.e0", "type": "compound", "text": [ "L-carnitine" ], "offsets": [ [ 463, 474 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10918" } ] }, { "id": "DS.d180.s2.e1", "type": "protein", "text": [ "Fas ligands" ], "offsets": [ [ 531, 542 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P36940" }, { "db_name": "UniProt", "db_id": "P41047" }, { "db_name": "UniProt", "db_id": "P48023" }, { "db_name": "UniProt", "db_id": "P63306" }, { "db_name": "UniProt", "db_id": "P63307" }, { "db_name": "UniProt", "db_id": "P63308" }, { "db_name": "UniProt", "db_id": "Q861W5" }, { "db_name": "UniProt", "db_id": "Q9BDN1" }, { "db_name": "UniProt", "db_id": "Q9BEA8" } ] }, { "id": "DS.d180.s2.e2", "type": "protein", "text": [ "Bcl-2" ], "offsets": [ [ 576, 581 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10417" }, { "db_name": "UniProt", "db_id": "P49950" } ] } ]
[]
[]
[ { "id": "DS.d180.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d180.s0.e2", "arg2_id": "DS.d180.s0.e0", "normalized": [] }, { "id": "DS.d180.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d180.s0.e2", "arg2_id": "DS.d180.s0.e1", "normalized": [] }, { "id": "DS.d180.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d180.s1.e0", "arg2_id": "DS.d180.s1.e1", "normalized": [] }, { "id": "DS.d180.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d180.s2.e0", "arg2_id": "DS.d180.s2.e1", "normalized": [] }, { "id": "DS.d180.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d180.s2.e0", "arg2_id": "DS.d180.s2.e2", "normalized": [] } ]
DS.d181
18445079
[ { "id": "DS.d181.s0", "type": "", "text": [ "Merlin is known to bind paxillin, beta1 integrin and focal adhesion kinase, members of focal contacts, multi-protein complexes that mediate cell adhesion to the extracellular matrix." ], "offsets": [ [ 0, 182 ] ] } ]
[ { "id": "DS.d181.s0.e0", "type": "compound", "text": [ "Merlin" ], "offsets": [ [ 0, 6 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "84098" } ] }, { "id": "DS.d181.s0.e1", "type": "protein", "text": [ "paxillin" ], "offsets": [ [ 24, 32 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P49023" }, { "db_name": "UniProt", "db_id": "P49024" }, { "db_name": "UniProt", "db_id": "Q5R7I1" }, { "db_name": "UniProt", "db_id": "Q66H76" }, { "db_name": "UniProt", "db_id": "Q8VI36" } ] } ]
[]
[]
[ { "id": "DS.d181.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d181.s0.e0", "arg2_id": "DS.d181.s0.e1", "normalized": [] } ]
DS.d182
18445307
[ { "id": "DS.d182.s0", "type": "", "text": [ "Furthermore, free radical overproduction and oxidative stress were associated with a significant decrease in hepatic glutathione levels in septic mice, and with an excessive NO production attributed to the induction of the inducible isoform of NO synthase (iNOS)." ], "offsets": [ [ 0, 263 ] ] }, { "id": "DS.d182.s1", "type": "", "text": [ "In fact, hepatic glutathione levels were significantly increased in the group of mice receiving the probiotic, and the increased iNOS expression both in the colon and lungs was down-regulated in those mice treated with L. fermentum." ], "offsets": [ [ 264, 496 ] ] } ]
[ { "id": "DS.d182.s0.e0", "type": "compound", "text": [ "glutathione" ], "offsets": [ [ 117, 128 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d182.s0.e1", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 257, 261 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] }, { "id": "DS.d182.s1.e0", "type": "compound", "text": [ "glutathione" ], "offsets": [ [ 281, 292 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d182.s1.e1", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 393, 397 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] } ]
[]
[]
[ { "id": "DS.d182.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d182.s1.e0", "arg2_id": "DS.d182.s1.e1", "normalized": [] } ]
DS.d183
18448193
[ { "id": "DS.d183.s0", "type": "", "text": [ "Furthermore, supplementation of specific inhibitors of PAL, C4H and 4CL in elicited cell cultures led to suppressed accumulation of p-hydroxybenzoic acid, which opens up interesting questions regarding the probable route of the biosynthesis of this phenolic acid in C. nucifera." ], "offsets": [ [ 0, 278 ] ] } ]
[ { "id": "DS.d183.s0.e0", "type": "protein", "text": [ "PAL" ], "offsets": [ [ 55, 58 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O03979" }, { "db_name": "UniProt", "db_id": "O04058" }, { "db_name": "UniProt", "db_id": "O93967" }, { "db_name": "UniProt", "db_id": "P10248" }, { "db_name": "UniProt", "db_id": "P10731" }, { "db_name": "UniProt", "db_id": "P11544" }, { "db_name": "UniProt", "db_id": "P14166" }, { "db_name": "UniProt", "db_id": "P14717" }, { "db_name": "UniProt", "db_id": "P14925" }, { "db_name": "UniProt", "db_id": "P19021" }, { "db_name": "UniProt", "db_id": "P26600" }, { "db_name": "UniProt", "db_id": "P35511" }, { "db_name": "UniProt", "db_id": "P35512" }, { "db_name": "UniProt", "db_id": "P45726" }, { "db_name": "UniProt", "db_id": "P45727" }, { "db_name": "UniProt", "db_id": "P45730" }, { "db_name": "UniProt", "db_id": "P45731" }, { "db_name": "UniProt", "db_id": "P45735" }, { "db_name": "UniProt", "db_id": "P52777" }, { "db_name": "UniProt", "db_id": "P83388" }, { "db_name": "UniProt", "db_id": "P91268" }, { "db_name": "UniProt", "db_id": "P97467" }, { "db_name": "UniProt", "db_id": "Q42609" }, { "db_name": "UniProt", "db_id": "Q43210" }, { "db_name": "UniProt", "db_id": "Q9P2V4" }, { "db_name": "UniProt", "db_id": "Q9PSN0" } ] }, { "id": "DS.d183.s0.e1", "type": "protein", "text": [ "C4H" ], "offsets": [ [ 60, 63 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24312" }, { "db_name": "UniProt", "db_id": "O81928" }, { "db_name": "UniProt", "db_id": "P37114" }, { "db_name": "UniProt", "db_id": "P37115" }, { "db_name": "UniProt", "db_id": "P48522" }, { "db_name": "UniProt", "db_id": "P92994" }, { "db_name": "UniProt", "db_id": "Q04468" }, { "db_name": "UniProt", "db_id": "Q42797" }, { "db_name": "UniProt", "db_id": "Q43033" }, { "db_name": "UniProt", "db_id": "Q43054" }, { "db_name": "UniProt", "db_id": "Q43067" }, { "db_name": "UniProt", "db_id": "Q43240" }, { "db_name": "UniProt", "db_id": "Q96423" }, { "db_name": "UniProt", "db_id": "Q9AR74" } ] }, { "id": "DS.d183.s0.e2", "type": "protein", "text": [ "4CL" ], "offsets": [ [ 68, 71 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O11451" }, { "db_name": "UniProt", "db_id": "O11452" }, { "db_name": "UniProt", "db_id": "O11453" }, { "db_name": "UniProt", "db_id": "O24540" }, { "db_name": "UniProt", "db_id": "O54075" }, { "db_name": "UniProt", "db_id": "O69140" }, { "db_name": "UniProt", "db_id": "P17814" }, { "db_name": "UniProt", "db_id": "P41636" }, { "db_name": "UniProt", "db_id": "P42516" }, { "db_name": "UniProt", "db_id": "P68763" }, { "db_name": "UniProt", "db_id": "P68764" }, { "db_name": "UniProt", "db_id": "P68765" }, { "db_name": "UniProt", "db_id": "P69180" }, { "db_name": "UniProt", "db_id": "P69181" }, { "db_name": "UniProt", "db_id": "P69182" }, { "db_name": "UniProt", "db_id": "P69183" }, { "db_name": "UniProt", "db_id": "P69184" } ] }, { "id": "DS.d183.s0.e3", "type": "compound", "text": [ "p-hydroxybenzoic acid" ], "offsets": [ [ 132, 153 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "135" } ] } ]
[]
[]
[ { "id": "DS.d183.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d183.s0.e3", "arg2_id": "DS.d183.s0.e0", "normalized": [] }, { "id": "DS.d183.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d183.s0.e3", "arg2_id": "DS.d183.s0.e2", "normalized": [] }, { "id": "DS.d183.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d183.s0.e3", "arg2_id": "DS.d183.s0.e1", "normalized": [] } ]
DS.d184
18449471
[ { "id": "DS.d184.s0", "type": "", "text": [ "Imatinib is transported by P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP), however, the exact impact of these transporters on absorption, distribution, metabolism and excretion (ADME) of imatinib is not fully understood due to incomplete data." ], "offsets": [ [ 0, 262 ] ] }, { "id": "DS.d184.s1", "type": "", "text": [ "In conclusion, P-gp and BCRP have only a modest effect on the ADME of imatinib in comparison to metabolic elimination." ], "offsets": [ [ 263, 381 ] ] }, { "id": "DS.d184.s2", "type": "", "text": [ "The considerable drug-drug interaction observed with elacridar or pantoprazole is only partly mediated by inhibition of P-gp and BCRP and far more by the inhibition of other elimination pathways." ], "offsets": [ [ 382, 577 ] ] } ]
[ { "id": "DS.d184.s0.e0", "type": "compound", "text": [ "Imatinib" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5291" } ] }, { "id": "DS.d184.s0.e1", "type": "protein", "text": [ "glycoprotein" ], "offsets": [ [ 29, 41 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08163" } ] }, { "id": "DS.d184.s0.e2", "type": "protein", "text": [ "Breast Cancer Resistance Protein" ], "offsets": [ [ 53, 85 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UNQ0" } ] }, { "id": "DS.d184.s0.e3", "type": "protein", "text": [ "BCRP" ], "offsets": [ [ 87, 91 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UNQ0" } ] }, { "id": "DS.d184.s0.e4", "type": "compound", "text": [ "imatinib" ], "offsets": [ [ 206, 214 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5291" } ] }, { "id": "DS.d184.s1.e0", "type": "protein", "text": [ "BCRP" ], "offsets": [ [ 287, 291 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UNQ0" } ] }, { "id": "DS.d184.s1.e1", "type": "compound", "text": [ "imatinib" ], "offsets": [ [ 333, 341 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5291" } ] }, { "id": "DS.d184.s2.e0", "type": "compound", "text": [ "elacridar" ], "offsets": [ [ 435, 444 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "119373" } ] }, { "id": "DS.d184.s2.e1", "type": "compound", "text": [ "pantoprazole" ], "offsets": [ [ 448, 460 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4679" } ] }, { "id": "DS.d184.s2.e2", "type": "protein", "text": [ "BCRP" ], "offsets": [ [ 511, 515 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9UNQ0" } ] } ]
[]
[]
[ { "id": "DS.d184.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d184.s0.e4", "arg2_id": "DS.d184.s0.e3", "normalized": [] }, { "id": "DS.d184.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d184.s0.e4", "arg2_id": "DS.d184.s0.e2", "normalized": [] }, { "id": "DS.d184.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d184.s0.e0", "arg2_id": "DS.d184.s0.e1", "normalized": [] }, { "id": "DS.d184.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d184.s0.e0", "arg2_id": "DS.d184.s0.e3", "normalized": [] }, { "id": "DS.d184.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d184.s0.e0", "arg2_id": "DS.d184.s0.e2", "normalized": [] }, { "id": "DS.d184.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d184.s0.e4", "arg2_id": "DS.d184.s0.e1", "normalized": [] }, { "id": "DS.d184.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d184.s1.e1", "arg2_id": "DS.d184.s1.e0", "normalized": [] }, { "id": "DS.d184.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d184.s2.e1", "arg2_id": "DS.d184.s2.e2", "normalized": [] }, { "id": "DS.d184.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d184.s2.e0", "arg2_id": "DS.d184.s2.e2", "normalized": [] } ]
DS.d185
18449536
[ { "id": "DS.d185.s0", "type": "", "text": [ "There is clear evidence for TREK-1 and TASK-1 in the heart and these channels are likely to regulate cardiac action potential duration through their regulation by stretch, polyunsaturated fatty acids, pH, and neurotransmitters." ], "offsets": [ [ 0, 227 ] ] }, { "id": "DS.d185.s1", "type": "", "text": [ "TREK-1 may also have a critical role in mediating the vasodilator response of resistance arteries to polyunsaturated fatty acids, thus contributing to their protective effect on the cardiovascular system." ], "offsets": [ [ 228, 432 ] ] } ]
[ { "id": "DS.d185.s0.e0", "type": "protein", "text": [ "TREK" ], "offsets": [ [ 28, 32 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O95069" } ] }, { "id": "DS.d185.s0.e1", "type": "protein", "text": [ "TASK" ], "offsets": [ [ 39, 43 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O14649" } ] }, { "id": "DS.d185.s0.e2", "type": "compound", "text": [ "polyunsaturated fatty acids" ], "offsets": [ [ 172, 199 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "56842239" } ] }, { "id": "DS.d185.s1.e0", "type": "protein", "text": [ "TREK" ], "offsets": [ [ 228, 232 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O95069" } ] }, { "id": "DS.d185.s1.e1", "type": "compound", "text": [ "polyunsaturated fatty acids" ], "offsets": [ [ 329, 356 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "56842239" } ] } ]
[]
[]
[ { "id": "DS.d185.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d185.s0.e2", "arg2_id": "DS.d185.s0.e1", "normalized": [] }, { "id": "DS.d185.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d185.s0.e2", "arg2_id": "DS.d185.s0.e0", "normalized": [] }, { "id": "DS.d185.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d185.s1.e1", "arg2_id": "DS.d185.s1.e0", "normalized": [] } ]
DS.d186
18449944
[ { "id": "DS.d186.s0", "type": "", "text": [ "Alumina ceramic particles, in comparison with titanium particles, hardly affect the expression of RANK-, TNF-alpha-, and OPG-mRNA in the THP-1 human monocytic cell line." ], "offsets": [ [ 0, 169 ] ] } ]
[ { "id": "DS.d186.s0.e0", "type": "compound", "text": [ "titanium" ], "offsets": [ [ 46, 54 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23963" } ] }, { "id": "DS.d186.s0.e1", "type": "protein", "text": [ "RANK" ], "offsets": [ [ 98, 102 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9Y6Q6" } ] }, { "id": "DS.d186.s0.e2", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 105, 114 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d186.s0.e3", "type": "protein", "text": [ "OPG" ], "offsets": [ [ 121, 124 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00300" } ] } ]
[]
[]
[]
DS.d187
18450412
[ { "id": "DS.d187.s0", "type": "", "text": [ "Indirubin-3-oxime-induced growth inhibition was associated with induction of Cdk inhibitor p21, inhibition of cyclin D1 and activation of caspase-3." ], "offsets": [ [ 0, 148 ] ] } ]
[ { "id": "DS.d187.s0.e0", "type": "compound", "text": [ "Indirubin-3-oxime" ], "offsets": [ [ 0, 17 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5326739" } ] }, { "id": "DS.d187.s0.e1", "type": "protein", "text": [ "cyclin" ], "offsets": [ [ 110, 116 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O01377" }, { "db_name": "UniProt", "db_id": "O16852" }, { "db_name": "UniProt", "db_id": "P04961" }, { "db_name": "UniProt", "db_id": "P12004" }, { "db_name": "UniProt", "db_id": "P17070" }, { "db_name": "UniProt", "db_id": "P17917" }, { "db_name": "UniProt", "db_id": "P17918" }, { "db_name": "UniProt", "db_id": "P18248" }, { "db_name": "UniProt", "db_id": "P22177" }, { "db_name": "UniProt", "db_id": "P24314" }, { "db_name": "UniProt", "db_id": "P31008" }, { "db_name": "UniProt", "db_id": "P53358" }, { "db_name": "UniProt", "db_id": "P61074" }, { "db_name": "UniProt", "db_id": "Q00265" }, { "db_name": "UniProt", "db_id": "Q00268" } ] } ]
[]
[]
[ { "id": "DS.d187.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d187.s0.e0", "arg2_id": "DS.d187.s0.e1", "normalized": [] } ]
DS.d188
18452177
[ { "id": "DS.d188.s0", "type": "", "text": [ "Three proteins, porcine somatotropin, bovine serum albumin, and immunoglobulin, as well as materials with a strong calorimetric glass transition (T(g)), that is, indomethacin and poly(vinypyrrolidone) (PVP), were studied by both TSC and differential scanning calorimetry (DSC)." ], "offsets": [ [ 0, 277 ] ] } ]
[ { "id": "DS.d188.s0.e0", "type": "protein", "text": [ "somatotropin" ], "offsets": [ [ 24, 36 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10766" }, { "db_name": "UniProt", "db_id": "P20391" }, { "db_name": "UniProt", "db_id": "P20392" }, { "db_name": "UniProt", "db_id": "P33092" }, { "db_name": "UniProt", "db_id": "P34005" }, { "db_name": "UniProt", "db_id": "P34006" }, { "db_name": "UniProt", "db_id": "P34747" }, { "db_name": "UniProt", "db_id": "P37885" }, { "db_name": "UniProt", "db_id": "P55755" } ] }, { "id": "DS.d188.s0.e1", "type": "protein", "text": [ "serum albumin" ], "offsets": [ [ 45, 58 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21847" }, { "db_name": "UniProt", "db_id": "P83517" } ] }, { "id": "DS.d188.s0.e2", "type": "compound", "text": [ "indomethacin" ], "offsets": [ [ 162, 174 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3715" } ] } ]
[]
[]
[]
DS.d189
18454352
[ { "id": "DS.d189.s0", "type": "", "text": [ "The recombinant protein exhibited high PAL activity and could catalyze the conversion of L:-Phe to trans-cinnamic acid." ], "offsets": [ [ 0, 119 ] ] } ]
[ { "id": "DS.d189.s0.e0", "type": "protein", "text": [ "PAL" ], "offsets": [ [ 39, 42 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O03979" }, { "db_name": "UniProt", "db_id": "O04058" }, { "db_name": "UniProt", "db_id": "O93967" }, { "db_name": "UniProt", "db_id": "P10248" }, { "db_name": "UniProt", "db_id": "P10731" }, { "db_name": "UniProt", "db_id": "P11544" }, { "db_name": "UniProt", "db_id": "P14166" }, { "db_name": "UniProt", "db_id": "P14717" }, { "db_name": "UniProt", "db_id": "P14925" }, { "db_name": "UniProt", "db_id": "P19021" }, { "db_name": "UniProt", "db_id": "P26600" }, { "db_name": "UniProt", "db_id": "P35511" }, { "db_name": "UniProt", "db_id": "P35512" }, { "db_name": "UniProt", "db_id": "P45726" }, { "db_name": "UniProt", "db_id": "P45727" }, { "db_name": "UniProt", "db_id": "P45730" }, { "db_name": "UniProt", "db_id": "P45731" }, { "db_name": "UniProt", "db_id": "P45735" }, { "db_name": "UniProt", "db_id": "P52777" }, { "db_name": "UniProt", "db_id": "P83388" }, { "db_name": "UniProt", "db_id": "P91268" }, { "db_name": "UniProt", "db_id": "P97467" }, { "db_name": "UniProt", "db_id": "Q42609" }, { "db_name": "UniProt", "db_id": "Q43210" }, { "db_name": "UniProt", "db_id": "Q9P2V4" }, { "db_name": "UniProt", "db_id": "Q9PSN0" } ] }, { "id": "DS.d189.s0.e1", "type": "compound", "text": [ "trans-cinnamic acid" ], "offsets": [ [ 99, 118 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444539" } ] } ]
[]
[]
[]
DS.d190
18456422
[ { "id": "DS.d190.s0", "type": "", "text": [ "Only the beta-lactamases of pI 5.4 and superior to 7.6 hydrolyze the cefotaxime." ], "offsets": [ [ 0, 80 ] ] } ]
[ { "id": "DS.d190.s0.e0", "type": "protein", "text": [ "beta-lactamases" ], "offsets": [ [ 9, 24 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P80298" }, { "db_name": "UniProt", "db_id": "P80545" }, { "db_name": "UniProt", "db_id": "P81173" } ] }, { "id": "DS.d190.s0.e1", "type": "compound", "text": [ "cefotaxime" ], "offsets": [ [ 69, 79 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5479527" }, { "db_name": "PubChem", "db_id": "5742673" }, { "db_name": "PubChem", "db_id": "6540461" } ] } ]
[]
[]
[ { "id": "DS.d190.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d190.s0.e1", "arg2_id": "DS.d190.s0.e0", "normalized": [] } ]
DS.d191
18457934
[ { "id": "DS.d191.s0", "type": "", "text": [ "To investigate this relationship, we used actively growing young Sprague-Dawley rats and CKD-732, one of the angiogenesis inhibitor (AI) to reveal the relationship of angiogenesis in the effect of PTH." ], "offsets": [ [ 0, 201 ] ] } ]
[ { "id": "DS.d191.s0.e0", "type": "compound", "text": [ "CKD-732" ], "offsets": [ [ 89, 96 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6918502" } ] }, { "id": "DS.d191.s0.e1", "type": "protein", "text": [ "PTH" ], "offsets": [ [ 197, 200 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O27732" }, { "db_name": "UniProt", "db_id": "O28185" }, { "db_name": "UniProt", "db_id": "O66677" }, { "db_name": "UniProt", "db_id": "O74017" }, { "db_name": "UniProt", "db_id": "O74806" }, { "db_name": "UniProt", "db_id": "O83975" }, { "db_name": "UniProt", "db_id": "O84806" }, { "db_name": "UniProt", "db_id": "O85235" }, { "db_name": "UniProt", "db_id": "P01268" }, { "db_name": "UniProt", "db_id": "P01269" }, { "db_name": "UniProt", "db_id": "P01270" }, { "db_name": "UniProt", "db_id": "P04089" }, { "db_name": "UniProt", "db_id": "P0A281" }, { "db_name": "UniProt", "db_id": "P0A282" }, { "db_name": "UniProt", "db_id": "P0A7D1" }, { "db_name": "UniProt", "db_id": "P0A7D2" }, { 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}, { "db_name": "UniProt", "db_id": "Q9X1W1" }, { "db_name": "UniProt", "db_id": "Q9XT35" }, { "db_name": "UniProt", "db_id": "Q9YBD6" }, { "db_name": "UniProt", "db_id": "Q9Z6V6" }, { "db_name": "UniProt", "db_id": "Q9ZCV4" }, { "db_name": "UniProt", "db_id": "Q9ZJC3" } ] } ]
[]
[]
[]
DS.d192
18458677
[ { "id": "DS.d192.s0", "type": "", "text": [ "Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment." ], "offsets": [ [ 0, 158 ] ] } ]
[ { "id": "DS.d192.s0.e0", "type": "protein", "text": [ "interleukin-6" ], "offsets": [ [ 32, 45 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P41693" } ] }, { "id": "DS.d192.s0.e1", "type": "compound", "text": [ "ribavirin" ], "offsets": [ [ 138, 147 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "37542" } ] } ]
[]
[]
[ { "id": "DS.d192.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d192.s0.e1", "arg2_id": "DS.d192.s0.e0", "normalized": [] } ]
DS.d193
18458952
[ { "id": "DS.d193.s0", "type": "", "text": [ "An alpha-numeric code for representing N-linked glycan structures in secreted glycoproteins." ], "offsets": [ [ 0, 92 ] ] }, { "id": "DS.d193.s1", "type": "", "text": [ "Towards this end, we propose a fixed-length alpha-numeric code for representing N-linked glycan structures commonly found in secreted glycoproteins from mammalian cell cultures." ], "offsets": [ [ 93, 270 ] ] } ]
[ { "id": "DS.d193.s0.e0", "type": "compound", "text": [ "glycan" ], "offsets": [ [ 48, 54 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "871" } ] }, { "id": "DS.d193.s0.e1", "type": "protein", "text": [ "glycoproteins" ], "offsets": [ [ 78, 91 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08163" } ] }, { "id": "DS.d193.s1.e0", "type": "compound", "text": [ "glycan" ], "offsets": [ [ 182, 188 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "871" } ] }, { "id": "DS.d193.s1.e1", "type": "protein", "text": [ "glycoproteins" ], "offsets": [ [ 227, 240 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08163" } ] } ]
[]
[]
[ { "id": "DS.d193.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d193.s0.e0", "arg2_id": "DS.d193.s0.e1", "normalized": [] }, { "id": "DS.d193.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d193.s1.e0", "arg2_id": "DS.d193.s1.e1", "normalized": [] } ]
DS.d194
18458994
[ { "id": "DS.d194.s0", "type": "", "text": [ "There was a significant increase in cytochrome-c oxidase activity at 2.5 mg/L, which might indicate irgarol's disruption of the mitochondrial membrane and subsequently ATP synthesis." ], "offsets": [ [ 0, 182 ] ] } ]
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"db_name": "UniProt", "db_id": "P62895" }, { "db_name": "UniProt", "db_id": "P62896" }, { "db_name": "UniProt", "db_id": "P67881" }, { "db_name": "UniProt", "db_id": "P67882" }, { "db_name": "UniProt", "db_id": "P68096" }, { "db_name": "UniProt", "db_id": "P68097" }, { "db_name": "UniProt", "db_id": "P68098" }, { "db_name": "UniProt", "db_id": "P68099" }, { "db_name": "UniProt", "db_id": "P68100" }, { "db_name": "UniProt", "db_id": "P68517" }, { "db_name": "UniProt", "db_id": "P68518" }, { "db_name": "UniProt", "db_id": "P68519" }, { "db_name": "UniProt", "db_id": "P81280" }, { "db_name": "UniProt", "db_id": "P81459" }, { "db_name": "UniProt", "db_id": "P99998" }, { "db_name": "UniProt", "db_id": "P99999" }, { "db_name": "UniProt", "db_id": "Q41346" }, { "db_name": "UniProt", "db_id": "Q4HVX7" }, { "db_name": "UniProt", "db_id": "Q52V08" }, { "db_name": "UniProt", "db_id": "Q52V09" }, { "db_name": "UniProt", "db_id": "Q52V10" }, { "db_name": "UniProt", "db_id": "Q5RFH4" }, { "db_name": "UniProt", "db_id": "Q640U4" }, { "db_name": "UniProt", "db_id": "Q6C9Q0" }, { "db_name": "UniProt", "db_id": "Q6IQM2" }, { "db_name": "UniProt", "db_id": "Q6Q4H8" }, { "db_name": "UniProt", "db_id": "Q6QLW4" }, { "db_name": "UniProt", "db_id": "Q6WUX8" }, { "db_name": "UniProt", "db_id": "Q753F4" }, { "db_name": "UniProt", "db_id": "Q7YR71" }, { "db_name": "UniProt", "db_id": "Q96VP3" } ] }, { "id": "DS.d194.s0.e1", "type": "compound", "text": [ "irgarol" ], "offsets": [ [ 100, 107 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "91590" } ] }, { "id": "DS.d194.s0.e2", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 168, 171 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] } ]
[]
[]
[ { "id": "DS.d194.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d194.s0.e1", "arg2_id": "DS.d194.s0.e0", "normalized": [] }, { "id": "DS.d194.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d194.s0.e2", "arg2_id": "DS.d194.s0.e0", "normalized": [] } ]
DS.d195
18459128
[ { "id": "DS.d195.s0", "type": "", "text": [ "Treatment of A549, which express wild-type p53, and H1299, which are p53-deficient, human lung cancer cells with berberine resulted in inhibition of cell proliferation and an increase in apoptotic cell death ; however, A549 cells were more sensitive to the berberine-induced cytotoxic effects than H1299 cells." ], "offsets": [ [ 0, 310 ] ] } ]
[ { "id": "DS.d195.s0.e0", "type": "protein", "text": [ "p53" ], "offsets": [ [ 43, 46 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O09185" }, { "db_name": "UniProt", "db_id": "O12946" }, { "db_name": "UniProt", "db_id": "O57538" }, { "db_name": "UniProt", "db_id": "O93379" }, { "db_name": "UniProt", "db_id": "P02340" }, { "db_name": "UniProt", "db_id": "P04637" }, { "db_name": "UniProt", "db_id": "P10361" }, { "db_name": "UniProt", "db_id": "P19558" }, { "db_name": "UniProt", "db_id": "P19559" }, { "db_name": "UniProt", "db_id": "P56423" }, { "db_name": "UniProt", "db_id": "P56424" }, { "db_name": "UniProt", "db_id": "P61260" }, { "db_name": "UniProt", "db_id": "P79820" }, { "db_name": "UniProt", "db_id": "P79892" }, { "db_name": "UniProt", "db_id": "Q29537" }, { "db_name": "UniProt", "db_id": "Q42578" }, { "db_name": "UniProt", "db_id": "Q8SPZ3" }, { "db_name": "UniProt", "db_id": "Q92143" }, { "db_name": "UniProt", "db_id": "Q9TTA1" }, { "db_name": "UniProt", "db_id": "Q9TUB2" }, { "db_name": "UniProt", "db_id": "Q9W678" }, { "db_name": "UniProt", "db_id": "Q9W679" } ] }, { "id": "DS.d195.s0.e1", "type": "protein", "text": [ "p53" ], "offsets": [ [ 69, 72 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O09185" }, { "db_name": "UniProt", "db_id": "O12946" }, { "db_name": "UniProt", "db_id": "O57538" }, { "db_name": "UniProt", "db_id": "O93379" }, { "db_name": "UniProt", "db_id": "P02340" }, { "db_name": "UniProt", "db_id": "P04637" }, { "db_name": "UniProt", "db_id": "P10361" }, { "db_name": "UniProt", "db_id": "P19558" }, { "db_name": "UniProt", "db_id": "P19559" }, { "db_name": "UniProt", "db_id": "P56423" }, { "db_name": "UniProt", "db_id": "P56424" }, { "db_name": "UniProt", "db_id": "P61260" }, { "db_name": "UniProt", "db_id": "P79820" }, { "db_name": "UniProt", "db_id": "P79892" }, { "db_name": "UniProt", "db_id": "Q29537" }, { "db_name": "UniProt", "db_id": "Q42578" }, { "db_name": "UniProt", "db_id": "Q8SPZ3" }, { "db_name": "UniProt", "db_id": "Q92143" }, { "db_name": "UniProt", "db_id": "Q9TTA1" }, { "db_name": "UniProt", "db_id": "Q9TUB2" }, { "db_name": "UniProt", "db_id": "Q9W678" }, { "db_name": "UniProt", "db_id": "Q9W679" } ] }, { "id": "DS.d195.s0.e2", "type": "compound", "text": [ "berberine" ], "offsets": [ [ 113, 122 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2353" } ] }, { "id": "DS.d195.s0.e3", "type": "compound", "text": [ "berberine" ], "offsets": [ [ 257, 266 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2353" } ] } ]
[]
[]
[ { "id": "DS.d195.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d195.s0.e2", "arg2_id": "DS.d195.s0.e0", "normalized": [] } ]
DS.d196
18459941
[ { "id": "DS.d196.s0", "type": "", "text": [ "Furthermore atorvastatin treatment markedly decreased the levels of TNF-alpha, IL-6 and MCP-1, reduced myocardial infiltration of macrophages and significantly increased myocardial and serum levels of the anti-inflammatory cytokine IL-10." ], "offsets": [ [ 0, 238 ] ] }, { "id": "DS.d196.s1", "type": "", "text": [ "Our study suggests that the modulation of the balance between pro- and anti-inflammatory cytokines towards the anti-inflammatory cytokine IL-10 is one salutary mechanism underlying how atorvastatin influences post-MI remodelling and thus improves LV function." ], "offsets": [ [ 239, 498 ] ] } ]
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"db_name": "UniProt", "db_id": "Q9TSJ4" }, { "db_name": "UniProt", "db_id": "Q9Z1Y5" } ] }, { "id": "DS.d196.s1.e0", "type": "protein", "text": [ "IL-10" ], "offsets": [ [ 377, 382 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46673" }, { "db_name": "UniProt", "db_id": "O97798" }, { "db_name": "UniProt", "db_id": "P18893" }, { "db_name": "UniProt", "db_id": "P22301" }, { "db_name": "UniProt", "db_id": "P29456" }, { "db_name": "UniProt", "db_id": "P43480" }, { "db_name": "UniProt", "db_id": "P46651" }, { "db_name": "UniProt", "db_id": "P47965" }, { "db_name": "UniProt", "db_id": "P48411" }, { "db_name": "UniProt", "db_id": "P51496" }, { "db_name": "UniProt", "db_id": "P51497" }, { "db_name": "UniProt", "db_id": "P51746" }, { "db_name": "UniProt", "db_id": "P55029" }, { "db_name": "UniProt", "db_id": "P79338" }, { "db_name": "UniProt", "db_id": "Q0Z972" }, { "db_name": "UniProt", "db_id": "Q25BC1" }, { "db_name": "UniProt", "db_id": "Q28374" }, { "db_name": "UniProt", "db_id": 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[]
[]
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DS.d197
18459944
[ { "id": "DS.d197.s0", "type": "", "text": [ "In addition, AUDA treatment attenuated macrophage infiltration and inhibited urinary excretion of MCP-1 (monocyte chemoattractant protein-1) and kidney cortex MCP-1 gene expression." ], "offsets": [ [ 0, 181 ] ] } ]
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[]
[]
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DS.d198
18462831
[ { "id": "DS.d198.s0", "type": "", "text": [ "Exogenous spermidine, arsenic and beta-aminobutyric acid modulate tobacco resistance to tobacco mosaic virus, and affect local and systemic glucosylsalicylic acid levels and arginine decarboxylase gene expression in tobacco leaves." ], "offsets": [ [ 0, 231 ] ] }, { "id": "DS.d198.s1", "type": "", "text": [ "Moreover, this phenotypic response was correlated with changes in the endogenous concentration of the SAR-related molecule salicylic acid and in transcript levels of some pathogenesis/stress-related genes (pathogenesis-related proteins PR-1a and PR-2 and arginine decarboxylase (ADC))." ], "offsets": [ [ 232, 517 ] ] } ]
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[]
[]
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DS.d199
18462962
[ { "id": "DS.d199.s0", "type": "", "text": [ "She had a mutation in PANK2 gene consisting of an aminoacid change of Alanine to Valine in exon 5 (A382V)." ], "offsets": [ [ 0, 106 ] ] } ]
[ { "id": "DS.d199.s0.e0", "type": "protein", "text": [ "PANK2" ], "offsets": [ [ 22, 27 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9BZ23" } ] }, { "id": "DS.d199.s0.e1", "type": "compound", "text": [ "Alanine" ], "offsets": [ [ 70, 77 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "602" }, { "db_name": "PubChem", "db_id": "4580" }, { "db_name": "PubChem", "db_id": "5950" }, { "db_name": "PubChem", "db_id": "71080" } ] }, { "id": "DS.d199.s0.e2", "type": "compound", "text": [ "Valine" ], "offsets": [ [ 81, 87 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6287" } ] } ]
[]
[]
[ { "id": "DS.d199.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d199.s0.e2", "arg2_id": "DS.d199.s0.e0", "normalized": [] }, { "id": "DS.d199.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d199.s0.e1", "arg2_id": "DS.d199.s0.e0", "normalized": [] } ]