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1.0alpha7.train.1300
5162135
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1.0alpha7.train.1301
20555390
[ { "id": "1.0alpha7.train.1301.sent", "type": "sentence", "text": [ "The binding of cyclin A to CDC2 (sometimes referred to as CDK1) or CDK2 is a pre-requisite for kinase activity and promotes phosphorylation on Thr161 or Thr160 (for CDC2 or CDK2, respectively), by the CDK-activating kinase (CAK) [17-21] ." ], "offsets": [ [ 0, 252 ] ] } ]
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1.0alpha7.train.1302
1275633
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[]
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1.0alpha7.train.1303
12592334
[ { "id": "1.0alpha7.train.1303.sent", "type": "sentence", "text": [ "In particular, binding of APC to β-Catenin (Rubinfeld et al. 1993) is thought to regulate the activity of β-Catenin in the evolutionary conserved Wingless (Wnt) signal transduction pathway (for review, see Polakis 1997; Wodarz and Nusse 1998; Peifer 1999)." ], "offsets": [ [ 0, 256 ] ] } ]
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[]
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1.0alpha7.train.1304
15936957
[ { "id": "1.0alpha7.train.1304.sent", "type": "sentence", "text": [ "Axil bound not only to GSK-3beta but also to beta-catenin, and the GSK-3beta-binding site of Axil was distinct from the beta-catenin-binding site." ], "offsets": [ [ 0, 151 ] ] } ]
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1.0alpha7.train.1305
15100930
[ { "id": "1.0alpha7.train.1305.sent", "type": "sentence", "text": [ "Mutation of the CTCF binding site of mouse 3HS1 was accomplished using the QuikChange site-directed mutagenesis kit (Stratagene, La Jolla, Calif.) according to the manufacturers directions." ], "offsets": [ [ 0, 191 ] ] } ]
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1.0alpha7.train.1306
16879649
[ { "id": "1.0alpha7.train.1306.sent", "type": "sentence", "text": [ "These gels show that LC8 specifically binds to the PTH mRNA 3-UTR." ], "offsets": [ [ 0, 68 ] ] } ]
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1.0alpha7.train.1307
2062750
[ { "id": "1.0alpha7.train.1307.sent", "type": "sentence", "text": [ "Actin binding of cultured cell TMs, caldesmon, and human fascin was assayed in the following four conditions." ], "offsets": [ [ 0, 109 ] ] } ]
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[]
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1.0alpha7.train.1308
8849789
[ { "id": "1.0alpha7.train.1308.sent", "type": "sentence", "text": [ "At all concentrations tested, reduced binding of the mAb to the 230 kDa protein from FA-A cells was observed compared with mAb binding to this protein from normal or HeLa cells (Figure 5B )." ], "offsets": [ [ 0, 196 ] ] } ]
[ { "id": "1.0alpha7.train.1308.ent0_0", "type": "cell", "text": [ "FA-A" ], "offsets": [ [ 88, 92 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1308.ent1_0", "type": "reagent", "text": [ "mAb" ], "offsets": [ [ 54, 57 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1308.ent2_1", "type": "reagent", "text": [ "mAb" ], "offsets": [ [ 127, 130 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1308.ent3_0", "type": "cell", "text": [ "HeLa" ], "offsets": [ [ 171, 175 ] ], "normalized": [] } ]
[]
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[]
1.0alpha7.train.1309
18009000
[ { "id": "1.0alpha7.train.1309.sent", "type": "sentence", "text": [ "Moreover, it has been shown that mutations in the N-terminal region of actin, which yielded a change of charge, affect myosin S1 binding to actin and thereby reduce in vitro motility (Aspenström and Karlsson, 1991; Aspenström et al., 1992; Sutoh et al., 1991; Miller et al., 1996)." ], "offsets": [ [ 0, 281 ] ] } ]
[ { "id": "1.0alpha7.train.1309.ent0_0", "type": "protein", "text": [ "actin" ], "offsets": [ [ 71, 76 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "58" }, { "db_name": "hgnc", "db_id": "ACTA1" }, { "db_name": "uniprot", "db_id": "P68133" } ] }, { "id": "1.0alpha7.train.1309.ent1_1", "type": "protein", "text": [ "actin" ], "offsets": [ [ 140, 145 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "58" }, { "db_name": "hgnc", "db_id": "ACTA1" }, { "db_name": "uniprot", "db_id": "P68133" } ] }, { "id": "1.0alpha7.train.1309.ent2_0", "type": "protein-region", "text": [ "myosin S1" ], "offsets": [ [ 119, 128 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.1309.coref0", "entity_ids": [ "1.0alpha7.train.1309.ent0_0", "1.0alpha7.train.1309.ent1_1" ] }, { "id": "1.0alpha7.train.1309.coref1", "entity_ids": [ "1.0alpha7.train.1309.ent2_0" ] } ]
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1.0alpha7.train.1310
4976758
[ { "id": "1.0alpha7.train.1310.sent", "type": "sentence", "text": [ "Binding of Tubulin to Synaptotagmin I" ], "offsets": [ [ 0, 37 ] ] } ]
[ { "id": "1.0alpha7.train.1310.ent0_0", "type": "protein-family", "text": [ "Tubulin" ], "offsets": [ [ 11, 18 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000217" } ] }, { "id": "1.0alpha7.train.1310.ent1_0", "type": "protein", "text": [ "Synaptotagmin I" ], "offsets": [ [ 22, 37 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6857" }, { "db_name": "hgnc", "db_id": "SYT1" }, { "db_name": "uniprot", "db_id": "P21579" } ] } ]
[]
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1.0alpha7.train.1311
24687339
[ { "id": "1.0alpha7.train.1311.sent", "type": "sentence", "text": [ "To test whether Rad9p binds to Rad53p FHA1 or FHA2, protein extracts were prepared from untreated yeast cultures and from cultures treated either with MMS or the UV-mimetic agent 4-nitroquinoline oxide (4-NQO; this drug generates bulky DNA adducts that are repaired mainly by the base excision repair pathway [Siede et al. 1993])." ], "offsets": [ [ 0, 330 ] ] } ]
[ { "id": "1.0alpha7.train.1311.ent0_0", "type": "protein", "text": [ "Rad9p" ], "offsets": [ [ 16, 21 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "G2WAW3" } ] }, { "id": "1.0alpha7.train.1311.ent1_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 236, 239 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.1311.ent2_0", "type": "protein", "text": [ "Rad53p" ], "offsets": [ [ 31, 37 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P35187" } ] }, { "id": "1.0alpha7.train.1311.ent3_0", "type": "chemical", "text": [ "MMS" ], "offsets": [ [ 151, 154 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "4156" } ] }, { "id": "1.0alpha7.train.1311.ent4_0", "type": "chemical", "text": [ "4-NQO" ], "offsets": [ [ 203, 208 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5955" } ] }, { "id": "1.0alpha7.train.1311.ent5_0", "type": "chemical", "text": [ "4-nitroquinoline oxide" ], "offsets": [ [ 179, 201 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5955" } ] }, { "id": "1.0alpha7.train.1311.ent6_0", "type": "protein-domain", "text": [ "FHA1" ], "offsets": [ [ 38, 42 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1311.ent7_0", "type": "protein-domain", "text": [ "FHA2" ], "offsets": [ [ 46, 50 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1312
9631032
[ { "id": "1.0alpha7.train.1312.sent", "type": "sentence", "text": [ "Binding of Ponsin to Vinculin." ], "offsets": [ [ 0, 30 ] ] } ]
[ { "id": "1.0alpha7.train.1312.ent0_0", "type": "protein", "text": [ "Vinculin" ], "offsets": [ [ 21, 29 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7414" }, { "db_name": "hgnc", "db_id": "VCL" }, { "db_name": "uniprot", "db_id": "P18206" } ] }, { "id": "1.0alpha7.train.1312.ent1_0", "type": "protein", "text": [ "Ponsin" ], "offsets": [ [ 11, 17 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "10580" }, { "db_name": "hgnc", "db_id": "SORBS1" }, { "db_name": "uniprot", "db_id": "Q9BX66" } ] } ]
[]
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1.0alpha7.train.1313
9242730
[ { "id": "1.0alpha7.train.1313.sent", "type": "sentence", "text": [ "We provide evidence that the two subunits of U2AF bind to the Py-tract and distal AG to facilitate spliceosome assembly, and we identify the spliceosomal protein SPF45 as a second step splicing factor important for both recognition and utilization of the proximal 3′ ss of Sxl exon 3." ], "offsets": [ [ 0, 284 ] ] } ]
[ { "id": "1.0alpha7.train.1313.ent0_0", "type": "RNA", "text": [ "Sxl exon 3" ], "offsets": [ [ 273, 283 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1313.ent1_0", "type": "RNA", "text": [ "AG" ], "offsets": [ [ 82, 84 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1313.ent2_0", "type": "RNA", "text": [ "3′ ss" ], "offsets": [ [ 264, 269 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1313.ent3_0", "type": "protein-RNA-complex", "text": [ "spliceosome" ], "offsets": [ [ 99, 110 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1313.ent4_0", "type": "gene", "text": [ "Sxl" ], "offsets": [ [ 273, 276 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1313.ent5_0", "type": "RNA", "text": [ "Py-tract" ], "offsets": [ [ 62, 70 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1313.ent6_0", "type": "protein-complex", "text": [ "U2AF" ], "offsets": [ [ 45, 49 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1313.ent7_0", "type": "protein", "text": [ "SPF45" ], "offsets": [ [ 162, 167 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "84991" }, { "db_name": "hgnc", "db_id": "RBM17" }, { "db_name": "uniprot", "db_id": "Q96I25" } ] } ]
[]
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1.0alpha7.train.1314
3915109
[ { "id": "1.0alpha7.train.1314.sent", "type": "sentence", "text": [ "In addition to binding directly to TBP, TFIIA stabilized the binding of TBP with TATA DNA in electrophoretic mobility shift assays (EMSA) ( 14, 15)." ], "offsets": [ [ 0, 153 ] ] } ]
[ { "id": "1.0alpha7.train.1314.ent0_0", "type": "protein-complex", "text": [ "TFIIA" ], "offsets": [ [ 42, 47 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1314.ent1_0", "type": "protein", "text": [ "TBP" ], "offsets": [ [ 36, 39 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.1314.ent2_1", "type": "protein", "text": [ "TBP" ], "offsets": [ [ 75, 78 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.1314.ent3_0", "type": "assay", "text": [ "EMSA" ], "offsets": [ [ 136, 140 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1314.ent4_0", "type": "DNA", "text": [ "TATA DNA" ], "offsets": [ [ 85, 93 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1315
9428606
[ { "id": "1.0alpha7.train.1315.sent", "type": "sentence", "text": [ "The regular appearance of the crossbands within the arrays (slanted or straight) indicates that the binding of fimbrin to actin occurs only at very specific binding sites and not in a random manner." ], "offsets": [ [ 0, 200 ] ] } ]
[ { "id": "1.0alpha7.train.1315.ent0_0", "type": "protein", "text": [ "fimbrin" ], "offsets": [ [ 112, 119 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5357" }, { "db_name": "hgnc", "db_id": "PLS1" }, { "db_name": "uniprot", "db_id": "Q14651" } ] }, { "id": "1.0alpha7.train.1315.ent1_0", "type": "protein", "text": [ "actin" ], "offsets": [ [ 124, 129 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "58" }, { "db_name": "hgnc", "db_id": "ACTA1" }, { "db_name": "uniprot", "db_id": "P68133" } ] } ]
[]
[ { "id": "1.0alpha7.train.1315.coref0", "entity_ids": [ "1.0alpha7.train.1315.ent0_0" ] }, { "id": "1.0alpha7.train.1315.coref1", "entity_ids": [ "1.0alpha7.train.1315.ent1_0" ] } ]
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1.0alpha7.train.1316
2334823
[ { "id": "1.0alpha7.train.1316.sent", "type": "sentence", "text": [ "Another indication that CBP coordinates the transduction of a stimulus to the initiation complex on the PEPCK gene promoter is its susceptibility to the action of E1A, which binds CBP at the E1A binding domain located near the C-terminal of CBP (37)." ], "offsets": [ [ 0, 250 ] ] } ]
[ { "id": "1.0alpha7.train.1316.ent0_0", "type": "protein", "text": [ "E1A" ], "offsets": [ [ 163, 166 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P03255" } ] }, { "id": "1.0alpha7.train.1316.ent1_1", "type": "protein", "text": [ "E1A" ], "offsets": [ [ 191, 194 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P03255" } ] }, { "id": "1.0alpha7.train.1316.ent2_0", "type": "DNA", "text": [ "PEPCK gene promoter" ], "offsets": [ [ 104, 123 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1316.ent3_0", "type": "protein", "text": [ "CBP" ], "offsets": [ [ 24, 27 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1387" }, { "db_name": "hgnc", "db_id": "CREBBP" }, { "db_name": "uniprot", "db_id": "Q92793" } ] }, { "id": "1.0alpha7.train.1316.ent4_1", "type": "protein", "text": [ "CBP" ], "offsets": [ [ 180, 183 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1387" }, { "db_name": "hgnc", "db_id": "CREBBP" }, { "db_name": "uniprot", "db_id": "Q92793" } ] }, { "id": "1.0alpha7.train.1316.ent5_2", "type": "protein", "text": [ "CBP" ], "offsets": [ [ 241, 244 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1387" }, { "db_name": "hgnc", "db_id": "CREBBP" }, { "db_name": "uniprot", "db_id": "Q92793" } ] }, { "id": "1.0alpha7.train.1316.ent6_0", "type": "gene", "text": [ "PEPCK" ], "offsets": [ [ 104, 109 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5106" }, { "db_name": "hgnc", "db_id": "PCK2" } ] }, { "id": "1.0alpha7.train.1316.ent7_0", "type": "protein-domain", "text": [ "E1A binding domain" ], "offsets": [ [ 191, 209 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1317
18264900
[ { "id": "1.0alpha7.train.1317.sent", "type": "sentence", "text": [ "The GTP-bound form of ARF1 recruits protein coats, including the clathrin-associated adaptor proteins AP-1 and AP-3 and the nonclathrin coatomer, to membranes and initiates budding of the membrane vesicles (Lenhard et al., 1992; Donaldson and Klausner, 1994; Boman and Kahn, 1995; Dittie et al., 1996; Ooi et al., 1998; Springer et al., 1999)." ], "offsets": [ [ 0, 343 ] ] } ]
[ { "id": "1.0alpha7.train.1317.ent0_0", "type": "protein", "text": [ "GTP-bound form of ARF1" ], "offsets": [ [ 4, 26 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1317.ent1_0", "type": "protein", "text": [ "clathrin" ], "offsets": [ [ 65, 73 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1211" }, { "db_name": "hgnc", "db_id": "CLTA" }, { "db_name": "uniprot", "db_id": "P09496" } ] }, { "id": "1.0alpha7.train.1317.ent2_0", "type": "protein", "text": [ "ARF1" ], "offsets": [ [ 22, 26 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "375" }, { "db_name": "hgnc", "db_id": "ARF1" }, { "db_name": "uniprot", "db_id": "P84077" } ] }, { "id": "1.0alpha7.train.1317.ent3_0", "type": "protein-complex", "text": [ "AP-3" ], "offsets": [ [ 111, 115 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1317.ent4_0", "type": "chemical", "text": [ "GTP" ], "offsets": [ [ 4, 7 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "135398633" } ] }, { "id": "1.0alpha7.train.1317.ent5_0", "type": "protein-family", "text": [ "clathrin-associated adaptor proteins" ], "offsets": [ [ 65, 101 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1317.ent6_0", "type": "protein-complex", "text": [ "coatomer" ], "offsets": [ [ 136, 144 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1317.ent7_0", "type": "protein-complex", "text": [ "AP-1" ], "offsets": [ [ 102, 106 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1317.ent8_0", "type": "protein-family", "text": [ "protein coats" ], "offsets": [ [ 36, 49 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1318
3617477
[ { "id": "1.0alpha7.train.1318.sent", "type": "sentence", "text": [ "C, Zic2 competes with Sp1 and Sp3 binding to AR1." ], "offsets": [ [ 0, 53 ] ] } ]
[ { "id": "1.0alpha7.train.1318.ent0_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 24, 27 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.1318.ent1_0", "type": "protein", "text": [ "Sp3" ], "offsets": [ [ 33, 36 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6670" }, { "db_name": "hgnc", "db_id": "SP3" }, { "db_name": "uniprot", "db_id": "Q02447" } ] }, { "id": "1.0alpha7.train.1318.ent2_0", "type": "protein", "text": [ "Zic2" ], "offsets": [ [ 4, 8 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7546" }, { "db_name": "hgnc", "db_id": "ZIC2" }, { "db_name": "uniprot", "db_id": "O95409" } ] }, { "id": "1.0alpha7.train.1318.ent3_0", "type": "DNA", "text": [ "AR1" ], "offsets": [ [ 49, 52 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.1318.coref0", "entity_ids": [ "1.0alpha7.train.1318.ent0_0" ] }, { "id": "1.0alpha7.train.1318.coref1", "entity_ids": [ "1.0alpha7.train.1318.ent1_0" ] }, { "id": "1.0alpha7.train.1318.coref2", "entity_ids": [ "1.0alpha7.train.1318.ent2_0" ] }, { "id": "1.0alpha7.train.1318.coref3", "entity_ids": [ "1.0alpha7.train.1318.ent3_0" ] } ]
[ { "id": "1.0alpha7.train.1318.rel0s1.0alpha7.train.1318.ent2_0.o1.0alpha7.train.1318.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.1318.ent2_0", "arg2_id": "1.0alpha7.train.1318.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.1318.rel1s1.0alpha7.train.1318.ent0_0.o1.0alpha7.train.1318.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.1318.ent0_0", "arg2_id": "1.0alpha7.train.1318.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.1318.rel2s1.0alpha7.train.1318.ent1_0.o1.0alpha7.train.1318.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.1318.ent1_0", "arg2_id": "1.0alpha7.train.1318.ent3_0", "normalized": [] } ]
1.0alpha7.train.1319
12541576
[ { "id": "1.0alpha7.train.1319.sent", "type": "sentence", "text": [ "Labeled dCtBP binds weakly to the GST-Brinker fusion protein (asterisk, lane 3), whereas Groucho binds strongly to the fusion protein (arrow, lane 6)." ], "offsets": [ [ 0, 155 ] ] } ]
[ { "id": "1.0alpha7.train.1319.ent0_0", "type": "protein", "text": [ "Brinker" ], "offsets": [ [ 39, 46 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1319.ent1_0", "type": "protein-family", "text": [ "Groucho" ], "offsets": [ [ 92, 99 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR009146" } ] }, { "id": "1.0alpha7.train.1319.ent2_0", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 35, 38 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1319.ent3_0", "type": "protein", "text": [ "dCtBP" ], "offsets": [ [ 8, 13 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "O46036" } ] }, { "id": "1.0alpha7.train.1319.ent4_0", "type": "experimental-construct", "text": [ "GST-Brinker" ], "offsets": [ [ 35, 46 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1320
2173097
[ { "id": "1.0alpha7.train.1320.sent", "type": "sentence", "text": [ "Binding of native synaptotagmin I and AP-2 to the immobilized fusion proteins was assayed as described in the legend to Fig. 1." ], "offsets": [ [ 0, 131 ] ] } ]
[ { "id": "1.0alpha7.train.1320.ent0_0", "type": "protein", "text": [ "synaptotagmin I" ], "offsets": [ [ 19, 34 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6857" }, { "db_name": "hgnc", "db_id": "SYT1" }, { "db_name": "uniprot", "db_id": "P21579" } ] }, { "id": "1.0alpha7.train.1320.ent1_0", "type": "protein-complex", "text": [ "AP-2" ], "offsets": [ [ 40, 44 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.1320.coref0", "entity_ids": [ "1.0alpha7.train.1320.ent0_0" ] }, { "id": "1.0alpha7.train.1320.coref1", "entity_ids": [ "1.0alpha7.train.1320.ent1_0" ] } ]
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1.0alpha7.train.1321
1726436
[ { "id": "1.0alpha7.train.1321.sent", "type": "sentence", "text": [ "Either Cdc42 or Rac shows no significant binding to the target proteins of RhoA, such as Rho-kinase and the others described above." ], "offsets": [ [ 0, 136 ] ] } ]
[ { "id": "1.0alpha7.train.1321.ent0_0", "type": "protein", "text": [ "RhoA" ], "offsets": [ [ 79, 83 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "387" }, { "db_name": "hgnc", "db_id": "RHOA" }, { "db_name": "uniprot", "db_id": "P61586" } ] }, { "id": "1.0alpha7.train.1321.ent1_0", "type": "protein", "text": [ "Rho-kinase" ], "offsets": [ [ 94, 104 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6093" }, { "db_name": "hgnc", "db_id": "ROCK1" }, { "db_name": "uniprot", "db_id": "Q13464" } ] }, { "id": "1.0alpha7.train.1321.ent2_0", "type": "protein-family", "text": [ "Rac" ], "offsets": [ [ 18, 21 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR039027" } ] }, { "id": "1.0alpha7.train.1321.ent3_0", "type": "protein", "text": [ "Cdc42" ], "offsets": [ [ 8, 13 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "998" }, { "db_name": "hgnc", "db_id": "CDC42" }, { "db_name": "uniprot", "db_id": "P60953" } ] } ]
[]
[ { "id": "1.0alpha7.train.1321.coref0", "entity_ids": [ "1.0alpha7.train.1321.ent0_0" ] }, { "id": "1.0alpha7.train.1321.coref1", "entity_ids": [ "1.0alpha7.train.1321.ent1_0" ] }, { "id": "1.0alpha7.train.1321.coref2", "entity_ids": [ "1.0alpha7.train.1321.ent2_0" ] }, { "id": "1.0alpha7.train.1321.coref3", "entity_ids": [ "1.0alpha7.train.1321.ent3_0" ] } ]
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1.0alpha7.train.1322
11752077
[ { "id": "1.0alpha7.train.1322.sent", "type": "sentence", "text": [ "The SIN3-RPD3 complex is the predominant form of chromatin-bound SIN3 and RPD3" ], "offsets": [ [ 0, 78 ] ] } ]
[ { "id": "1.0alpha7.train.1322.ent0_0", "type": "protein", "text": [ "SIN3" ], "offsets": [ [ 4, 8 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25942" }, { "db_name": "hgnc", "db_id": "SIN3A" }, { "db_name": "uniprot", "db_id": "Q96ST3" } ] }, { "id": "1.0alpha7.train.1322.ent1_1", "type": "protein", "text": [ "SIN3" ], "offsets": [ [ 65, 69 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25942" }, { "db_name": "hgnc", "db_id": "SIN3A" }, { "db_name": "uniprot", "db_id": "Q96ST3" } ] }, { "id": "1.0alpha7.train.1322.ent2_0", "type": "protein-complex", "text": [ "SIN3-RPD3" ], "offsets": [ [ 4, 13 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1322.ent3_0", "type": "protein", "text": [ "RPD3" ], "offsets": [ [ 9, 13 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3065" }, { "db_name": "hgnc", "db_id": "HDAC1" }, { "db_name": "uniprot", "db_id": "Q13547" } ] }, { "id": "1.0alpha7.train.1322.ent4_1", "type": "protein", "text": [ "RPD3" ], "offsets": [ [ 74, 78 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3065" }, { "db_name": "hgnc", "db_id": "HDAC1" }, { "db_name": "uniprot", "db_id": "Q13547" } ] } ]
[]
[ { "id": "1.0alpha7.train.1322.coref0", "entity_ids": [ "1.0alpha7.train.1322.ent0_0", "1.0alpha7.train.1322.ent1_1" ] }, { "id": "1.0alpha7.train.1322.coref1", "entity_ids": [ "1.0alpha7.train.1322.ent2_0" ] }, { "id": "1.0alpha7.train.1322.coref2", "entity_ids": [ "1.0alpha7.train.1322.ent3_0", "1.0alpha7.train.1322.ent4_1" ] } ]
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1.0alpha7.train.1323
11752077
[ { "id": "1.0alpha7.train.1323.sent", "type": "sentence", "text": [ "The binding patterns of SIN3 and RPD3 on polytene chromosomes were highly coincident, suggesting that the SIN3-RPD3 complex is the major form of chromatin-bound SIN3 and RPD3 in salivary gland cells." ], "offsets": [ [ 0, 199 ] ] } ]
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[]
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1.0alpha7.train.1324
12544109
[ { "id": "1.0alpha7.train.1324.sent", "type": "sentence", "text": [ "The ability of Emi1 to inhibit an already activated APC would be a necessary feature for Emi1 to inactivate Cdh1 already bound to the APC at the G1-S transition." ], "offsets": [ [ 0, 167 ] ] } ]
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[]
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1.0alpha7.train.1325
11711202
[ { "id": "1.0alpha7.train.1325.sent", "type": "sentence", "text": [ "Amino acids in the GCN2 HisRS domain corresponding to key residues required for tRNA binding by class II synthetases (the m2 motif) are required for GCN2 kinase activity in vivo and in cell extracts, and for binding of tRNA to the isolated HisRS domain in vitro (Wek et al., 1995; Zhu et al., 1996). " ], "offsets": [ [ 0, 300 ] ] } ]
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[]
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1.0alpha7.train.1326
24648733
[ { "id": "1.0alpha7.train.1326.sent", "type": "sentence", "text": [ "CUGBP2 Binds In Vivo to AU Sequences in COX-2 3'UTR" ], "offsets": [ [ 0, 51 ] ] } ]
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[]
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1.0alpha7.train.1327
12923158
[ { "id": "1.0alpha7.train.1327.sent", "type": "sentence", "text": [ "Like SAS2, mutations in PCNA and CDC45 depended upon the ORC binding site of the HMR-E silencer for repression and hence did not completely bypass the silencer." ], "offsets": [ [ 0, 168 ] ] } ]
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[]
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1.0alpha7.train.1328
6189206
[ { "id": "1.0alpha7.train.1328.sent", "type": "sentence", "text": [ "Indeed, deletion of E-cadherin cytoplasmic sequence 604-615, which is required for p120 binding to E-cadherin (Fig. 2B, lanes 4 and 12; and ref. 21), also abolished E-cadherin-PS1 binding (Fig. 2B, lanes 4 and 8), showing that this sequence is critical for E-cadherin binding of both PS1 and p120." ], "offsets": [ [ 0, 297 ] ] } ]
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[]
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1.0alpha7.train.1329
9737602
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[]
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1.0alpha7.train.1330
22209757
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[]
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1.0alpha7.train.1331
1156280
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[]
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1.0alpha7.train.1332
1440099
[ { "id": "1.0alpha7.train.1332.sent", "type": "sentence", "text": [ "There was no detectable paxillin bound to GST alone immobilized on glutathione beads, indicating that the pp125FAK and CAKbeta sequences mediated binding to paxillin." ], "offsets": [ [ 0, 172 ] ] } ]
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[]
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1.0alpha7.train.1333
3671679
[ { "id": "1.0alpha7.train.1333.sent", "type": "sentence", "text": [ "The displacement of the C-tail likely removes a positively charged residue, Arg382, from the polar core, the neutralization of which per se ( R382N mutation) has been shown to enhance arrestin binding to P-Rh*, P-Rh, and Rh* ( 15)." ], "offsets": [ [ 0, 236 ] ] } ]
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[]
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1.0alpha7.train.1334
9664175
[ { "id": "1.0alpha7.train.1334.sent", "type": "sentence", "text": [ "However, an inhibition of kinesin's binding to MTs has not been directly demonstrated, a correlation of the folded conformation with the inhibited state has not been established, and the LC and HC domains responsible for the postulated inhibition have not been identified." ], "offsets": [ [ 0, 272 ] ] } ]
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[]
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1.0alpha7.train.1335
9155509
[ { "id": "1.0alpha7.train.1335.sent", "type": "sentence", "text": [ "These sequences overlap or encompass the beta-catenin binding region of E-cadherin and were hypothesized to be sequestered by beta-catenin, thereby protecting bound cadherins from degradation ( Huber et al., 2001 )." ], "offsets": [ [ 0, 224 ] ] } ]
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[]
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1.0alpha7.train.1336
22476422
[ { "id": "1.0alpha7.train.1336.sent", "type": "sentence", "text": [ "An alternative explanation is that DM molecules bind to DR αβ and proteolytic fragments of Ii independently." ], "offsets": [ [ 0, 108 ] ] } ]
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[]
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1.0alpha7.train.1337
3843752
[ { "id": "1.0alpha7.train.1337.sent", "type": "sentence", "text": [ "SNAPs act as adapters and are required for binding of NSF to the 7 S complex." ], "offsets": [ [ 0, 78 ] ] } ]
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[]
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1.0alpha7.train.1338
3267958
[ { "id": "1.0alpha7.train.1338.sent", "type": "sentence", "text": [ "The PI bound to PI-TPalpha is delivered as a substrate for phospholipase A2 ( PLA2)." ], "offsets": [ [ 0, 85 ] ] } ]
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[]
[ { "id": "1.0alpha7.train.1338.coref0", "entity_ids": [ "1.0alpha7.train.1338.ent0_0" ] }, { "id": "1.0alpha7.train.1338.coref1", "entity_ids": [ "1.0alpha7.train.1338.ent1_0", "1.0alpha7.train.1338.ent2_0" ] }, { "id": "1.0alpha7.train.1338.coref2", "entity_ids": [ "1.0alpha7.train.1338.ent3_0", "1.0alpha7.train.1338.ent4_1" ] } ]
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1.0alpha7.train.1339
24681680
[ { "id": "1.0alpha7.train.1339.sent", "type": "sentence", "text": [ "It is not clear whether PS1 binds directly to E-cadherin; their interaction might be mediated by other components of the cadherin/ cadherin system." ], "offsets": [ [ 0, 151 ] ] } ]
[ { "id": "1.0alpha7.train.1339.ent0_0", "type": "protein-family", "text": [ "cadherin" ], "offsets": [ [ 50, 58 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR039808" } ] }, { "id": "1.0alpha7.train.1339.ent1_1", "type": "protein-family", "text": [ "cadherin" ], "offsets": [ [ 124, 132 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR039808" } ] }, { "id": "1.0alpha7.train.1339.ent2_2", "type": "protein-family", "text": [ "cadherin" ], "offsets": [ [ 134, 142 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR039808" } ] }, { "id": "1.0alpha7.train.1339.ent3_0", "type": "protein", "text": [ "PS1" ], "offsets": [ [ 25, 28 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5663" }, { "db_name": "hgnc", "db_id": "PSEN1" }, { "db_name": "uniprot", "db_id": "P49768" } ] }, { "id": "1.0alpha7.train.1339.ent4_0", "type": "protein-family", "text": [ "E-cadherin" ], "offsets": [ [ 48, 58 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "999" }, { "db_name": "hgnc", "db_id": "CDH1" }, { "db_name": "uniprot", "db_id": "P12830" } ] } ]
[]
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1.0alpha7.train.1340
6265474
[ { "id": "1.0alpha7.train.1340.sent", "type": "sentence", "text": [ "To examine this phenomenon further, we assessed the binding of p300 to liganded PR." ], "offsets": [ [ 0, 85 ] ] } ]
[ { "id": "1.0alpha7.train.1340.ent0_0", "type": "protein", "text": [ "PR" ], "offsets": [ [ 82, 84 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5241" }, { "db_name": "hgnc", "db_id": "PGR" }, { "db_name": "uniprot", "db_id": "P06401" } ] }, { "id": "1.0alpha7.train.1340.ent1_0", "type": "protein", "text": [ "p300" ], "offsets": [ [ 64, 68 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2033" }, { "db_name": "hgnc", "db_id": "EP300" }, { "db_name": "uniprot", "db_id": "Q09472" } ] } ]
[]
[ { "id": "1.0alpha7.train.1340.coref0", "entity_ids": [ "1.0alpha7.train.1340.ent0_0" ] }, { "id": "1.0alpha7.train.1340.coref1", "entity_ids": [ "1.0alpha7.train.1340.ent1_0" ] } ]
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1.0alpha7.train.1341
19945814
[ { "id": "1.0alpha7.train.1341.sent", "type": "sentence", "text": [ "Since hMms2 was unable to co-elute with GST alone ( Fig. 4A, lane 2), this result showed that hMms2 was stably bound to the mUbc13 component of GST-mUbc13 on the column." ], "offsets": [ [ 0, 172 ] ] } ]
[ { "id": "1.0alpha7.train.1341.ent0_0", "type": "protein", "text": [ "hMms2" ], "offsets": [ [ 6, 11 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7336" }, { "db_name": "hgnc", "db_id": "UBE2V2" }, { "db_name": "uniprot", "db_id": "Q15819" } ] }, { "id": "1.0alpha7.train.1341.ent1_1", "type": "protein", "text": [ "hMms2" ], "offsets": [ [ 96, 101 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7336" }, { "db_name": "hgnc", "db_id": "UBE2V2" }, { "db_name": "uniprot", "db_id": "Q15819" } ] }, { "id": "1.0alpha7.train.1341.ent2_0", "type": "protein", "text": [ "mUbc13" ], "offsets": [ [ 126, 132 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1341.ent3_1", "type": "protein", "text": [ "mUbc13" ], "offsets": [ [ 151, 157 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1341.ent4_0", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 41, 44 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] }, { "id": "1.0alpha7.train.1341.ent5_1", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 147, 150 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] }, { "id": "1.0alpha7.train.1341.ent6_0", "type": "experimental-construct", "text": [ "GST-mUbc13" ], "offsets": [ [ 147, 157 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1342
15727640
[ { "id": "1.0alpha7.train.1342.sent", "type": "sentence", "text": [ "TRX binding fragments of the bxd region contain both TREs and PREs." ], "offsets": [ [ 0, 71 ] ] } ]
[ { "id": "1.0alpha7.train.1342.ent0_0", "type": "protein", "text": [ "TRX" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7295" }, { "db_name": "hgnc", "db_id": "TXN" }, { "db_name": "uniprot", "db_id": "P10599" } ] }, { "id": "1.0alpha7.train.1342.ent1_0", "type": "DNA", "text": [ "TREs" ], "offsets": [ [ 56, 60 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1342.ent2_0", "type": "DNA", "text": [ "bxd" ], "offsets": [ [ 31, 34 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1342.ent3_0", "type": "DNA", "text": [ "PREs" ], "offsets": [ [ 66, 70 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1343
4360338
[ { "id": "1.0alpha7.train.1343.sent", "type": "sentence", "text": [ "For instance, PS1 binds to beta-catenin and modulates beta-catenin signaling." ], "offsets": [ [ 0, 80 ] ] } ]
[ { "id": "1.0alpha7.train.1343.ent0_0", "type": "protein-family", "text": [ "beta-catenin" ], "offsets": [ [ 29, 41 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR013284" } ] }, { "id": "1.0alpha7.train.1343.ent1_1", "type": "protein-family", "text": [ "beta-catenin" ], "offsets": [ [ 57, 69 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR013284" } ] }, { "id": "1.0alpha7.train.1343.ent2_0", "type": "protein", "text": [ "PS1" ], "offsets": [ [ 15, 18 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5663" }, { "db_name": "hgnc", "db_id": "PSEN1" }, { "db_name": "uniprot", "db_id": "P49768" } ] } ]
[]
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1.0alpha7.train.1344
15305109
[ { "id": "1.0alpha7.train.1344.sent", "type": "sentence", "text": [ "These observations led to the hypothesis that c-Myb could be binding to S2 and mediating silencer function." ], "offsets": [ [ 0, 109 ] ] } ]
[ { "id": "1.0alpha7.train.1344.ent0_0", "type": "protein", "text": [ "c-Myb" ], "offsets": [ [ 47, 52 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4602" }, { "db_name": "hgnc", "db_id": "MYB" }, { "db_name": "uniprot", "db_id": "P10242" } ] }, { "id": "1.0alpha7.train.1344.ent1_0", "type": "DNA", "text": [ "S2" ], "offsets": [ [ 74, 76 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1345
4381665
[ { "id": "1.0alpha7.train.1345.sent", "type": "sentence", "text": [ "This is consistent with the most recent results with myosin Iβ and myosin V and supports the idea that calmodulin dissociation is not the inhibitory mechanism of calmodulin binding myosins." ], "offsets": [ [ 0, 189 ] ] } ]
[ { "id": "1.0alpha7.train.1345.ent0_0", "type": "protein-family", "text": [ "myosins" ], "offsets": [ [ 181, 188 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1345.ent1_0", "type": "protein-isoform", "text": [ "myosin Iβ" ], "offsets": [ [ 53, 62 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1345.ent2_0", "type": "protein-family", "text": [ "calmodulin" ], "offsets": [ [ 103, 113 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR039030" } ] }, { "id": "1.0alpha7.train.1345.ent3_1", "type": "protein-family", "text": [ "calmodulin" ], "offsets": [ [ 162, 172 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR039030" } ] }, { "id": "1.0alpha7.train.1345.ent4_0", "type": "protein-family", "text": [ "myosin V" ], "offsets": [ [ 67, 75 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.1345.coref0", "entity_ids": [ "1.0alpha7.train.1345.ent0_0" ] }, { "id": "1.0alpha7.train.1345.coref1", "entity_ids": [ "1.0alpha7.train.1345.ent1_0" ] }, { "id": "1.0alpha7.train.1345.coref2", "entity_ids": [ "1.0alpha7.train.1345.ent2_0", "1.0alpha7.train.1345.ent3_1" ] }, { "id": "1.0alpha7.train.1345.coref3", "entity_ids": [ "1.0alpha7.train.1345.ent4_0" ] } ]
[]
1.0alpha7.train.1346
1464837
[ { "id": "1.0alpha7.train.1346.sent", "type": "sentence", "text": [ "The inhibition of Sp1 binding by EDTA was not abrogated by the addition of ZnCl2." ], "offsets": [ [ 0, 83 ] ] } ]
[ { "id": "1.0alpha7.train.1346.ent0_0", "type": "chemical", "text": [ "ZnCl2" ], "offsets": [ [ 77, 82 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5727" } ] }, { "id": "1.0alpha7.train.1346.ent1_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 19, 22 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.1346.ent2_0", "type": "reagent", "text": [ "EDTA" ], "offsets": [ [ 35, 39 ] ], "normalized": [] } ]
[]
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[]
1.0alpha7.train.1347
6607179
[ { "id": "1.0alpha7.train.1347.sent", "type": "sentence", "text": [ "This effect might be due to inhibition of TFIIA binding to TBP because TFIIA and TAND-2 competitively bind to TBP ( 18)." ], "offsets": [ [ 0, 124 ] ] } ]
[ { "id": "1.0alpha7.train.1347.ent0_0", "type": "protein-complex", "text": [ "TFIIA" ], "offsets": [ [ 43, 48 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1347.ent1_1", "type": "protein-complex", "text": [ "TFIIA" ], "offsets": [ [ 74, 79 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1347.ent2_0", "type": "protein", "text": [ "TBP" ], "offsets": [ [ 61, 64 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.1347.ent3_1", "type": "protein", "text": [ "TBP" ], "offsets": [ [ 114, 117 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.1347.ent4_0", "type": "protein-domain", "text": [ "TAND-2" ], "offsets": [ [ 84, 90 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.1347.coref0", "entity_ids": [ "1.0alpha7.train.1347.ent0_0", "1.0alpha7.train.1347.ent1_1" ] }, { "id": "1.0alpha7.train.1347.coref1", "entity_ids": [ "1.0alpha7.train.1347.ent2_0", "1.0alpha7.train.1347.ent3_1" ] }, { "id": "1.0alpha7.train.1347.coref2", "entity_ids": [ "1.0alpha7.train.1347.ent4_0" ] } ]
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1.0alpha7.train.1348
2692783
[ { "id": "1.0alpha7.train.1348.sent", "type": "sentence", "text": [ "Direct Interaction of Axin with Plakoglobin" ], "offsets": [ [ 0, 43 ] ] } ]
[ { "id": "1.0alpha7.train.1348.ent0_0", "type": "protein", "text": [ "Axin" ], "offsets": [ [ 22, 26 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8312" }, { "db_name": "hgnc", "db_id": "AXIN1" }, { "db_name": "uniprot", "db_id": "O15169" } ] }, { "id": "1.0alpha7.train.1348.ent1_0", "type": "protein", "text": [ "Plakoglobin" ], "offsets": [ [ 32, 43 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3728" }, { "db_name": "hgnc", "db_id": "JUP" }, { "db_name": "uniprot", "db_id": "P14923" } ] } ]
[]
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1.0alpha7.train.1349
2692783
[ { "id": "1.0alpha7.train.1349.sent", "type": "sentence", "text": [ "To examine whether Axin binds directly to plakoglobin, GST-plakoglobin (full length) and MBP-rAxin (full length) were purified (Fig.2 B)." ], "offsets": [ [ 0, 137 ] ] } ]
[ { "id": "1.0alpha7.train.1349.ent0_0", "type": "protein", "text": [ "Axin" ], "offsets": [ [ 19, 23 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1349.ent1_0", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 55, 58 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1349.ent2_0", "type": "experimental-construct", "text": [ "MBP-rAxin" ], "offsets": [ [ 89, 98 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1349.ent3_0", "type": "protein", "text": [ "rAxin" ], "offsets": [ [ 93, 98 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1349.ent4_0", "type": "experimental-construct", "text": [ "GST-plakoglobin" ], "offsets": [ [ 55, 70 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1349.ent5_0", "type": "protein", "text": [ "plakoglobin" ], "offsets": [ [ 42, 53 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3728" }, { "db_name": "hgnc", "db_id": "JUP" }, { "db_name": "uniprot", "db_id": "P14923" } ] }, { "id": "1.0alpha7.train.1349.ent6_1", "type": "protein", "text": [ "plakoglobin" ], "offsets": [ [ 59, 70 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3728" }, { "db_name": "hgnc", "db_id": "JUP" }, { "db_name": "uniprot", "db_id": "P14923" } ] }, { "id": "1.0alpha7.train.1349.ent7_0", "type": "experiment-tag", "text": [ "MBP" ], "offsets": [ [ 89, 92 ] ], "normalized": [] } ]
[]
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[ { "id": "1.0alpha7.train.1349.rel0s1.0alpha7.train.1349.ent0_0.o1.0alpha7.train.1349.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.1349.ent0_0", "arg2_id": "1.0alpha7.train.1349.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.1349.rel0s1.0alpha7.train.1349.ent0_0.o1.0alpha7.train.1349.ent6_1", "type": "bind", "arg1_id": "1.0alpha7.train.1349.ent0_0", "arg2_id": "1.0alpha7.train.1349.ent6_1", "normalized": [] }, { "id": "1.0alpha7.train.1349.rel1s1.0alpha7.train.1349.ent1_0.o1.0alpha7.train.1349.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.1349.ent1_0", "arg2_id": "1.0alpha7.train.1349.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.1349.rel1s1.0alpha7.train.1349.ent1_0.o1.0alpha7.train.1349.ent6_1", "type": "bind", "arg1_id": "1.0alpha7.train.1349.ent1_0", "arg2_id": "1.0alpha7.train.1349.ent6_1", "normalized": [] }, { "id": "1.0alpha7.train.1349.rel2s1.0alpha7.train.1349.ent3_0.o1.0alpha7.train.1349.ent7_0", "type": "bind", "arg1_id": "1.0alpha7.train.1349.ent3_0", "arg2_id": "1.0alpha7.train.1349.ent7_0", "normalized": [] } ]
1.0alpha7.train.1350
12769611
[ { "id": "1.0alpha7.train.1350.sent", "type": "sentence", "text": [ "p50 and Bruno can bind the BRE independently, as the BRE is bound by p50 in extracts that lack Bruno protein (Kim-Ha et al. 1995 ), and a mutant RNA containing BRE consensus sequences binds Bruno efficiently but not p50." ], "offsets": [ [ 0, 230 ] ] } ]
[ { "id": "1.0alpha7.train.1350.ent0_0", "type": "RNA", "text": [ "RNA" ], "offsets": [ [ 152, 155 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1350.ent1_0", "type": "RNA", "text": [ "BRE" ], "offsets": [ [ 29, 32 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1350.ent2_1", "type": "RNA", "text": [ "BRE" ], "offsets": [ [ 56, 59 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1350.ent3_2", "type": "RNA", "text": [ "BRE" ], "offsets": [ [ 168, 171 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1350.ent4_0", "type": "protein", "text": [ "p50" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4790" }, { "db_name": "hgnc", "db_id": "NFKB1" }, { "db_name": "uniprot", "db_id": "P19838" } ] }, { "id": "1.0alpha7.train.1350.ent5_1", "type": "protein", "text": [ "p50" ], "offsets": [ [ 73, 76 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4790" }, { "db_name": "hgnc", "db_id": "NFKB1" }, { "db_name": "uniprot", "db_id": "P19838" } ] }, { "id": "1.0alpha7.train.1350.ent6_2", "type": "protein", "text": [ "p50" ], "offsets": [ [ 226, 229 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4790" }, { "db_name": "hgnc", "db_id": "NFKB1" }, { "db_name": "uniprot", "db_id": "P19838" } ] }, { "id": "1.0alpha7.train.1350.ent7_0", "type": "protein", "text": [ "Bruno" ], "offsets": [ [ 9, 14 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1350.ent8_1", "type": "protein", "text": [ "Bruno" ], "offsets": [ [ 100, 105 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1350.ent9_2", "type": "protein", "text": [ "Bruno" ], "offsets": [ [ 199, 204 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.1350.coref0", "entity_ids": [ "1.0alpha7.train.1350.ent0_0" ] }, { "id": "1.0alpha7.train.1350.coref1", "entity_ids": [ "1.0alpha7.train.1350.ent1_0", "1.0alpha7.train.1350.ent2_1", "1.0alpha7.train.1350.ent3_2" ] }, { "id": "1.0alpha7.train.1350.coref2", "entity_ids": [ "1.0alpha7.train.1350.ent4_0", "1.0alpha7.train.1350.ent5_1", "1.0alpha7.train.1350.ent6_2" ] }, { "id": "1.0alpha7.train.1350.coref3", "entity_ids": [ "1.0alpha7.train.1350.ent7_0", "1.0alpha7.train.1350.ent8_1", "1.0alpha7.train.1350.ent9_2" ] } ]
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1.0alpha7.train.1351
15742850
[ { "id": "1.0alpha7.train.1351.sent", "type": "sentence", "text": [ "Furthermore, no binding of GST with MBP-RBP26 or MBP-RBP4 is observed (data not shown)." ], "offsets": [ [ 0, 90 ] ] } ]
[ { "id": "1.0alpha7.train.1351.ent0_0", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 28, 31 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] }, { "id": "1.0alpha7.train.1351.ent1_0", "type": "experimental-construct", "text": [ "MBP-RBP4" ], "offsets": [ [ 52, 60 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1351.ent2_0", "type": "experimental-construct", "text": [ "MBP-RBP26" ], "offsets": [ [ 38, 47 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1351.ent3_0", "type": "protein", "text": [ "RBP26" ], "offsets": [ [ 42, 47 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "A0A3L6LAD9" } ] }, { "id": "1.0alpha7.train.1351.ent4_0", "type": "protein", "text": [ "RBP4" ], "offsets": [ [ 56, 60 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5950" }, { "db_name": "hgnc", "db_id": "RBP4" } ] }, { "id": "1.0alpha7.train.1351.ent5_0", "type": "experiment-tag", "text": [ "MBP" ], "offsets": [ [ 38, 41 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1351.ent6_1", "type": "experiment-tag", "text": [ "MBP" ], "offsets": [ [ 52, 55 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.1351.coref0", "entity_ids": [ "1.0alpha7.train.1351.ent0_0" ] }, { "id": "1.0alpha7.train.1351.coref1", "entity_ids": [ "1.0alpha7.train.1351.ent1_0" ] }, { "id": "1.0alpha7.train.1351.coref2", "entity_ids": [ "1.0alpha7.train.1351.ent2_0" ] }, { "id": "1.0alpha7.train.1351.coref3", "entity_ids": [ "1.0alpha7.train.1351.ent3_0" ] }, { "id": "1.0alpha7.train.1351.coref4", "entity_ids": [ "1.0alpha7.train.1351.ent4_0" ] }, { "id": "1.0alpha7.train.1351.coref5", "entity_ids": [ "1.0alpha7.train.1351.ent5_0", "1.0alpha7.train.1351.ent6_1" ] } ]
[ { "id": "1.0alpha7.train.1351.rel0s1.0alpha7.train.1351.ent0_0.o1.0alpha7.train.1351.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.1351.ent0_0", "arg2_id": "1.0alpha7.train.1351.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.1351.rel1s1.0alpha7.train.1351.ent0_0.o1.0alpha7.train.1351.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.1351.ent0_0", "arg2_id": "1.0alpha7.train.1351.ent1_0", "normalized": [] } ]
1.0alpha7.train.1352
563289
[ { "id": "1.0alpha7.train.1352.sent", "type": "sentence", "text": [ "A model depicting binding of adducin tails to actin and capping the barbed end of the actin filament by adducin heads is shown in Fig. 5 ." ], "offsets": [ [ 0, 145 ] ] } ]
[ { "id": "1.0alpha7.train.1352.ent0_0", "type": "protein", "text": [ "actin" ], "offsets": [ [ 49, 54 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "58" }, { "db_name": "hgnc", "db_id": "ACTA1" }, { "db_name": "uniprot", "db_id": "P68133" } ] }, { "id": "1.0alpha7.train.1352.ent1_1", "type": "protein", "text": [ "actin" ], "offsets": [ [ 90, 95 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "58" }, { "db_name": "hgnc", "db_id": "ACTA1" }, { "db_name": "uniprot", "db_id": "P68133" } ] }, { "id": "1.0alpha7.train.1352.ent2_0", "type": "protein-family", "text": [ "adducin" ], "offsets": [ [ 31, 38 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR027766" } ] }, { "id": "1.0alpha7.train.1352.ent3_1", "type": "protein-family", "text": [ "adducin" ], "offsets": [ [ 110, 117 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR027766" } ] } ]
[]
[ { "id": "1.0alpha7.train.1352.coref0", "entity_ids": [ "1.0alpha7.train.1352.ent0_0", "1.0alpha7.train.1352.ent1_1" ] }, { "id": "1.0alpha7.train.1352.coref1", "entity_ids": [ "1.0alpha7.train.1352.ent2_0", "1.0alpha7.train.1352.ent3_1" ] } ]
[ { "id": "1.0alpha7.train.1352.rel0s1.0alpha7.train.1352.ent0_0.o1.0alpha7.train.1352.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.1352.ent0_0", "arg2_id": "1.0alpha7.train.1352.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.1352.rel0s1.0alpha7.train.1352.ent0_0.o1.0alpha7.train.1352.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.1352.ent0_0", "arg2_id": "1.0alpha7.train.1352.ent3_1", "normalized": [] }, { "id": "1.0alpha7.train.1352.rel0s1.0alpha7.train.1352.ent1_1.o1.0alpha7.train.1352.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.1352.ent1_1", "arg2_id": "1.0alpha7.train.1352.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.1352.rel0s1.0alpha7.train.1352.ent1_1.o1.0alpha7.train.1352.ent3_1", "type": "bind", "arg1_id": "1.0alpha7.train.1352.ent1_1", "arg2_id": "1.0alpha7.train.1352.ent3_1", "normalized": [] } ]
1.0alpha7.train.1353
20417780
[ { "id": "1.0alpha7.train.1353.sent", "type": "sentence", "text": [ "Since transcriptional repression of E2F-responsive genes by Suv39H1 is most likely mediated through HP1 binding to the methylated histone H3 ( 28), it could be envisioned that HP1 recruitment also requires histone deacetylases." ], "offsets": [ [ 0, 233 ] ] } ]
[ { "id": "1.0alpha7.train.1353.ent0_0", "type": "protein", "text": [ "Suv39H1" ], "offsets": [ [ 62, 69 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6839" }, { "db_name": "hgnc", "db_id": "SUV39H1" }, { "db_name": "uniprot", "db_id": "O43463" } ] }, { "id": "1.0alpha7.train.1353.ent1_0", "type": "protein-family", "text": [ "H3" ], "offsets": [ [ 142, 144 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000164" } ] }, { "id": "1.0alpha7.train.1353.ent2_0", "type": "protein-family", "text": [ "E2F" ], "offsets": [ [ 37, 40 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR015633" } ] }, { "id": "1.0alpha7.train.1353.ent3_0", "type": "protein", "text": [ "HP1" ], "offsets": [ [ 103, 106 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "23468" }, { "db_name": "hgnc", "db_id": "CBX5" }, { "db_name": "uniprot", "db_id": "P45973" } ] }, { "id": "1.0alpha7.train.1353.ent4_1", "type": "protein", "text": [ "HP1" ], "offsets": [ [ 181, 184 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "23468" }, { "db_name": "hgnc", "db_id": "CBX5" }, { "db_name": "uniprot", "db_id": "P45973" } ] } ]
[]
[ { "id": "1.0alpha7.train.1353.coref0", "entity_ids": [ "1.0alpha7.train.1353.ent0_0" ] }, { "id": "1.0alpha7.train.1353.coref1", "entity_ids": [ "1.0alpha7.train.1353.ent1_0" ] }, { "id": "1.0alpha7.train.1353.coref2", "entity_ids": [ "1.0alpha7.train.1353.ent2_0" ] }, { "id": "1.0alpha7.train.1353.coref3", "entity_ids": [ "1.0alpha7.train.1353.ent3_0", "1.0alpha7.train.1353.ent4_1" ] } ]
[ { "id": "1.0alpha7.train.1353.rel0s1.0alpha7.train.1353.ent1_0.o1.0alpha7.train.1353.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.1353.ent1_0", "arg2_id": "1.0alpha7.train.1353.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.1353.rel0s1.0alpha7.train.1353.ent1_0.o1.0alpha7.train.1353.ent4_1", "type": "bind", "arg1_id": "1.0alpha7.train.1353.ent1_0", "arg2_id": "1.0alpha7.train.1353.ent4_1", "normalized": [] } ]
1.0alpha7.train.1354
43371
[ { "id": "1.0alpha7.train.1354.sent", "type": "sentence", "text": [ "However, a recent report on the oligonucleotide d(GGGTTGG), conjugated to an intercalating agent, states that this oligonucleotide, which also has about 70% Gs but only two GpT or TpG steps, binds to the purine strand in an antiparallel orientation (39)." ], "offsets": [ [ 0, 254 ] ] } ]
[ { "id": "1.0alpha7.train.1354.ent0_0", "type": "chemical", "text": [ "GpT" ], "offsets": [ [ 173, 176 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1354.ent1_0", "type": "chemical", "text": [ "TpG" ], "offsets": [ [ 180, 183 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1354.ent2_0", "type": "chemical", "text": [ "Gs" ], "offsets": [ [ 157, 159 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1354.ent3_0", "type": "chemical", "text": [ "d(GGGTTGG)" ], "offsets": [ [ 48, 58 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.1354.coref0", "entity_ids": [ "1.0alpha7.train.1354.ent0_0" ] }, { "id": "1.0alpha7.train.1354.coref1", "entity_ids": [ "1.0alpha7.train.1354.ent1_0" ] }, { "id": "1.0alpha7.train.1354.coref2", "entity_ids": [ "1.0alpha7.train.1354.ent2_0" ] }, { "id": "1.0alpha7.train.1354.coref3", "entity_ids": [ "1.0alpha7.train.1354.ent3_0" ] } ]
[]
1.0alpha7.train.1355
5486327
[ { "id": "1.0alpha7.train.1355.sent", "type": "sentence", "text": [ "The affinity of Lc753-893, the II-III loop that links domains II-III of the CaV1.2 α1 subunit (32) and GST-C2A wt (31) or GST-C2A* mutant (17) was determined using (i) Biacore 3000 system (Biacore AB) based on surface plasmon resonance methodology and (ii) glutathione-S-transferase (GST) binding assay using GST-agarose beads." ], "offsets": [ [ 0, 327 ] ] } ]
[ { "id": "1.0alpha7.train.1355.ent0_0", "type": "brand", "text": [ "Biacore AB" ], "offsets": [ [ 189, 199 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1355.ent1_0", "type": "protein-region", "text": [ "II-III loop" ], "offsets": [ [ 31, 42 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1355.ent2_0", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 103, 106 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] }, { "id": "1.0alpha7.train.1355.ent3_1", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 122, 125 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] }, { "id": "1.0alpha7.train.1355.ent4_2", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 284, 287 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] }, { "id": "1.0alpha7.train.1355.ent5_3", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 309, 312 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] }, { "id": "1.0alpha7.train.1355.ent6_0", "type": "protein-domain", "text": [ "C2A" ], "offsets": [ [ 107, 110 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1355.ent7_1", "type": "protein-domain", "text": [ "C2A" ], "offsets": [ [ 126, 129 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1355.ent8_0", "type": "protein-domain", "text": [ "C2A wt" ], "offsets": [ [ 107, 113 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1355.ent9_0", "type": "protein-family", "text": [ "glutathione-S-transferase" ], "offsets": [ [ 257, 282 ] ], "normalized": [ { "db_name": "intenz", "db_id": "https://www.ebi.ac.uk/intenz/query?cmd" } ] }, { "id": "1.0alpha7.train.1355.ent10_0", "type": "protein-region", "text": [ "Lc753-893" ], "offsets": [ [ 16, 25 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1355.ent11_0", "type": "experimental-construct", "text": [ "GST-C2A* mutant" ], "offsets": [ [ 122, 137 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1355.ent12_0", "type": "protein-domain", "text": [ "C2A* mutant" ], "offsets": [ [ 126, 137 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1355.ent13_0", "type": "protein", "text": [ "CaV1.2 α1" ], "offsets": [ [ 76, 85 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1355.ent14_0", "type": "reagent", "text": [ "GST-agarose beads" ], "offsets": [ [ 309, 326 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1355.ent15_0", "type": "experimental-construct", "text": [ "GST-C2A wt" ], "offsets": [ [ 103, 113 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1355.ent16_0", "type": "protein-domain", "text": [ "domains II-III" ], "offsets": [ [ 54, 68 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1356
15794464
[ { "id": "1.0alpha7.train.1356.sent", "type": "sentence", "text": [ " To ask whether phosphorylation of pRB under the control of a heterologous KRXL motif was functionally significant, asynchronously growing SAOS2 cells were transfected with plasmids encoding HA-tagged pRB(1-864) fused to 12 amino acids (GRPPVKRRLDLE) spanning the wild-type cyclin-cdk2 binding sequence of E2F1 [pRB(1-864) E21yWT] or HA-tagged pRB(1-928) in the presence or absence of plasmids encoding cyclin A and cdk2. " ], "offsets": [ [ 0, 431 ] ] } ]
[ { "id": "1.0alpha7.train.1356.ent0_0", "type": "experimental-construct", "text": [ "HA-tagged pRB" ], "offsets": [ [ 193, 206 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1356.ent1_0", "type": "cell", "text": [ "SAOS2" ], "offsets": [ [ 140, 145 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1356.ent2_0", "type": "protein", "text": [ "E2F1" ], "offsets": [ [ 310, 314 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1869" }, { "db_name": "hgnc", "db_id": "E2F1" }, { "db_name": "uniprot", "db_id": "Q01094" } ] }, { "id": "1.0alpha7.train.1356.ent3_0", "type": "protein", "text": [ "pRB" ], "offsets": [ [ 36, 39 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5925" }, { "db_name": "hgnc", "db_id": "RB1" }, { "db_name": "uniprot", "db_id": "P06400" } ] }, { "id": "1.0alpha7.train.1356.ent4_1", "type": "protein", "text": [ "pRB" ], "offsets": [ [ 203, 206 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5925" }, { "db_name": "hgnc", "db_id": "RB1" }, { "db_name": "uniprot", "db_id": "P06400" } ] }, { "id": "1.0alpha7.train.1356.ent5_2", "type": "protein", "text": [ "pRB" ], "offsets": [ [ 316, 319 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5925" }, { "db_name": "hgnc", "db_id": "RB1" }, { "db_name": "uniprot", "db_id": "P06400" } ] }, { "id": "1.0alpha7.train.1356.ent6_3", "type": "protein", "text": [ "pRB" ], "offsets": [ [ 349, 352 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5925" }, { "db_name": "hgnc", "db_id": "RB1" }, { "db_name": "uniprot", "db_id": "P06400" } ] }, { "id": "1.0alpha7.train.1356.ent7_0", "type": "protein-family", "text": [ "cyclin" ], "offsets": [ [ 277, 283 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1356.ent8_1", "type": "protein-family", "text": [ "cyclin" ], "offsets": [ [ 410, 416 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1356.ent9_0", "type": "protein-motif", "text": [ "KRXL" ], "offsets": [ [ 76, 80 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1356.ent10_0", "type": "protein-region", "text": [ "[pRB(1-864) E21yWT]" ], "offsets": [ [ 315, 334 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1356.ent11_0", "type": "protein", "text": [ "cdk2" ], "offsets": [ [ 284, 288 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1017" }, { "db_name": "hgnc", "db_id": "CDK2" }, { "db_name": "uniprot", "db_id": "P24941" } ] }, { "id": "1.0alpha7.train.1356.ent12_1", "type": "protein", "text": [ "cdk2" ], "offsets": [ [ 424, 428 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1017" }, { "db_name": "hgnc", "db_id": "CDK2" }, { "db_name": "uniprot", "db_id": "P24941" } ] }, { "id": "1.0alpha7.train.1356.ent13_0", "type": "protein-complex", "text": [ "cyclin-cdk2" ], "offsets": [ [ 277, 288 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1356.ent14_0", "type": "peptide", "text": [ "GRPPVKRRLDLE" ], "offsets": [ [ 239, 251 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1356.ent15_0", "type": "protein", "text": [ "cyclin A" ], "offsets": [ [ 410, 418 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8900" }, { "db_name": "hgnc", "db_id": "CCNA1" }, { "db_name": "uniprot", "db_id": "P78396" } ] } ]
[]
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1.0alpha7.train.1357
11366838
[ { "id": "1.0alpha7.train.1357.sent", "type": "sentence", "text": [ "This indicates that DR4 binds to DM-DO with higher affinity and/or stability than to DM." ], "offsets": [ [ 0, 91 ] ] } ]
[ { "id": "1.0alpha7.train.1357.ent0_0", "type": "protein-complex", "text": [ "DM-DO" ], "offsets": [ [ 35, 40 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1357.ent1_0", "type": "protein", "text": [ "DO" ], "offsets": [ [ 38, 40 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1357.ent2_0", "type": "protein", "text": [ "DM" ], "offsets": [ [ 35, 37 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1357.ent3_1", "type": "protein", "text": [ "DM" ], "offsets": [ [ 88, 90 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1357.ent4_0", "type": "protein-isoform", "text": [ "DR4" ], "offsets": [ [ 21, 24 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1358
22131794
[ { "id": "1.0alpha7.train.1358.sent", "type": "sentence", "text": [ " Since the binding affinity of dI for NADH is ~10-fold greater than that for NAD+ [ 46], the affinity of dIII for NADPH in the E** state (signified ``>>'') is 100-fold greater than that for NADP+ (signified ``>'). " ], "offsets": [ [ 0, 220 ] ] } ]
[ { "id": "1.0alpha7.train.1358.ent0_0", "type": "chemical", "text": [ "NAD+" ], "offsets": [ [ 79, 83 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "925" } ] }, { "id": "1.0alpha7.train.1358.ent1_0", "type": "chemical", "text": [ "NADH" ], "offsets": [ [ 40, 44 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "439153" } ] }, { "id": "1.0alpha7.train.1358.ent2_0", "type": "protein", "text": [ "E**" ], "offsets": [ [ 132, 135 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1358.ent3_0", "type": "protein-domain", "text": [ "dI" ], "offsets": [ [ 32, 34 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1358.ent4_0", "type": "chemical", "text": [ "NADPH" ], "offsets": [ [ 118, 123 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5885" } ] }, { "id": "1.0alpha7.train.1358.ent5_0", "type": "chemical", "text": [ "NADP+" ], "offsets": [ [ 195, 200 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5885" } ] }, { "id": "1.0alpha7.train.1358.ent6_0", "type": "protein-domain", "text": [ "dIII" ], "offsets": [ [ 108, 112 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1359
15771263
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[]
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1.0alpha7.train.1360
2806168
[ { "id": "1.0alpha7.train.1360.sent", "type": "sentence", "text": [ "The distances between the S2 and S4 and the S1 and S2 actin-binding sites on the filament indicate that there must be large scale conformational changes before S1, S2, and S4 can simultaneously bind actin." ], "offsets": [ [ 0, 213 ] ] } ]
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[]
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1.0alpha7.train.1361
4240494
[ { "id": "1.0alpha7.train.1361.sent", "type": "sentence", "text": [ "As for p41 and p44, p97 was detected bound to the AP-1 DNA beads if nuclear extracts were directly subjected to DNA affinity chromatography, or if they were preincubated with mut AP-1 oligo, but not if they were preincubated with wt AP-1 oligo." ], "offsets": [ [ 0, 250 ] ] } ]
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[]
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[]
1.0alpha7.train.1362
3992517
[ { "id": "1.0alpha7.train.1362.sent", "type": "sentence", "text": [ "Similarly, activin binds to either ActRII or ActRIIB, with activin type IB receptor (ALK4) or possibly ActRI (ALK2) then joining the complex ( 14-19)." ], "offsets": [ [ 0, 155 ] ] } ]
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[]
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1.0alpha7.train.1363
15252155
[ { "id": "1.0alpha7.train.1363.sent", "type": "sentence", "text": [ "Binding of U7 snRNP to the pre-mRNA occurs by base pairing between the 5' end of U7 snRNA and the HDE ( 5, 48) and is stabilized by interaction of SLBP bound to the histone pre-mRNA with a component of U7 snRNP, most likely hZFP100 ( 9)." ], "offsets": [ [ 0, 237 ] ] } ]
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[]
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1.0alpha7.train.1364
11366808
[ { "id": "1.0alpha7.train.1364.sent", "type": "sentence", "text": [ "Moreover, in lysosomal compartments of B cells, a considerable fraction of DM remains bound to empty DR dimers in order to prevent their aggregation or denaturation at low pH (Denzin et al., 1996 ; Kropshofer et al., 1997b )." ], "offsets": [ [ 0, 232 ] ] } ]
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[]
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1.0alpha7.train.1365
3431569
[ { "id": "1.0alpha7.train.1365.sent", "type": "sentence", "text": [ "This fact suggests that, in addition to blocking the “adhesive sites” of desmosomal cadherins with anti-Dsg PV IgG, binding of pemphigus antibodies to KC initiates an intracellular signaling cascade that can lead to disassembly of other types of intercellular junctions comprised of classical cadherins, such as tight junctions, adherence junctions, and gap junctions, all of which can mediate keratinocyte cell-to-cell adhesion at low Ca2+ (51-53)." ], "offsets": [ [ 0, 449 ] ] } ]
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[]
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[]
1.0alpha7.train.1366
12520239
[ { "id": "1.0alpha7.train.1366.sent", "type": "sentence", "text": [ " Importantly, the mutant that does not affect binding of PcG proteins to PRE, E(z)Trm, retained HMT activity which appears indistinguishable from the wild-type protein (Fig. ​4C). " ], "offsets": [ [ 0, 180 ] ] } ]
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[]
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1.0alpha7.train.1367
9637330
[ { "id": "1.0alpha7.train.1367.sent", "type": "sentence", "text": [ "If γ-tubulin binds a guanine nucleotide, it will be important to determine whether nucleotide exchange and hydrolysis contribute to its ability to assemble, disassemble, nucleate, or release MTs, or whether the bound nucleotide has a structural role, as is the case for α-tubulin." ], "offsets": [ [ 0, 280 ] ] } ]
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[]
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1.0alpha7.train.1368
19726165
[ { "id": "1.0alpha7.train.1368.sent", "type": "sentence", "text": [ "However, in the developing R4, Fmi, Diego, and Dsh form a complex in which Pk and Stbm are bound to Dsh, thereby preventing N from binding to Dsh." ], "offsets": [ [ 0, 153 ] ] } ]
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[]
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1.0alpha7.train.1369
15993346
[ { "id": "1.0alpha7.train.1369.sent", "type": "sentence", "text": [ " The binding of Raf-1 to Rb occurs subsequent to mitogen stimulation, and this interaction can be detected only in proliferating cells. " ], "offsets": [ [ 0, 139 ] ] } ]
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[]
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1.0alpha7.train.1370
9509068
[ { "id": "1.0alpha7.train.1370.sent", "type": "sentence", "text": [ " Our data indicate that Tiam1 binds to ankyrin (ANK1; Fig 4 B, a) directly. " ], "offsets": [ [ 0, 81 ] ] } ]
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[]
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1.0alpha7.train.1371
9631083
[ { "id": "1.0alpha7.train.1371.sent", "type": "sentence", "text": [ "Binding regions of ponsin and vinculin." ], "offsets": [ [ 0, 42 ] ] } ]
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[]
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1.0alpha7.train.1372
25196673
[ { "id": "1.0alpha7.train.1372.sent", "type": "sentence", "text": [ "(A) Specific binding of tomosyn to syntaxin-1a." ], "offsets": [ [ 0, 49 ] ] } ]
[ { "id": "1.0alpha7.train.1372.ent0_0", "type": "protein", "text": [ "syntaxin-1a" ], "offsets": [ [ 37, 48 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6804" }, { "db_name": "hgnc", "db_id": "STX1A" }, { "db_name": "uniprot", "db_id": "Q16623" } ] }, { "id": "1.0alpha7.train.1372.ent1_0", "type": "protein", "text": [ "tomosyn" ], "offsets": [ [ 25, 32 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "134957" }, { "db_name": "hgnc", "db_id": "STXBP5" }, { "db_name": "uniprot", "db_id": "Q5T5C0" } ] } ]
[]
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1.0alpha7.train.1373
2434919
[ { "id": "1.0alpha7.train.1373.sent", "type": "sentence", "text": [ " Consistent with the in vitro results, the middle region of Axin confers GSK-3beta binding. " ], "offsets": [ [ 0, 96 ] ] } ]
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[]
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1.0alpha7.train.1374
15977855
[ { "id": "1.0alpha7.train.1374.sent", "type": "sentence", "text": [ "alpha-NAC stabilizes the binding of c-Jun to the AP-1 site." ], "offsets": [ [ 0, 61 ] ] } ]
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[]
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1.0alpha7.train.1375
19438591
[ { "id": "1.0alpha7.train.1375.sent", "type": "sentence", "text": [ "In vitro experiments have shown that Cdc42 binds to the GBD of Drf3 in two-hybrid assays and in a GTP-dependent manner [11] ." ], "offsets": [ [ 0, 131 ] ] } ]
[ { "id": "1.0alpha7.train.1375.ent0_0", "type": "chemical", "text": [ "GTP" ], "offsets": [ [ 102, 105 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "135398633" } ] }, { "id": "1.0alpha7.train.1375.ent1_0", "type": "protein-domain", "text": [ "GBD" ], "offsets": [ [ 58, 61 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR010473" } ] }, { "id": "1.0alpha7.train.1375.ent2_0", "type": "protein", "text": [ "Drf3" ], "offsets": [ [ 66, 70 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "81624" }, { "db_name": "hgnc", "db_id": "DIAPH3" }, { "db_name": "uniprot", "db_id": "Q9NSV4" } ] }, { "id": "1.0alpha7.train.1375.ent3_0", "type": "assay", "text": [ "two-hybrid" ], "offsets": [ [ 74, 84 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1375.ent4_0", "type": "protein", "text": [ "Cdc42" ], "offsets": [ [ 38, 43 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "998" }, { "db_name": "hgnc", "db_id": "CDC42" }, { "db_name": "uniprot", "db_id": "P60953" } ] } ]
[]
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1.0alpha7.train.1376
15053100
[ { "id": "1.0alpha7.train.1376.sent", "type": "sentence", "text": [ " To map the region of PCL that binds RPD3, we in vitro translated different parts of PCL and tested their ability to bind to GST-RPD3. " ], "offsets": [ [ 0, 140 ] ] } ]
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[]
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1.0alpha7.train.1377
584275
[ { "id": "1.0alpha7.train.1377.sent", "type": "sentence", "text": [ " C3G did not bind to either Grb2, Shc, or Crk in vivo. " ], "offsets": [ [ 0, 61 ] ] } ]
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[]
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1.0alpha7.train.1378
20252333
[ { "id": "1.0alpha7.train.1378.sent", "type": "sentence", "text": [ "Xenopus TCF3 binds to the distal Tcf-motif in the myf-5 gene in vitro." ], "offsets": [ [ 0, 73 ] ] } ]
[ { "id": "1.0alpha7.train.1378.ent0_0", "type": "DNA", "text": [ "myf-5 gene" ], "offsets": [ [ 53, 63 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1378.ent1_0", "type": "DNA", "text": [ "Tcf-motif" ], "offsets": [ [ 34, 43 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1378.ent2_0", "type": "protein", "text": [ "TCF3" ], "offsets": [ [ 8, 12 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6929" }, { "db_name": "hgnc", "db_id": "TCF3" } ] }, { "id": "1.0alpha7.train.1378.ent3_0", "type": "organism", "text": [ "Xenopus" ], "offsets": [ [ 0, 7 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.1378.coref0", "entity_ids": [ "1.0alpha7.train.1378.ent0_0" ] }, { "id": "1.0alpha7.train.1378.coref1", "entity_ids": [ "1.0alpha7.train.1378.ent1_0" ] }, { "id": "1.0alpha7.train.1378.coref2", "entity_ids": [ "1.0alpha7.train.1378.ent2_0" ] }, { "id": "1.0alpha7.train.1378.coref3", "entity_ids": [ "1.0alpha7.train.1378.ent3_0" ] } ]
[ { "id": "1.0alpha7.train.1378.rel0s1.0alpha7.train.1378.ent1_0.o1.0alpha7.train.1378.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.1378.ent1_0", "arg2_id": "1.0alpha7.train.1378.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.1378.rel1s1.0alpha7.train.1378.ent0_0.o1.0alpha7.train.1378.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.1378.ent0_0", "arg2_id": "1.0alpha7.train.1378.ent2_0", "normalized": [] } ]
1.0alpha7.train.1379
4156491
[ { "id": "1.0alpha7.train.1379.sent", "type": "sentence", "text": [ "CEP2 and CEP5 bind to Cdc42." ], "offsets": [ [ 0, 30 ] ] } ]
[ { "id": "1.0alpha7.train.1379.ent0_0", "type": "protein", "text": [ "CEP2" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "11190" }, { "db_name": "hgnc", "db_id": "CEP250" }, { "db_name": "uniprot", "db_id": "Q9BV73" } ] }, { "id": "1.0alpha7.train.1379.ent1_0", "type": "protein", "text": [ "CEP5" ], "offsets": [ [ 10, 14 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "148170" }, { "db_name": "hgnc", "db_id": "CDC42EP5" }, { "db_name": "uniprot", "db_id": "Q6NZY7" } ] }, { "id": "1.0alpha7.train.1379.ent2_0", "type": "protein", "text": [ "Cdc42" ], "offsets": [ [ 24, 29 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "998" }, { "db_name": "hgnc", "db_id": "CDC42" }, { "db_name": "uniprot", "db_id": "P60953" } ] } ]
[]
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[ { "id": "1.0alpha7.train.1379.rel0s1.0alpha7.train.1379.ent0_0.o1.0alpha7.train.1379.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.1379.ent0_0", "arg2_id": "1.0alpha7.train.1379.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.1379.rel1s1.0alpha7.train.1379.ent1_0.o1.0alpha7.train.1379.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.1379.ent1_0", "arg2_id": "1.0alpha7.train.1379.ent2_0", "normalized": [] } ]
1.0alpha7.train.1380
9014586
[ { "id": "1.0alpha7.train.1380.sent", "type": "sentence", "text": [ "Cytochrome c binds to Apaf-1 and in the presence of dATP/ATP promotes assembly of the apoptosome. " ], "offsets": [ [ 0, 98 ] ] } ]
[ { "id": "1.0alpha7.train.1380.ent0_0", "type": "protein", "text": [ "Apaf-1" ], "offsets": [ [ 22, 28 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "317" }, { "db_name": "hgnc", "db_id": "APAF1" }, { "db_name": "uniprot", "db_id": "O14727" } ] }, { "id": "1.0alpha7.train.1380.ent1_0", "type": "chemical", "text": [ "dATP" ], "offsets": [ [ 52, 56 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "15993" } ] }, { "id": "1.0alpha7.train.1380.ent2_0", "type": "protein-complex", "text": [ "Cytochrome c" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1380.ent3_0", "type": "chemical", "text": [ "ATP" ], "offsets": [ [ 57, 60 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5957" } ] }, { "id": "1.0alpha7.train.1380.ent4_0", "type": "protein-complex", "text": [ "apoptosome" ], "offsets": [ [ 86, 96 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.1380.coref0", "entity_ids": [ "1.0alpha7.train.1380.ent0_0" ] }, { "id": "1.0alpha7.train.1380.coref1", "entity_ids": [ "1.0alpha7.train.1380.ent1_0" ] }, { "id": "1.0alpha7.train.1380.coref2", "entity_ids": [ "1.0alpha7.train.1380.ent2_0" ] }, { "id": "1.0alpha7.train.1380.coref3", "entity_ids": [ "1.0alpha7.train.1380.ent3_0" ] }, { "id": "1.0alpha7.train.1380.coref4", "entity_ids": [ "1.0alpha7.train.1380.ent4_0" ] } ]
[ { "id": "1.0alpha7.train.1380.rel0s1.0alpha7.train.1380.ent0_0.o1.0alpha7.train.1380.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.1380.ent0_0", "arg2_id": "1.0alpha7.train.1380.ent2_0", "normalized": [] } ]
1.0alpha7.train.1381
9041585
[ { "id": "1.0alpha7.train.1381.sent", "type": "sentence", "text": [ "dTCF binds a canonical TCF DNA motif and interacts with the beta-catenin homolog Armadillo." ], "offsets": [ [ 0, 94 ] ] } ]
[ { "id": "1.0alpha7.train.1381.ent0_0", "type": "protein", "text": [ "beta-catenin" ], "offsets": [ [ 63, 75 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1499" }, { "db_name": "hgnc", "db_id": "CTNNB1" }, { "db_name": "uniprot", "db_id": "P35222" } ] }, { "id": "1.0alpha7.train.1381.ent1_0", "type": "protein", "text": [ "dTCF" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P91943" } ] }, { "id": "1.0alpha7.train.1381.ent2_0", "type": "protein-motif", "text": [ "Armadillo" ], "offsets": [ [ 84, 93 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000225" } ] }, { "id": "1.0alpha7.train.1381.ent3_0", "type": "DNA", "text": [ "TCF DNA motif" ], "offsets": [ [ 24, 38 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.1381.coref0", "entity_ids": [ "1.0alpha7.train.1381.ent0_0" ] }, { "id": "1.0alpha7.train.1381.coref1", "entity_ids": [ "1.0alpha7.train.1381.ent1_0" ] }, { "id": "1.0alpha7.train.1381.coref2", "entity_ids": [ "1.0alpha7.train.1381.ent2_0" ] }, { "id": "1.0alpha7.train.1381.coref3", "entity_ids": [ "1.0alpha7.train.1381.ent3_0" ] } ]
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1.0alpha7.train.1382
7092210
[ { "id": "1.0alpha7.train.1382.sent", "type": "sentence", "text": [ "TAFII250 binds to GST-TAT but not to GST or GST-Snap23" ], "offsets": [ [ 0, 54 ] ] } ]
[ { "id": "1.0alpha7.train.1382.ent0_0", "type": "protein", "text": [ "TAT" ], "offsets": [ [ 22, 25 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6898" }, { "db_name": "hgnc", "db_id": "TAT" }, { "db_name": "uniprot", "db_id": "P17735" } ] }, { "id": "1.0alpha7.train.1382.ent1_0", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 18, 21 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] }, { "id": "1.0alpha7.train.1382.ent2_1", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 37, 40 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] }, { "id": "1.0alpha7.train.1382.ent3_2", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 44, 47 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] }, { "id": "1.0alpha7.train.1382.ent4_0", "type": "protein", "text": [ "Snap23" ], "offsets": [ [ 48, 54 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8773" }, { "db_name": "hgnc", "db_id": "SNAP23" }, { "db_name": "uniprot", "db_id": "O00161" } ] }, { "id": "1.0alpha7.train.1382.ent5_0", "type": "protein", "text": [ "TAFII250" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P51123" } ] }, { "id": "1.0alpha7.train.1382.ent6_0", "type": "experimental-construct", "text": [ "GST-Snap23" ], "offsets": [ [ 44, 54 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1382.ent7_0", "type": "experimental-construct", "text": [ "GST-TAT" ], "offsets": [ [ 18, 25 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.1382.coref0", "entity_ids": [ "1.0alpha7.train.1382.ent0_0" ] }, { "id": "1.0alpha7.train.1382.coref1", "entity_ids": [ "1.0alpha7.train.1382.ent1_0", "1.0alpha7.train.1382.ent2_1", "1.0alpha7.train.1382.ent3_2" ] }, { "id": "1.0alpha7.train.1382.coref2", "entity_ids": [ "1.0alpha7.train.1382.ent4_0" ] }, { "id": "1.0alpha7.train.1382.coref3", "entity_ids": [ "1.0alpha7.train.1382.ent5_0" ] }, { "id": "1.0alpha7.train.1382.coref4", "entity_ids": [ "1.0alpha7.train.1382.ent6_0" ] }, { "id": "1.0alpha7.train.1382.coref5", "entity_ids": [ "1.0alpha7.train.1382.ent7_0" ] } ]
[ { "id": "1.0alpha7.train.1382.rel0s1.0alpha7.train.1382.ent5_0.o1.0alpha7.train.1382.ent7_0", "type": "bind", "arg1_id": "1.0alpha7.train.1382.ent5_0", "arg2_id": "1.0alpha7.train.1382.ent7_0", "normalized": [] }, { "id": "1.0alpha7.train.1382.rel1s1.0alpha7.train.1382.ent1_0.o1.0alpha7.train.1382.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.1382.ent1_0", "arg2_id": "1.0alpha7.train.1382.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.1382.rel1s1.0alpha7.train.1382.ent2_1.o1.0alpha7.train.1382.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.1382.ent2_1", "arg2_id": "1.0alpha7.train.1382.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.1382.rel1s1.0alpha7.train.1382.ent3_2.o1.0alpha7.train.1382.ent5_0", "type": "bind", "arg1_id": "1.0alpha7.train.1382.ent3_2", "arg2_id": "1.0alpha7.train.1382.ent5_0", "normalized": [] }, { "id": "1.0alpha7.train.1382.rel2s1.0alpha7.train.1382.ent5_0.o1.0alpha7.train.1382.ent6_0", "type": "bind", "arg1_id": "1.0alpha7.train.1382.ent5_0", "arg2_id": "1.0alpha7.train.1382.ent6_0", "normalized": [] } ]
1.0alpha7.train.1383
21945746
[ { "id": "1.0alpha7.train.1383.sent", "type": "sentence", "text": [ "HIP1 and HIP12 Display Differential Binding to F-actin, AP2, and Clathrin" ], "offsets": [ [ 0, 73 ] ] } ]
[ { "id": "1.0alpha7.train.1383.ent0_0", "type": "protein", "text": [ "F-actin" ], "offsets": [ [ 47, 54 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1383.ent1_0", "type": "protein-complex", "text": [ "AP2" ], "offsets": [ [ 56, 59 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1383.ent2_0", "type": "protein", "text": [ "Clathrin" ], "offsets": [ [ 65, 73 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1211" }, { "db_name": "hgnc", "db_id": "CLTA" }, { "db_name": "uniprot", "db_id": "P09496" } ] }, { "id": "1.0alpha7.train.1383.ent3_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 49, 54 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR004000" } ] }, { "id": "1.0alpha7.train.1383.ent4_0", "type": "protein", "text": [ "HIP1" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3092" }, { "db_name": "hgnc", "db_id": "HIP1" } ] }, { "id": "1.0alpha7.train.1383.ent5_0", "type": "protein", "text": [ "HIP12" ], "offsets": [ [ 9, 14 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "9026" }, { "db_name": "hgnc", "db_id": "HIP1R" }, { "db_name": "uniprot", "db_id": "O75146" } ] } ]
[]
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1.0alpha7.train.1384
9858316
[ { "id": "1.0alpha7.train.1384.sent", "type": "sentence", "text": [ " p120ctn inhibits Rho ( Anastasiadis et al., 2000; Noren et al., 2000), and cadherin binding to p120ctn functions as a regulator of adhesion through Rho GTPases ( Anastasiadis and Reynolds, 2001). " ], "offsets": [ [ 0, 202 ] ] } ]
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[]
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1.0alpha7.train.1385
2164935
[ { "id": "1.0alpha7.train.1385.sent", "type": "sentence", "text": [ " A, Diva binds to Apaf-1 as a competitor of Bcl-XL. " ], "offsets": [ [ 0, 56 ] ] } ]
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[]
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1.0alpha7.train.1386
15090723
[ { "id": "1.0alpha7.train.1386.sent", "type": "sentence", "text": [ " Bcr increases binding of AF-6 to Ras, and an exchange of Thr 893 to Val reduces this interaction. " ], "offsets": [ [ 0, 104 ] ] } ]
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[]
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1.0alpha7.train.1387
3714120
[ { "id": "1.0alpha7.train.1387.sent", "type": "sentence", "text": [ "p62 binds directly to Arp1." ], "offsets": [ [ 0, 28 ] ] } ]
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[]
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1.0alpha7.train.1388
9615346
[ { "id": "1.0alpha7.train.1388.sent", "type": "sentence", "text": [ "The Binding of PIX and PAK to Paxillin Is Mediated by p95PKL" ], "offsets": [ [ 0, 60 ] ] } ]
[ { "id": "1.0alpha7.train.1388.ent0_0", "type": "protein", "text": [ "PIX" ], "offsets": [ [ 15, 18 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1388.ent1_0", "type": "protein-family", "text": [ "PAK" ], "offsets": [ [ 23, 26 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5058" }, { "db_name": "hgnc", "db_id": "PAK1" }, { "db_name": "uniprot", "db_id": "Q13153" } ] }, { "id": "1.0alpha7.train.1388.ent2_0", "type": "protein", "text": [ "Paxillin" ], "offsets": [ [ 30, 38 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5829" }, { "db_name": "hgnc", "db_id": "PXN" }, { "db_name": "uniprot", "db_id": "P49023" } ] }, { "id": "1.0alpha7.train.1388.ent3_0", "type": "protein", "text": [ "p95PKL" ], "offsets": [ [ 54, 60 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1389
25166666
[ { "id": "1.0alpha7.train.1389.sent", "type": "sentence", "text": [ "TRP Binds to Calmodulin in a Gel Overlay Assay" ], "offsets": [ [ 0, 46 ] ] } ]
[ { "id": "1.0alpha7.train.1389.ent0_0", "type": "protein-family", "text": [ "TRP" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "1.0alpha7.train.1389.ent1_0", "type": "protein", "text": [ "Calmodulin" ], "offsets": [ [ 13, 23 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "801" }, { "db_name": "hgnc", "db_id": "CALM1" }, { "db_name": "uniprot", "db_id": "P0DP23" } ] }, { "id": "1.0alpha7.train.1389.ent2_0", "type": "assay", "text": [ "Gel Overlay Assay" ], "offsets": [ [ 29, 46 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1390
3099142
[ { "id": "1.0alpha7.train.1390.sent", "type": "sentence", "text": [ "SLB binds to Lhx3 and Lhx4 both in vitro and in vivo." ], "offsets": [ [ 0, 57 ] ] } ]
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[]
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1.0alpha7.train.1391
1419954
[ { "id": "1.0alpha7.train.1391.sent", "type": "sentence", "text": [ "IL-2 induced DNA binding of STAT3 and STAT5 is clearly discernible within 1 min of exposure to the cytokine and maximal by 10 min (Fig. 1 A)." ], "offsets": [ [ 0, 145 ] ] } ]
[ { "id": "1.0alpha7.train.1391.ent0_0", "type": "protein", "text": [ "STAT3" ], "offsets": [ [ 29, 34 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6774" }, { "db_name": "hgnc", "db_id": "STAT3" } ] }, { "id": "1.0alpha7.train.1391.ent1_0", "type": "protein", "text": [ "STAT5" ], "offsets": [ [ 40, 45 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6776" }, { "db_name": "hgnc", "db_id": "STAT5A" }, { "db_name": "uniprot", "db_id": "P42229" } ] }, { "id": "1.0alpha7.train.1391.ent2_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 13, 16 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.1391.ent3_0", "type": "protein", "text": [ "IL-2" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3558" }, { "db_name": "hgnc", "db_id": "IL2" }, { "db_name": "uniprot", "db_id": "P60568" } ] } ]
[]
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1.0alpha7.train.1392
12543909
[ { "id": "1.0alpha7.train.1392.sent", "type": "sentence", "text": [ "Emi1 binds Cdh1 and inhibits APCCdh1 activity" ], "offsets": [ [ 0, 45 ] ] } ]
[ { "id": "1.0alpha7.train.1392.ent0_0", "type": "protein", "text": [ "Emi1" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "26271" }, { "db_name": "hgnc", "db_id": "FBXO5" }, { "db_name": "uniprot", "db_id": "Q9UKT4" } ] }, { "id": "1.0alpha7.train.1392.ent1_0", "type": "protein", "text": [ "Cdh1" ], "offsets": [ [ 11, 15 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "999" }, { "db_name": "hgnc", "db_id": "CDH1" }, { "db_name": "uniprot", "db_id": "P12830" } ] }, { "id": "1.0alpha7.train.1392.ent2_0", "type": "protein", "text": [ "APCCdh1" ], "offsets": [ [ 29, 36 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.1393
12683804
[ { "id": "1.0alpha7.train.1393.sent", "type": "sentence", "text": [ "Gro binds Rpd3 in vitro and in vivo" ], "offsets": [ [ 0, 35 ] ] } ]
[ { "id": "1.0alpha7.train.1393.ent0_0", "type": "protein", "text": [ "Gro" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2919" }, { "db_name": "hgnc", "db_id": "CXCL1" }, { "db_name": "uniprot", "db_id": "P09341" } ] }, { "id": "1.0alpha7.train.1393.ent1_0", "type": "protein", "text": [ "Rpd3" ], "offsets": [ [ 10, 14 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q94517" } ] } ]
[]
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1.0alpha7.train.1394
6065793
[ { "id": "1.0alpha7.train.1394.sent", "type": "sentence", "text": [ "Plexin-B1 C terminus binds the PDZ domain of LARG." ], "offsets": [ [ 0, 52 ] ] } ]
[ { "id": "1.0alpha7.train.1394.ent0_0", "type": "protein", "text": [ "LARG" ], "offsets": [ [ 47, 51 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "23365" }, { "db_name": "hgnc", "db_id": "ARHGEF12" }, { "db_name": "uniprot", "db_id": "Q9NZN5" } ] }, { "id": "1.0alpha7.train.1394.ent1_0", "type": "protein", "text": [ "Plexin-B1" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5364" }, { "db_name": "hgnc", "db_id": "PLXNB1" }, { "db_name": "uniprot", "db_id": "O43157" } ] }, { "id": "1.0alpha7.train.1394.ent2_0", "type": "protein-domain", "text": [ "PDZ" ], "offsets": [ [ 32, 35 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR001478" } ] } ]
[]
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1.0alpha7.train.1395
11295190
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[]
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1.0alpha7.train.1396
9407176
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[]
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1.0alpha7.train.1397
15773808
[ { "id": "1.0alpha7.train.1397.sent", "type": "sentence", "text": [ "Binding of Hairy derivatives to Gro in vitro." ], "offsets": [ [ 0, 45 ] ] } ]
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[]
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1.0alpha7.train.1398
9541952
[ { "id": "1.0alpha7.train.1398.sent", "type": "sentence", "text": [ "GBP binding to Xgsk-3 may block access of protein substrates to the active site ( Fig 7 b)." ], "offsets": [ [ 0, 92 ] ] } ]
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[]
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1.0alpha7.train.1399
2748028
[ { "id": "1.0alpha7.train.1399.sent", "type": "sentence", "text": [ "Binding of biotinylated NCS-1 and calmodulin to calcineurin." ], "offsets": [ [ 0, 65 ] ] } ]
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[]
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