Datasets:

stilletto

/

peptide_target_residues_affinity

like 0

[INST] Generate new ligand in SMILES that have affinity to this target MFERFTDRARRV(V)(V)LA(Q)EEAKMLNHNYIGTEHILLGLIHEGEGVAAKSLESLGISLEGVRSQVEEIIGQGQQAPSG(H)I(P)(F)TPRA(K)KVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGAELTRVRQQVIQLLS known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(C)C)C(O)OC

[INST] Generate new ligand in SMILES that have affinity to this target CSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWR(S)RPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQ(D)AEAAALFSREC(R)PSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSGHRQTVRVLLVVVLAFIICWLPFHVG(R)II(Y)INTE(D)SRM(M)YFS(Q)YF(N)IVA(L)QLFYLSASINPILYNLISKKYRAAAFKLLL known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H]([NH3+])Cc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=[NH2+])C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCC[NH3+])C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(N)=[NH2+])C(=O)N[C@H](C=O)CC(N)=O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target MSEEQVAQDTEEVFRSYVFYRHQQEQAPADPEMVTLPLQPSSTMGQVGRQLAI(I)GDD(I)NRR(Y)DSE(F)QT(M)LQ(H)(L)QPTAENAYEYFTK(I)AT(S)(L)FESGI(N)(W)(G)(R)VVALLGFGYRLALHVYQHGLFLGQVTRFVVDFMLHHSIARWIAQRGGWVAALN(L) known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(=O)[O-])C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C=O)CO)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)CC

[INST] Generate new ligand in SMILES that have affinity to this target VRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIK(W)ADNN[C]YLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGE[L](G)(D)VRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAP(P)AQYELKHGTFTCASE(Y)TG(N)(Y)QC[G](H)YKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTI known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]COC(O)CCCNC(=O)CNC(=O)CNC(O)C1CCN([C@H](C)C2CCCC3CCCCC32)CC1,CO[C@H](O)CCCNC(=O)CNC(=O)CNC(O)C1CCN([C@H](C)C2CCCC3CCCCC32)CC1

[INST] Generate new ligand in SMILES that have affinity to this target TIKVFTTVDNINLHTQVVDMSQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNN(C)(Y)LATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGE(L)(G)(D)VRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAP(P)AQYELKHGTFTCASE(Y)TGN(Y)Q(C)(G)H(Y)KHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTI known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CO[C@H](O)CCCNC(=O)CNC(=O)CNC(O)C1CCN([C@H](C)C2CCCC3CCCCC32)CC1

[INST] Generate new ligand in SMILES that have affinity to this target IEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYAAGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTNAAAVTIVKPIV(Y)GNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKL(H)E(S)(Y)GNPLRVVTKPPYEITET(G)(W)(G)(E)(F)EIIIKIF(F)IDPN(E)(R)PVTLYHLLKL(F)QSDTNAMLGKKTVVS(E)(F)(Y)D(E)(M)(I)(F)QDPTAMMQQLLT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@H](C=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O,CC(O)NCCCC[C@H](NC(=O)CNC(=O)CN)C(O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C=O

[INST] Generate new ligand in SMILES that have affinity to this target KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYAAGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTNAAAVTIVKPIV(Y)GNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKL(H)(E)(S)(Y)GNPLRVVTKPPYEITET(G)(W)(G)(E)FEIIIKIFFIDPN(E)(R)P(V)TLYHLLKL(F)QSAMLGKKTVVS(E)(F)(Y)(D)(E)(M)(I)(F)QDPTAMMQQLLTT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](C)N)C(O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C=O,C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@H](C=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target ASVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKL(H)E(S)(Y)GNPLRVVTKPPYEITET(G)(W)(G)(E)F(E)IIIKIFFIDPN(E)(R)PVTL(Y)H(L)LKL(F)QSDTNAMLGKKTVVSEFY(D)(E)(M)(I)(F)QDPTAMMQQLLTT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(O)NCCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(O)N[C@@H](CO)C(=O)N[C@H](C=O)[C@@H](C)O.OCC(O)CO,CC(O)NCCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(O)N[C@@H](CO)C(=O)N[C@H](C=O)[C@@H](C)O.OCC(O)CO.OS(O)(O)O

[INST] Generate new ligand in SMILES that have affinity to this target ASVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHE(S)(Y)GNPLRVVTKPPYEITET(G)(W)(G)(E)(F)(E)IIIKIFFIDPN(E)(R)P(V)T(L)(Y)HLLKL(F)QSDTNAMLGKKTVVSEFY(D)(E)(M)(I)(F)QDPTAMMQQLLT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(O)NCCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(O)N[C@@H](CO)C(=O)N[C@H](C=O)[C@@H](C)O.OCC(O)CO,CC(O)NCCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(O)N[C@@H](CO)C(=O)N[C@H](C=O)[C@@H](C)O.OCC(O)CO.OS(O)(O)O

[INST] Generate new ligand in SMILES that have affinity to this target GHTNNWAVLVCTSRFWFNY(R)HVANTLSVYRSVKRLGIPDSHIVLMLADDMACNPRNPKPATVFSHKNMELNVYGDDVEVDYRSYEVTVENFLRVLTGRIPPSTPRSKRLLSDDRSNILIYMTGH(G)GNG(F)L(K)FQDSE(E)ITNIELADAFEQMWQKRRYNELLFIIDT(C)QGASMYERFYSPNIMALASSQVGED(S)(L)(S)HQPDPAIGV(H)LMDRYTFYVLEFLEEINPASQTNMNDLFQVCPKSLCVSTPGHRTDLFQRDPKNVLITDFFGSVRKVEITTETIKLQKLMEPLKYAEQLPVAQIIHQKPKLKDWHPPGGFILGLWALIIMVFFKTYG known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCCCCCCCCCCCCCCCCCCC(O)O[C@H](COCCCCCCCCCCCCCCCCCC)CO[PH](O)(O)O[C@@H]1[C@H](OC(O)CCCCCCCCCCCCCCC)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O[C@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H](CO[C@H]3O[C@H](CO[PH](O)(O)OCCN)[C@@H](O)[C@H](O)[C@@H]3O[C@H]3O[C@H](CO[PH](O)(O)OCCNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCSC)[C@@H](O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H](O)[C@@H]2O[PH](O)(O)OCCN)[C@H](O)[C@H]1N,CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](OC(O)CCC(O)O)CC[C@]4(C)[C@H]3CC[C@]12C.CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CN)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC

[INST] Generate new ligand in SMILES that have affinity to this target AAAGAAATHLEVARGKRAALFFAAVAIVLGLPLWWKTTETYRASLPYSQISGLNALQLRLMVPVTVVFTKLPFTVVHEREIPLKYKMKIKCRFQKAYRRALDVQEAEAMLDEPQEQAEGSLTVYVISEHSSLLPQDMMSYIGPKRTAVVRGAFNIIGRRIVQVAQAMSLTEDVLAAALADHLPEEKRRPLKSSLGYEITFSLLNPDPKSHDVYWDIEGAVRRYVQPFLNALGAAGNFSVDSQILYYAMLGVNPRFDSASSSYYLDMHSLPHVINPVESRLGSSAASLYPVLNFLLYVPELAHSPLYIQDKDGAPVATNAFHSPRWGGIMVYNVDSKTYNASVLPVRVEVDMVRVMEVFLAQLRLLFGIAQPQLPPKCLLSGPTSEGLMTWELDRLLWARSVENLATATTTLTSLAQLLGKISNIVIKDDVASEVYKAVAAVQKSAEELASGHLASAFVASQEAVTSSELAFFDPSLLHLLYFPDD(Q)K(F)(A)IYIPLF(L)(P)MA(V)PILLSLVKIFLET known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](OC(O)CCC(O)O)CC[C@]4(C)[C@H]3CC[C@]12C.CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CN)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC

[INST] Generate new ligand in SMILES that have affinity to this target PPRDSLREELVITPLPSGDVAATFQFRTRWDSELQREGVSHYRLFPKALGQLISKYSLRELHLSFTQGFWRTRYWGPPFLQAPSGAELWVWFQDTVTDVDKSWKELSNVLSGIFCASLNFIDSTNTVTPTASFKPLGLANDTDHYFLRYAVLPREVVCTENLTPWKKLLPCSSKAGLSVLLKADRLFHTSYHSQAVHIRPVCRNARCTSISWELRQTLSVVFDAFITGQGKKDWSLFRMFSRTLTEPCPLASESRVYVDITTYNQDNETLEVHPPPTTTYQDVILGTRKTYAIYDLLDTAMINNSRNLNIQLKWKRPPENEAPPVPFLHAQRYVSGYGLQKGELSTLLYNTHPYRAFPVLLLDTVPWYLRLYVHTLTITSKGKENKPSYIHYQPAQDRLQPHLLEMLIQLPANSVTKVSIQFERALLKWTEYTPDPNHGFYVSPSVLSALVPSMVAAKPVDWEESPLFNSLFPVSDGSNYFVRLYTEPLLVNLPTPDFSM(P)(Y)(N)VI(C)LTC(T)VVAVCYGSFYNLLTRTFHIE known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](OC(O)CCC(O)O)CC[C@]4(C)[C@H]3CC[C@]12C.CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CN)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC

[INST] Generate new ligand in SMILES that have affinity to this target LDLAASFSAVLTRIQVFVRRLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFALPYPRFRPMASCLSTVWTCIIIVCKMLYQIQNHLQILLLLVFEAVVYRRQEHYRRQHRQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFMVILHGCWLVAILTRRRREAIARLWPNYCLFLTLFLLYQYLLCLGMNSALIKWLYLPPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRGEPNPIPNFIHCRSYLDMLKVAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACFYLLLFGTTLLQKDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFCWVIQLFSLIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQASRGFALYNAANLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQASDHATVIHSGDYFLFESDSEEGQATVDGLTRWLRAFTKHHRTMSDVLCAERYLLTQELLRVGEVRRGVLDQLASELLLDRRLHIPELEEAERFEAQQGRTLRLLRAGYQCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVMVVTKYLFQFGFFPPPRILGLEKTDSYIKYDLVQLMALFFHRSQLLCYGLWPLQRFFHDILHTKYRAATDVYALMFLADIVDIIIIIFGFWAFQVPQAFLFMLLVQFGTMVIDRALYLRKTVLGKLAFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYN(H)LNLFLF(Q)GFR(L)VPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYA(N)IFIIKC(S)(R)ETEKKYPQPKGQKK(K)K(I)(V)KYG(M)GGLIILFLIAIIWFPLLFMSLIRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPYPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKQELYNGTADITLRFTWNFQRDLAKGGTVEYTNEKHTLELAPNSTARRQLAQLLEGRPDQSVVIPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLGVRIQLRREQVGGTKASDFLEWWVIELQDCKADCNLLPMVIFSDKVSPPSLGFLAGYGIVGLYVSIVLVVGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTRERE known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CS)[C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target LDLAASFSAVLTRIQVFVRRLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFALPYPRFRPMASCLSTVWTCIIIVCKMLYQIQNHLQILLLLVFEAVVYRRQEHYRRQHRQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFMVILHGCWLVAILTRRRREAIARLWPNYCLFLTLFLLYQYLLCLGMNSALIKWLYLPPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRGEPNPIPNFIHCRSYLDMLKVAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACFYLLLFGTTLLQKDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFCWVIQLFSLIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQASRGFALYNAANLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQASDHATVIHSGDYFLFESDSEEGQATVDGLTRWLRAFTKHHRTMSDVLCAERYLLTQELLRVGEVRRGVLDQLASELLLDRRLHIPELEEAERFEAQQGRTLRLLRAGYQCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVMVVTKYLFQFGFFPPPRILGLEKTDSYIKYDLVQLMALFFHRSQLLCYGLWPLQRFFHDILHTKYRAATDVYALMFLADIVDIIIIIFGFWAFQVPQAFLFMLLVQFGTMVIDRALYLRKTVLGKLAFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYN(H)LNL(F)LF(Q)GFR(L)VPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKC(S)(R)ETEKKYPQPKGQKK(K)KI(V)KYG(M)GGLIILFLIAIIWFPLLFMSLIRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPYPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKQELYNGTADITLRFTWNFQRDLAKGGTVEYTNEKHTLELAPNSTARRQLAQLLEGRPDQSVVIPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLGVRIQLRREQVGGTKASDFLEWWVIELQDCKADCNLLPMVIFSDKVSPPSLGFLAGYGIVGLYVSIVLVVGKFVRGFFSEISHSIMF(E)ELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTRERE known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CS)[C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target LDLAASFSAVLTRIQVFVRRLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFALPYPRFRPMASCLSTVWTCIIIVCKMLYQIQNHLQILLLLVFEAVVYRRQEHYRRQHRQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFMVILHGCWLVAILTRRRREAIARLWPNYCLFLTLFLLYQYLLCLGMNSALIKWLYLPPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRGEPNPIPNFIHCRSYLDMLKVAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACFYLLLFGTTLLQKDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFCWVIQLFSLIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQASRGFALYNAANLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQASDHATVIHSGDYFLFESDSEEGQATVDGLTRWLRAFTKHHRTMSDVLCAERYLLTQELLRVGEVRRGVLDQLASELLLDRRLHIPELEEAERFEAQQGRTLRLLRAGYQCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVMVVTKYLFQFGFFPPPRILGLEKTDSYIKYDLVQLMALFFHRSQLLCYGLWPLQRFFHDILHTKYRAATDVYALMFLADIVDIIIIIFGFWAFQVPQAFLFMLLVQFGTMVIDRALYLRKTVLGKLAFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYN(H)LNL(F)LF(Q)GFR(L)VPFLVELRAVMDWVWTDTTLS(L)(S)NWMCVEDIYA(N)IF(I)IKC(S)(R)ETEKKYPQPKGQKKKKI(V)KYG(M)GGLIILFLIAIIWFPLLFMSLIRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPYPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKQELYNGTADITLRFTWNFQRDLAKGGTVEYTNEKHTLELAPNSTARRQLAQLLEGRPDQSVVIPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLGVRIQLRREQVGGTKASDFLEWWVIELQDCKADCNLLPMVIFSDKVSPPSLGFLAGYGIVGLYVSIVLVVGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTRERE known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CS)[C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target IAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAW(E)TIT(I)YLLNNKHLVIADAFV(R)HI(D)(N)VF(D)SM(I)(C)ISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVF(I)LY(S)ESTYV(I)LCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASRTSMQGAVTVTMLLGVFTVCWAPFFLHLTL(M)LSCPQNLYCSRFMSH(F)(N)MYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICC known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C=O)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target CEQVFIKPEV(F)LSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNAL(E)TIM(I)AIVHSDYLTFE(D)QF(I)QHM(D)(N)IF(D)SM(I)CISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVF(I)VY(S)(E)SKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPQHSCMKGAVTITILLGVFIFCWAPFFL(H)LVL(I)ITCPTNPYCICYTAH(F)NTY(L)VLIMCNSVIDPLIYAFRSLELRNTFREI known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C=O)Cc1ccccc1

[INST] Generate new ligand in SMILES that have affinity to this target VMVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAYALAEHLSELYPKQIRAMLGQFSQAEALLMKAGVQPGTFDGVLMDLGCSSMQLDTPERGFSLRKDGPLDMRMDGGRYP(D)M(P)TAA(D)VV(N)(A)LDQQALA(S)ILRT(Y)GEEKHAKKIASAIVQARSIYPITRTQQLASIVAGAFPPSAIYTRKDLLQRSTHIATKTFQALRI(F)VN(N)EL(N)ELYTGLKTAQKFLRPGGRLVALSFHSLEDRIVKRFLLGISMLMWELIHKKVLSAKLRAAIKL known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@H](C=O)CC(=O)O)[C@@H](C)CC

[INST] Generate new ligand in SMILES that have affinity to this target MVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAYALAEHLSELYPKQIRAMLGQFSQAEALLMKAGVQPGTFDGVLMDLGCSSMQLDTPERGFSLRKDGPLDMRMDGGRYPDM(P)TAA(D)VV(N)(A)(L)DQQALASILRT(Y)GEEKHAKKIASAIVQARSIYPITRTQQLASIVAGAFPPSAIYTRKDLLQRSTHIATKTFQALRI(F)VN(N)ELNELYTGLKTAQKFLRPGGRLVALSFHSLEDRIVKRFLLGISMLMWELIHKKVAKLRAAIKL known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C=O)CC(=O)O)[C@@H](C)CC

[INST] Generate new ligand in SMILES that have affinity to this target MSQSNRELVVDFLSYKLSQKGYSWSQFSDSEMAAVKQALREAGDE(F)ELR(Y)RRA(F)SDLTS(Q)LHITPGTAYQSFEQ(V)VNE(L)FRDGV(N)W(G)(R)IVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVEL(Y)G known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C=O

[INST] Generate new ligand in SMILES that have affinity to this target MSQSNRELVVDFLSYKLSQKGYSWSQFSDSEMAAVKQALREAGDE(F)ELR(Y)RRA(F)SDLTSQLHITPGTAYQ(S)FEQ(V)VN(E)(L)FR(D)GV(N)(W)(G)(R)IVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVEL(Y)G known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C=O

[INST] Generate new ligand in SMILES that have affinity to this target MSQSNRELVVDFLSYKLSQKGYSWSQFSDSEMAAVKQALREAGDE(F)EL(R)(Y)RRA(F)SDLTS(Q)LHITPGTAYQSFEQ(V)VNE(L)FRDGV(N)W(G)(R)IVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVEL(Y)G known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C=O

[INST] Generate new ligand in SMILES that have affinity to this target MSQSNRELVVDFLSYKLSQKGYSWSQFSDSEMAAVKQALREAGDE(F)ELR(Y)RRA(F)SDLTS(Q)LHITPGTAYQSFEQ(V)VN(E)(L)FRDGV(N)W(G)(R)IVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVEL(Y)G known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C=O

[INST] Generate new ligand in SMILES that have affinity to this target YDNREIVMKYIHYKLSQRGYEWDAESEVVHLTLRQAGDD(F)SRR(Y)RRDFAE(M)SSQLHLTPFTARGRFAT(V)VE(E)LFRDGV(N)W(G)(R)IV(A)FFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVEL(Y)GP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C=O)C(C)C)[C@@H](C)CC

[INST] Generate new ligand in SMILES that have affinity to this target YDNREIVMKYIHYKLSQRGYEWDAESEVVHLTLRQAGDD(F)SRR(Y)RR(D)FAE(M)SS(Q)LHLTPFTARGRFATVVE(E)(L)FR(D)GV(N)WG(R)IV(A)FFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVE(L)(Y)GP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C=O)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target EDELYRQSLEIISRYLREQATGAKDTKSGATSRKALETLRR(V)GDG(V)QRN(H)ETAFQG(M)LRK(L)DIKNEDDVKSLSR(V)MI(H)(V)FSDGVTNW(G)(R)I(V)(T)LISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEF(F)HV known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](C)C=O)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target PKHIIQM(T)GFK(M)EE(K)EALVKLLLKLDCTFI(K)S(E)KYKNCTHLIAE(R)LC(K)(S)E(K)FLAACAAGKWILTKDYIIHSAKSGRWLDETTYEWGYKIEKDSRYSPQMQSAPKRWREELKRTGAPGAFHRWKVVLLV(R)TDKRSDSLIRVLEAGKANVILPKSSPSGITHVIASNARIKAEKEKDNFKAPFYPI(Q)YLGDFLLEKLE known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@H](CO)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCC(=O)O)[C@@H](C)CC

[INST] Generate new ligand in SMILES that have affinity to this target TPKHIIQM(T)(G)FK(M)EE(K)EALVKLLLKLDCTFI(K)S(E)KYKNCTHLIAE(R)LC(K)(S)E(K)F(L)AACAAGKWILTKDYIIHSAKSGRWLDETTYEWGYKIEKDSRYSPQMQSAPKRWREELKRTGAPGAFHRWKVVLLVRTDKRSDSLIRVLEAGKANVILPKSSPSGITHVIASNARIKAEKEKDNFKAPFYPI(Q)YLGDFLLEKLEH known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@H](CO)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CO)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CC(C)C)[C@@H](C)CC

[INST] Generate new ligand in SMILES that have affinity to this target PKHIIQM(T)GFK(M)EE(K)EALVKLLLKLDCTFI(K)S(E)KYKNCTHLIAE(R)LC(K)(S)E(K)FLAACAAGKWILTKDYIIHSAKSGRWLDETTYEWGYKIEKDSRYSPQMQSAPKRWREELKRTGAPGAFHRWKVVLLV(R)TD(K)RSDS(L)IRVLEAGKANVILPKSSPSGITHVIASNARIKAEKEKDNFKAPFYPI(Q)YLGDFLLEKLE known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCC(=O)O)[C@@H](C)CC

[INST] Generate new ligand in SMILES that have affinity to this target TPKHIIQM(T)(G)FK(M)EE(K)EALVKLLLKLDCTFI(K)S(E)KYKNCTHLIAERLC(K)(S)E(K)FLAACAAGKWILTKDYIIHSAKSGRWLDETTYEWGYKIEKDSRYSPQMQSAPKRWREELKRTGAPGAFHRWKVVLLVRTDK(R)SDS(L)IRVLEAGKANVILPKSSPSGITHVIASNARIKAEKEKDNFKAPFYPI(Q)YLGDFLLEKLE known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CO)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CC(C)C)[C@@H](C)CC

[INST] Generate new ligand in SMILES that have affinity to this target GSHSMR(Y)FSTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDE(E)TG(K)VKA(H)SQ(T)DR(E)(N)LR(I)ALR(Y)YNQSEAGSHTLQ(M)M(F)GCDVGSDGRFLRGY(H)QYAYDGKDYIALKEDLRSWTAADMAAQI(T)KR(K)(W)EAAHVAEQ(Q)RA(Y)LEG(T)CVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CS)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target GSHSMR(Y)FSTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDE(E)TG(K)(V)KA(H)SQ(T)DRE(N)LR(I)ALR(Y)YNQSEAGSHTLQ(M)M(F)GCDVGSDGRFLRGY(H)QYAYDGKDYIALKEDLRSWTAADMAAQI(T)KR(K)(W)EAAHVAEQ(Q)RA(Y)LEG(T)CVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CS)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target MTRLTVALSGDCMVTRGGLITSDPAAERLRDLLRGTDFAVTNL(E)VVPSDGRGHPVHNA(V)(G)(G)GCLIADSAVLDEVTAAGFSVLGCANN(H)AMDLGTEGVLGTMDLLRARGIPYAGIGADLTGARRPVYADRPGGSLALLSCTATFLPGQEAADPSPELPGRPGLNPLRHTATMQVTADQMDVLRTIDAETGLRARRAEARALLGVDPALLGPDRLALFGTRFRTADAPGFTTECDPRDLDEIARWVGEARLRADLVVVSVHS(H)(E)(P)GPTPETPGEFLRVFAHRMIDEGAHAVVGHGP(H)FLRGVELYRNKPIFYSLGNIVSQIELTDRVSAEDYAKVTAERPLTPGRYYDRLSGHGTRL(F)APHRRYWQSLVPVLTFEDGTLTAARLHPVDLGFGRPVHRRGRPRLADRAEAEKTLTDVAQLSQPYGTAIEVMDDGTGELALDV known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]NCC(=O)N[C@@H](CSSC[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O)C(=O)NCC(=O)N[C@H](C=O)Cc1ccc(O)cc1

[INST] Generate new ligand in SMILES that have affinity to this target SPWPVWSGYALCFVPLAAVILGFIIAARFTDKQATSA(Y)(L)RLDPAKAN known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C=O

[INST] Generate new ligand in SMILES that have affinity to this target SPWPVWSGYALCFVPLAAVILGFIIAARFTDKQATSA(Y)(L)RLDPAKAN known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C=O

[INST] Generate new ligand in SMILES that have affinity to this target GQKECDNALRQLETVRELLENPVQPINDMSYFGCLDSV(M)EN(S)(K)VL(G)EA(M)TGI(S)QNAKNGNLPEFGDAIATASKALCGFTEAAAQAAYLVGVSDPNSQAQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPRWSVLAGHSRTVSDSIKKLITSMRD known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@H](C=O)CCC(N)=O

[INST] Generate new ligand in SMILES that have affinity to this target PGQKECDNALRQLETVRELLENPVQPINDMSYFGCLDSV(M)EN(S)(K)VL(G)EA(M)(T)GISQNA(K)NGNLPEFGDAIATASKALCGFTEAAAQAAYLVGVSDPNSQAQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPRWSVLAGHSRTVSDSIKKLITSMR known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@H](C=O)CCC(N)=O

[INST] Generate new ligand in SMILES that have affinity to this target (P)PCQGP(I)EIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIP(I)(N)VY(K)LLA(E)DWPFGAEMCKLVPFI(Q)KASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIIT(M)D(Y)KGSYLR(I)C(L)LH(P)VQKTAFMQFYKTAKDWW(L)FSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLP(L)HLS(R)IL(K)LTL(Y)N(Q)NDPN(R)CEL(L)SFL(L)VL(D)(Y)IGINMASLNSCINPIALYLVSKRFKNCFKSCLCC known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC

[INST] Generate new ligand in SMILES that have affinity to this target (P)PCQGP(I)EIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPI(N)VY(K)LLA(E)D(W)PFGAEMCKLVPFI(Q)(K)ASVGITVLSLCALSIDRYRAVASWSRTAVEIVLIWVVSVVLAVPEAIGFDI(I)T(M)(D)(Y)KGSY(L)R(I)C(L)LH(P)VQKTAFMQFYKTA(K)DWWLFSFYFCLPLAITAFFYTLMTCEMLRKRREVAKTVFCLVLVFALCWLP(L)HLS(R)IL(K)LTL(Y)N(Q)NDPN(R)CEL(L)SFL(L)VL(D)(Y)IGINMASLNSCINPIALYLVSKRFKNCFKSCLCC known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC

[INST] Generate new ligand in SMILES that have affinity to this target LEVLFQGPNSKLLSTSAKRIQKELADITLDPPPNSSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIYHPNI(N)(S)QGVI(C)LDIL(K)DNWSPALTISKVLLSISSLLTDPNPADP(L)(V)(G)(S)IATQYMTNRAEHDRMARQWTKRYAT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C=O)CO

[INST] Generate new ligand in SMILES that have affinity to this target EVLFQGPNSKLLSTSAKRIQKELADITLDPPPNSSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIYHPNI(N)(S)QGVI(C)LDILKDNW(S)(P)(A)LTISKVLLSISSLLTDPNPADP(L)(V)(G)(S)IATQYMTNRAEHDRMARQWTKRYAT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C=O)CO

[INST] Generate new ligand in SMILES that have affinity to this target SKLLSTSAKRIQKELADITLDPPPNSSAGPKGDNIYEWRSTILGPP(G)SVY(E)GGVFFLDITFTPEYPFKPPKVTFRTRIYHPNI(N)(S)QGVI(C)LDILKDNWSPALTISKVLLSISSLLTDPNPADP(L)(V)(G)(S)IATQYMTNRAEHDRMARQWTKRYAT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C=O)CO

[INST] Generate new ligand in SMILES that have affinity to this target TPVYVGGFLARYDQSPDEAELLLPRDVVEHWLHAVALPLNI(N)(H)DDTAVVGHVAAMQSVRDGLFCLGCVTSPRFLEIVRRASEKSELVSRGPVSPLQPDKVVEFLSGSYAGL(S)(L)(S)(S)RRTPF(K)HVAL(C)SV(G)(R)RRGTLAVYGRDPEWVTQRFPDLTAADRDGLRAQWQRCGSTAVDASGDPFRSDSYGLLGNSV(D)ALY(I)RERLP(K)LRYDKQLVGVTEESYVKA known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccccc2)N[C@@H](O)CSC[C@@H](CO)NC(=O)[C@@H]2CCCN2C1=O

[INST] Generate new ligand in SMILES that have affinity to this target TPVYVGGFLARYDQSPDEAELLLPRDVVEHWLHAVALPLNI(N)(H)DDTAVVGHVAAMQSVRDGLFCLGCVTSPRFLEIVRRASEKSE(L)VS(R)GPVSPLQPDKVVEFLSGSYAGL(S)(L)(S)(S)PFK(H)VAL(C)S(V)(G)(R)RRGTLAVYGRDPEWVTQRFPDLTAADRDGLRAQWQSTAVDASGDPFRSDSYGLLGNSV(D)ALY(I)RERLP(K)LRYDKQLVGVTERESYVKA known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N[C@@H](O)CSC[C@@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC1=O,CC(C)C[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccccc2)N[C@H](O)CSC[C@@H](CO)NC(=O)[C@@H]2CCCN2C1=O

[INST] Generate new ligand in SMILES that have affinity to this target TPVYVGGFLARYDQSPDEA(E)LLLPRDVVEHWLHAVALPLNI(N)(H)DDTAVVGHVAAMQSVRDGLFCLGCVTSPRFLEIVRRASEKSELVSRGPVSPLQPDKVVEFLSGSYAGL(S)(L)(S)(S)PF(K)HVAL(C)S(V)(G)(R)RRGTLAVYGRDPEWVTQRFPDLTAADRDGLRAQWQGDPFRSDSYGLLGNSV(D)ALY(I)RERLP(K)LRYDKQLVGVTERESYVKA known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N[C@@H](O)CSC[C@@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC1=O

[INST] Generate new ligand in SMILES that have affinity to this target VSLWERFCAWITSTEN(R)LYIGWFGCLMFPTLLTATSCFIIAFIAAPPVDIDGIREPVSGS(L)LYGN(N)IISGAVVPSSNAIGMHFYPIWEAASVDEWLYNGGPYQLIVLHFLLGVSAYMGREWELSYRLGMRPWIFVAFSAPVAAASAVFLVYPIGQGSFSDGMPLGISGTFNFMLVFQAEHNILMHPFHMAGVAGVFGGSLFSAMHGSLVTSSLIRETTENESTNYGYK(F)GQEEETYNIVAAHGYFGRLIFQYASFNNSRALHFFLALWPVVGIWITAMGISTMAFNLNGFNFNQSVVDSQGRVINTWADILNRANLGIEVMHERNAHNFPLDL known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCSC)C(C)C)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@H](C=O)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target TGPNPNKQAVELN(R)TSL(Y)WGLLLIFVLAVLF(S)SYF(F)N known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCSC)C(C)C)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@H](C=O)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target E(V)QFGA(Y)LAVLLGTFLPALFLVNLFIQTEARKAGKAGGQDS known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCSC)C(C)C)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@H](C=O)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target VSLWERFCAWITSTEN(R)LYIGWFGCLMFPTLLTATSCFIIAFIAAPPVDIDGIREPVSGS(L)LYGN(N)IISGAVVPSSNAIGMHFYPIWEAASVDEWLYNGGPYQLIVLHFLLGVSAYMGREWELSYRLGMRPWIFVAFSAPVAAASAVFLVYPIGQGSFSDGMPLGISGTFNFMLVFQAEHNILMHPFHMAGVAGVFGGSLFSAMHGSLVTSSLIRETTENESTNYGYK(F)GQEEETYNIVAAHGYFGRLIFQYASFNNSRALHFFLALWPVVGIWITAMGISTMAFNLNGFNFNQSVVDSQGRVINTWADILNRANLGIEVMHERNAHNFPLDL known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCSC)C(C)C)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@H](C=O)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target TGPNPNKQAVELN(R)TSL(Y)WGLLLIFVLAVLF(S)SYF(F)N known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCSC)C(C)C)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@H](C=O)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target E(V)QFGA(Y)LAVLLGTFLPALFLVNLFIQTEARKAGKAGGQDS known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCSC)C(C)C)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@H](C=O)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target RPFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFN(W)(L)RA known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H](N)CCSC)[C@@H](C)O)[C@@H](C)CC)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C=O)CO.CC[C@H]1[C@H]2CC3C(C)[C@H]4C(O)[C@H](C(O)OC)[C@@H]5C4N3[Mg@]34N6C(C[C@@H]7[C@@H](C)[C@H](CCC(O)OCCC(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H]5N73)C(C)C(C(C)O)C6CC([C@@H]1C)N24

[INST] Generate new ligand in SMILES that have affinity to this target NDLVPDQWKPLFNNAQWLVHDIVVK(T)IYGGLIIAVIAHV(L)CWA(W)TPWIR known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H](N)CCSC)[C@@H](C)O)[C@@H](C)CC)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C=O)CO.CC[C@H]1[C@H]2CC3C(C)[C@H]4C(O)[C@H](C(O)OC)[C@@H]5C4N3[Mg@]34N6C(C[C@@H]7[C@@H](C)[C@H](CCC(O)OCCC(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H]5N73)C(C)C(C(C)O)C6CC([C@@H]1C)N24

[INST] Generate new ligand in SMILES that have affinity to this target WNEPPVILSMVILSLTFLLGLPGNGLVLWVAGLKMQRTVNTIWFLHLTLADLLCCLSLPF(S)LA(H)LALQGQWPYGRFLCKLIPSI(I)VLN(M)FASVFLLTAISLDRCLVVFKPIWCQNHRNVGMACSICGCIWVVAFVMCIPVFVYREIFTTDNHNRCG(Y)(K)TPLVAITIT(R)LVVGFLLPSVIMIACYSFIVFRMQRGRFAKSQSKTFRVAVVVVAVFLVCWTP(Y)HIFGVL(S)LL(T)(D)(P)ETPLGKTLMSW(D)(H)VC(I)ALASANSCFNPFLYALLGKDFRKKARQSI known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target (T)(R)(V)(F)(K)(K)SSPNGKLTVYLGK(R)DFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTVAFRYGREDCDVLGLSFRKDLFIANYQAFPPTPNPPRPPTRLQE(R)(L)LR(K)LGQHAHPFFFTIPQNLPSSVTLQPGPEDTGKALGVDFEIRAFVAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADIVLFSTAQYKVPVAQVEQDDQVSPSSTFSKVYTITPFLANNREKRGLALDGKL(K)HEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPH known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](CO)NC(O)[C@@H](NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@@H](NC(O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O[PH](O)(O)O)C(C)C)[C@@H](C)O[PH](O)(O)O)C(=O)NCC=O

[INST] Generate new ligand in SMILES that have affinity to this target (T)(R)(V)(F)(K)(K)SSPNGKLTVYLGK(R)DFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTVAFRYGREDCDVLGLSFRKDLFIANYQAFPPTPNPPRPPTRLQE(R)LLR(K)LGQHAHPFFFTIPQNLPSSVTLQPGPEDTGKALGVDFEIRAFVAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADIVLFSTAQYKVPVAQVEQDDQVSPSSTFSKVYTITPFLANNREKRGLALDGKL(K)HEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPH known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](CO)NC(O)[C@@H](NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@@H](NC(O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O[PH](O)(O)O)C(C)C)[C@@H](C)O[PH](O)(O)O)C(=O)NCC=O

[INST] Generate new ligand in SMILES that have affinity to this target (T)(R)(V)(F)(K)(K)(S)SPNGKLTVYLGK(R)DFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTVAFRYGREDCDVLGLSFRKDLFIANYQAFPPTPNPPRPPTRLQE(R)LLR(K)LGQHAHPFFFTIPQNLPSSVTLQPGPEDTGKALGVDFEIRAFVAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADIVLFSTAQYKVPVAQVEQDDQVSPSSTFSKVYTITPFLANNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPH known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](CO)NC(O)[C@@H](NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@@H](NC(O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O[PH](O)(O)O)C(C)C)[C@@H](C)O[PH](O)(O)O)C(=O)NCC=O

[INST] Generate new ligand in SMILES that have affinity to this target SDIQMTQSPSSLSASVGDRVTITCRASQSV(S)SAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGS(R)SGTDFTLTISSLQPEDFATYYCQQYKYVPVTFGQGTKVEI known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](CO)NC(O)[C@@H](NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@@H](NC(O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O[PH](O)(O)O)C(C)C)[C@@H](C)O[PH](O)(O)O)C(=O)NCC=O

[INST] Generate new ligand in SMILES that have affinity to this target PG(T)(R)(V)(F)(K)(K)SSPNGKLTVYLGK(R)DFVDHLDKVDPVDGVVLVDPD(Y)LKD(R)KVFVTLTVAFRYGREDCDVLGLSFRKDLFIANYQAFPPTPNPPRPPTRLQE(R)LLR(K)LGQHAHPFFFTIPQNLPSSVTLQPGPEDTGKALGVDFEIRAFVAKSLEE(K)S(H)K(R)NSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADIVLFSTAQYKVPVAQVEQDDQVSPSSTFSKVYTITPFLANNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPHDYATDDDIVFEDFARLRLK known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(O)[C@H](CO[PH](O)(O)O)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@H](CCC(=O)O)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@H](CS)NC(O)[C@H](CO[PH](O)(O)O)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@H](CC(C)C)NC(O)[C@@H](N)CO[PH](O)(O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)N[C@@H](C)C=O)[C@@H](C)O[PH](O)(O)O

[INST] Generate new ligand in SMILES that have affinity to this target PG(T)(R)(V)F(K)KSSPNGKLTVYLGKRDFVDHLDKVDPVDGVVLVDPD(Y)LKD(R)KVFVTLTVAFRYGREDCDVLGLSFRKDLFIANYQAFPPTPNPPRPPTRLQERLLR(K)LGQHAHPFFFTIPQNLPSSVTLQPGPEDTGKALGVDFEIRAFVAKSLEE(K)S(H)K(R)NSVR(L)VIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADIVLFSTAQYKVPVAQVEQDDQVSPSSTFSKVYTITPFLANNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPHDYATDDDIVFEDFARLRLK known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(O)[C@H](CO[PH](O)(O)O)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@H](CCC(=O)O)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@H](CS)NC(O)[C@H](CO[PH](O)(O)O)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@H](CC(C)C)NC(O)[C@@H](N)CO[PH](O)(O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)N[C@@H](C)C=O)[C@@H](C)O[PH](O)(O)O

[INST] Generate new ligand in SMILES that have affinity to this target (T)(R)(V)F(K)(K)ASPNGKLTVYLGK(R)DFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQE(R)LIK(K)LGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVDVAVELPFTLMHPKPK known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(O)[C@H](CO[PH](O)(O)O)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@H](CCC(=O)O)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@@H](N)CS)C(=O)N[C@H](C=O)CC(C)C

[INST] Generate new ligand in SMILES that have affinity to this target (T)(R)(V)F(K)(K)ASPNGKLTVYLGK(R)DFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQE(R)LIK(K)LGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVDVAVELPFTLMHPKPK known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(O)[C@H](CO[PH](O)(O)O)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@H](CCC(=O)O)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@@H](N)CS)C(=O)N[C@H](C=O)CC(C)C

[INST] Generate new ligand in SMILES that have affinity to this target SDIQMTQSPSSLSASVGDRVTITCRASQSV(S)SAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGS(R)SGTDFTLTISSLQPEDFATYYCQQYKYVPVTFGQGTKVEI known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(O)[C@H](CO[PH](O)(O)O)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@H](CCC(=O)O)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@@H](N)CS)C(=O)N[C@H](C=O)CC(C)C

[INST] Generate new ligand in SMILES that have affinity to this target SDIQMTQSPSSLSASVGDRVTITCRASQSV(S)SAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGS(R)SGTDFTLTISSLQPEDFATYYCQQYKYVPVTFGQGTKVEI known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(O)[C@H](CO[PH](O)(O)O)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@H](CCC(=O)O)NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@@H](N)CS)C(=O)N[C@H](C=O)CC(C)C

[INST] Generate new ligand in SMILES that have affinity to this target (G)(T)(R)(V)(F)(K)(K)ASPNGKLTVYLGK(R)DFVDHIDLVEPVDGVVLVDPEYLKERRVYVTLTCAFRYGRTFRKDLFVANVQSFPPLTRLQE(R)LIKKLGEHAYPFTFEIPPNLPCSVTLQPCGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKL(K)HEDTNLASSTLLREGILGIIVSYKVKVKLVVSRSDVAVELPFTLMHPKPK known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(O)[C@H](CO[PH](O)(O)O)NC(O)[C@@H](NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@@H](NC(O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)N)[C@@H](C)O[PH](O)(O)O)C(C)C)[C@@H](C)O[PH](O)(O)O)C(=O)NCC=O

[INST] Generate new ligand in SMILES that have affinity to this target (R)(V)F(K)(K)ASPNGKLTV(Y)LGK(R)DFVDHIDLVDPVDGVVPEYLKERRVYVTLTCAFKDLFVANVQSFPPEDKKPLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSAVELPFTLMHPKPK known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)N[C@@H](O)[C@@H](N)CO[PH](O)(O)O)C(=O)N[C@H](C(O)N[C@@H](C)C(=O)N[C@@H](CO[PH](O)(O)O)[C@H](O)N[C@H]([C@@H](O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C=O)CS)[C@@H](C)O[PH](O)(O)O)[C@@H](C)O[PH](O)(O)O

[INST] Generate new ligand in SMILES that have affinity to this target (R)(V)F(K)(K)ASPNGKLTV(Y)LGK(R)DFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSAVELPFTLMHPKPK known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)N[C@@H](O)[C@@H](N)CO[PH](O)(O)O)C(=O)N[C@H]([C@H](O)N[C@@H](C)C(=O)N[C@@H](CO[PH](O)(O)O)C(O)N[C@H](C(O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C=O)CS)[C@@H](C)O[PH](O)(O)O)[C@@H](C)O[PH](O)(O)O

[INST] Generate new ligand in SMILES that have affinity to this target G(T)(R)(V)(F)(K)KASPNGKLTVYLGKRDFVDHIDLVEPVDGVVLVDPEYLKERRVYVTLTCAFRYLTFRKDLFVANVQFPPAPEDKKPLTRLQERLIK(K)LHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKL(K)HEDTNLASSTLILGIIVSYKVKVKLVVSSDVAVELPFTLMHPKPKEEPPH known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(O)[C@H](CO[PH](O)(O)O)NC(O)[C@@H](NC(O)[C@H](CO[PH](O)(O)O)NC(=O)[C@@H](NC(O)[C@@H](N)[C@@H](C)O[PH](O)(O)O)C(C)C)[C@@H](C)O[PH](O)(O)O)C(=O)NCC=O

[INST] Generate new ligand in SMILES that have affinity to this target EWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLA(Y)SSY(V)HQ(Y)SSGKFDNALFHAERAIGIITHILPEDHLLLASSK(R)VKALILEEIA(I)DCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYG(N)LG(R)LY(Q)SMRKFKEAEEMHIKAIQIKEQLLGQEDYEVA(L)SVG(H)LASLYN(Y)DMNQYENAEKLYLRSIAIGKKLFGEGYS(G)LE(Y)DY(R)GLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLISQ known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target EWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLA(Y)SSY(V)HQ(Y)SSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIA(I)DCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYG(N)LG(R)LY(Q)(S)MRKFKEAEEMHIKAIQIKEQLLGQED(Y)EVA(L)SVG(H)LA(S)LYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLE(Y)DYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLISQ known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target EWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLA(Y)SSY(V)HQ(Y)SSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIA(I)DCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTA(K)HYG(N)LG(R)LY(Q)(S)MRKFKEAEEMHIKAIQIKEQLLGQED(Y)EVA(L)SVG(H)LASLYN(Y)DMNQYENAEKLYLRSIAIGKKLFGEGYS(G)LE(Y)DYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLISQ known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target EWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLA(Y)SSY(V)HQ(Y)SSGKFDNALFHAERAIGIITHILPEDHLLLASSK(R)VKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTA(K)HYG(N)LG(R)LY(Q)(S)MRKFKEAEEMHIKAIQIKEQLLGQED(Y)EVA(L)SVG(H)LA(S)LYN(Y)DMNQYENAEKLYLRSIAIGKKLFGEGYSGLE(Y)DYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLIS known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target WIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLA(Y)SS(Y)(V)HQ(Y)SSGKFDNALFHAERAIGIITHILPEDHLLLA(S)SK(R)(V)KALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTA(K)HYG(N)LG(R)LY(Q)(S)MRKFKEAEEMHIKAIQIKEQLLGQED(Y)EVALSVG(H)LA(S)LYN(Y)DMNQYENAEKLYLRSIAIGKKLFGEGYSGLE(Y)DYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLISQ known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target EWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLA(Y)SS(Y)(V)HQ(Y)SSGKFDNALFHAERAIGIITHILPEDHLLLA(S)SK(R)(V)KALIL(E)EIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTA(K)HYGNLG(R)LY(Q)(S)MRKFKEAEEMHIKAIQIKEQLLGQEDYEVA(L)SVG(H)LA(S)LYN(Y)DMNQYENAEKLYLRSIAIGKKLFGEGYSGLE(Y)DYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLISQN known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target EWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLA(Y)SS(Y)VHQ(Y)SSGKFDNALFHAERAIGIITHILPEDHLLLASSK(R)VKALIL(E)EIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNV(Q)TA(K)HYGNLG(R)LY(Q)(S)MRKFKEAEEMHIKAIQIKEQLLGQEDYEVA(L)SVG(H)LASLYN(Y)DMNQYENAEKLYLRSIAIGKKLFGEGYSGLE(Y)DY(R)GLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLISQ known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target EWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLA(Y)SSY(V)HQ(Y)(S)SGKFDNALFHAERAIGIITHILPEDHLLLA(S)SK(R)VKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTA(K)HYG(N)LG(R)LY(Q)(S)MRKFKEAEEMHIKAIQIKEQLLGQEDYEVA(L)SVG(H)LASLYN(Y)DMNQYENAEKLYLRSIAIGKKLFGEGYS(G)LE(Y)DYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLISQ known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target EWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLA(Y)SS(Y)VHQ(Y)SSGKFDNALFHAERAIGIITHILPEDHLLLASSK(R)VKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTA(K)HYG(N)LG(R)LYQSMRKFKEAEEMHIKAIQIKEQLLGQED(Y)(E)VA(L)SVG(H)LASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLE(Y)DYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLIS known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target EWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLA(Y)SS(Y)VHQ(Y)SSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIA(I)DCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTA(K)HYG(N)LG(R)LYQ(S)MRKFKEAEEMHIKAIQIKEQLLGQEDY(E)VA(L)SVG(H)LASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLE(Y)DYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLISQ known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target EWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLA(Y)SS(Y)VHQ(Y)SSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILE(E)IA(I)DCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTA(K)HY(G)(N)LG(R)LYQ(S)MRKFKEAEEMHIKAIQIKEQLLGQEDYEVA(L)SVG(H)LA(S)LYN(Y)DMNQYENAEKLYLRSIAIGKKLFGEGYSGLE(Y)DYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLISQ known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target EWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLA(Y)SS(Y)VHQ(Y)SSGKFDNALFHAERAIGIITHILPEDHLLLASSK(R)VKALILE(E)IA(I)DCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYG(N)LG(R)LY(Q)SMRKFKEAEEMHIKAIQIKEQLLGQEDYEVA(L)SVG(H)LASLYN(Y)DMNQYENAEKLYLRSIAIGKKLFGEGYSGLE(Y)DY(R)GLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLISQ known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target EWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLA(Y)SSYVHQ(Y)SSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTA(K)HYG(N)LG(R)LY(Q)SMRKFKEAEEMHIKAIQI(K)EQLLGQEDYEVALSVG(H)LA(S)LYN(Y)DMNQYENAEKLYLRSIAIGKKLFGEGYSGLE(Y)DYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLIS known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target VGRIQMRTR(R)TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDS(Y)TTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSK(S)(G)RLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD(D)(G)(M)AVATGSWDSFLKIWN known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C=O)CCC(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target SMQFTGKNVLITGASKGIGAEIARTLASMGLKVWINYRSNAEVADALKNELEEKGYKAAVIKFDAASESDFVEAIQAIVQSDGGLSYLVNNAGVVRDKLAIKMKTEDFHHVIDNNLTSAFIGCREALKVM(S)(K)SRFGSVVNIASIIGERGNMGQTNYSASKGGMIAMSKSFAYEGAL(R)NIRFNSVTPGFIETDYVKNIPLNRLGAAKEVAEAVAFLLSDHSSYITGETLKVNGGLYM known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CC(C)C)C(C)C)C(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C=O

[INST] Generate new ligand in SMILES that have affinity to this target SMQFTGKNVLITGASKGIGAEIARTLASMGLKVWINYRSNAEVADALKNELEEKGYKAAVIKFDAASESDFVEAIQAIVQSDGGLSYLVNNAGVVRDK(L)A(I)(K)MKTEDFHHVIDNNLTSAFIGCREALKVMSKSRFGSVVNIASIIGERGNMGQTNYSASKGGMIAMSKSFAYEGALRNIRFNSVTPGFIETADYVKNIPLNRLGAAKEVAEAVAFLLSDHSSYITGETLKVNGGLYM known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C=O)CC(=O)O)C(C)C)C(C)C.CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CC(C)C)C(C)C)C(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C=O

[INST] Generate new ligand in SMILES that have affinity to this target SMQFTGKNVLITGASKGIGAEIARTLASMGLKVWINYRSNAEVADALKNELEEKGYKAAVIKFDAASESDFVEAIQAIVQSDGGLSYLVNNAGVVRDKLAIKMKTEDFHHVIDNNLTSAFIGCREALKVMS(K)SRFGSVVNIASIIGERGNMGQTNYSASKGGMIAMSKSFAYEGAL(R)NIRFNSVTPGFIETDMYVKNIPLNRLGAAKEVAEAVAFLLSDHSSYITGETLKVNGGLYM known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C=O)CC(=O)O)C(C)C)C(C)C.CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CC(C)C)C(C)C)C(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C=O

[INST] Generate new ligand in SMILES that have affinity to this target V(S)LWETVQK(W)REYRRQCQRSLTEDPPPATDLFCNRTFD(E)(Y)ACWPDGEPGSFVNVSCPW(Y)(L)PWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEEP(E)EQLLFLYII(Y)TVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFI(K)DAALKWM(Y)(S)TAAQQHQ(W)DGLLSYQDSLSCRLVFLLMQYC(V)AANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCW(T)(R)NSNMNY(W)LIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTL(R)FIK(L)FT(E)(L)SFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLE known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCCCCCCCCCCCCCC[C@@H](O)N[C@@H](CC[C@H](O)[NH2+]CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]([NH3+])Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)NCC=O)C(C)C)C([O-])O

[INST] Generate new ligand in SMILES that have affinity to this target (Q)V(M)DF(L)FEKWKLYGDQCHHNLSLLPPPTELVCNRTF(D)(K)YSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGP(R)(G)QP(W)RDA(S)QCQMDGEEIEVQKEV(A)KM(Y)SSF(Q)VM(Y)TVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLL(R)TR(Y)SQKI(G)(D)(D)TWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCW(T)(S)(N)DNMGF(W)WIL(R)FP(V)FLAILINFFIFVRIVQLLVAKLRARQMHYKFRLAKSTLTLIPLLGVHEVVFAFVGTLRSAKLFF(D)LFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRW known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C=O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target TV(S)(L)WETVQK(W)REYRRQCQRSLTEDPPPATDLFCNRTFD(E)YACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECE(E)EQ(L)LFLYII(Y)TVG(Y)ALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFI(K)DAALKWM(Y)STAAQ(Q)HQW(D)GLLSYQDSLSCRLVFLLM(Q)YC(V)AANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCW(T)(R)(N)SNMNY(W)LIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTL(R)FIKLFTE(L)SFTSFQGLMVAILYCFVNNEVQLEFRKSWERWR known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCCCCCCCCCCCCCC[C@@H](O)N[C@@H](CC[C@@H](O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC=O)[C@@H](C)CC)C(O)O

[INST] Generate new ligand in SMILES that have affinity to this target (V)S(L)WET(V)QK(W)REYRRQCQRSLTEDPPPATDLFCNRTFDE(Y)ACWPDGEPGSFVNVSCPW(Y)LPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEEPEEQ(L)LFLYII(Y)TVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFI(K)DAALKWMYSTAAQQHQ(W)DGLLSYQDSLSCRLVFLLM(Q)YC(V)AANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCW(T)(R)(N)SNMNY(W)LIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMD(E)HARGTL(R)FIKLFTE(L)SFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLE known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C=O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target (Q)(V)(M)DFLFEK(W)KLYGDQCHHNLSLLPPPTELVCNRTFD(K)(Y)SCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEV(Q)KEV(A)KM(Y)SSF(Q)VM(Y)TVG(Y)SLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASS(V)LVIDGLLRTRYSQK(I)(G)DDLSVST(W)LSDGAVAGCRVAAVFMQYG(I)VANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCW(T)S(N)DNMGF(W)WILRFP(V)FLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTL(R)SA(K)LFF(D)(L)FLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLG known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCCCCCCCCCCCCCCC(O)N[C@@H](CCC(O)[NH2+]CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]([NH3+])Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)NCC=O)C(C)C)C([O-])O

[INST] Generate new ligand in SMILES that have affinity to this target (Q)(V)(M)DF(L)FEK(W)KLYGDQCHHNLSLLPPPTELVCNRTFDK(Y)SCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQC(Q)MDGEEIEV(Q)KE(V)AKM(Y)SSF(Q)VM(Y)TVG(Y)SLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTR(Y)SQKI(G)D(D)LSVST(W)LSDGAVAGCRVAAVFM(Q)YG(I)VANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCW(T)S(N)DNMGF(W)WILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTL(R)SAK(L)FFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLG known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCCCCCCCCCCCCCCC(O)N[C@@H](CC[C@@H](O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)N[C@H](O)[C@@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC=O)[C@@H](C)CC)C(O)O

[INST] Generate new ligand in SMILES that have affinity to this target STEYKLVV(V)GADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILD(T)AGQ(E)EYSAM(R)DQY(M)RTGEGFLCVFAINNTKSFE(D)IH(H)(Y)RE(Q)IK(R)VKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEK known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@@H]1NC(O)[C@H](C)N(C)[C@@H](O)C[C@@H](C(O)N2CCCC2)N[C@H](O)[C@H](CC(C)C)N(C)C(O)[C@H](CC2CCCCC2)N(C)C(=O)[C@H](CC(C)C)NC(O)[C@H](CC[C@H]2CC[C@@H](C(F)(F)F)CC2)NC(O)CN(C)C(O)[C@H](CC2CCC(Cl)CC2)N(C)C(O)CN(C)[C@@H](O)CN(C)C1=O

[INST] Generate new ligand in SMILES that have affinity to this target HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSK(W)V(D)YSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSE(H)(L)(L)KAGANITPREARLPYLRTWF(R)TRSAIILHLSNGSVQINF(F)QD(H)T(K)LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSR known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](C(O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O[PH](O)(O)O

[INST] Generate new ligand in SMILES that have affinity to this target HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVS(K)(W)V(D)YSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRN(Y)M(S)(E)(H)(L)(L)KAGANITPARLPYLRTWF(R)TRSAIILHLSNGSVQINFFQD(H)T(K)LILCPLMAAVTYIDEK(R)DFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSR known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]C[C@@H](O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CO)C(=O)N[C@H](C(O)N1CCC[C@H]1C(=O)N[C@H](C=O)CCCNC(=N)N)[C@@H](C)O[PH](O)(O)O

[INST] Generate new ligand in SMILES that have affinity to this target SSE(L)(D)VNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGY(Y)FLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVC(T)PTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEPGRVQALRHGVRVLRAVVIAFVVCWLPYHV(R)RLM(F)CYISDEQ(W)T(P)FL(Y)DF(Y)HYF(Y)MVTNALFYVSSTINPILYNLVSANFRHIFLAT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)[NH3+])NC(=O)[C@@H](N)CCCNC(=N)[NH3+])C(=O)N[C@@H](CC(C)C)C(=O)[O-]

[INST] Generate new ligand in SMILES that have affinity to this target S(E)LDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLTVHYHLGSLALSDLLTLLLAMPVELYN(F)IWVHHPWAFGDAGCRGY(Y)FLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGL(V)C(T)PTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEPGRVQALRHGVRVLRAVVIAFVVCWLPYHV(R)RLM(F)CYISDEQ(W)TPFL(Y)DF(Y)(H)YF(Y)MVTNALFYVSSTINPILYNLVSANFRHIFLAT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)[NH3+])NC(=O)[C@@H](N)CCCNC(=N)[NH3+])C(=O)N[C@@H](CC(C)C)C(=O)[O-]

[INST] Generate new ligand in SMILES that have affinity to this target SSE(L)DVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGY(Y)FLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVC(T)PTIHTATVKVV(I)QVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEPGRVQALRHGVRVLRAVVIAFVVCWLPYHV(R)RLM(F)CYISDEQ(W)TPFL(Y)DF(Y)HYF(Y)MVTNALFYVSSTINPILYNLVSANFRHIFLAT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target QVMDFLFEKWKLYGDQCHHNLEIEVQKEVAKM(Y)SSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGL(L)RTR(Y)SQKIGDSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGF(W)WILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEEESCTTASSSLAK known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C=O

[INST] Generate new ligand in SMILES that have affinity to this target GYSL(F)PNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNT(L)(A)(H)(A)(F)APGTGLGGDAHFDEDERWTDGSSLGINFLY(A)AT(H)(Q)LG(H)SLGMG(H)SSDPNAVMY(P)TYNFKLSQDDIKGIQKLYGKRS known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)CNC(O)CC[C@H](NS(O)(O)[C@@H]1CC[C@H](Cl)C(C(F)(F)F)C1)C(O)O)C(=O)N[C@H]([C@@H](O)N1CCC[C@H]1C[C@@H](N)O)C(C)(C)C

[INST] Generate new ligand in SMILES that have affinity to this target GYSL(F)PNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDS(Y)PFDGPGNT(L)(A)(H)(A)(F)APGTGLGGDAHFDEDERWTDGSSLGINFLY(A)AT(H)(Q)LG(H)SLGMG(H)SSDPNAVMY(P)TYGNFKLSQDDIKGIQKLYGKR known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)(C)[C@H](NC(O)[C@H](CC1CCNCC1)NC(=O)CNC(O)CC[C@H](NS(O)(O)[C@@H]1CCC(Cl)[C@@H](C(F)(F)F)C1)C(O)O)[C@@H](O)N1CCC[C@H]1C[C@H](N)O